In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction(i.e.,chemodynamic therapy,CDT)has been attracted more attentions in recent years,the limited Fenton reaction efficiency is the...In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction(i.e.,chemodynamic therapy,CDT)has been attracted more attentions in recent years,the limited Fenton reaction efficiency is the important obstacle to further application in clinic.Herein,we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin(FeO/MoS2-BSA)with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared(NIR II)light.In the tumor microenvironments,the MoS2 nanosheets not only can accelerate the conversion of Fe3+ions to Fe2+ions by Mo4+ions on their surface to improve Fenton reaction efficiency,but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy(PTT).Consequently,benefiting from the synergetic-enhanced CDT/PTT,the tumors are eradicated completely in vivo.This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.展开更多
A gold tetrahedral nanocage, i.e., a tetrananocage, that converts near-infrared (NIR) light into heat was fabricated by using a simple method. Silver tetrahedra with good homogeneity and dispersity were synthesized ...A gold tetrahedral nanocage, i.e., a tetrananocage, that converts near-infrared (NIR) light into heat was fabricated by using a simple method. Silver tetrahedra with good homogeneity and dispersity were synthesized by a hydrothermal route. Gold tetrananocages were obtained using a galvanic replacement reaction between Ag tetrahedra and HAuC14 solution. The surface plasmon resonance (SPR) of gold tetrananocages was tuned from 412 nm to 850 nm through controlling the volume of HAuC14 solution added. This Au tetrananocage can effectively convert NIR light into heat when the SPR couples with the exciting light. When cancer cells are cultured with the gold tetrananocages for several hours and irradiated, the gold tetrananocages destroy the cancer cells effectively and demonstrate themselves to be a good candidate for combating cancer.展开更多
Photothermal therapy becomes a hotspot in the treatment of bone tumors. Magnesium and its alloys are regarded as potential bone implants for their favorable mechanical property and biodegradable in vivo. However, ther...Photothermal therapy becomes a hotspot in the treatment of bone tumors. Magnesium and its alloys are regarded as potential bone implants for their favorable mechanical property and biodegradable in vivo. However, there is few research devoted to fabricating a photothermal coating on Mg alloy. In the present study, reduced graphene oxide coating with a strong photothermal effect was prepared on the surface of AZ31via two steps. Firstly, graphene oxide coating was deposited on the surface via electrophoresis deposited(GO#), followed by a reduction process of the graphene oxide coating in ultrapure water(rGO#). GO# and rGO# coatings were characterized by SEM, Raman, XRD, FTIR,and XPS. The results revealed that, compared with GO# coating, the content of oxygen-containing(C-O/C-O-C, C=O, O-C=O) groups on rGO# coating was significantly decreased. rGO# coating was found tightly adhered to AZ31 substrate. According to the first-principles calculations, the well-bonded heterostructure between MgO and rGO is the main reason for the strong bonding force. Moreover, the prepared rGO# coating showed a superior photothermal effect, which brings a new strategy to the treatment of bone tumors with Mg-based implants.展开更多
The insensitivity of semiconductors to visible and infrared light is a key constraint on the utilization of light energy in photocatalytic reactions.Constructing photocatalysts with full-spectrum absorption through su...The insensitivity of semiconductors to visible and infrared light is a key constraint on the utilization of light energy in photocatalytic reactions.Constructing photocatalysts with full-spectrum absorption through surface engineering is an effective approach to fully harnessing light energy in semiconductor materials.Herein,a novel stable Ti_(3)C_(2)T_(x)MXene/CdS heterojunction catalyst is obtained by in-situ epitaxial growth of two-dimensional(2D)CdS nanosheets on 2D MXene interface via a solvothermal method.The exceptional light absorption properties of MXene confer outstanding full-spectrum driven photocat-alytic hydrogen evolution capability upon the heterogeneous catalyst.The unique 2D/2D structure effectively mitigated the recombination of photogenerated carriers,enhancing the photocatalytic performance of the catalyst.Moreover,the composite catalyst exhibits a significantly higher surface temperature of 80.4℃under visible light irradiation at an intensity of 0.1 W/cm^(2),which is 1.84 times higher than that of CdS.Under irradiation of visible and near infrared light,the composite catalyst with photothermal ef-fect demonstrates a remarkable hydrogen evolution rate of 65.4 mmol g^(-1)h^(-1),which is 7.2 times higher than that of CdS catalyst.This study introduces a novel approach for constructing full-spectrum absorption catalysts and expands the application of the photothermal effect in photocatalytic hydrogen evolution research.展开更多
Photothermal effect has been widely employed in the H2 evolution process at the advantage of using clean energy sources to produce another one of higher benefits.The solar-to-heat conversion have various forms and hea...Photothermal effect has been widely employed in the H2 evolution process at the advantage of using clean energy sources to produce another one of higher benefits.The solar-to-heat conversion have various forms and heat can facilitate reactions in a variety of dimensions.Hence,summarizing the sources and destinations of heat is important for constructing hydrogen production systems of higher efficiency.This view mainly focuses on the recent state-of-art progress of hydrogen evolution reaction(HER)based on photothermal effect.First,we introduce the main pathways of photothermal conversions applied in H2 evolution.Then,the functions of the photothermal effect are clearly summarized.Furthermore,we go beyond the catalytic reaction and introduce a method to improve the catalytic system by changing the catalytic bulk phase through thermal means.In the end,we sort out the challenges and outlook to offer some noble insights for this promising area.展开更多
Efficient determination of tumor exosomes using portable devices is crucial for the establishment of facile and convenient early cancer diagnostic methods. However, it is still challenging to effectively amplify the d...Efficient determination of tumor exosomes using portable devices is crucial for the establishment of facile and convenient early cancer diagnostic methods. However, it is still challenging to effectively amplify the detection signal to achieve tumor exosomes detection with high sensitivity by portable devices. To address this issue, we developed a portable multi-amplified temperature sensing strategy for highly sensitive detecting tumor exosomes based on multifunctional manganese dioxide/IR780 nanosheets(MnO_(2)/IR780 NSs) nanozyme with high oxidase-like activity and enhanced photothermal performance.Inspiringly, MnO_(2)/IR780 NSs were synthesized via a facile one-step method with mild experimental conditions, which not only exhibited a stronger photothermal effect than that of MnO_(2) but also showed excellent oxidase-like activity that can catalyze the oxidation of 3',3',5',5'-tetramethylbenzidine(TMB) to generate TMB oxide(oxTMB) with a robust photothermal property, thus conjoining with MnO_(2)/IR780 NSs to further enhance the temperature signal. The present assay enables highly sensitive determination of tumor exosomes with the detection limit down to 5.1×10~3 particles/mL, which was comparable or superior to those of the most previously reported sensors. Furthermore, detection of tumor exosomes spiked in biological samples was successfully realized. More importantly, our method showed the recommendable portability, robust applicability, and easy manipulation. By taking advantages of these features,this high-performance photothermal sensor offered a promising alternative means for nondestructive early cancer diagnosis and treatment efficacy evaluation.展开更多
Background:Treatment of methicillin-resistant Staphylococcus aureus(MRSA)biofilm infections in implant placement surgery is limited by the lack of antimicrobial activity of titanium(Ti)implants.There is a need to expl...Background:Treatment of methicillin-resistant Staphylococcus aureus(MRSA)biofilm infections in implant placement surgery is limited by the lack of antimicrobial activity of titanium(Ti)implants.There is a need to explore more effective approaches for the treatment of MRSA biofilm infections.Methods:Herein,an interfacial functionalization strategy is proposed by the integration of mesoporous polydopamine nanoparticles(PDA),nitric oxide(NO)release donor sodium nitroprusside(SNP)and osteogenic growth peptide(OGP)onto Ti implants,denoted as Ti-PDA@SNP-OGP.The physical and chemical properties of Ti-PDA@SNP-OGP were assessed by scanning electron microscopy,X-ray photoelectron spectroscope,water contact angle,photothermal property and NO release behavior.The synergistic antibacterial effect and elimination of the MRSA biofilms were evaluated by 2′,7′-dichlorofluorescein diacetate probe,1-N-phenylnaphthylamine assay,adenosine triphosphate intensity,O-nitrophenyl-β-D-galactopyranoside hydrolysis activity,bicinchoninic acid leakage.Fluorescence staining,assays for alkaline phosphatase activity,collagen secretion and extracellular matrix mineralization,quantitative real‑time reverse transcription‑polymerase chain reaction,and enzyme-linked immunosorbent assay(ELISA)were used to evaluate the inflammatory response and osteogenic ability in bone marrow stromal cells(MSCs),RAW264.7 cells and their co-culture system.Giemsa staining,ELISA,micro-CT,hematoxylin and eosin,Masson's trichrome and immunohistochemistry staining were used to evaluate the eradication of MRSA biofilms,inhibition of inflammatory response,and promotion of osseointegration of Ti-PDA@SNP-OGP in vivo.Results:Ti-PDA@SNP-OGP displayed a synergistic photothermal and NO-dependent antibacterial effect against MRSA following near-infrared light(NIR)irradiation,and effectively eliminated the formed MRSA biofilms by inducing reactive oxygen species(ROS)-mediated oxidative stress,destroying bacterial membrane integrity and causing leakage of intracellular components(P<0.01).In vitro experiments revealed that Ti-PDA@SNP-OGP not only facilitated osteogenic differentiation of MSCs,but also promoted the polarization of pro-inflammatory M1 macrophages to the anti-inflammatory M2-phenotype(P<0.05 or P<0.01).The favorable osteo-immune microenvironment further facilitated osteogenesis of MSCs and the anti-inflammation of RAW264.7 cells via multiple paracrine signaling pathways(P<0.01).In vivo evaluation confirmed the aforementioned results and revealed that Ti-PDA@SNP-OGP induced ameliorative osseointegration in an MRSA-infected femoral defect implantation model(P<0.01).Conclusions:Ti-PDA@SNP-OGP is a promising multi-functional material for the high-efficient treatment of MRSA infections in implant replacement surgeries.展开更多
Rational design of photocatalyst to maximize the use of sunlight is one of the issues to be solved in photocatalysis technology.In this study,the CuFe_(2)O_(4)@C/Cd_(0.9)Zn_(0.1)S(CFO@C/CZS)S-scheme photocatalyst with...Rational design of photocatalyst to maximize the use of sunlight is one of the issues to be solved in photocatalysis technology.In this study,the CuFe_(2)O_(4)@C/Cd_(0.9)Zn_(0.1)S(CFO@C/CZS)S-scheme photocatalyst with photothermal effect was synthesized by ultrasonic self-assembly combined with calcination.The dark CFO@C absorbed visible light and partly converted into heat to promote the hydrogen evolution reaction.The presence of heterojunctions inhibited the photogenerated electron-hole recombination.The graphite-carbon layer provided a stable channel for electron transfer,and the presence of magnetic CFO made recycle easier.Under the action of photothermal assistance and heterojunction,the hydrogen evolution rate of the optimal CFO@C/CZS was 80.79 mmol g^(-1) h^(-1),which was 2.55 times and 260.61 times of that of pure CZS and CFO@C,respectively.Notably,the composite samples also exhibit excellent stability and a wide range of environmental adaptability.Through experimental tests and first-principles simulation calculation methods,the plausible mechanism of photoactivity enhancement was proposed.This work provided a feasible strategy of photothermal assistance for the development of heterojunction photocatalysts with distinctive hydrogen evolution.展开更多
Molecular motions of the luminescent liquid crystals(LLCs)show a significant effect on fluorescent emission and heat generation.In this article,a series of cyanostilbene-based LLCs(CSs:CS1-6,CS1-12,CS2-6 and CS2-12)ar...Molecular motions of the luminescent liquid crystals(LLCs)show a significant effect on fluorescent emission and heat generation.In this article,a series of cyanostilbene-based LLCs(CSs:CS1-6,CS1-12,CS2-6 and CS2-12)are synthesized to investigate how the pho-toluminescence and photothermal effect balanced.Among these materials,the mesogens peripheried by single alkyl chains formed enantiotropic nematic(CS1-6)or smectic C(CS1-12)phase with different alkyl tail lengths.When the single aliphatic chain is re-placed by mini-dendrons,room temperature(RT)monotropic hexagonal columnar phase(CS2-12)or molecular liquid(CS2-6)is formed.The results revealed that all these materials exhibited high efficiency emission with the highest quantum yield reaching 59.0%.The photoluminescence and photothermal effect can be effectively tuned by dispersing CSs into a commercially available RT liquid crystal matrix 8CB,which output significantly improved photothermal conversion efficiency of 63.2%.Furthermore,the pho-tothermal can rapidly trigger the Smectic A-Nematic-Isotropic sequence transitions of 8CB doped with CSs.This work paves a way of adjusting the balance of photoluminescence and photothermal properties of the LLC materials.展开更多
3D flower-like hierarchical mesoporous Bi_(4)O_(5)I_(2)/MoS_(2)Z-scheme layered heterojunction photocatalyst was fabricated by oil bath and hydrothermal methods.The heterojunction with narrow band gap of~1.95 eV exten...3D flower-like hierarchical mesoporous Bi_(4)O_(5)I_(2)/MoS_(2)Z-scheme layered heterojunction photocatalyst was fabricated by oil bath and hydrothermal methods.The heterojunction with narrow band gap of~1.95 eV extended the photoresponse to near-infrared region,which showed obvious photothermal effect due to the introduction of MoS_(2) with broad spectrum response.MoS_(2) nanosheets were anchored onto the surface of flower-like hierarchical mesoporous Bi_(4)O_(5)I_(2) nanosheets,thereby forming efficient layered heterojunctions,the solar-driven photocatalytic efficiency in degradation of highly toxic dichlorophenol and reduction of hexavalent chromium was improved to 98.5%and 99.2%,which was~4 and 7 times higher than that of the pristine Bi_(4)O_(5)I_(2),respectively.In addition,the photocatalytic hydrogen production rate reached 496.78 μmol h^(-1)g^(-1),which was~6 times higher than that of the pristine Bi_(4)O_(5)I_(2).The excellent photocatalytic performance can be ascribed to the promoted photothermal effect,as well as,the formation of compact Z-scheme layered heterojunctions.The 3D flower-like hierarchical mesoporous structure provided adequate surface active-sites,which was conducive to the mass transfer.Moreover,the high stability of the prepared photocatalyst further promoted its potential practical application.This strategy also provides new insights for fabricating layered Zscheme heterojunctions photocatalysts with highly photothermal-photocatalytic efficiency.展开更多
The high therapeutic resistance of tumor is the primary cause behind tumor recurrence and incurability.In recent years,scientists have devoted themselves to find a variety of treatments to solve this problem.Herein,we...The high therapeutic resistance of tumor is the primary cause behind tumor recurrence and incurability.In recent years,scientists have devoted themselves to find a variety of treatments to solve this problem.Herein,we propose a multi-hit strategy that is based on the biodegradable hollow mesoporous Prussian blue(HMPB)-based nanosystem for tumor-specific therapy that encapsulated the critical heat shock protein 90(HSP90)inhibitor 17-dimethylamino-ethylamino-17-demethoxydeldanamycin(17-DMAG).The nanosystem was further modified using thermotropic phase transition material star-PEG-PCL(sPP)and hyaluronic acid(HA),which offers near infrared light(NIR)responsive release characteristic,as well as enhanced tumor cell endocytosis.Upon cell internalization of 17-DMAG-HMPB@sPP@HA and under 808 nm laser irradiation,photothermal-conversion effect of HMPB directly kills cells using hyperthermia,which further causes phase transition of sPP to trigger release of 17-DMAG,inhibits HSP90 activity and blocks multiple signaling pathways,including cell cycle,Akt and HIF pathways.Additionally,the down-regulation of GPX4 protein expression by 17-DMAG and the release of ferric and ferrous ions from gradual degradation of HMPB in the endogenous mild acidic microenvironment in tumors promoted the occurrence of ferroptosis.Importantly,the antitumor effect of 17-DMAG and ferroptosis damage were amplified using photothermal effect of HMPB by accelerating release of ferric and ferrous ions,and reducing HSP90 expression in cells,which induced powerful antitumor effect in vitro and in vivo.This multi-hit therapeutic nanosystem helps provide a novel perspective for solving the predicament of cancer treatment,as well as a promising strategy for design of a novel cancer treatment nanoplatform.展开更多
Pathogenic bacterial infection is severely threatening public health globally.The multi-modal antibacterial nanoplatforms could significantly improve the antibacterial efficiency.Here,we report a metal(Ti)-organic fra...Pathogenic bacterial infection is severely threatening public health globally.The multi-modal antibacterial nanoplatforms could significantly improve the antibacterial efficiency.Here,we report a metal(Ti)-organic framework(MOF)derived nanocarbon(C-Ti-MOF)as a biosafety material for synergistic sterilization of pathogenic bacteria via efficient photodynamic catalysis and robust photothermal effects.The C-Ti-MOF consists of abundant TiO_(2) nanodots embedded in graphitic carbon frameworks.Under visible light irradiation,TiO_(2) nanodots can catalyze H_(2)O_(2) and O_(2) to produce superoxide anion(•O_(2)^(–))and singlet oxygen(1O2),respectively.Meanwhile,under near-infrared irradiation(NIR),C-Ti-MOF can generate massive heat to destroy bacterial membranes.Systematic antibacterial experiments reveal that the C-Ti-MOF nanoagents have a long-lasting and nearly 100%bactericidal ratio at an extremely low dose(0.16 mg/mL),which is much better than the state-of-the-art TiO_(2)(Commercial TiO_(2)(P25),0.64 mg/mL).Furthermore,the C-Ti-MOF can be electrospun into an antibacterial nanofiber membrane via mixing with polymeric matrix for treating bacteriacontaminated wastewater,and the membranes possess integrated antibacterial activity and excellent biocompatibility.Our study demonstrates a promising Ti-MOF-based biosafety material for efficient and long-life disinfection,which may stimulate new research in MOF-related biological applications in various disciplines ranging from water decontaminations to nanotherapeutics.展开更多
Solvent free DNA-surfactant melts are receiving continuous attractions in recent years.Their physical properties could be regulated via changing the alkyl chain length of surfactants.As an ideal external stimulus,ligh...Solvent free DNA-surfactant melts are receiving continuous attractions in recent years.Their physical properties could be regulated via changing the alkyl chain length of surfactants.As an ideal external stimulus,light has been used in the regulation of mechanical properties of DNA thermotropic liquid crystal(TLC)containing an azobenzene motif,while in this case,the UV light is the only effective excitation source.However,in comparison with visible light,UV light causes damage to DNA and has low tissue-penetration efficiency problem.In this work,a new type of DNA-didodecyldimethylammonium bromide(DNA-DDAB)TLCs fabricating with gold nanoparticles(AuNPs)was demonstrated.The visible light-induced photothermal effect of AuNPs could change the mechanical properties of AuNPs/DNA-DDAB TLCs,as shown by clearly boundary motion activity and viscoelasticity change.Furthermore,the ratio of AuNPs and charge stoichiometry of DNA:DDAB also affected photocurrent generation property of these DNA melts.The development of this visible light responsive DNA melt might facilitate the related studies in biomedicine and biomaterials.展开更多
Introduction of the photothermal effect into transition-metal oxide photoanodes has been proven to be an effective method to improve the photoelectrochemical(PEC)water-splitting performance.However,the precise role of...Introduction of the photothermal effect into transition-metal oxide photoanodes has been proven to be an effective method to improve the photoelectrochemical(PEC)water-splitting performance.However,the precise role of the photothermal effect on the PEC performance of photoanodes is still not well understood.Herein,spinel-structured ZnFe_(2)O_(4)nanoparticles are deposited on the surface of hematite(Fe_(2)O_(3)),and the ZnFe_(2)O_(4)/Fe_(2)O_(3)photoanode achieves a high photocurrent density of 3.17 mA cm^(-2)at 1.23 V versus a reversible hydrogen electrode(VRHE)due to the photothermal effect of ZnFe_(2)O_(4).Considering that the hopping of electron small polarons induced by oxygen vacancies is thermally activated,we clarify that the main reason for the enhanced PEC performance via the photothermal effect is the promoted mobility of electron small polarons that are bound to positively charged oxygen vacancies.Under the synergistic effect of oxygen vacancies and the photothermal effect,the electron conductivity and PEC performance are significantly improved,which provide fundamental insights into the impact of the photothermal effect on the PEC performance of small polaron-type semiconductor photoanodes.展开更多
Photothermal catalysis realizes the synergistic effect of solar energy and thermochemistry,which also has the potential to improve the reaction rate and optimize the selectivity.In this review,the research progress of...Photothermal catalysis realizes the synergistic effect of solar energy and thermochemistry,which also has the potential to improve the reaction rate and optimize the selectivity.In this review,the research progress of photothermal catalytic removal of volatile organic compounds(VOCs)by nano-catalysts in recent years is systematically reviewed.First,the fundamentals of photothermal catalysis and the fabrication of catalysts are described,and the design strategy of optimizing photothermal catalysis performance is proposed.Second,the performance for VOC degradation with photothermal catalysis is evaluated and compared for the batch and continuous systems.Particularly,the catalytic mechanism of VOC oxidation is systematically introduced based on experimental and theoretical study.Finally,the future limitations and challenges have been discussed,and potential research directions and priorities are highlighted.A broad view of recent photothermal catalyst fabrication,applications,challenges,and prospects can be systemically provided by this review.展开更多
Interstitial laser immunotherapy(ILIT)is designed to use photothermal and immunological inter-actions for treatment of metastatic cancers.The photothermal ffect is crucial in inducing anti-tumorimmune responses in the...Interstitial laser immunotherapy(ILIT)is designed to use photothermal and immunological inter-actions for treatment of metastatic cancers.The photothermal ffect is crucial in inducing anti-tumorimmune responses in the host.Tissue temperature and tssue optical properties are important factorsin this process.In this study,a device combining interstitial photoacoustic(PA)technique andinterstitial laser photothermal interaction is proposed.Together with computational simulation,thisdevice was designed to determine temperature distributions and tissue optical properties during lasertreatment.Experiments were performed usinger-ivoFporcine liver tissue.Our results demonstratedthat interstitial PA signal amplitude was linearly dependent on tisue temperature in the tempera-ture ranges of 20-60℃,as wll as 65-80℃,with a dfferent slope,due to the change of tissue opticalproperties.Using the directly measured temperature in the tissue around the interstitial optical fiberdiffusion tip for calibration,the theoretical temperature distribution predicted by the bioheatequation was used to extract optical properties of tssue.Finally,the three-dimensional temperature distribution was simulated to guide tumor destruction and immunological stimulation,Thus,thisnovel device and method could be used for monitoring and controlling ILIT for cancer treatment.展开更多
Physiotherapeutic effects of infrared lasers have been proved in clinic.These infrared-based regulations of the bioelectrical activities can roughly be classied into enhancement and suppression of action potential(AP)...Physiotherapeutic effects of infrared lasers have been proved in clinic.These infrared-based regulations of the bioelectrical activities can roughly be classied into enhancement and suppression of action potential(AP),which are described by sodium(Na)and potassium(K)transmembrane current equations,named as Hodgkin and Huxley(HH)-model.The enhancement effect is able to evoke or strengthen the AP when infrared light is applied.Its corresponding mechanism is commonly ascribed to the changes of the cell membrane capacitance,which is transiently increased in response to the infrared radiation.The distinctive feature of the suppression effect is to inhibit or reduce the AP by the designed protocols of infrared radiation.However,its mechanism presents more complexity than that in enhancement cases.HH-model describes how the Na current determines the initial phase of AP.So,the enhancement and suppression of AP can be also ascribed to the regulations of the corresponding Na currents.Here,a continuous infrared light at the wavelength of 980 nm(CIS-980)was employed to stimulate a freshly isolated hippocampal neuron in vitro and a suppression effect on the Na currents of the neuron cell was observed.Both Na and K currents,which are named as whole cell currents,were simultaneously recorded with the cell membrane capacitance current by using a patch clamp combined with infrared irradiation.The results demonstrated that the CIS-980 was able to reversibly increase the capacitance currents,completely suppressed Na currents,but little changed K currents,which forms the steady outward whole cell currents and plays a major role on the AP repolarization.A conrmation experiment was designed and carried out by synchronizing tens of milliseconds of infrared stimulation on the same kinds of hippocampal neuron cells.After the blocked K channel,a reduction of Na current amplitude was still recorded.This proved that infrared suppression of Na current was irrelevant to K channel.A membrane capacitance mediation process was preliminarily proposed to explain the Na channel suppression process.展开更多
Design of artificial ligaments possessing both osteogenic activity and antibacterial effect that promotes ligament-bone healing and prevents bacterial infection in bone tunnels for anterior cruciate ligament(ACL)recon...Design of artificial ligaments possessing both osteogenic activity and antibacterial effect that promotes ligament-bone healing and prevents bacterial infection in bone tunnels for anterior cruciate ligament(ACL)reconstruction remains a significant challenge.In this study,black tantalic oxide(BTO)submicro-particles with oxygen vacancies and structure defects were fabricated by using traditional white tan-talic oxide(WTO)through magnesium thermal reduction(MTR)method,and BTO was coated on polyetheretherketone(PEEK)fibers(PKF),which were woven into fabrics(PBT)as artificial ligaments.PBT with BTO coating exhibited excellent photothermal performance,which possessed not only antibac-terial effects in vitro but also anti-infective ability in vivo.PBT with optimized surface properties(e.g.,submicro-topography and hydrophilicity)not only significantly facilitated rat bone mesenchymal stem cells(BMSC)responses(e.g.,proliferation and osteogenic differentiation)in vitro but also stimulated new bone formation for ligament-bone healing in vivo.The presence of oxygen vacancies and structure de-fects in BTO did not change the surface properties and osteogenic activity of BPT while displaying an outstanding photothermal antibacterial effect.In summary,BPT with osteogenic activity and photother-mal antibacterial effect promoted bone regeneration and prevented bacterial infection,thereby promoting ligament-bone healing.Therefore,PBT would have tremendous potential as a novel artificial ligament for ACL reconstruction.展开更多
The silver nanowires(Ag NWs)electrodes,which consist of incompact Ag nanoparticles(NPs)formed by multi-photon photoreduction,usually have poor conductivities.An effective strategy for enhancing conductivity of the Ag ...The silver nanowires(Ag NWs)electrodes,which consist of incompact Ag nanoparticles(NPs)formed by multi-photon photoreduction,usually have poor conductivities.An effective strategy for enhancing conductivity of the Ag NWs elec-trodes is plasmon-enhanced nanosoldering(PLNS)by laser irradiation.Here,plasmon-enhanced photothermal effect is used to locally solder Ag NPs and then aggregates of these NPs grow into large irregular particles in PLNS process.Fi-nite element method(FEM)simulations indicate that the soldering process is triggered by localized surface plasmon-in-duced electric field enhancement at“hot-spots”.The effectiveness of PLNS for enhancing conductivity depends on laser power density and irradiation time.By optimizing the conditions of PLNS,the electrical conductivity of Ag NWs is signific-antly enhanced and the conductivityσs is increased to 2.45×107 S/m,which is about 39%of the bulk Ag.This PLNS of Ag NWs provides an efficient and cost-effective technique to rapidly produce large-area metal nanowire electrodes and capacitors with high conductivity,excellent uniformity,and good flexibility.展开更多
In this work,hollow manganese dioxide/gold nanoparticle(MnO2/GNPs)hybrid drug nanocarriers were prepared by coupling the gold nanoparticles(GNPs)with hollow structure manganese dioxide(MnO2).Among them,GNPs have been ...In this work,hollow manganese dioxide/gold nanoparticle(MnO2/GNPs)hybrid drug nanocarriers were prepared by coupling the gold nanoparticles(GNPs)with hollow structure manganese dioxide(MnO2).Among them,GNPs have been used as near-infrared(NIR)-responsive element for photothermal effect under NIR laser irradiation.The glutathione(GSH)-responsive and p H-responsive performances of drug release were derived from hollow MnO2.Particularly,Doxorubicin hydrochloride(DOX)can be loaded into hollow MnO2/GNPs with the drug loading efficiency up to 82.0%.Moreover,the photothermal effect and GSH-/pH-responsive properties of hollow MnO2/GNPs were investigated.The hollow MnO2/GNPs possessed satisfactory drug release efficiency(ca.87.4%of loaded drug released in 12 h)and have high photothermal conversion efficiency,multiresponsive properties,and degradability.Finally,the kinetics of drug release was discussed in detail.Thus,our finding highlights that the multiresponsive nanocarriers are of great potential in the field of drug controlled release.展开更多
基金This work was supported by the financial aid from the National Natural Science Foundation of China(Grant Nos.51502284,21834007,21521092,21590794,and 21673220)the Program of Science and Technology Development Plan of Jilin Province of China(No.20170101186JC)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB20030300)the Youth Innovation Promotion Association of Chinese Academy of Sciences(2019232).
文摘In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction(i.e.,chemodynamic therapy,CDT)has been attracted more attentions in recent years,the limited Fenton reaction efficiency is the important obstacle to further application in clinic.Herein,we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin(FeO/MoS2-BSA)with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared(NIR II)light.In the tumor microenvironments,the MoS2 nanosheets not only can accelerate the conversion of Fe3+ions to Fe2+ions by Mo4+ions on their surface to improve Fenton reaction efficiency,but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy(PTT).Consequently,benefiting from the synergetic-enhanced CDT/PTT,the tumors are eradicated completely in vivo.This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.
基金supported by the National Natural Science Foundation of China (Grant Nos. 51272246 and 81172082)the Fundamental Research Funds for the Central Universities of China (Grant No. 2030000001)
文摘A gold tetrahedral nanocage, i.e., a tetrananocage, that converts near-infrared (NIR) light into heat was fabricated by using a simple method. Silver tetrahedra with good homogeneity and dispersity were synthesized by a hydrothermal route. Gold tetrananocages were obtained using a galvanic replacement reaction between Ag tetrahedra and HAuC14 solution. The surface plasmon resonance (SPR) of gold tetrananocages was tuned from 412 nm to 850 nm through controlling the volume of HAuC14 solution added. This Au tetrananocage can effectively convert NIR light into heat when the SPR couples with the exciting light. When cancer cells are cultured with the gold tetrananocages for several hours and irradiated, the gold tetrananocages destroy the cancer cells effectively and demonstrate themselves to be a good candidate for combating cancer.
基金financially supported by the National Natural Science Foundation of China (31771044)China Postdoctoral Science Foundation (2019M662830)+2 种基金Shanghai Committee of Science and Technology,China (19JC1415500,18ZR1445000)International Partnership Program of Chinese Academy of Sciences (GJHZ1850)Natural Science Foundation of Guangdong Province,China (2020A1515011447)。
文摘Photothermal therapy becomes a hotspot in the treatment of bone tumors. Magnesium and its alloys are regarded as potential bone implants for their favorable mechanical property and biodegradable in vivo. However, there is few research devoted to fabricating a photothermal coating on Mg alloy. In the present study, reduced graphene oxide coating with a strong photothermal effect was prepared on the surface of AZ31via two steps. Firstly, graphene oxide coating was deposited on the surface via electrophoresis deposited(GO#), followed by a reduction process of the graphene oxide coating in ultrapure water(rGO#). GO# and rGO# coatings were characterized by SEM, Raman, XRD, FTIR,and XPS. The results revealed that, compared with GO# coating, the content of oxygen-containing(C-O/C-O-C, C=O, O-C=O) groups on rGO# coating was significantly decreased. rGO# coating was found tightly adhered to AZ31 substrate. According to the first-principles calculations, the well-bonded heterostructure between MgO and rGO is the main reason for the strong bonding force. Moreover, the prepared rGO# coating showed a superior photothermal effect, which brings a new strategy to the treatment of bone tumors with Mg-based implants.
基金supported by the National Natural Science Foundation of China(Nos.22078118,21972048,22274059)the Guangdong Laboratory of Lingnan Modern Agriculture Project(Nos.NZ2021029,NT2021010)+1 种基金the Guangzhou Science and Technology Planning Project(No.202201010728)the Guangdong Provincial Key Laboratory of Distributed Energy Systems(No.2020B1212060075).
文摘The insensitivity of semiconductors to visible and infrared light is a key constraint on the utilization of light energy in photocatalytic reactions.Constructing photocatalysts with full-spectrum absorption through surface engineering is an effective approach to fully harnessing light energy in semiconductor materials.Herein,a novel stable Ti_(3)C_(2)T_(x)MXene/CdS heterojunction catalyst is obtained by in-situ epitaxial growth of two-dimensional(2D)CdS nanosheets on 2D MXene interface via a solvothermal method.The exceptional light absorption properties of MXene confer outstanding full-spectrum driven photocat-alytic hydrogen evolution capability upon the heterogeneous catalyst.The unique 2D/2D structure effectively mitigated the recombination of photogenerated carriers,enhancing the photocatalytic performance of the catalyst.Moreover,the composite catalyst exhibits a significantly higher surface temperature of 80.4℃under visible light irradiation at an intensity of 0.1 W/cm^(2),which is 1.84 times higher than that of CdS.Under irradiation of visible and near infrared light,the composite catalyst with photothermal ef-fect demonstrates a remarkable hydrogen evolution rate of 65.4 mmol g^(-1)h^(-1),which is 7.2 times higher than that of CdS catalyst.This study introduces a novel approach for constructing full-spectrum absorption catalysts and expands the application of the photothermal effect in photocatalytic hydrogen evolution research.
基金the Natural Science Foundation of China(No.51902101)Natural Science Foundation of Jiangsu Province(No.BK20201381)+1 种基金Science Foundation of Nanjing University of Posts and Telecommunications(No.NY219144)Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.SJCX22_0254).
文摘Photothermal effect has been widely employed in the H2 evolution process at the advantage of using clean energy sources to produce another one of higher benefits.The solar-to-heat conversion have various forms and heat can facilitate reactions in a variety of dimensions.Hence,summarizing the sources and destinations of heat is important for constructing hydrogen production systems of higher efficiency.This view mainly focuses on the recent state-of-art progress of hydrogen evolution reaction(HER)based on photothermal effect.First,we introduce the main pathways of photothermal conversions applied in H2 evolution.Then,the functions of the photothermal effect are clearly summarized.Furthermore,we go beyond the catalytic reaction and introduce a method to improve the catalytic system by changing the catalytic bulk phase through thermal means.In the end,we sort out the challenges and outlook to offer some noble insights for this promising area.
基金financially supported by the National Natural Science Foundation of China(Nos.22174083 and 22076090)Shandong Provincial Natural Science Foundation(No.ZR2020ZD37)+2 种基金Special Foundation for Taishan Scholar of Shandong Province(No.TSQN202103093)Shandong Province Higher Educational Program for Young Innovation Talentsthe Research Foundation for Distinguished Scholars of Qingdao Agricultural University(No.6651119006)。
文摘Efficient determination of tumor exosomes using portable devices is crucial for the establishment of facile and convenient early cancer diagnostic methods. However, it is still challenging to effectively amplify the detection signal to achieve tumor exosomes detection with high sensitivity by portable devices. To address this issue, we developed a portable multi-amplified temperature sensing strategy for highly sensitive detecting tumor exosomes based on multifunctional manganese dioxide/IR780 nanosheets(MnO_(2)/IR780 NSs) nanozyme with high oxidase-like activity and enhanced photothermal performance.Inspiringly, MnO_(2)/IR780 NSs were synthesized via a facile one-step method with mild experimental conditions, which not only exhibited a stronger photothermal effect than that of MnO_(2) but also showed excellent oxidase-like activity that can catalyze the oxidation of 3',3',5',5'-tetramethylbenzidine(TMB) to generate TMB oxide(oxTMB) with a robust photothermal property, thus conjoining with MnO_(2)/IR780 NSs to further enhance the temperature signal. The present assay enables highly sensitive determination of tumor exosomes with the detection limit down to 5.1×10~3 particles/mL, which was comparable or superior to those of the most previously reported sensors. Furthermore, detection of tumor exosomes spiked in biological samples was successfully realized. More importantly, our method showed the recommendable portability, robust applicability, and easy manipulation. By taking advantages of these features,this high-performance photothermal sensor offered a promising alternative means for nondestructive early cancer diagnosis and treatment efficacy evaluation.
基金financially supported by the National Natural Science Foundation of China(82101069,82102537,82160411,82002278)the Natural Science Foundation of Chongqing Science and Technology Commission(CSTC2021JCYJ-MSXMX0170,CSTB2022BSXM-JCX0039)+2 种基金the First Affiliated Hospital of Chongqing Medical University Cultivating Fund(PYJJ2021-02)the Beijing Municipal Science&Technology Commission(Z221100007422130)the Youth Incubation Program of Medical Science and Technology of PLA(21QNPY116).
文摘Background:Treatment of methicillin-resistant Staphylococcus aureus(MRSA)biofilm infections in implant placement surgery is limited by the lack of antimicrobial activity of titanium(Ti)implants.There is a need to explore more effective approaches for the treatment of MRSA biofilm infections.Methods:Herein,an interfacial functionalization strategy is proposed by the integration of mesoporous polydopamine nanoparticles(PDA),nitric oxide(NO)release donor sodium nitroprusside(SNP)and osteogenic growth peptide(OGP)onto Ti implants,denoted as Ti-PDA@SNP-OGP.The physical and chemical properties of Ti-PDA@SNP-OGP were assessed by scanning electron microscopy,X-ray photoelectron spectroscope,water contact angle,photothermal property and NO release behavior.The synergistic antibacterial effect and elimination of the MRSA biofilms were evaluated by 2′,7′-dichlorofluorescein diacetate probe,1-N-phenylnaphthylamine assay,adenosine triphosphate intensity,O-nitrophenyl-β-D-galactopyranoside hydrolysis activity,bicinchoninic acid leakage.Fluorescence staining,assays for alkaline phosphatase activity,collagen secretion and extracellular matrix mineralization,quantitative real‑time reverse transcription‑polymerase chain reaction,and enzyme-linked immunosorbent assay(ELISA)were used to evaluate the inflammatory response and osteogenic ability in bone marrow stromal cells(MSCs),RAW264.7 cells and their co-culture system.Giemsa staining,ELISA,micro-CT,hematoxylin and eosin,Masson's trichrome and immunohistochemistry staining were used to evaluate the eradication of MRSA biofilms,inhibition of inflammatory response,and promotion of osseointegration of Ti-PDA@SNP-OGP in vivo.Results:Ti-PDA@SNP-OGP displayed a synergistic photothermal and NO-dependent antibacterial effect against MRSA following near-infrared light(NIR)irradiation,and effectively eliminated the formed MRSA biofilms by inducing reactive oxygen species(ROS)-mediated oxidative stress,destroying bacterial membrane integrity and causing leakage of intracellular components(P<0.01).In vitro experiments revealed that Ti-PDA@SNP-OGP not only facilitated osteogenic differentiation of MSCs,but also promoted the polarization of pro-inflammatory M1 macrophages to the anti-inflammatory M2-phenotype(P<0.05 or P<0.01).The favorable osteo-immune microenvironment further facilitated osteogenesis of MSCs and the anti-inflammation of RAW264.7 cells via multiple paracrine signaling pathways(P<0.01).In vivo evaluation confirmed the aforementioned results and revealed that Ti-PDA@SNP-OGP induced ameliorative osseointegration in an MRSA-infected femoral defect implantation model(P<0.01).Conclusions:Ti-PDA@SNP-OGP is a promising multi-functional material for the high-efficient treatment of MRSA infections in implant replacement surgeries.
基金supported by the Shandong Provincial Natural Science Foundation(ZR2022ME179,ZR2021QE086)the Shandong Provincial Key Research and Development Program(Public Welfare Science and Technology Research)(2019GGX103010)+2 种基金the Science and Technology Planning Project of Higher School in Shandong Province(J18KA243)the Liaocheng Key Research and Development Program(Policy guidance category)(2022YDSF90)the Liaocheng University High-level Talents&PhD Research Startup Foundation(318051619)。
文摘Rational design of photocatalyst to maximize the use of sunlight is one of the issues to be solved in photocatalysis technology.In this study,the CuFe_(2)O_(4)@C/Cd_(0.9)Zn_(0.1)S(CFO@C/CZS)S-scheme photocatalyst with photothermal effect was synthesized by ultrasonic self-assembly combined with calcination.The dark CFO@C absorbed visible light and partly converted into heat to promote the hydrogen evolution reaction.The presence of heterojunctions inhibited the photogenerated electron-hole recombination.The graphite-carbon layer provided a stable channel for electron transfer,and the presence of magnetic CFO made recycle easier.Under the action of photothermal assistance and heterojunction,the hydrogen evolution rate of the optimal CFO@C/CZS was 80.79 mmol g^(-1) h^(-1),which was 2.55 times and 260.61 times of that of pure CZS and CFO@C,respectively.Notably,the composite samples also exhibit excellent stability and a wide range of environmental adaptability.Through experimental tests and first-principles simulation calculation methods,the plausible mechanism of photoactivity enhancement was proposed.This work provided a feasible strategy of photothermal assistance for the development of heterojunction photocatalysts with distinctive hydrogen evolution.
基金supported bythe National Natural ScienceFoundation of China(Nos.21875143and21875157)the InnovationResearch Foundationof Shenzhen(No.JCYJ20180507182229597)the Natural Science Foundation of Guangdong Province(No.2016-A030312002)and theopen foundation of State Key Laboraatory of Chemical Engineering(No.SKL ChE-20B04).
文摘Molecular motions of the luminescent liquid crystals(LLCs)show a significant effect on fluorescent emission and heat generation.In this article,a series of cyanostilbene-based LLCs(CSs:CS1-6,CS1-12,CS2-6 and CS2-12)are synthesized to investigate how the pho-toluminescence and photothermal effect balanced.Among these materials,the mesogens peripheried by single alkyl chains formed enantiotropic nematic(CS1-6)or smectic C(CS1-12)phase with different alkyl tail lengths.When the single aliphatic chain is re-placed by mini-dendrons,room temperature(RT)monotropic hexagonal columnar phase(CS2-12)or molecular liquid(CS2-6)is formed.The results revealed that all these materials exhibited high efficiency emission with the highest quantum yield reaching 59.0%.The photoluminescence and photothermal effect can be effectively tuned by dispersing CSs into a commercially available RT liquid crystal matrix 8CB,which output significantly improved photothermal conversion efficiency of 63.2%.Furthermore,the pho-tothermal can rapidly trigger the Smectic A-Nematic-Isotropic sequence transitions of 8CB doped with CSs.This work paves a way of adjusting the balance of photoluminescence and photothermal properties of the LLC materials.
基金support of this research by the National Natural Science Foundation of China(21871078)the Natural Science Foundation of Heilongjiang Province(JQ2019B001 and B2018010)+3 种基金the Heilongjiang Postdoctoral Startup Fund(LBH-Q14135)the Heilongjiang University Science Fund for Distinguished Young Scholars(JCL201802)the Heilongjiang Provincial Institutions of Higher Learning Basic Research Funds Basic Research Projects(KJCX201909)the Heilongjiang Touyan Innovation Team Program.
文摘3D flower-like hierarchical mesoporous Bi_(4)O_(5)I_(2)/MoS_(2)Z-scheme layered heterojunction photocatalyst was fabricated by oil bath and hydrothermal methods.The heterojunction with narrow band gap of~1.95 eV extended the photoresponse to near-infrared region,which showed obvious photothermal effect due to the introduction of MoS_(2) with broad spectrum response.MoS_(2) nanosheets were anchored onto the surface of flower-like hierarchical mesoporous Bi_(4)O_(5)I_(2) nanosheets,thereby forming efficient layered heterojunctions,the solar-driven photocatalytic efficiency in degradation of highly toxic dichlorophenol and reduction of hexavalent chromium was improved to 98.5%and 99.2%,which was~4 and 7 times higher than that of the pristine Bi_(4)O_(5)I_(2),respectively.In addition,the photocatalytic hydrogen production rate reached 496.78 μmol h^(-1)g^(-1),which was~6 times higher than that of the pristine Bi_(4)O_(5)I_(2).The excellent photocatalytic performance can be ascribed to the promoted photothermal effect,as well as,the formation of compact Z-scheme layered heterojunctions.The 3D flower-like hierarchical mesoporous structure provided adequate surface active-sites,which was conducive to the mass transfer.Moreover,the high stability of the prepared photocatalyst further promoted its potential practical application.This strategy also provides new insights for fabricating layered Zscheme heterojunctions photocatalysts with highly photothermal-photocatalytic efficiency.
基金This work was supported by:National Natural Science Foundation of China(Grant No:81503020)Natural Science Foundation of Liaoning Province(Grant No:2019-ZD-0459,2020-MS-196)and the Basic Research Project of Liaoning Provincial Department of Education(Grant No:2019LJC04).
文摘The high therapeutic resistance of tumor is the primary cause behind tumor recurrence and incurability.In recent years,scientists have devoted themselves to find a variety of treatments to solve this problem.Herein,we propose a multi-hit strategy that is based on the biodegradable hollow mesoporous Prussian blue(HMPB)-based nanosystem for tumor-specific therapy that encapsulated the critical heat shock protein 90(HSP90)inhibitor 17-dimethylamino-ethylamino-17-demethoxydeldanamycin(17-DMAG).The nanosystem was further modified using thermotropic phase transition material star-PEG-PCL(sPP)and hyaluronic acid(HA),which offers near infrared light(NIR)responsive release characteristic,as well as enhanced tumor cell endocytosis.Upon cell internalization of 17-DMAG-HMPB@sPP@HA and under 808 nm laser irradiation,photothermal-conversion effect of HMPB directly kills cells using hyperthermia,which further causes phase transition of sPP to trigger release of 17-DMAG,inhibits HSP90 activity and blocks multiple signaling pathways,including cell cycle,Akt and HIF pathways.Additionally,the down-regulation of GPX4 protein expression by 17-DMAG and the release of ferric and ferrous ions from gradual degradation of HMPB in the endogenous mild acidic microenvironment in tumors promoted the occurrence of ferroptosis.Importantly,the antitumor effect of 17-DMAG and ferroptosis damage were amplified using photothermal effect of HMPB by accelerating release of ferric and ferrous ions,and reducing HSP90 expression in cells,which induced powerful antitumor effect in vitro and in vivo.This multi-hit therapeutic nanosystem helps provide a novel perspective for solving the predicament of cancer treatment,as well as a promising strategy for design of a novel cancer treatment nanoplatform.
基金supported by the National Key R&D Program of China(2021YFE0205000)National Natural Science Foundation of China(Nos.52161145402,52173133,82102064,82102065,82001020,and 82001829)+6 种基金the Science and Technology Project of Sichuan Province(Nos.2021YFH0135,2021YFS0050,2021YJ0434,2021YFH0180,2021YFH0087,and 2021YFG0238)the 1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Grant No.ZYJC21047)the innovation project of Med-X Center for Materials,Sichuan University(Grant No.MCM202102)the China Postdoctoral Science Foundation(Grant Nos.2021 M702334,2021 M692291,2021 M692288,and 2021 M692303)the Post-Doctor Research Project,West China Hospital,Sichuan University(Grant Nos.2021SCU12034,2021SCU12013,and 2020HXBH071)Prof.Cheng acknowledges the financial support of the State Key Laboratory of Polymer Materials Engineering(Grant No.sklpme2021-4-02)Fundamental Research Funds for the Central Universities.
文摘Pathogenic bacterial infection is severely threatening public health globally.The multi-modal antibacterial nanoplatforms could significantly improve the antibacterial efficiency.Here,we report a metal(Ti)-organic framework(MOF)derived nanocarbon(C-Ti-MOF)as a biosafety material for synergistic sterilization of pathogenic bacteria via efficient photodynamic catalysis and robust photothermal effects.The C-Ti-MOF consists of abundant TiO_(2) nanodots embedded in graphitic carbon frameworks.Under visible light irradiation,TiO_(2) nanodots can catalyze H_(2)O_(2) and O_(2) to produce superoxide anion(•O_(2)^(–))and singlet oxygen(1O2),respectively.Meanwhile,under near-infrared irradiation(NIR),C-Ti-MOF can generate massive heat to destroy bacterial membranes.Systematic antibacterial experiments reveal that the C-Ti-MOF nanoagents have a long-lasting and nearly 100%bactericidal ratio at an extremely low dose(0.16 mg/mL),which is much better than the state-of-the-art TiO_(2)(Commercial TiO_(2)(P25),0.64 mg/mL).Furthermore,the C-Ti-MOF can be electrospun into an antibacterial nanofiber membrane via mixing with polymeric matrix for treating bacteriacontaminated wastewater,and the membranes possess integrated antibacterial activity and excellent biocompatibility.Our study demonstrates a promising Ti-MOF-based biosafety material for efficient and long-life disinfection,which may stimulate new research in MOF-related biological applications in various disciplines ranging from water decontaminations to nanotherapeutics.
基金supported by the National Natural Science Foundation of China(21805150)Natural Science Foundation of Shandong Province(ZR2019BB034)+1 种基金the Taishan Scholar Program of Shandong Province of China(ts20110829)Science and Technology Planning Project of Guangdong Province of China(2016B030309002)
文摘Solvent free DNA-surfactant melts are receiving continuous attractions in recent years.Their physical properties could be regulated via changing the alkyl chain length of surfactants.As an ideal external stimulus,light has been used in the regulation of mechanical properties of DNA thermotropic liquid crystal(TLC)containing an azobenzene motif,while in this case,the UV light is the only effective excitation source.However,in comparison with visible light,UV light causes damage to DNA and has low tissue-penetration efficiency problem.In this work,a new type of DNA-didodecyldimethylammonium bromide(DNA-DDAB)TLCs fabricating with gold nanoparticles(AuNPs)was demonstrated.The visible light-induced photothermal effect of AuNPs could change the mechanical properties of AuNPs/DNA-DDAB TLCs,as shown by clearly boundary motion activity and viscoelasticity change.Furthermore,the ratio of AuNPs and charge stoichiometry of DNA:DDAB also affected photocurrent generation property of these DNA melts.The development of this visible light responsive DNA melt might facilitate the related studies in biomedicine and biomaterials.
基金This work was supported by the National Natural Science Foundation of China(51902297,52002361,52003300,and 22109120)the Zhejiang Provincial Natural Science Foundation of China(LQ21B030002)the fund of the Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education,and Hubei Key Laboratory of Catalysis and Materials Science.
文摘Introduction of the photothermal effect into transition-metal oxide photoanodes has been proven to be an effective method to improve the photoelectrochemical(PEC)water-splitting performance.However,the precise role of the photothermal effect on the PEC performance of photoanodes is still not well understood.Herein,spinel-structured ZnFe_(2)O_(4)nanoparticles are deposited on the surface of hematite(Fe_(2)O_(3)),and the ZnFe_(2)O_(4)/Fe_(2)O_(3)photoanode achieves a high photocurrent density of 3.17 mA cm^(-2)at 1.23 V versus a reversible hydrogen electrode(VRHE)due to the photothermal effect of ZnFe_(2)O_(4).Considering that the hopping of electron small polarons induced by oxygen vacancies is thermally activated,we clarify that the main reason for the enhanced PEC performance via the photothermal effect is the promoted mobility of electron small polarons that are bound to positively charged oxygen vacancies.Under the synergistic effect of oxygen vacancies and the photothermal effect,the electron conductivity and PEC performance are significantly improved,which provide fundamental insights into the impact of the photothermal effect on the PEC performance of small polaron-type semiconductor photoanodes.
基金sponsored financially by the National Natural Science Foundation of China (No.21906104 and No.12175145)the Shanghai Rising-Star Program (21QA1406600).
文摘Photothermal catalysis realizes the synergistic effect of solar energy and thermochemistry,which also has the potential to improve the reaction rate and optimize the selectivity.In this review,the research progress of photothermal catalytic removal of volatile organic compounds(VOCs)by nano-catalysts in recent years is systematically reviewed.First,the fundamentals of photothermal catalysis and the fabrication of catalysts are described,and the design strategy of optimizing photothermal catalysis performance is proposed.Second,the performance for VOC degradation with photothermal catalysis is evaluated and compared for the batch and continuous systems.Particularly,the catalytic mechanism of VOC oxidation is systematically introduced based on experimental and theoretical study.Finally,the future limitations and challenges have been discussed,and potential research directions and priorities are highlighted.A broad view of recent photothermal catalyst fabrication,applications,challenges,and prospects can be systemically provided by this review.
基金sponsored in part by National Natural Science Foundation of China(No.61675043/81571726)Fujian Provincial Natural Science Foundation(2015J01006)by the US National Institutes of Health(R21 EB0155091).
文摘Interstitial laser immunotherapy(ILIT)is designed to use photothermal and immunological inter-actions for treatment of metastatic cancers.The photothermal ffect is crucial in inducing anti-tumorimmune responses in the host.Tissue temperature and tssue optical properties are important factorsin this process.In this study,a device combining interstitial photoacoustic(PA)technique andinterstitial laser photothermal interaction is proposed.Together with computational simulation,thisdevice was designed to determine temperature distributions and tissue optical properties during lasertreatment.Experiments were performed usinger-ivoFporcine liver tissue.Our results demonstratedthat interstitial PA signal amplitude was linearly dependent on tisue temperature in the tempera-ture ranges of 20-60℃,as wll as 65-80℃,with a dfferent slope,due to the change of tissue opticalproperties.Using the directly measured temperature in the tissue around the interstitial optical fiberdiffusion tip for calibration,the theoretical temperature distribution predicted by the bioheatequation was used to extract optical properties of tssue.Finally,the three-dimensional temperature distribution was simulated to guide tumor destruction and immunological stimulation,Thus,thisnovel device and method could be used for monitoring and controlling ILIT for cancer treatment.
基金This study was financially supported by the National Natural Science Foundation of China(No.31370835)National Science and Technology Major Special Project on new drug innovation(No.2012ZX09503-001-003)funding from the Dalian University of Technology for the corresponding author(No.DUT21YG121).
文摘Physiotherapeutic effects of infrared lasers have been proved in clinic.These infrared-based regulations of the bioelectrical activities can roughly be classied into enhancement and suppression of action potential(AP),which are described by sodium(Na)and potassium(K)transmembrane current equations,named as Hodgkin and Huxley(HH)-model.The enhancement effect is able to evoke or strengthen the AP when infrared light is applied.Its corresponding mechanism is commonly ascribed to the changes of the cell membrane capacitance,which is transiently increased in response to the infrared radiation.The distinctive feature of the suppression effect is to inhibit or reduce the AP by the designed protocols of infrared radiation.However,its mechanism presents more complexity than that in enhancement cases.HH-model describes how the Na current determines the initial phase of AP.So,the enhancement and suppression of AP can be also ascribed to the regulations of the corresponding Na currents.Here,a continuous infrared light at the wavelength of 980 nm(CIS-980)was employed to stimulate a freshly isolated hippocampal neuron in vitro and a suppression effect on the Na currents of the neuron cell was observed.Both Na and K currents,which are named as whole cell currents,were simultaneously recorded with the cell membrane capacitance current by using a patch clamp combined with infrared irradiation.The results demonstrated that the CIS-980 was able to reversibly increase the capacitance currents,completely suppressed Na currents,but little changed K currents,which forms the steady outward whole cell currents and plays a major role on the AP repolarization.A conrmation experiment was designed and carried out by synchronizing tens of milliseconds of infrared stimulation on the same kinds of hippocampal neuron cells.After the blocked K channel,a reduction of Na current amplitude was still recorded.This proved that infrared suppression of Na current was irrelevant to K channel.A membrane capacitance mediation process was preliminarily proposed to explain the Na channel suppression process.
基金supported by the National Natu-ral Science Foundation of China(Nos.32171340,81772343 and 81771990)the Key Medical Program of Science and Technol-ogy Development of Shanghai(No.20S31900400)the National Science Foundation of Shanghai(No.21ZR1447900).
文摘Design of artificial ligaments possessing both osteogenic activity and antibacterial effect that promotes ligament-bone healing and prevents bacterial infection in bone tunnels for anterior cruciate ligament(ACL)reconstruction remains a significant challenge.In this study,black tantalic oxide(BTO)submicro-particles with oxygen vacancies and structure defects were fabricated by using traditional white tan-talic oxide(WTO)through magnesium thermal reduction(MTR)method,and BTO was coated on polyetheretherketone(PEEK)fibers(PKF),which were woven into fabrics(PBT)as artificial ligaments.PBT with BTO coating exhibited excellent photothermal performance,which possessed not only antibac-terial effects in vitro but also anti-infective ability in vivo.PBT with optimized surface properties(e.g.,submicro-topography and hydrophilicity)not only significantly facilitated rat bone mesenchymal stem cells(BMSC)responses(e.g.,proliferation and osteogenic differentiation)in vitro but also stimulated new bone formation for ligament-bone healing in vivo.The presence of oxygen vacancies and structure de-fects in BTO did not change the surface properties and osteogenic activity of BPT while displaying an outstanding photothermal antibacterial effect.In summary,BPT with osteogenic activity and photother-mal antibacterial effect promoted bone regeneration and prevented bacterial infection,thereby promoting ligament-bone healing.Therefore,PBT would have tremendous potential as a novel artificial ligament for ACL reconstruction.
文摘The silver nanowires(Ag NWs)electrodes,which consist of incompact Ag nanoparticles(NPs)formed by multi-photon photoreduction,usually have poor conductivities.An effective strategy for enhancing conductivity of the Ag NWs elec-trodes is plasmon-enhanced nanosoldering(PLNS)by laser irradiation.Here,plasmon-enhanced photothermal effect is used to locally solder Ag NPs and then aggregates of these NPs grow into large irregular particles in PLNS process.Fi-nite element method(FEM)simulations indicate that the soldering process is triggered by localized surface plasmon-in-duced electric field enhancement at“hot-spots”.The effectiveness of PLNS for enhancing conductivity depends on laser power density and irradiation time.By optimizing the conditions of PLNS,the electrical conductivity of Ag NWs is signific-antly enhanced and the conductivityσs is increased to 2.45×107 S/m,which is about 39%of the bulk Ag.This PLNS of Ag NWs provides an efficient and cost-effective technique to rapidly produce large-area metal nanowire electrodes and capacitors with high conductivity,excellent uniformity,and good flexibility.
基金supported by the National Natural Science Foundation of China(Grant Nos.:21776046,21606043)the Six Talent Peaks Project in Jiangsu Province(Grant No.:XCL-079)+2 种基金the Fundamental Research Funds for the Central Universities(Grant No.:2242019K40145)the Cooperative Research Project between Southeast University and China Pharmaceutical Universitythe Recruitment Program for Young Professionals(the Thousand Youth Talents Plan)。
文摘In this work,hollow manganese dioxide/gold nanoparticle(MnO2/GNPs)hybrid drug nanocarriers were prepared by coupling the gold nanoparticles(GNPs)with hollow structure manganese dioxide(MnO2).Among them,GNPs have been used as near-infrared(NIR)-responsive element for photothermal effect under NIR laser irradiation.The glutathione(GSH)-responsive and p H-responsive performances of drug release were derived from hollow MnO2.Particularly,Doxorubicin hydrochloride(DOX)can be loaded into hollow MnO2/GNPs with the drug loading efficiency up to 82.0%.Moreover,the photothermal effect and GSH-/pH-responsive properties of hollow MnO2/GNPs were investigated.The hollow MnO2/GNPs possessed satisfactory drug release efficiency(ca.87.4%of loaded drug released in 12 h)and have high photothermal conversion efficiency,multiresponsive properties,and degradability.Finally,the kinetics of drug release was discussed in detail.Thus,our finding highlights that the multiresponsive nanocarriers are of great potential in the field of drug controlled release.