An oxidative tandem(4+2)-cyclization/aromatization of N-aryl glycine derivatives with electron-deficient alkenes was first achieved using Ru(bpy)_(3)Cl_(2) as a photocatalyst and TBHP as an oxidant in combination with...An oxidative tandem(4+2)-cyclization/aromatization of N-aryl glycine derivatives with electron-deficient alkenes was first achieved using Ru(bpy)_(3)Cl_(2) as a photocatalyst and TBHP as an oxidant in combination with visible-light irradiation by blue LEDs.One-electron oxidation and the followingα-deprotonation of glycine derivatives affordα-amino alkyl radicals,which were then trapped by electrophilic maleimides.As an atom-economic and efficient method,a variety of pyrrolo[3,4-c]quinoline-1,3-diones have been obtained in good yields under mild reaction conditions.展开更多
基金We thank the National Natural Science Foundation of China(No.21961033)for financially supporting this work.
文摘An oxidative tandem(4+2)-cyclization/aromatization of N-aryl glycine derivatives with electron-deficient alkenes was first achieved using Ru(bpy)_(3)Cl_(2) as a photocatalyst and TBHP as an oxidant in combination with visible-light irradiation by blue LEDs.One-electron oxidation and the followingα-deprotonation of glycine derivatives affordα-amino alkyl radicals,which were then trapped by electrophilic maleimides.As an atom-economic and efficient method,a variety of pyrrolo[3,4-c]quinoline-1,3-diones have been obtained in good yields under mild reaction conditions.
