目的:观察益气养阴活血汤对冠状动脉粥样硬化性心脏病介入治疗术后患者血脂水平的影响。方法:选取2014年2月至2016年4月本院收治入院的行介入治疗的冠状动脉粥样硬化性心脏病患者80例,随机分为对照组和治疗组,每组各40例。对照组给予瑞...目的:观察益气养阴活血汤对冠状动脉粥样硬化性心脏病介入治疗术后患者血脂水平的影响。方法:选取2014年2月至2016年4月本院收治入院的行介入治疗的冠状动脉粥样硬化性心脏病患者80例,随机分为对照组和治疗组,每组各40例。对照组给予瑞舒伐他汀,治疗组在对照组的基础上联合益气养阴活血汤。观察两组患者治疗前后血脂水平[三酰甘油(three acyl glycerol,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白(high density lipoprotein,HDL)及低密度脂蛋白(low density lipoprotein,LDL)]变化、心脏缺血事件发生情况及不良反应情况。结果:两组患者治疗后TC及LDL-C水平低于治疗前,且治疗组低于对照组,差异具有统计学意义(P<0.05)。对照组心脏缺血发生率为45.0%,治疗组心脏缺血发生率为10.0%,两组患者心脏缺血发生率比较,差异具有统计学意义(P<0.05)。对照组不良反应发生率为5.0%,治疗组不良反应发生率为27.5%,两组患者不良反应发生率比较,差异具有统计学意义(P<0.05)。结论:益气养阴活血汤运用于冠状动脉粥样硬化性心脏病介入治疗后,能够有效改善患者TC、LDL-C水平,还可有效避免心脏缺血及不良反应发生率。展开更多
OBJECTIVE: To investigate the effect of Daiqin phlegm-expelling pill, prepared with Traditional Chinese Medicine(TCM), on the development of inflammation in Sprague-Dawley(SD) rats with chronic obstructive pulmonary d...OBJECTIVE: To investigate the effect of Daiqin phlegm-expelling pill, prepared with Traditional Chinese Medicine(TCM), on the development of inflammation in Sprague-Dawley(SD) rats with chronic obstructive pulmonary disease(COPD) induced by lipopolysaccharide(LPS) and smoke, and to identity the possible underlying mechanism.METHODS: Sixty male rats were divided into 6 groups(healthy control group, untreated group,Daiqin phlegm-expelling pill low, middle and high dose, and ambroxol hydrochloride tablet group).COPD was established in SD rats by sootiness and tracheal instillation with LPS. The rats were treated with Daiqin phlegm-expelling pill at the indicated doses for 28 d, the inflammatory cells in bronchoalveolar lavage fluid(BALF), the concentration of tumor necrosis factor-α(TNF-α), interleukin(IL)-8 and IL-6 in blood and the inflammation in lung were evaluated.RESULTS: The number of inflammatory cells in the BALF and TNF-ficantly redα, IL-8 and IL-6 level in plasma were signiuced in rats with COPD when treated with Daiqin phlegm-expelling pill or ambroxol hydrochloride tablet, compared with those without any treatment. The Daiqin phlegm-expelling pill treated rats with COPD had a attenuated inflammation in lung tissue, compared with the untreated group.CONCLUSION: Daiqin phlegm-expelling pill can significantly restrain the airway inflammation in rats with LPS-smoke induced COPD.展开更多
文摘目的:观察益气养阴活血汤对冠状动脉粥样硬化性心脏病介入治疗术后患者血脂水平的影响。方法:选取2014年2月至2016年4月本院收治入院的行介入治疗的冠状动脉粥样硬化性心脏病患者80例,随机分为对照组和治疗组,每组各40例。对照组给予瑞舒伐他汀,治疗组在对照组的基础上联合益气养阴活血汤。观察两组患者治疗前后血脂水平[三酰甘油(three acyl glycerol,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白(high density lipoprotein,HDL)及低密度脂蛋白(low density lipoprotein,LDL)]变化、心脏缺血事件发生情况及不良反应情况。结果:两组患者治疗后TC及LDL-C水平低于治疗前,且治疗组低于对照组,差异具有统计学意义(P<0.05)。对照组心脏缺血发生率为45.0%,治疗组心脏缺血发生率为10.0%,两组患者心脏缺血发生率比较,差异具有统计学意义(P<0.05)。对照组不良反应发生率为5.0%,治疗组不良反应发生率为27.5%,两组患者不良反应发生率比较,差异具有统计学意义(P<0.05)。结论:益气养阴活血汤运用于冠状动脉粥样硬化性心脏病介入治疗后,能够有效改善患者TC、LDL-C水平,还可有效避免心脏缺血及不良反应发生率。
基金Natural Science Foundation of Jiangsu Province(No.BK20171098)Jiangsu Province 12th Five-Year Plan for the construction of Key Traditional Chinese Medicine Discipline(No.JS1302)Project of Affiliated Hospital of Nanjing University of Traditional Chinese Medicine(No.Y17002)
文摘OBJECTIVE: To investigate the effect of Daiqin phlegm-expelling pill, prepared with Traditional Chinese Medicine(TCM), on the development of inflammation in Sprague-Dawley(SD) rats with chronic obstructive pulmonary disease(COPD) induced by lipopolysaccharide(LPS) and smoke, and to identity the possible underlying mechanism.METHODS: Sixty male rats were divided into 6 groups(healthy control group, untreated group,Daiqin phlegm-expelling pill low, middle and high dose, and ambroxol hydrochloride tablet group).COPD was established in SD rats by sootiness and tracheal instillation with LPS. The rats were treated with Daiqin phlegm-expelling pill at the indicated doses for 28 d, the inflammatory cells in bronchoalveolar lavage fluid(BALF), the concentration of tumor necrosis factor-α(TNF-α), interleukin(IL)-8 and IL-6 in blood and the inflammation in lung were evaluated.RESULTS: The number of inflammatory cells in the BALF and TNF-ficantly redα, IL-8 and IL-6 level in plasma were signiuced in rats with COPD when treated with Daiqin phlegm-expelling pill or ambroxol hydrochloride tablet, compared with those without any treatment. The Daiqin phlegm-expelling pill treated rats with COPD had a attenuated inflammation in lung tissue, compared with the untreated group.CONCLUSION: Daiqin phlegm-expelling pill can significantly restrain the airway inflammation in rats with LPS-smoke induced COPD.
