Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity.With the i...Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity.With the increased degree and duration of distraction,spinal cord injuries become more serious in terms of their neurophysiology,histology,and behavior.Very few studies have been published on the specific characteristics of distraction spinal cord injury.In this study,we systematically review 22 related studies involving animal models of distraction spinal cord injury,focusing particularly on the neurophysiological,histological,and behavioral characteristics of this disease.In addition,we summarize the mechanisms underlying primary and secondary injuries caused by distraction spinal cord injury and clarify the effects of different degrees and durations of distraction on the primary injuries associated with spinal cord injury.We provide new concepts for the establishment of a model of distraction spinal cord injury and related basic research,and provide reference guidelines for the clinical diagnosis and treatment of this disease.展开更多
背景:失用性骨质疏松较为常见,因其特殊的病因,预防治疗缺乏有效手段,给社会和家庭带来了巨大的负担。目的:分析失用性骨质疏松的病因、发病机制及预防治疗方法,为失用性骨质疏松的有效预防提供参考。方法:检索CNKI和PUBMED数据库,2002...背景:失用性骨质疏松较为常见,因其特殊的病因,预防治疗缺乏有效手段,给社会和家庭带来了巨大的负担。目的:分析失用性骨质疏松的病因、发病机制及预防治疗方法,为失用性骨质疏松的有效预防提供参考。方法:检索CNKI和PUBMED数据库,2002年1月至2012年9月收录的失用性骨质疏松症的相关文献,中文检索词为"废用性骨质疏松或失用性骨质疏松",共检索到中文67篇;英文检索词为"disuse osteoporosis AND English"检索到111篇相关文献,对文章进行初审,纳入文献主题与此文联系密切,原创、论点论据可靠的文章,观点明确,分析全面的文章;排除内容陈旧或重复文献及试验设计不是随机对照试验的文章。结果与结论:共纳入符合标准的文献50篇(中文25篇,英文25篇)。目前对失用性骨质疏松症的病因大致归为3大类,即机械负重的减少、微重力状态、脊髓及神经损伤。失用性骨质疏松的预防和治疗主要有:药物预防治疗,包括降钙素、中草药、双膦酸盐、维生素、钙、锶盐及神经生长因子等;物理治疗:脉冲电磁场、超声波、共振波、被动运动及电针治疗。目前临床上对失用性骨质疏松症没有理想的预防治疗措施,近年来研究者们开始试图从遗传学角度探讨其发病机制,在一些信号通道蛋白、特异性基因位点的研究中取得了一定进展。展开更多
基金supported by the National Natural Science Foundation of China,No.81772421(to YH).
文摘Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity.With the increased degree and duration of distraction,spinal cord injuries become more serious in terms of their neurophysiology,histology,and behavior.Very few studies have been published on the specific characteristics of distraction spinal cord injury.In this study,we systematically review 22 related studies involving animal models of distraction spinal cord injury,focusing particularly on the neurophysiological,histological,and behavioral characteristics of this disease.In addition,we summarize the mechanisms underlying primary and secondary injuries caused by distraction spinal cord injury and clarify the effects of different degrees and durations of distraction on the primary injuries associated with spinal cord injury.We provide new concepts for the establishment of a model of distraction spinal cord injury and related basic research,and provide reference guidelines for the clinical diagnosis and treatment of this disease.
文摘背景:失用性骨质疏松较为常见,因其特殊的病因,预防治疗缺乏有效手段,给社会和家庭带来了巨大的负担。目的:分析失用性骨质疏松的病因、发病机制及预防治疗方法,为失用性骨质疏松的有效预防提供参考。方法:检索CNKI和PUBMED数据库,2002年1月至2012年9月收录的失用性骨质疏松症的相关文献,中文检索词为"废用性骨质疏松或失用性骨质疏松",共检索到中文67篇;英文检索词为"disuse osteoporosis AND English"检索到111篇相关文献,对文章进行初审,纳入文献主题与此文联系密切,原创、论点论据可靠的文章,观点明确,分析全面的文章;排除内容陈旧或重复文献及试验设计不是随机对照试验的文章。结果与结论:共纳入符合标准的文献50篇(中文25篇,英文25篇)。目前对失用性骨质疏松症的病因大致归为3大类,即机械负重的减少、微重力状态、脊髓及神经损伤。失用性骨质疏松的预防和治疗主要有:药物预防治疗,包括降钙素、中草药、双膦酸盐、维生素、钙、锶盐及神经生长因子等;物理治疗:脉冲电磁场、超声波、共振波、被动运动及电针治疗。目前临床上对失用性骨质疏松症没有理想的预防治疗措施,近年来研究者们开始试图从遗传学角度探讨其发病机制,在一些信号通道蛋白、特异性基因位点的研究中取得了一定进展。
