Bio-inertness and post-surgery infection on titanium(Ti)are the main causes of failure of biomedical implants in vivo.Near-infrared(NIR)photoactivated antibacterial therapy including photothermal and photodynamic ther...Bio-inertness and post-surgery infection on titanium(Ti)are the main causes of failure of biomedical implants in vivo.Near-infrared(NIR)photoactivated antibacterial therapy including photothermal and photodynamic therapies has attracted increasing attention due to the high bactericidal efficiency and little side effects.Although micro-arc oxidation(MAO)is an effective method to improve the biological activity of Ti implants,the porous TiO_(2)coatings prepared by MAO do not respond to near-infrared(NIR)light to kill bacteria by the photothermal and photodynamic effects.In this work,graphene oxide(GO)-modified TiO_(2)coatings(TiO_(2)/GO)are prepared on Ti to improve the photothermal and photodynamic ability of the MAO coatings.The TiO_(2)/GO coatings exhibit excellent antibacterial activity both in vitro and in vivo against Streptococcus mutans(S.mutans)under 808-nm NIR light irradiation due to the synergistic effects rendered by hyperthermia and reactive oxygen species(ROS).The NIR light-responsive antibacterial MAO coatings have large potential in combating implant-associated infections in clinical applications.展开更多
基金This work was financially supported by the National Natural Science Foundation of China(No.31870934)the Major Projects in Research and Development of Shanxi(No.201803D421090)+1 种基金City University of Hong Kong Strategic Research Grant(No.7005264)Guangdong-Hong Kong Technology Cooperation Funding Scheme GHP/085/18SZ(No.CityU 9440230)。
文摘Bio-inertness and post-surgery infection on titanium(Ti)are the main causes of failure of biomedical implants in vivo.Near-infrared(NIR)photoactivated antibacterial therapy including photothermal and photodynamic therapies has attracted increasing attention due to the high bactericidal efficiency and little side effects.Although micro-arc oxidation(MAO)is an effective method to improve the biological activity of Ti implants,the porous TiO_(2)coatings prepared by MAO do not respond to near-infrared(NIR)light to kill bacteria by the photothermal and photodynamic effects.In this work,graphene oxide(GO)-modified TiO_(2)coatings(TiO_(2)/GO)are prepared on Ti to improve the photothermal and photodynamic ability of the MAO coatings.The TiO_(2)/GO coatings exhibit excellent antibacterial activity both in vitro and in vivo against Streptococcus mutans(S.mutans)under 808-nm NIR light irradiation due to the synergistic effects rendered by hyperthermia and reactive oxygen species(ROS).The NIR light-responsive antibacterial MAO coatings have large potential in combating implant-associated infections in clinical applications.
