Main observation and conclusion Herein,we describe a novel catalytic Pictet-Spengler-type cyclization using CO_(2) as a nontoxic and sustainable C1 feedstock with envi-ronmentally benign and non-precious-metal iron as...Main observation and conclusion Herein,we describe a novel catalytic Pictet-Spengler-type cyclization using CO_(2) as a nontoxic and sustainable C1 feedstock with envi-ronmentally benign and non-precious-metal iron as catalyst.The reaction is achieved by selective four-electron reduction of CO_(2) into methylene level intermediate through carefully tuning the reaction parameters.A variety of tetrahydro-B-carbolines and other nitro-gen-containing heterocycles can be easily obtained under mild conditions.Mechanistic studies have shown that tetrahy-dro-B-carbolines are probably obtained via spiroindolenine intermediates.展开更多
基金We are grateful to the financial support from NSFC(Nos.21772208,21702212,21602230)the Key Research Program of Frontier Sciences of CAS(No.QYZDJSSW-SLH051).
文摘Main observation and conclusion Herein,we describe a novel catalytic Pictet-Spengler-type cyclization using CO_(2) as a nontoxic and sustainable C1 feedstock with envi-ronmentally benign and non-precious-metal iron as catalyst.The reaction is achieved by selective four-electron reduction of CO_(2) into methylene level intermediate through carefully tuning the reaction parameters.A variety of tetrahydro-B-carbolines and other nitro-gen-containing heterocycles can be easily obtained under mild conditions.Mechanistic studies have shown that tetrahy-dro-B-carbolines are probably obtained via spiroindolenine intermediates.
