X线微机图像系统对桡骨远端等骨折骨痂生长情况的定量分析方法

Ｘ线微机图像系统对骨痂生长情况的定量分析方法能对桡骨远端骨折及其它四肢骨干骨折患者不同时期所摄的Ｘ线片进行骨折恢复程度、是否痊愈、骨折固定后出现的继发性骨质疏松情况进行定量分析观察。

从作品中挖掘音乐要素,在教学中实现融会贯通——以《图画展览会》的音乐要素提取为例

音乐作品中包含了众多的基本音乐要素,如节奏、节拍、调式、调性、和声、复调、音色等,从中提取相应的音乐要素并运用于视唱练耳课堂教学对于丰富教学手段,扩展教学内容,增强课堂的趣味性等有着积极地意义。通过认真分析音乐作品,对其各项细节进行研究是了解音乐要素与提取音乐要素的前提条件。本文试图以《图画展览会》中部分段落为例,讲述从作品中提取音乐要素并将其运用于视唱练耳课堂教学的方法,以达到抛砖引玉的作用。

图片对读者可信度知觉影响的实验研究

目的探讨新闻图片对读者可信度的影响情况。方法应用E-P rim e软件,在计算机上操作。通过对120名被试在不同阅读条件(有无图片)下对新闻材料相信度的判断进行测验。结果①被试倾向于相信有图组新闻的真实性高于无图组新闻,差异显著(t=2.827,P<0.01);②两组实验中,被试对娱乐类新闻的相信度均低于社会类新闻的相信度,但差异不显著(t=1.235,P>0.05);③不同性别对被试可信度的影响无显著差异(t=-0.434,P>0.05);④已有经验对被试可信度知觉的影响差异不显著(F=0.513,P>0.05)。结论图片可增强读者对新闻的相信度;可信度判断受性别、已有经验等因素影响较小。

道路工程项目施工质量模糊因果分析法

通过对道路工程项目质量管理中的因果分析法的研究,将模糊质量理论中的模糊因素评判原理引入到工程项目施工质量原因分析中,并进一步提出了"工程项目施工质量模糊因果分析"的概念,对项目质量原因分析及控制方法的理论构架和实践操作进行了一些有一定现实意义的探讨。

miR-495 andmiR-5688 are down-regulated in non-small cell lung cancer under hypoxia to maintain interleukin-11 expression

Background:Hypoxia is a hallmark of cancer and is associated with poor prognosis.However,the molecular mechanism by which hypoxia promotes tumor progression remains unclear.MicroRNAs dysregulation has been shown to play a critical role in the tumor and tumor microenvironment.Here,we investigated the roles ofmiR-495 and miR-5688 in human non-small cell lung cancer(NSCLC)and their underlying mechanism.Methods:The expression levels of miR-495 and miR-5688 in human NSCLC tissue specimens were measured by quantitative real-time polymerase chain reaction(qRT-PCR).Deferoxamine(DFO)was used to determine whether the regulation of miR-495 and miR-5688 under hypoxia was dependent on hypoxia-inducible factor 1-alpha(HIF-1α).Furthermore,the functions of miR-495 and miR-5688 in tumor progression were evaluated using colony formation,3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2Htetrazolium(MTS),wound healing,transwell assays,and xenograft model.Two algorithms,PicTAR and Targetscan,were used to predict the target gene of these two miRNAs,and dual-luciferase reporter assay was conducted to confirm the target.The unpaired two-tailed t test,Pearson correlation analysis,and Fisher’s exact probability test were performed for statistical analyses.Results:Two miRNAs,miR-495 and miR-5688,were found to participate in NSCLC progression under hypoxia.They were down-regulated in NSCLC tissues compared with normal tissues.We determined that hypoxia led to the down-regulation of miR-495 and miR-5688 in NSCLC cells,which was independent of HIF-1αand cellular metabolic energy.In addition,miR-495 and miR-5688 suppressed cell proliferation,migration,and invasion in vitro.The NSCLC xenograft model showed that miR-495 and miR-5688 inhibited tumor formation in vivo.Interestingly,we found that miR-495 and miR-5688 had the same target,interleukin-11(IL-11).Recombinant human IL-11 counteracted the effects of miR-495 and miR-5688 on NSCLC cells,suggesting that miR-495 and miR-5688 executed their tumor suppressive role by repressing IL-11 expression.Conclusion:We found that hypoxia down-regulated the expression levels of miR-495 and miR-5688 in NSCLCto enhance IL-11 expression and tumor progression,indicating that the miR-495/miR-5688/IL-11 axismay serve as a therapeutic target and potential biomarker for NSCLC.

运动情境情绪图片刺激材料库的初步编制与评定

目的:建立运动情境情绪图片刺激材料库。方法:广泛搜集运动情境情绪图片(彩色)400张,首先,由4名专家评价者对图片进行类别的初步评定,选取评价一致的图片。其次,由66名大学生运动员评价者对图片进行类别和情绪强烈程度的判定,后者为9点量表评分(1为最弱,9为最强)。统计各类型图片的认同率和强烈程度得分,选取认同率在70%以上,强度在5分以上的图片。最后,邀请大学生运动员81人,随机分为3组,每组观看一种情绪效价类型的图片,记录情绪自评量表的前测后测分数,进行重复测量方差分析。结果:得到一系列具有代表性的3类运动情境情绪图片,并且每张图片都有其相应的认同率和情绪强烈程度分数。3组被试的情绪自评前测后测差异显著(P<0.001),图片确实启动了大学生运动员被试不同效价的情绪。结论:初步建立了一套标准化的运动情境情绪图片刺激材料库,可作为后续运动领域情绪研究的选取材料。