Physical interactions between activated microglia and injured axons:do all contacts lead to phagocytosis?

Axonal injury is a pathological hallmark of both head injury and inflammatory-mediated neurological disorders,including multiple sclerosis（Schirmer et al.,2013）.Such axonal disruptions and/or disconnections typically result in proximal axonal segments that remain in continuity with the neuronal somawhile losing contact with their distal targets.

SINO-GERMAN WORKSHOP ON CHEMICAL AND PHYSICAL INTERACTIONS BETWEEN PARTICLES AND FLUIDS

1. Introduction Supported by the Sino-German Center for Research Promotion, and organized jointly by the National Natural Science Foundation of China (NSFC) and the German Research Foundation (DFG), the third Sino-German workshop on particle fluid systems was held on Oct. 24-31, 2004 in Beijing, China, following the two previous successful workshops held on Aug. 30-31,1999 in Hamburg, Germany (Li and Werther, Chem. Eng. Technol., 23(4), 378, 2000) and May 18-19, 2001 in Beijing, China (Li, Ge, Werther and Bruhns, Chem. Eng. Technol., 24(11), 1097, 2001). Thirty-one scientists from China, Germany, Japan and The Netherlands came together for interdisciplinary discussion over the core problem of multi-phase reaction systems in the name of "Chemical and Physical Interactions between Particles and Fluids".

Unstable Tropical Air-Sea Interaction Waves and Their Physical Mechanisms

In this paper, the tropical air-sea interaction is discussed by using a simple air-sea coupled model, in which the inertia-gravity waves are filtered off and only the equatorial Rossby waves are reserved in both the atmosphere and the ocean. There exist two kinds of air-sea interaction waves in the coupled model, that is, the high-frequency fast waves and the low-frequency slow waves. The phase speed of the fast waves is westward and the frequencies are close to those of the equatorial Rossby waves in the atmosphere. The slow waves propagate westward in the part of short wavelengths and eastward in that of long wavelengths. There exist instabilities for both the westward and eastward propagating slow waves. If the fast waves are filtered off, there is little effect on the slow waves which have great influence on the long range process in the tropical air-sea coupled system. According to the tropical air-sea interaction waves we obtain here, a possible explanation to the propagating process of ENSO events is given.

Physical Mechanism of Organic Matter-Mineral Interaction in Longmaxi Shale,Sichuan Basin,China

Objective Shale gas is as an important kind of unconventional natural gas,with a great resource potential,and its exploration and development has attracted much attention around the world.Organic matter（OM）pores are a common constituent in shales and form the dominant pore network of many shale gas systems.

Assessing effect of interaction between the FTO A/T polymorphism(rs9939609)and physical activity on obesity-related traits

Background： The first described obesity-susceptibility gene was the fat mass and obesity-associated （FTO） gene. However, knowledge about FTO＇s potential modifying effect on changes in body weight achieved through a training program is still limited. We decided to study the association between the FTO A/T polymorphism （rs9939609） and obesity-related traits. Additionally, we investigated whether body mass and body composition, as well as metabolic variables observed in physically active participants, are modulated by the FTO polymorphism. Methods： A group of 201 young Polish women were recruited for the study. The genotype distribution was examined in participants measured for selected changes before and after the completion of a 12-week training program. Results： Our results confirm the association between the common FTO A/T polymorphism and increased body mass index （BMI）. Subjects with AA and AT genotypes had higher BMI during the entire study period compared with the TT genotype. Although parameters such as BMI, basal metabolism rate, tissue independence, fat mass percentage, fat mass, fat-free mass, total body water, high-density lipoprotein, and glucose changed significantly during the training program, none of the examined parameters changed significantly across the FTO genotypes （genotype × training interaction）. Conclusion： We confirm an association between the FTO A/T polymorphism and increased BMI; this polymorphism is therefore a candidate for influencing obesity and other disease-related phenotypes. Although the gene x physical activity interaction was not shown, we want to point out that promoting physical activity is an important approach to controlling the increasing obesity epidemic.2018 Published by Elsevier B.V. on behalf of Shanghai University of Sport. This is an open access article under the CC BY-NC-ND license. （http：//creativecommons.org/licenses/by-nc-nd/4.0/）.

Teaching the User By Learning From the User:Personalizing Movement Control in Physical Human-robot Interaction

This paper proposes a novel approach for physical human-robot interactions(pHRI), where a robot provides guidance forces to a user based on the user performance. This framework tunes the forces in regards to behavior of each user in coping with different tasks, where lower performance results in higher intervention from the robot. This personalized physical human-robot interaction(p2HRI) method incorporates adaptive modeling of the interaction between the human and the robot as well as learning from demonstration(LfD) techniques to adapt to the users' performance. This approach is based on model predictive control where the system optimizes the rendered forces by predicting the performance of the user. Moreover, continuous learning of the user behavior is added so that the models and personalized considerations are updated based on the change of user performance over time. Applying this framework to a field such as haptic guidance for skill improvement, allows a more personalized learning experience where the interaction between the robot as the intelligent tutor and the student as the user,is better adjusted based on the skill level of the individual and their gradual improvement. The results suggest that the precision of the model of the interaction is improved using this proposed method,and the addition of the considered personalized factors to a more adaptive strategy for rendering of guidance forces.

基于Interactive Physics的物理习题教学--以2023年高考全国乙卷25题和湖北卷15题为例

在传统高中物理教学中,多过程碰撞的物理过程很难在板书上展现出来,成为教学的一大难点。基于Interactive Physics仿真功能,以2023年高考全国乙卷25题和湖北卷15题为例,将多过程碰撞的物理过程可视化,直观展现物理模型,帮助学生理解题目的复杂情境,有效缩短学习时间,提高教学质量和教学效率,实现最优化的教学目标。

Information Interaction Is the Fifth Type of Fundamental Interactions

Information is an integral part of the Universe. By its physical essence information is heterogeneity of matter and energy. Therefore information is inseparably connected with matter and energy. The universal measure of information in physical heterogeneity is the Shannon information entropy. An information approach along with a physical one allows to obtain new, sometimes more general data in relation to data obtained on the ground of physical rules only. The results presented in this paper show the effectiveness of informational approach for studying the interactions in the Universe. The paper shows that, along with the physical interactions the gravitational, electromagnetic, strong, weak interactions exists fifth type of fundamental interactions--information interaction, whose magnitude is not dependent on distance. The existence of information interaction is determined by the entanglement of quantum states, of quantum subsystems. The magnitude of information interaction is measured in bits.

Augmented Virtual Stiffness Rendering of a Cable-driven SEA for Human-Robot Interaction

Human-robot interaction(HRI) is fundamental for human-centered robotics, and has been attracting intensive research for more than a decade. The series elastic actuator(SEA) provides inherent compliance, safety and further benefits for HRI, but the introduced elastic element also brings control difficulties. In this paper, we address the stiffness rendering problem for a cable-driven SEA system, to achieve either low stiffness for good transparency or high stiffness bigger than the physical spring constant, and to assess the rendering accuracy with quantified metrics. By taking a velocity-sourced model of the motor, a cascaded velocity-torque-impedance control structure is established. To achieve high fidelity torque control, the 2-DOF(degree of freedom) stabilizing control method together with a compensator has been used to handle the competing requirements on tracking performance, noise and disturbance rejection,and energy optimization in the cable-driven SEA system. The conventional passivity requirement for HRI usually leads to a conservative design of the impedance controller, and the rendered stiffness cannot go higher than the physical spring constant. By adding a phase-lead compensator into the impedance controller,the stiffness rendering capability was augmented with guaranteed relaxed passivity. Extensive simulations and experiments have been performed, and the virtual stiffness has been rendered in the extended range of 0.1 to 2.0 times of the physical spring constant with guaranteed relaxed passivity for physical humanrobot interaction below 5 Hz. Quantified metrics also verified good rendering accuracy.

Deposition pattern of stony and muddy debris flow at the confluence area

Debris flow fan affects the river profile and landscape evolution.The propagation of multiple debris flows along a river can cause inundation and breaching risk,which can be exemplified by the Min River after the Wenchuan earthquake,Sichuan province,China.In this work,large flume tests were conducted to examine the interactions between debris flows and water current with the fan geometry,momentum,runout distance,deposited width,the relative water level upstream and dominated stress.The results reveal that stony flow commonly travels at a high speed and forms a long rectangle shape fan,while the muddy flow generally travels at a low speed and forms a fan-shaped depositional area.The stony flow can block a river even when the momentum is close to the water current;the muddy flow can block a river when the momentum is lower than that of water current.In case of complete river damming,the relative water level upstream indicates that the inundation risk from the muddy flow damming river would be higher than the inundation risk of stony flow.The diversion ratio of muddy flow decreases as damming ratio.Comparison of dimensionless numbers reveals that stony flow is dominated by grain collision stress combined with turbulent mixing stress,while the muddy flow is dominated by viscous shear stress over friction stress.The fan geometry,damming ratio,diversion ratio,and the dominated stress all together indicate that stony flow strongly interacts with water current while the muddy flow does not.The results can be helpful for understanding the physical interactions between water current and various debris flows,and debris flow dynamics at the channel confluence area.

Laboratory Investigation of Disintegration Characteristics of Purple Mudstone under Different Hydrothermal Conditions

Disintegration of rock is one of the primary processes of soil formation and geomorphology and is affected considerably by water and heat.This study focused on the disintegration characteristics under laboratory conditions of typical purple mudstone from the Tuodian group of Jurassic red beds(J3t) in Tuodian Town,Shuangbai county,Yunnan Province of southern China.The fresh mudstone was subjected to alternating applications of water,heat and hydrothermal interaction during five treatments:wetting-drying(WD),saturation(ST),refrigeration-heating(RH),a combination of wetting-drying and refrigeration-heating(WDRH),and a combination of saturation and refrigeration-heating(STRH).Each treatment was run in twenty-four cycles.The results showed that there are three types of disintegration:collapsing disintegration,exfoliation disintegration and imperceptible disintegration.The cumulative disintegration rate(percentage of cumulative disintegrated mass to the initiative sample mass passed through a 2 mm sieve) produced a 'S'-shape function when related to treatment cycle time and closely fit a logistic model(R2 > 0.99).The rank order of the cumulative disintegration rate resulting from the five treatments was as the following:WDRH > STRH > ST > WD > RH.Because of alternating periods of moisture and dryness,WD caused the most disintegration,while RH alone resulted in imperceptible disintegration.Additionally,there was a negative correlation between the disintegration rate of each treatment cycle(percentage of disintegrated mass to the treated sample mass) and treatment cycle number.There was a positive correlation between this rate and temperature change under moist conditions,indicating that a change in temperature greatly accelerates the disintegration of parent rock when water was supplied.

Physical human-robot interaction estimation based control scheme for a hydraulically actuated exoskeleton designed for power amplification

We proposed a lower extremity exoskeleton for power amplification that perceives intended human motion via humanexoskeleton interaction signals measured by biomedical or mechanical sensors, and estimates human gait trajectories to implement corresponding actions quickly and accurately. In this study, torque sensors mounted on the exoskeleton links are proposed for obtaining physical human-robot interaction（pHRI） torque information directly. A Kalman smoother is adopted for eliminating noise and smoothing the signal data. Simultaneously, the mapping from the pHRI torque to the human gait trajectory is defined. The mapping is derived from the real-time state of the robotic exoskeleton during movement. The walking phase is identified by the threshold approach using ground reaction force. Based on phase identification, the human gait can be estimated by applying the proposed algorithm, and then the gait is regarded as the reference input for the controller. A proportional-integral-derivative control strategy is constructed to drive the robotic exoskeleton to follow the human gait trajectory. Experiments were performed on a human subject who walked on the floor at a natural speed wearing the robotic exoskeleton. Experimental results show the effectiveness of the proposed strategy.

Main Problems of the Theoretical Physics and Artifacts of Local Physics

Shortcomings of the Boltzmann physical kinetics are considered. Boltzmann equation is only plausible equation. The cosequences originated from this fact are considered in the different fields of theoretical physics from the point of view of nonlocal physics. Namely: main principles of nonlocal physics;generalized hydrodynamic equations;magnetic field evolution in the superconductor of the second type;Hubble expansion;special theory of relativity;the problem of the interaction of matter (M) with physical vacuum (PV) is considered including the PV—M energy exchange. Application nonlocal physics to the problem of the dark matter existence—dark matter does not exist, analytical investigation.

Delicate scale multipeak and flat-top structures of solitary waves in multicomponent plasmas

Numerically the delicate scale multipeak structures of the electrostatic solitary waves are found for the three-component（electron-positron-ion,i.e.,EPI） plasmas.The complicated homoclinic phase portraits for this two-degree-of-freedom system are presented,which indicate that the system exhibits more abundant nonlinear phenomena.This finding is very useful to unveil the coherent dynamical behavior in laser-plasma interaction.It has an implication of electron acceleration by a laser with soliton wave mechanism.

Enhanced photon emission and pair production in laser-irradiated plasmas

Enhanced photon emission and pair production due to heavy ion mass in the interaction of an ultraintense laser with overdense plasmas is explored by particle-in-cell simulation. It is found that plasmas with heavier ion mass can excite a higher and broader electrostatic field, which causes the enhancement of backward photon emission. The pair yields are then enhanced due to the increase of backwards photons colliding with the incoming laser pulse. By examining the density evolution and angle distribution of each particle species, the origin of pair yield enhancement is clarified.

A variable structure passivity control method for elastic joint robots based on cascaded high-order state estimation

Passivity-based controllers are widely used to facilitate physical interaction between humans and elastic joint robots,as they enhance the stability of the interaction system.However,the joint position tracking performance can be limited by the structures of these controllers when the system is faced with uncertainties and rough high-order system state measurements(such as joint accelerations and jerks).This study presents a variable structure passivity(VSP)control method for joint position tracking of elastic joint robots,which combines the advantages of passive control and variable structure control.This method ensures the tracking error converges in a finite time,even when the system faces uncertainties.The method also preserves the passivity of the system.Moreover,a cascaded observer,called CHOSSO,is also proposed to accurately estimate high-order system states,relying only on position and velocity signals.This observer allows independent implementation of disturbance compensation in the acceleration and jerk estimation channels.In particular,the observer has an enhanced ability to handle fast time-varying disturbances in physical human-robot interaction.The effectiveness of the proposed method is verified through simulations and experiments on a lower limb rehabilitation robot equipped with elastic joints.

Leading order relativistic hyperon-nucleon interactions in chiral effective field theory

We apply a recently proposed covariant power counting in nucleon-nucleon interactions to study strangeness S =-1 ΛN-Σ N interactions in chiral effective field theory. At leading order, Lorentz invariance introduces 12 low energy constants, in contrast to the heavy baryon approach, where only five appear. The Kadyshevsky equation is adopted to resum the potential in order to account for the non-perturbative nature of hyperon-nucleon interactions.A fit to the 36 hyperon-nucleon scattering data points yields χ2 16, which is comparable with the sophisticated phenomenological models and the next-to-leading order heavy baryon approach. However, one cannot achieve a simultaneous description of the nucleon-nucleon phase shifts and strangeness S =-1 hyperon-nucleon scattering data at leading order.

An EMG-Based Biomimetic Variable Stiffness Modulation Strategy for Bilateral Motor Skills Relearning of Upper Limb Elbow Joint Rehabilitation

Bilateral rehabilitation systems with bilateral or unilateral assistive robots have been developed for hemiplegia patients to recover their one-side paralysis.However,the compliant robotic assistance to promote bilateral inter-limb coordination remains a challenge that should be addressed.In this paper,a biomimetic variable stiffness modulation strategy for the Variable Stiffness Actuator(VSA)integrated robotic is proposed to improve bilateral limb coordination and promote bilateral motor skills relearning.An Electromyography(EMG)-driven synergy reference stiffness estimation model of the upper limb elbow joint is developed to reproduce the muscle synergy effect on the affected side limb by independent real-time stiffness control.Additionally,the bilateral impedance control is incorporated for realizing compliant patient-robot interaction.Preliminary experiments were carried out to evaluate the tracking performance and investigate the multiple task intensities’influence on bilateral motor skills relearning.Experimental results evidence the proposed method could enable bilateral motor task skills relearning with wide-range task intensities and further promote bilateral inter-limb coordination.

Web Resources for Stem Cell Research

In this short review, we have presented a brief overview on major web resources relevant to stem cell research. To facilitate more efficient use of these resources, we have provided a preliminary rating based on our own user experience of the overall quality for each resource. We plan to update the information on an annual basis.