A novel and efficient method for the preparation of nucleoside 5＇-tetraphosphates has been developed by coupling nucleoside 5＇-phosphoropiperidates with triphosphate reagent in the presence of 4, 5-dicyanoimidazole ...A novel and efficient method for the preparation of nucleoside 5＇-tetraphosphates has been developed by coupling nucleoside 5＇-phosphoropiperidates with triphosphate reagent in the presence of 4, 5-dicyanoimidazole （DCI） activator. Further coupling of the nucleoside 5＇-tetraphosphates with nucleoside 5＇-phosphoropiperidates via the P（V）-N activation strategy provided a reliable synthetic method for both symmetrical and asymmetrical dinucleoside pentaphosphates.展开更多
基金the National Natural Science Foundation of China(Nos.21002041 and 21262014)Key Project of Chinese Ministry of Education(No.212092)+1 种基金Scientific Research Foundation of Chinese Ministry of Human Resources and Social Security for Returned Chinese Scholars(2011),and Research Funds(Nos.ky2012zy08 and 2013QNBJRC001)Startup Funds for PhDs(2010)from JXSTNU for financial support
文摘A novel and efficient method for the preparation of nucleoside 5＇-tetraphosphates has been developed by coupling nucleoside 5＇-phosphoropiperidates with triphosphate reagent in the presence of 4, 5-dicyanoimidazole （DCI） activator. Further coupling of the nucleoside 5＇-tetraphosphates with nucleoside 5＇-phosphoropiperidates via the P（V）-N activation strategy provided a reliable synthetic method for both symmetrical and asymmetrical dinucleoside pentaphosphates.
