AIM: To explore the effects of liniment levamisole on cellular immune functions of patients with chronic hepatitis B. METHODS: The levels of T lymphocyte subsets and mlL-2R in peripheral blood mononuclear cells (PBMCs...AIM: To explore the effects of liniment levamisole on cellular immune functions of patients with chronic hepatitis B. METHODS: The levels of T lymphocyte subsets and mlL-2R in peripheral blood mononuclear cells (PBMCs) were measured by biotin-streptavidin (BSA) technique in patients with chronic hepatitis B before and after the treatment with liniment levamisole. RESULTS: After one course of treatment with liniment levamisole, the levels of CD3+, CD4+, and the ratio of CD4+/CD8+ increased as compared to those before the treatment but the level of CD8+ decreased. The total expression level of mIL-2R in PBMCs increased before and after the treatment with liniment levamisole. CONCLUSION: Liniment levamisole may reinforce cellular immune functions of patients with chronic hepatitis B.展开更多
[Objectives]To observe and analyze the clinical efficacy and possible mechanism of Chuanbai antipruritic lotion"water film"wet compress combined with chloramphenicol prednisone liniment in the treatment of a...[Objectives]To observe and analyze the clinical efficacy and possible mechanism of Chuanbai antipruritic lotion"water film"wet compress combined with chloramphenicol prednisone liniment in the treatment of acute eczema.[Methods]A total of 76 acute eczema cases admitted to Shiyan Taihe Hospital from January 2022 to March 2023 were divided into Western medicine treatment group and integrated traditional Chinese and Western medicine group.In the Western medicine treatment group,chloramphenicol and prednisone liniment was applied to the skin lesions and oral administration of cetirizine hydrochloride.The course of treatment in both groups was 2 weeks(w).The levels of interferon-γ(IFN-γ),interleukin-4(IL-4)and the ratio of IFN-γ/IL-4 in the peripheral blood of patients before and 2 weeks after treatment,as well as serum immunoglobulin E(IgE),anti-IgE antibody and histamine(HA)level,and with skin lesions disappearing time,skin oil,transepidermal water loss(TEWL),eczema area and severity index(EASI)score,total effective rate,degree of pruritus and traditional Chinese medicine quality of life scale(EPQOLS)score to evaluate the efficacy.[Results]Compared with the Western medicine treatment group at 2 w,the disappearance time of skin lesions in the integrated traditional Chinese and Western medicine group was shortened,TEWL,itching degree and EASI score,serum IgE and HA,and peripheral blood IL-4 levels were all decreased(P<0.05).IFN-γand IFN-γ/IL-4 ratio,anti-IgE antibody,EPQOLS score and total effective rate were all increased(P<0.05),and the difference was statistically significant.[Conclusions]Chuanbai antipruritic lotion"water film"wet compress combined with chloramphenicol prednisone liniment is an optimized and safe and efficient method for the treatment of acute eczema,which can quickly relieve the symptoms of inflammatory damage of eczema and restore the skin barrier function,dry dampness and relieve itch.Inhibition of the release of histamine active substances and regulation of immunity may be the main mechanisms.展开更多
目的:观察光动力联合疗法治疗玫瑰痤疮的临床疗效。方法:选取2022年1月-2023年1月笔者医院就诊的200例玫瑰痤疮患者。采用随机数字表法分为研究组、对照组,各100例,并根据分型分为红斑毛细血管扩张型、丘疹脓疱型两个亚组。对照组给予...目的:观察光动力联合疗法治疗玫瑰痤疮的临床疗效。方法:选取2022年1月-2023年1月笔者医院就诊的200例玫瑰痤疮患者。采用随机数字表法分为研究组、对照组,各100例,并根据分型分为红斑毛细血管扩张型、丘疹脓疱型两个亚组。对照组给予外用克林霉素甲硝唑搽剂及医用愈肤生物膜治疗,研究组在对照组基础上给予5-氨基酮戊酸光动力疗法。比较两组治疗前、治疗4周后临床症状评分、皮损部位角质层含水量、经皮水丢失量(Trans epidermal water loss,TEWL)、血清白介素-17(IL-17)、干扰素-γ(IFN-γ)水平,记录两组疗效、蠕形螨转阴率、不良反应。结果:两种亚型研究组总有效率、蠕形螨转阴率均高于对照组(P<0.05);治疗4周后,两种亚型研究组临床症状评分均低于对照组(P<0.05);治疗4周后,两种亚型研究组角质层含水量均高于对照组,TEWL均低于对照组(P<0.05);治疗4周后,两种亚型研究组血清IL-17、IFN-γ水平均低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:光动力联合疗法治疗红斑毛细血管扩张型、丘疹脓疱型玫瑰痤疮,可减轻临床症状,降低炎症因子表达,改善皮肤屏障功能,有效驱除蠕形螨,效果显著。展开更多
文摘AIM: To explore the effects of liniment levamisole on cellular immune functions of patients with chronic hepatitis B. METHODS: The levels of T lymphocyte subsets and mlL-2R in peripheral blood mononuclear cells (PBMCs) were measured by biotin-streptavidin (BSA) technique in patients with chronic hepatitis B before and after the treatment with liniment levamisole. RESULTS: After one course of treatment with liniment levamisole, the levels of CD3+, CD4+, and the ratio of CD4+/CD8+ increased as compared to those before the treatment but the level of CD8+ decreased. The total expression level of mIL-2R in PBMCs increased before and after the treatment with liniment levamisole. CONCLUSION: Liniment levamisole may reinforce cellular immune functions of patients with chronic hepatitis B.
文摘[Objectives]To observe and analyze the clinical efficacy and possible mechanism of Chuanbai antipruritic lotion"water film"wet compress combined with chloramphenicol prednisone liniment in the treatment of acute eczema.[Methods]A total of 76 acute eczema cases admitted to Shiyan Taihe Hospital from January 2022 to March 2023 were divided into Western medicine treatment group and integrated traditional Chinese and Western medicine group.In the Western medicine treatment group,chloramphenicol and prednisone liniment was applied to the skin lesions and oral administration of cetirizine hydrochloride.The course of treatment in both groups was 2 weeks(w).The levels of interferon-γ(IFN-γ),interleukin-4(IL-4)and the ratio of IFN-γ/IL-4 in the peripheral blood of patients before and 2 weeks after treatment,as well as serum immunoglobulin E(IgE),anti-IgE antibody and histamine(HA)level,and with skin lesions disappearing time,skin oil,transepidermal water loss(TEWL),eczema area and severity index(EASI)score,total effective rate,degree of pruritus and traditional Chinese medicine quality of life scale(EPQOLS)score to evaluate the efficacy.[Results]Compared with the Western medicine treatment group at 2 w,the disappearance time of skin lesions in the integrated traditional Chinese and Western medicine group was shortened,TEWL,itching degree and EASI score,serum IgE and HA,and peripheral blood IL-4 levels were all decreased(P<0.05).IFN-γand IFN-γ/IL-4 ratio,anti-IgE antibody,EPQOLS score and total effective rate were all increased(P<0.05),and the difference was statistically significant.[Conclusions]Chuanbai antipruritic lotion"water film"wet compress combined with chloramphenicol prednisone liniment is an optimized and safe and efficient method for the treatment of acute eczema,which can quickly relieve the symptoms of inflammatory damage of eczema and restore the skin barrier function,dry dampness and relieve itch.Inhibition of the release of histamine active substances and regulation of immunity may be the main mechanisms.
文摘目的:观察光动力联合疗法治疗玫瑰痤疮的临床疗效。方法:选取2022年1月-2023年1月笔者医院就诊的200例玫瑰痤疮患者。采用随机数字表法分为研究组、对照组,各100例,并根据分型分为红斑毛细血管扩张型、丘疹脓疱型两个亚组。对照组给予外用克林霉素甲硝唑搽剂及医用愈肤生物膜治疗,研究组在对照组基础上给予5-氨基酮戊酸光动力疗法。比较两组治疗前、治疗4周后临床症状评分、皮损部位角质层含水量、经皮水丢失量(Trans epidermal water loss,TEWL)、血清白介素-17(IL-17)、干扰素-γ(IFN-γ)水平,记录两组疗效、蠕形螨转阴率、不良反应。结果:两种亚型研究组总有效率、蠕形螨转阴率均高于对照组(P<0.05);治疗4周后,两种亚型研究组临床症状评分均低于对照组(P<0.05);治疗4周后,两种亚型研究组角质层含水量均高于对照组,TEWL均低于对照组(P<0.05);治疗4周后,两种亚型研究组血清IL-17、IFN-γ水平均低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:光动力联合疗法治疗红斑毛细血管扩张型、丘疹脓疱型玫瑰痤疮,可减轻临床症状,降低炎症因子表达,改善皮肤屏障功能,有效驱除蠕形螨,效果显著。
