[Objectives]To explore the effectiveness and safety of Yinma Zhisou Decoction in the treatment of AECOPD with phlegm-heat obstructing lung syndrome,and observe the symptoms of Yinma Zhisou decoction in the treatment o...[Objectives]To explore the effectiveness and safety of Yinma Zhisou Decoction in the treatment of AECOPD with phlegm-heat obstructing lung syndrome,and observe the symptoms of Yinma Zhisou decoction in the treatment of AECOPD patients with phlegm-heat stagnation lung syndrome improvement,inflammatory indicators,lung function,blood gas analysis,etc.[Methods]A total of 92 cases who met the inclusion criteria and exclusion criteria were included in the study according to 1∶1 were randomly divided into treatment group and control group,control group with conventional Western medicine treatment,the treatment group on the basis of control group with Yinma Zhisou decoction treatment,a course of 10 d.The changes in TCM syndrome score,arterial blood gas analysis,pulmonary function,serum inflammatory indicator,mMRC score,and the CAT scores between the two groups after treatment were observed.All collected data were statistically analyzed with SPSS 26.0.[Results](i)Comparison of the curative effect between the two groups.After treatment,the total effective rate of the treatment group was 93.5%,which was higher than that of the control group(76.1%,P<0.05).The curative effect of the treatment group was better than that of the control group(P<0.05).(ii)Comparison of single TCM symptom scores.After treatment,the single TCM symptom scores of the two groups were lower than before(P<0.05),but the improvement of wheezing,cough,phlegm and chest pain in the treatment group was better than that in the control group(P<0.05).There was no significant difference in the improvement of wheezing sound(P>0.05),but there was a trend of difference.(iii)Comparison of mMRC score and CAT score between the two groups.After treatment,the mMRC score and CAT score of the two groups were significantly improved(P<0.05),and the difference was statistically significant.(iv)Comparison of blood gas analysis indicators between the two groups.Intra-group comparison after treatment:PaOof the control group and the treatment group after treatment was significantly improved compared with that before treatment(P<0.05),and the difference was statistically significant.Comparison between the two groups after treatment:PaOand PaCOof the two groups after treatment(P>0.05),and the difference was not statistically significant.It indicated that Yinma Zhisou decoction had more advantages in improving hypoxia.(v)Comparison of pulmonary function between the two groups.After treatment,the FEV1/FVC of the treatment group and the control group was significantly different(P<0.05),and there was a statistical difference(P<0.05).(vi)Comparison of inflammatory indicators between the two groups.Intra-group comparison after treatment:the inflammatory indicators WBC,CRP and PCT in the control group and the treatment group were significantly lower than before treatment(P<0.05),and the differences were statistically significant.It indicated that Yinma Zhisou decoction could effectively control inflammation and reduce inflammation reaction.[Conclusions]Compared with the control group,Yinma Zhisou decoction has obvious advantages in improving cough,expectoration and wheezing,and can significantly improve the total effective rate.Compared with Western medicine alone,Yinma Zhisou decoction can significantly improve patients’hypoxia,reduce mMRC and CAT scores,improve body activity tolerance,improve airway symptoms,and significantly reduce WBC,CRP,PCT and other serum inflammatory indicators.It can be seen that Yinma Zhisou decoction combined with Western medicine treatment is obviously better than simple Western medicine treatment,the curative effect is better,and the safety is better,and there are no serious adverse reactions in the course of the trial.展开更多
目的:观察二陈平胃散和三子养亲汤加减治疗痰湿蕴肺型咳嗽的临床疗效。方法:将痰湿蕴肺型咳嗽患者90例随机分为对照组(西药治疗)和试验组(加用二陈平胃散和三子养亲汤加减)各45例。观察两组患者肺机能恢复情况、呼吸困难程度、咳嗽症状...目的:观察二陈平胃散和三子养亲汤加减治疗痰湿蕴肺型咳嗽的临床疗效。方法:将痰湿蕴肺型咳嗽患者90例随机分为对照组(西药治疗)和试验组(加用二陈平胃散和三子养亲汤加减)各45例。观察两组患者肺机能恢复情况、呼吸困难程度、咳嗽症状、视觉模拟量表(visual analog scale,VAS)评分、生活质量及唾液分泌型免疫球蛋白A(secreted immunoglobulin A,SIgA)水平。结果:治疗后试验组、对照组显效率分别为82.2%、60.0%,差异有统计学意义(P<0.05)。两组患者治疗后呼吸困难程度、生存质量、VAS评分、咳嗽症状评分与治疗前比较差异有统计学意义(P<0.05),试验组低于对照组(P<0.05)。治疗后两组患者唾液sIgA水平与治疗前比较差异有统计学意义(P<0.05),试验组高于对照组(P<0.05)。结论:二陈平胃散和三子养亲汤加减联合西药能改善痰湿蕴肺型咳嗽患者临床症状、呼吸困难、生存质量及免疫功能,效果优于单纯西药治疗。展开更多
基金Supported by Applied Technology Research and Development Project of Nanchong Science and Technology Bureau(19YFZJ0007)Research Project of Sichuan Provincial Administration of Chinese Medicine(2020LC0150)。
文摘[Objectives]To explore the effectiveness and safety of Yinma Zhisou Decoction in the treatment of AECOPD with phlegm-heat obstructing lung syndrome,and observe the symptoms of Yinma Zhisou decoction in the treatment of AECOPD patients with phlegm-heat stagnation lung syndrome improvement,inflammatory indicators,lung function,blood gas analysis,etc.[Methods]A total of 92 cases who met the inclusion criteria and exclusion criteria were included in the study according to 1∶1 were randomly divided into treatment group and control group,control group with conventional Western medicine treatment,the treatment group on the basis of control group with Yinma Zhisou decoction treatment,a course of 10 d.The changes in TCM syndrome score,arterial blood gas analysis,pulmonary function,serum inflammatory indicator,mMRC score,and the CAT scores between the two groups after treatment were observed.All collected data were statistically analyzed with SPSS 26.0.[Results](i)Comparison of the curative effect between the two groups.After treatment,the total effective rate of the treatment group was 93.5%,which was higher than that of the control group(76.1%,P<0.05).The curative effect of the treatment group was better than that of the control group(P<0.05).(ii)Comparison of single TCM symptom scores.After treatment,the single TCM symptom scores of the two groups were lower than before(P<0.05),but the improvement of wheezing,cough,phlegm and chest pain in the treatment group was better than that in the control group(P<0.05).There was no significant difference in the improvement of wheezing sound(P>0.05),but there was a trend of difference.(iii)Comparison of mMRC score and CAT score between the two groups.After treatment,the mMRC score and CAT score of the two groups were significantly improved(P<0.05),and the difference was statistically significant.(iv)Comparison of blood gas analysis indicators between the two groups.Intra-group comparison after treatment:PaOof the control group and the treatment group after treatment was significantly improved compared with that before treatment(P<0.05),and the difference was statistically significant.Comparison between the two groups after treatment:PaOand PaCOof the two groups after treatment(P>0.05),and the difference was not statistically significant.It indicated that Yinma Zhisou decoction had more advantages in improving hypoxia.(v)Comparison of pulmonary function between the two groups.After treatment,the FEV1/FVC of the treatment group and the control group was significantly different(P<0.05),and there was a statistical difference(P<0.05).(vi)Comparison of inflammatory indicators between the two groups.Intra-group comparison after treatment:the inflammatory indicators WBC,CRP and PCT in the control group and the treatment group were significantly lower than before treatment(P<0.05),and the differences were statistically significant.It indicated that Yinma Zhisou decoction could effectively control inflammation and reduce inflammation reaction.[Conclusions]Compared with the control group,Yinma Zhisou decoction has obvious advantages in improving cough,expectoration and wheezing,and can significantly improve the total effective rate.Compared with Western medicine alone,Yinma Zhisou decoction can significantly improve patients’hypoxia,reduce mMRC and CAT scores,improve body activity tolerance,improve airway symptoms,and significantly reduce WBC,CRP,PCT and other serum inflammatory indicators.It can be seen that Yinma Zhisou decoction combined with Western medicine treatment is obviously better than simple Western medicine treatment,the curative effect is better,and the safety is better,and there are no serious adverse reactions in the course of the trial.
文摘目的:观察二陈平胃散和三子养亲汤加减治疗痰湿蕴肺型咳嗽的临床疗效。方法:将痰湿蕴肺型咳嗽患者90例随机分为对照组(西药治疗)和试验组(加用二陈平胃散和三子养亲汤加减)各45例。观察两组患者肺机能恢复情况、呼吸困难程度、咳嗽症状、视觉模拟量表(visual analog scale,VAS)评分、生活质量及唾液分泌型免疫球蛋白A(secreted immunoglobulin A,SIgA)水平。结果:治疗后试验组、对照组显效率分别为82.2%、60.0%,差异有统计学意义(P<0.05)。两组患者治疗后呼吸困难程度、生存质量、VAS评分、咳嗽症状评分与治疗前比较差异有统计学意义(P<0.05),试验组低于对照组(P<0.05)。治疗后两组患者唾液sIgA水平与治疗前比较差异有统计学意义(P<0.05),试验组高于对照组(P<0.05)。结论:二陈平胃散和三子养亲汤加减联合西药能改善痰湿蕴肺型咳嗽患者临床症状、呼吸困难、生存质量及免疫功能,效果优于单纯西药治疗。
