Diphenyl diamine-based phosphonyl imines attached by the N-isopropyl group in the auxiliary have been synthesized in good yields under convenient reaction conditions.These new chiral N-phosphonyl imines can react with...Diphenyl diamine-based phosphonyl imines attached by the N-isopropyl group in the auxiliary have been synthesized in good yields under convenient reaction conditions.These new chiral N-phosphonyl imines can react with glycine enolate smoothly to give chiral α-β diamino esters in good yields(72%-90%) and up to excellent diastereoselectivity(>99:1 dr).By treatment with HBr,the chiral auxiliary can be readily removed.The absolute structure has been unambiguously determined by converting a product to a known sample.展开更多
This paper presents nine novel pyrethroids containing phosphorous and five new phos- phorous ylids.A new synthetic route of β-substituted vinyl(thio)phosphonate having E configura- tion have been developed.The compou...This paper presents nine novel pyrethroids containing phosphorous and five new phos- phorous ylids.A new synthetic route of β-substituted vinyl(thio)phosphonate having E configura- tion have been developed.The compound li exhibited moderate insecticidal activities against Culex mosquitoes and Army worm.展开更多
Antigen 12, containing a phosphonyl peptide hapten with free C-terminal carboxylic group, was synthesized by 11 reaction steps. The design of the hapten was based on the transition state of peptide hydrolysis catalyze...Antigen 12, containing a phosphonyl peptide hapten with free C-terminal carboxylic group, was synthesized by 11 reaction steps. The design of the hapten was based on the transition state of peptide hydrolysis catalyzed by carboxypeptidase A.展开更多
基金supported by the National Institutes of Health (Grant Nos.1 RO3 DA026960-01)Robert Welch Foundation (Grant No.D-1361)
文摘Diphenyl diamine-based phosphonyl imines attached by the N-isopropyl group in the auxiliary have been synthesized in good yields under convenient reaction conditions.These new chiral N-phosphonyl imines can react with glycine enolate smoothly to give chiral α-β diamino esters in good yields(72%-90%) and up to excellent diastereoselectivity(>99:1 dr).By treatment with HBr,the chiral auxiliary can be readily removed.The absolute structure has been unambiguously determined by converting a product to a known sample.
文摘This paper presents nine novel pyrethroids containing phosphorous and five new phos- phorous ylids.A new synthetic route of β-substituted vinyl(thio)phosphonate having E configura- tion have been developed.The compound li exhibited moderate insecticidal activities against Culex mosquitoes and Army worm.
基金supported by the National Natural Science Foundation of China(20773089)Scientific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Education,China(20071108-18-15)~~
文摘Antigen 12, containing a phosphonyl peptide hapten with free C-terminal carboxylic group, was synthesized by 11 reaction steps. The design of the hapten was based on the transition state of peptide hydrolysis catalyzed by carboxypeptidase A.
基金supported by the National Natural Science Foundation of China (21403022,21572226)the Natural Science Foundation of Liaoning Province of China (2015020194)~~
