The present paper investigates the asymptotic behavior of solutions for a class of second order inhomogeneous quasilinear equations on a three dimensional semiinfinite cylinder. A Phragmen-Lindelof type alternative is...The present paper investigates the asymptotic behavior of solutions for a class of second order inhomogeneous quasilinear equations on a three dimensional semiinfinite cylinder. A Phragmen-Lindelof type alternative is obtained, i.e., it is shown that in appropriate norms solutions of the equations either grow or decay as some spatial variable tends to infinity.展开更多
Alternative educational practice has something in common that has been raised as an alternative to the crisis of traditional public education,but the causes,like background,and development patterns of alternative educ...Alternative educational practice has something in common that has been raised as an alternative to the crisis of traditional public education,but the causes,like background,and development patterns of alternative education may be different.As an alternative to restore education,various progressive schools or programs have been operated in Korea and China.The purpose of this study was to shed light on the alternative education in Korea and China,and seek to research its development process and practice.展开更多
Myotonic dystrophy type 1(DM1) is a spliceopathy related to the mis-splicing of several genes caused by sequestration of nuclear transcriptional RNA-binding factors from non-coding CUG repeats of DMPK pre-mRNAs. Dysre...Myotonic dystrophy type 1(DM1) is a spliceopathy related to the mis-splicing of several genes caused by sequestration of nuclear transcriptional RNA-binding factors from non-coding CUG repeats of DMPK pre-mRNAs. Dysregulation of ryanodine receptor 1(RYR1), sarcoplasmatic/endoplasmatic Ca^2+-ATPase(SERCA) and α1 S subunit of voltage-gated Ca^2+ channels(Cav1.1) is related to Ca^2+ homeostasis and excitation-contraction coupling impairment. Though no pharmacological treatment for DM1 exists, aberrant splicing correction represents one major therapeutic target for this disease. Resveratrol(RES, 3,5,4′-trihydroxy-trans-stilbene) is a promising pharmacological tools for DM1 treatment for its ability to directly bind the DNA and RNA influencing gene expression and alternative splicing. Herein, we analyzed the therapeutic effects of RES in DM1 myotubes in a pilot study including cultured myotubes from two DM1 patients and two healthy controls. Our results indicated that RES treatment corrected the aberrant splicing of RYR1, and this event appeared associated with restoring of depolarization-induced Ca^2+ release from RYR1 dependent on the electro-mechanical coupling between RYR1 and Cav1.1. Interestingly, immunoblotting studies showed that RES treatment was associated with a reduction in the levels of CUGBP Elav-like family member 1, while RYR1, Cav1.1 and SERCA1 protein levels were unchanged. Finally, RES treatment did not induce any major changes either in the amount of ribonuclear foci or sequestration of muscleblind-like splicing regulator 1. Overall, the results of this pilot study would support RES as an attractive compound for future clinical trials in DM1. Ethical approval was obtained from the Ethical Committee of IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy(rs9879/14) on May 20, 2014.展开更多
Some new Saul'yev type asymmetric difference schemes for Burgers' equation is given, by the use of the schemes, a kind of alternating group four points method for solving nonlinear Burgers' equation is con...Some new Saul'yev type asymmetric difference schemes for Burgers' equation is given, by the use of the schemes, a kind of alternating group four points method for solving nonlinear Burgers' equation is constructed here. The basic idea of the method is that the grid points on the same time level is divided into a number of groups, the difference equations of each group can be solved independently, hence the method with intrinsic parallelism can be used directly on parallel computer. The method is unconditionally stable by analysis of linearization procedure. The numerical experiments show that the method has good stability and accuracy.展开更多
The main purpose of this paper is to solve the class equation in an alternating group, (i.e. find the solutions set ) and find the number of these solutions where ranges over the conjugacy class in and d is a positive...The main purpose of this paper is to solve the class equation in an alternating group, (i.e. find the solutions set ) and find the number of these solutions where ranges over the conjugacy class in and d is a positive integer. In this paper we solve the class equation in where , for all . is the complement set of where { of , with all parts of are different and odd}. is conjugacy class of and form class depends on the cycle type of its elements If and , then splits into the two classes of .展开更多
Maximum likelihood and Bayes estimators of the parameters, survival function (SF) and hazard rate function (HRF) are obtained for the three-parameter exponentiated Burr type XII distribution when sample is available f...Maximum likelihood and Bayes estimators of the parameters, survival function (SF) and hazard rate function (HRF) are obtained for the three-parameter exponentiated Burr type XII distribution when sample is available from type II censored scheme. Bayes estimators have been developed using the standard Bayes and MCMC methods under square error and LINEX loss functions, using informative type of priors for the parameters. Simulation comparison of various estimation methods is made when n = 20, 40, 60 and censored data. The Bayes estimates are found to be, generally, better than the maximum likelihood estimates against the proposed prior, in the sense of having smaller mean square errors. This is found to be true whether the data are complete or censored. Estimates improve by increasing sample size. Analysis is also carried out for real life data.展开更多
This paper presents a class of Cn- continuous B- type spline curves with some paramet- ric factors.The length of their local support is equal to4.Taking the different values of the parametric factors,the curves can ...This paper presents a class of Cn- continuous B- type spline curves with some paramet- ric factors.The length of their local support is equal to4.Taking the different values of the parametric factors,the curves can become free- type curves or interpolate a set of given points even mix the both cases.When the parametric factors satisfy the certain conditions,the degrees of the curves can be decreased as low as possible.Besides,when all the parametric factors tend to zero,the curves globally approximate to the control polygon.展开更多
Whole-person care and holistic care approach has been proposed for complementary and integrative health care for type 2 diabetes mellitus.However,some doubts still exist on the feasibility of replicating processes fol...Whole-person care and holistic care approach has been proposed for complementary and integrative health care for type 2 diabetes mellitus.However,some doubts still exist on the feasibility of replicating processes followed in clinical trials and observational studies in real-world settings.This narrative literature review summarized and assessed existing clinical evidence(clinical trials,observational studies,and case reports)describing holistic and integrated care approach in adult and adolescent individuals with type 2 diabetes mellitus in clinical practice.The goal was to highlight existing evidence for implementation and outcomes of whole-medical systems and holistic integrated care approach for type 2 diabetes mellitus.A nonsystematic literature search was performed on Google Scholar,PubMed,Web of Science,ProQuest and ScienceDirect to identify clinical evidence from different parts of the world,evaluating the use of whole-medical systems and/or holistic care interventions in clinical practice for management of type 2 diabetes mellitus.Relevant keywords were used in the search.Data were analyzed using content analysis and simple descriptive statistics(percentages).Most of the studies(64%)were mainly conducted in Eastern countries(India,China and Israel)while 36%of the studies were conducted in the Western countries(USA,Netherlands,Canada and Mexico).Lifestyle medicine and integrated naturopathy were shown to be the commonly used whole-medical systems for type 2 diabetes mellitus management.Significant improvements in type 2 diabetes parameters,medication use,other symptoms,and overall feeling of wellness were observed in all studies.This review study revealed limited utilization and/or documentation of whole-medical systems or holistic care treatments for type 2 diabetes mellitus in regions of the world other than eastern countries.Lifestyle medicine,naturopathy,yoga,Ayurveda and traditional Chinese medicine were shown to be effective for type 2 diabetes mellitus,either as an alternative or as a complementary therapy.展开更多
文摘The present paper investigates the asymptotic behavior of solutions for a class of second order inhomogeneous quasilinear equations on a three dimensional semiinfinite cylinder. A Phragmen-Lindelof type alternative is obtained, i.e., it is shown that in appropriate norms solutions of the equations either grow or decay as some spatial variable tends to infinity.
文摘Alternative educational practice has something in common that has been raised as an alternative to the crisis of traditional public education,but the causes,like background,and development patterns of alternative education may be different.As an alternative to restore education,various progressive schools or programs have been operated in Korea and China.The purpose of this study was to shed light on the alternative education in Korea and China,and seek to research its development process and practice.
基金supported by grants from UniversitàCattolica and Italian Ministry of Scientific Research(grant number D1-2016 to GS)
文摘Myotonic dystrophy type 1(DM1) is a spliceopathy related to the mis-splicing of several genes caused by sequestration of nuclear transcriptional RNA-binding factors from non-coding CUG repeats of DMPK pre-mRNAs. Dysregulation of ryanodine receptor 1(RYR1), sarcoplasmatic/endoplasmatic Ca^2+-ATPase(SERCA) and α1 S subunit of voltage-gated Ca^2+ channels(Cav1.1) is related to Ca^2+ homeostasis and excitation-contraction coupling impairment. Though no pharmacological treatment for DM1 exists, aberrant splicing correction represents one major therapeutic target for this disease. Resveratrol(RES, 3,5,4′-trihydroxy-trans-stilbene) is a promising pharmacological tools for DM1 treatment for its ability to directly bind the DNA and RNA influencing gene expression and alternative splicing. Herein, we analyzed the therapeutic effects of RES in DM1 myotubes in a pilot study including cultured myotubes from two DM1 patients and two healthy controls. Our results indicated that RES treatment corrected the aberrant splicing of RYR1, and this event appeared associated with restoring of depolarization-induced Ca^2+ release from RYR1 dependent on the electro-mechanical coupling between RYR1 and Cav1.1. Interestingly, immunoblotting studies showed that RES treatment was associated with a reduction in the levels of CUGBP Elav-like family member 1, while RYR1, Cav1.1 and SERCA1 protein levels were unchanged. Finally, RES treatment did not induce any major changes either in the amount of ribonuclear foci or sequestration of muscleblind-like splicing regulator 1. Overall, the results of this pilot study would support RES as an attractive compound for future clinical trials in DM1. Ethical approval was obtained from the Ethical Committee of IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy(rs9879/14) on May 20, 2014.
文摘Some new Saul'yev type asymmetric difference schemes for Burgers' equation is given, by the use of the schemes, a kind of alternating group four points method for solving nonlinear Burgers' equation is constructed here. The basic idea of the method is that the grid points on the same time level is divided into a number of groups, the difference equations of each group can be solved independently, hence the method with intrinsic parallelism can be used directly on parallel computer. The method is unconditionally stable by analysis of linearization procedure. The numerical experiments show that the method has good stability and accuracy.
文摘The main purpose of this paper is to solve the class equation in an alternating group, (i.e. find the solutions set ) and find the number of these solutions where ranges over the conjugacy class in and d is a positive integer. In this paper we solve the class equation in where , for all . is the complement set of where { of , with all parts of are different and odd}. is conjugacy class of and form class depends on the cycle type of its elements If and , then splits into the two classes of .
文摘Maximum likelihood and Bayes estimators of the parameters, survival function (SF) and hazard rate function (HRF) are obtained for the three-parameter exponentiated Burr type XII distribution when sample is available from type II censored scheme. Bayes estimators have been developed using the standard Bayes and MCMC methods under square error and LINEX loss functions, using informative type of priors for the parameters. Simulation comparison of various estimation methods is made when n = 20, 40, 60 and censored data. The Bayes estimates are found to be, generally, better than the maximum likelihood estimates against the proposed prior, in the sense of having smaller mean square errors. This is found to be true whether the data are complete or censored. Estimates improve by increasing sample size. Analysis is also carried out for real life data.
文摘This paper presents a class of Cn- continuous B- type spline curves with some paramet- ric factors.The length of their local support is equal to4.Taking the different values of the parametric factors,the curves can become free- type curves or interpolate a set of given points even mix the both cases.When the parametric factors satisfy the certain conditions,the degrees of the curves can be decreased as low as possible.Besides,when all the parametric factors tend to zero,the curves globally approximate to the control polygon.
基金Central University of Technology,Free State(CUT)and National Research Foundation(NRF)of South Africa。
文摘Whole-person care and holistic care approach has been proposed for complementary and integrative health care for type 2 diabetes mellitus.However,some doubts still exist on the feasibility of replicating processes followed in clinical trials and observational studies in real-world settings.This narrative literature review summarized and assessed existing clinical evidence(clinical trials,observational studies,and case reports)describing holistic and integrated care approach in adult and adolescent individuals with type 2 diabetes mellitus in clinical practice.The goal was to highlight existing evidence for implementation and outcomes of whole-medical systems and holistic integrated care approach for type 2 diabetes mellitus.A nonsystematic literature search was performed on Google Scholar,PubMed,Web of Science,ProQuest and ScienceDirect to identify clinical evidence from different parts of the world,evaluating the use of whole-medical systems and/or holistic care interventions in clinical practice for management of type 2 diabetes mellitus.Relevant keywords were used in the search.Data were analyzed using content analysis and simple descriptive statistics(percentages).Most of the studies(64%)were mainly conducted in Eastern countries(India,China and Israel)while 36%of the studies were conducted in the Western countries(USA,Netherlands,Canada and Mexico).Lifestyle medicine and integrated naturopathy were shown to be the commonly used whole-medical systems for type 2 diabetes mellitus management.Significant improvements in type 2 diabetes parameters,medication use,other symptoms,and overall feeling of wellness were observed in all studies.This review study revealed limited utilization and/or documentation of whole-medical systems or holistic care treatments for type 2 diabetes mellitus in regions of the world other than eastern countries.Lifestyle medicine,naturopathy,yoga,Ayurveda and traditional Chinese medicine were shown to be effective for type 2 diabetes mellitus,either as an alternative or as a complementary therapy.
