OBJECTIVE Di.E and Gpm.E were separately extracted from two kinds of traditional Chinese medicine.The aim of this research is to investigate the combined anti-hyperuricemia effect of Di.E and Gpm.E on hyperuricemia ra...OBJECTIVE Di.E and Gpm.E were separately extracted from two kinds of traditional Chinese medicine.The aim of this research is to investigate the combined anti-hyperuricemia effect of Di.E and Gpm.E on hyperuricemia rats induced by high-purine diet,and to study the underlying mechanism.METHODS Sprague Dawley(SD)rats were divided into some groups according to their serum uric acid(UA),the normal control group received standard diet,while others were fed with high-purine diet.After the success of modeling,SD rats were divided into 5groups according to UA:normal control group,model control group,Di.E and Gpm.E(high,middle,low dosages).The treatment groups were simultaneously orally administered.Two days before the last administration,the urine N-acetyl beta-D Glucosaminidase(NAG),Lysozyme(LYS)activity were separately detected using the urine collected from metabolic cage for 24 h.After the last administration,the blood was taken from postcava to detect the level:① The related indexes of liver and kidney function:the serum UA,blood urea nitrogen(BUN),creatinine(CR),alanine aminotransferase(ALT);② The uric acid metabolism related enzymes:the serum and liver xanthine oxidase(XOD),adenosine deaminase(ADA),guanine deaminase(GD),xanthine dehydrogenase(XDH)activity;③ Fibrosis related indexes of renal tissue:connective tissue growth factor(CTGF),monocyte chemotactic protein-1(MCP-1),TGF-β1,TNF-α,NF-κB levels.RESULTS Di.E and Gpm.E(high,middle dosages)could markedly reduce the serum UA level significantly,also can decrease XOD,ADA,TNF-α,MCP-1,NF-κB activity significantly.CONCLUSION The results show that Di.E and Gpm.E can decrease the serum UA level significantly,improve the liver and kidney function and slow down the process of renal fibrosis;the therapeutic effects may be related to their inhibition of XOD,ADA activity.展开更多
The German Postal Reform I in 1989 introduced competition in the mobile cellular market. German cellular operators, DeTeMobil, Mannesmann, E-Plus and VIAG Interkom, built D1-, D2-, E1-and E2-Netze based on GSM standar...The German Postal Reform I in 1989 introduced competition in the mobile cellular market. German cellular operators, DeTeMobil, Mannesmann, E-Plus and VIAG Interkom, built D1-, D2-, E1-and E2-Netze based on GSM standards made in Europe. China Unicom was created in 1994 and China Telecom was separated from MPT in 1995. China Telecom and China Unicom competed in a duopoly from the mid-1990s onwards and the cellular services provided by them also rely on GSM standards. China Telecom additionally deployed XLT technology (PHS) from the late 1990s onwards. While DeTeMobil and Mannesmann conquered approximately 80%-90% of the market throughout the 1990s and were the two dominant market players in Germany, China's cellular market was mainly controlled by China Mobile. In Germany, prices related to cellular technology continued the downwards trend as a major result of the process of deregulation, liberalisation and competition. In China, price wars had led to significant price reductions in the cellular market. Although network operators in both countries strived to deliver differentiated cellular services, the two national markets in the 1990s were visibly shaped by product homogeneity.展开更多
From the stems ofMarsdenia tenacissima two new polyoxypregnanes were isolated, their structures were elucidated by 1D, 2D-NMR as 11α,12β-di-O-tigloyl-tenacigenin B （1） and tenacigenoside E （2）.
Three new naphthaline-type chromophores end-capped with different (p-substituted amino) styryl groups on the both sides (named as BPASN, BHMASN and BMASN) have been synthesized. Under excitation of 380 nm, strong gree...Three new naphthaline-type chromophores end-capped with different (p-substituted amino) styryl groups on the both sides (named as BPASN, BHMASN and BMASN) have been synthesized. Under excitation of 380 nm, strong green light-emitting locating at 517 nm with the fluorescence quantum yield of 0.88 in CH2Cl2 has been obtained. In the presence of b-cyclodextrin (b-CD), strong blue-emitting at 456 nm in DMF was also recorded.展开更多
Nel corso del 1991 è stato effettuato un censimento delle tane di Tasso Meles melesin un’area molto antropizzata della Pianura Padana posta alla conflaenza del flume Lambro nel flumePo, estesa per 103 Km^2. Si s...Nel corso del 1991 è stato effettuato un censimento delle tane di Tasso Meles melesin un’area molto antropizzata della Pianura Padana posta alla conflaenza del flume Lambro nel flumePo, estesa per 103 Km^2. Si sono individuate 24 tane (0,2 Km^2). Density and distribution of Badger’s setts (Meles meles) in the Lower Lodigiano (NorthernItaly). A census of the Badger’s setts (Meles meles) was carried out in 1991 in a densely inhabited areaof the Po Plain, near the mouth of the river Lambro into the Po. In the study area (extended for103 Km^2) 24 setts have been found (0,2 Km^2).展开更多
Nella presente nota vengono forniti dati di due nuove stazioni di Pseudoboldoria robiatii(Reit:er, 1889) in territorio lombardo, a sud-est del lago di Como, site l’una presso Paderno d’Adda,oltre le cerchie morenich...Nella presente nota vengono forniti dati di due nuove stazioni di Pseudoboldoria robiatii(Reit:er, 1889) in territorio lombardo, a sud-est del lago di Como, site l’una presso Paderno d’Adda,oltre le cerchie moreniche pleistoceniche più esterne, l’altra a oriente del flume Adda, sul monte Albenza.Tall stazioni, oltre ad ampliare considerevolmente l’areale noto della specie, permettono di ridiscuterele modalità di distribuzione della specie e di avanzare in proposito alcune ipotesi. In particolare vienerivalutata l’influenza della durata del Pleistocene sui fenomeni di speciazione e viene attribuita la distribu-zione delle popolazioni indifferenziate di P. robiatii alla fase di deglaciazione dell’anfiteatro morenicolariano nel Tardiglaciale. New data on the distribution of Pseudoboldoria robiatii (Reittet, 1889) and some conside-rations on the Pleistocene distribution of Bathysciinae in Lombardy (Coleoptera Catopidae). The Authorreports two new localities of Pseudoboldoria robiatii (Reitter, 1889) discovered in Lombardy, south-eastof Lake Como. One lies at Paderno d’Adda beyond the Pleistocene aesternmost moraines, the otheron Mount Albenza, east of the river Adda. These finds extend the distribution of the species and suggestsome hypotheses on its models of distribution. In particular, the Author reconsiders the influence ofthe duration of the Ice Age on the phenomena of speciation and attributes the distribution of undifferen-tiated populations of P. robiatii to the Late Glacial of the morainic amphitheatre of Lake Como.展开更多
基金The project supported by National Major Scientific and Technological Specialized Project for the Significant Formulation of New Drugs,China(2014ZX09301-307-13)
文摘OBJECTIVE Di.E and Gpm.E were separately extracted from two kinds of traditional Chinese medicine.The aim of this research is to investigate the combined anti-hyperuricemia effect of Di.E and Gpm.E on hyperuricemia rats induced by high-purine diet,and to study the underlying mechanism.METHODS Sprague Dawley(SD)rats were divided into some groups according to their serum uric acid(UA),the normal control group received standard diet,while others were fed with high-purine diet.After the success of modeling,SD rats were divided into 5groups according to UA:normal control group,model control group,Di.E and Gpm.E(high,middle,low dosages).The treatment groups were simultaneously orally administered.Two days before the last administration,the urine N-acetyl beta-D Glucosaminidase(NAG),Lysozyme(LYS)activity were separately detected using the urine collected from metabolic cage for 24 h.After the last administration,the blood was taken from postcava to detect the level:① The related indexes of liver and kidney function:the serum UA,blood urea nitrogen(BUN),creatinine(CR),alanine aminotransferase(ALT);② The uric acid metabolism related enzymes:the serum and liver xanthine oxidase(XOD),adenosine deaminase(ADA),guanine deaminase(GD),xanthine dehydrogenase(XDH)activity;③ Fibrosis related indexes of renal tissue:connective tissue growth factor(CTGF),monocyte chemotactic protein-1(MCP-1),TGF-β1,TNF-α,NF-κB levels.RESULTS Di.E and Gpm.E(high,middle dosages)could markedly reduce the serum UA level significantly,also can decrease XOD,ADA,TNF-α,MCP-1,NF-κB activity significantly.CONCLUSION The results show that Di.E and Gpm.E can decrease the serum UA level significantly,improve the liver and kidney function and slow down the process of renal fibrosis;the therapeutic effects may be related to their inhibition of XOD,ADA activity.
文摘The German Postal Reform I in 1989 introduced competition in the mobile cellular market. German cellular operators, DeTeMobil, Mannesmann, E-Plus and VIAG Interkom, built D1-, D2-, E1-and E2-Netze based on GSM standards made in Europe. China Unicom was created in 1994 and China Telecom was separated from MPT in 1995. China Telecom and China Unicom competed in a duopoly from the mid-1990s onwards and the cellular services provided by them also rely on GSM standards. China Telecom additionally deployed XLT technology (PHS) from the late 1990s onwards. While DeTeMobil and Mannesmann conquered approximately 80%-90% of the market throughout the 1990s and were the two dominant market players in Germany, China's cellular market was mainly controlled by China Mobile. In Germany, prices related to cellular technology continued the downwards trend as a major result of the process of deregulation, liberalisation and competition. In China, price wars had led to significant price reductions in the cellular market. Although network operators in both countries strived to deliver differentiated cellular services, the two national markets in the 1990s were visibly shaped by product homogeneity.
文摘From the stems ofMarsdenia tenacissima two new polyoxypregnanes were isolated, their structures were elucidated by 1D, 2D-NMR as 11α,12β-di-O-tigloyl-tenacigenin B （1） and tenacigenoside E （2）.
文摘Three new naphthaline-type chromophores end-capped with different (p-substituted amino) styryl groups on the both sides (named as BPASN, BHMASN and BMASN) have been synthesized. Under excitation of 380 nm, strong green light-emitting locating at 517 nm with the fluorescence quantum yield of 0.88 in CH2Cl2 has been obtained. In the presence of b-cyclodextrin (b-CD), strong blue-emitting at 456 nm in DMF was also recorded.
文摘Nel corso del 1991 è stato effettuato un censimento delle tane di Tasso Meles melesin un’area molto antropizzata della Pianura Padana posta alla conflaenza del flume Lambro nel flumePo, estesa per 103 Km^2. Si sono individuate 24 tane (0,2 Km^2). Density and distribution of Badger’s setts (Meles meles) in the Lower Lodigiano (NorthernItaly). A census of the Badger’s setts (Meles meles) was carried out in 1991 in a densely inhabited areaof the Po Plain, near the mouth of the river Lambro into the Po. In the study area (extended for103 Km^2) 24 setts have been found (0,2 Km^2).
文摘Nella presente nota vengono forniti dati di due nuove stazioni di Pseudoboldoria robiatii(Reit:er, 1889) in territorio lombardo, a sud-est del lago di Como, site l’una presso Paderno d’Adda,oltre le cerchie moreniche pleistoceniche più esterne, l’altra a oriente del flume Adda, sul monte Albenza.Tall stazioni, oltre ad ampliare considerevolmente l’areale noto della specie, permettono di ridiscuterele modalità di distribuzione della specie e di avanzare in proposito alcune ipotesi. In particolare vienerivalutata l’influenza della durata del Pleistocene sui fenomeni di speciazione e viene attribuita la distribu-zione delle popolazioni indifferenziate di P. robiatii alla fase di deglaciazione dell’anfiteatro morenicolariano nel Tardiglaciale. New data on the distribution of Pseudoboldoria robiatii (Reittet, 1889) and some conside-rations on the Pleistocene distribution of Bathysciinae in Lombardy (Coleoptera Catopidae). The Authorreports two new localities of Pseudoboldoria robiatii (Reitter, 1889) discovered in Lombardy, south-eastof Lake Como. One lies at Paderno d’Adda beyond the Pleistocene aesternmost moraines, the otheron Mount Albenza, east of the river Adda. These finds extend the distribution of the species and suggestsome hypotheses on its models of distribution. In particular, the Author reconsiders the influence ofthe duration of the Ice Age on the phenomena of speciation and attributes the distribution of undifferen-tiated populations of P. robiatii to the Late Glacial of the morainic amphitheatre of Lake Como.
