This paper presents a Shared Control Architecture(SCA)between a human pilot and a smart inceptor for nonlinear Pilot Induced Oscillations(PIOs),e.g.,category II or III PIOs.One innovation of this paper is that an inte...This paper presents a Shared Control Architecture(SCA)between a human pilot and a smart inceptor for nonlinear Pilot Induced Oscillations(PIOs),e.g.,category II or III PIOs.One innovation of this paper is that an intelligent shared control architecture is developed based on the intelligent active inceptor technique,i.e.,Smart Adaptive Flight Effective Cue(SAFE-Cue).A deep reinforcement learning approach namely Deep Deterministic Policy Gradient(DDPG)method is chosen to design a gain adaptation mechanism for the SAFE-Cue module.By doing this,the gains of the SAFE-Cue will be intelligently tuned once nonlinear PIOs triggered;meanwhile,the human pilot will receive a force cue from the SAFE-Cue,and will consequently adapting his/her control policy.The second innovation of this paper is that the reward function of the DDPG based gain adaptation approach is constructed according to flying qualities.Under the premise of considering failure situation,task completion qualities and pilot workload are also taken into account.Finally,the proposed approach is validated using numerical simulation experiments with two types of scenarios:lower actuator rate limits and airframe damages.The Inceptor Peak Power-Phase(IPPP)metric is adopted to analyze the human-vehicle system simulation results.Results and analysis show that the DDPG based sharing control approach can well address nonlinear PIO problems consisting of Categories Ⅱ and Ⅲ PIO events.展开更多
This paper proposes a method to predict nonlinear Pilot-Induced Oscillation(PIO)using an intelligent human pilot model.This method is based on a scalogram-based PIO metric,which uses wavelet transforms to analyze the ...This paper proposes a method to predict nonlinear Pilot-Induced Oscillation(PIO)using an intelligent human pilot model.This method is based on a scalogram-based PIO metric,which uses wavelet transforms to analyze the nonlinear characteristics of a time-varying system.The intelligent human pilot model includes three modules:perception module,decision and adaptive module,and execution module.Intelligent and adaptive features,including a neural network receptor,fuzzy decision and adaptation,are also introduced into the human pilot model to describe the behavior of the human pilot accommodating the nonlinear events.Furthermore,an algorithm is proposed to describe the procedure of the PIO prediction method with nonlinear evaluation cases.The prediction results obtained by numerical simulation are compared with the assessments of flight test data to validate the utility of the method.The flight test data were generated in the evaluation of the Smart-Cue/Smart-Gain,which is capable of reducing the PIO tendencies considerably.The results show that the method can be applied to predict the nonlinear PIO events by human pilot model simulation.展开更多
The vertically integrated emission rate,centroid altitude,peak emission rate,and peak height of the hydroxyl(OH)airglow were calculated from Thermosphere Ionosphere Mesosphere Energetics and Dynamics(TIMED)/Sounding o...The vertically integrated emission rate,centroid altitude,peak emission rate,and peak height of the hydroxyl(OH)airglow were calculated from Thermosphere Ionosphere Mesosphere Energetics and Dynamics(TIMED)/Sounding of the Atmosphere using Broadband Emission Radiometry(SABER)observations to study the seasonal and interannual variations in the intensity and location of the OH emission.The emission rate is inversely proportional to the height of the emission,with the semiannual oscillation dominating at low latitudes and the annual oscillation dominating at higher latitudes.The OH emission is modulated by the quasibiennial oscillation at the equator,and the quasibiennial oscillation signal is weak at other latitudes.We represented the vertical transport of atomic oxygen by using atomic oxygen concentrations obtained from a global atmospheric model,the Specified Dynamics Whole Atmosphere Community Climate Model with thermosphere and ionosphere eXtension simulations.Compared with the amplitudes of the migrating diurnal tide(DW1)calculated from temperature data observed by TIMED/SABER,we found that both the vertical transport of atomic oxygen and DW1 amplitudes in the equatorial region exhibit semiannual oscillation and quasibiennial oscillation,which have a strong correlation with the variations in the amplitude and phase of semiannual oscillation and quasibiennial oscillation in OH emission.It is likely that the DW1 affects the vertical transport of atomic oxygen that is involved in the reaction to produce O3,thus affecting the OH emission.We analyzed the relationship between OH emission and solar activity by using the solar radio flux at 10.7 cm as a proxy for solar activity.The results showed that the OH emission is well correlated with solar activity,and the modulation of OH emission by solar activity has a significant latitudinal variation.The small correlation between emission height and solar activity indicates that solar activity modulates OH emission mainly through chemical rather than dynamic processes.展开更多
This paper focuses on the characteristics of solutions of nonlinear oscillatory systems in the limit of very high oscillation energy, E;specifically, systems, in which the nonlinear driving force grows with energy muc...This paper focuses on the characteristics of solutions of nonlinear oscillatory systems in the limit of very high oscillation energy, E;specifically, systems, in which the nonlinear driving force grows with energy much faster for x(t) close to the turning point, a(E), than at any position, x(t), that is not too close to a(E). This behavior dominates important aspects of the solutions. It will be called “nonlinear violence”. In the vicinity of a turning point, the solution of a nonlinear oscillatory systems that is affected by nonlinear violence exhibits the characteristics of boundary-layer behavior (independently of whether the equation of motion of the system can or cannot be cast in the traditional form of a boundary-layer problem.): close to a(E), x(t) varies very rapidly over a short time interval (which vanishes for E → ∞). In traditional boundary layer systems this would be called the “inner” solution. Outside this interval, x(t) soon evolves into a moderate profile (e.g. linear in time, or constant)—the “outer” solution. In (1 + 1)-dimensional nonlinear energy-conserving oscillators, if the solution is reflection-invariant, nonlinear violence determines the characteristics of the whole solution. For large families of nonlinear oscillatory systems, as E → ∞, the solutions for x(t) tend to common, indistinguishable profiles, such as periodic saw-tooth profiles or step-functions. If such profiles are observed experimentally in high-energy oscillations, it may be difficult to decipher the dynamical equations that govern the motion. The solution of motion in a central field with a non-zero angular momentum exhibits extremely fast rotation around a turning point that is affected by nonlinear violence. This provides an example for the possibility of interesting phenomena in (1 + 2)-dimensional oscillatory systems.展开更多
In this paper, we study the second-order nonlinear differential systems of Liénard-type x˙=1a(x)[ h(y)−F(x) ], y˙=−a(x)g(x). Necessary and sufficient conditions to ensure that all nontrivial solutions are oscil...In this paper, we study the second-order nonlinear differential systems of Liénard-type x˙=1a(x)[ h(y)−F(x) ], y˙=−a(x)g(x). Necessary and sufficient conditions to ensure that all nontrivial solutions are oscillatory are established by using a new nonlinear integral inequality. Our results substantially extend and improve previous results known in the literature.展开更多
The kagome system has attracted great interest in condensed matter physics due to its unique structure that canhost various exotic states such as superconductivity(SC),charge density waves(CDWs)and nontrivial topologi...The kagome system has attracted great interest in condensed matter physics due to its unique structure that canhost various exotic states such as superconductivity(SC),charge density waves(CDWs)and nontrivial topological states.The topological semimetal RbTi_(3)Bi_(5)consisting of a Ti kagome layer shares a similar crystal structure to the topologicalcorrelated materials AV_(3)Sb_(5)(A=K,Rb,Cs)but without the absence of CDW and SC.Systematic de Haas-van Alphenoscillation measurements are performed on single crystals of RbTi_(3)Bi_(5)to pursue nontrivial topological physics and exoticstates.Combining this with theoretical calculations,the detailed Fermi surface topology and band structure are investigated.A two-dimensional Fermi pocket b is revealed with a light effective mass,consistent with the semimetal predictions.TheLandau fan diagram of RbTi_(3)Bi_(5)reveals a zero Berry phase for the b oscillation in contrast to that of CsTi_(3)Bi_(5).Theseresults suggest that kagome RbTi_(3)Bi_(5)is a good candidate for exploring nontrivial topological exotic states and topologicalcorrelated physics.展开更多
The importance of the Atlantic Multidecadal Oscillation(AMO)and Interdecadal Pacific Oscillation(IPO)in influencing zonally asymmetric changes in Antarctic surface air temperature(SAT)has been established.However,prev...The importance of the Atlantic Multidecadal Oscillation(AMO)and Interdecadal Pacific Oscillation(IPO)in influencing zonally asymmetric changes in Antarctic surface air temperature(SAT)has been established.However,previous studies have primarily concentrated on examining the combined impact of the contrasting phases of the AMO and IPO,which have been dominant since the advent of satellite observations in 1979.This study utilizes long-term reanalysis data to investigate the impact of four combinations of+AMO+IPO,–AMO–IPO,+AMO–IPO,and–AMO+IPO on Antarctic SAT over the past 115 years.The+AMO phase is characterized by a spatial mean temperature amplitude of up to 0.5℃over the North Atlantic Ocean,accompanied by positive sea surface temperature(SST)anomalies in the tropical eastern Pacific and negative SST anomalies in the extratropical-mid-latitude western Pacific,which are indicative of the+IPO phase.The Antarctic SAT exhibits contrasting spatial patterns during the+AMO+IPO and+AMO–IPO periods.However,during the–AMO+IPO period,apart from the Antarctic Peninsula and the vicinity of the Weddell Sea,the entire Antarctic region experiences a warming trend.The most pronounced signal in the SAT anomalies is observed during the austral autumn,whereas the combination of–AMO and–IPO exhibits the smallest magnitude across all the combinations.The wavetrain excited by the SST anomalies associated with the AMO and IPO induces upper-level and surface atmospheric circulation anomalies,which alter the SAT anomalies.Furthermore,downward longwave radiation anomalies related to anomalous cloud cover play a crucial role.In the future,if the phases of AMO and IPO were to reverse(AMO transitioning to a negative phase and IPO transitioning to a positive phase),Antarctica could potentially face more pronounced warming and accelerated melting compared to the current observations.展开更多
A 110-year ensemble simulation of an ocean general circulation model(OGCM)was analyzed to identify the modulation of salinity interdecadal variability on El Niño-Southern Oscillation(ENSO)amplitude in the tropica...A 110-year ensemble simulation of an ocean general circulation model(OGCM)was analyzed to identify the modulation of salinity interdecadal variability on El Niño-Southern Oscillation(ENSO)amplitude in the tropical Pacific during 1901-2010.The simulating results show that sea surface salinity(SSS)variation in the region exhibits notable and coherent interdecadal variability signal,which is closely associated with the Interdecadal Pacific Oscillation(IPO).As salinity increases or reduces,the SSS modulations on ENSO amplitude during its warm/cold events vary asymmetrically with positive/negative IPO phases.Physically,salinity interdecadal variability can enhance or reduce ENSO-related conditions in upper-ocean stratification,contributing noticeably to ENSO variability.Salinity anomalies associated with the mixed layer depth and barrier layer thickness can modulate ENSO amplitude during positive and negative IPO phases,resulting in the asymmetry of sea surface temperature(SST)anomaly in the tropical Pacific.During positive IPO phases,SSS interdecadal variability contributes positively to El Niño amplitude but negatively to La Niña amplitude by enhancing or reducing SSS interannual variability,and vice versa during negative IPO phases.Quantitatively,the results indicate that the modulation of the ENSO amplitude by the SSS interdecadal variability is 15%-28%during negative IPO phases and 30%-20%during positive IPO phases,respectively.Evidently,the SSS interdecadal variability associated with IPO and its modulation on ENSO amplitude in the tropical Pacific are among factors essentially contributing ENSO diversity.展开更多
The REAgSb_(2)(RE = rare earth and Y) family has drawn considerable research interest because the two-dimensional Sb net in their crystal structures hosts topological fermions and hence rich topological properties. We...The REAgSb_(2)(RE = rare earth and Y) family has drawn considerable research interest because the two-dimensional Sb net in their crystal structures hosts topological fermions and hence rich topological properties. We report herein the magnetization and magnetotransport measurements of SmAgSb_(2) single crystal, which unveil very large magnetoresistance and high carrier mobility up to 6.2 × 10^(3)% and 5.58 × 10^(3)cm^(2)·V^(-1)·s^(-1), respectively. The analysis of both Shubnikov–de Haas and de Haas–van Alphen quantum oscillations indicates nontrivial Berry phases in the paramagnetic state while trivial Berry curvature in the antiferromagnetic state, indicating a topological phase transition induced by the antiferromagnetic order. It is also supported by the first-principles calculations. The results not only provide a new interesting topological material but also offer valuable insights into the correlation between magnetism and nontrivial topological states.展开更多
Changes in the activities of the Boreal Summer Intraseasonal Oscillation(BSISO)at the end of 21st century under the SSP5-8.5 scenario are assessed by adopting 17 CMIP6 models and the weak-temperature-gradient assumpti...Changes in the activities of the Boreal Summer Intraseasonal Oscillation(BSISO)at the end of 21st century under the SSP5-8.5 scenario are assessed by adopting 17 CMIP6 models and the weak-temperature-gradient assumption.Results show that the intraseasonal variations become more structured.The BSISO-related precipitation anomaly shows a larger zonal scale and propagates further northward.However,there is no broad agreement among models on the changes in the eastward and northward propagation speeds and the frequency of individual phases.In the western North Pacific(WNP),the BSISO precipitation variance is significantly increased,at 4.62%K^(−1),due to the significantly increased efficiency of vertical moisture transport per unit of BSISO apparent heating.The vertical velocity variance is significantly decreased,at−3.51%K^(−1),in the middle troposphere,due to the significantly increased mean-state static stability.Changes in the lower-level zonal wind variance are relatively complex,with a significant increase stretching from the northwestern to southeastern WNP,but the opposite in other regions.This is probably due to the combined impacts of the northeastward shift of the BSISO signals and the reduced BSISO vertical velocity variance under global warming.Changes in strong and normal BSISO events in the WNP are also compared.They show same-signed changes in precipitation and large-scale circulation anomalies but opposite changes in the vertical velocity anomalies.This is probably because the precipitation anomaly of strong(normal)events changes at a rate much larger(smaller)than that of the meanstate static stability,causing enhanced(reduced)vertical motion.展开更多
High-frequency oscillation(HFO)of gridconnected wind power generation systems(WPGS)is one of the most critical issues in recent years that threaten the safe access of WPGS to the grid.Ensuring the WPGS can damp HFO is...High-frequency oscillation(HFO)of gridconnected wind power generation systems(WPGS)is one of the most critical issues in recent years that threaten the safe access of WPGS to the grid.Ensuring the WPGS can damp HFO is becoming more and more vital for the development of wind power.The HFO phenomenon of wind turbines under different scenarios usually has different mechanisms.Hence,engineers need to acquire the working mechanisms of the different HFO damping technologies and select the appropriate one to ensure the effective implementation of oscillation damping in practical engineering.This paper introduces the general assumptions of WPGS when analyzing HFO,systematically summarizes the reasons for the occurrence of HFO in different scenarios,deeply analyses the key points and difficulties of HFO damping under different scenarios,and then compares the technical performances of various types of HFO suppression methods to provide adequate references for engineers in the application of technology.Finally,this paper discusses possible future research difficulties in the problem of HFO,as well as the possible future trends in the demand for HFO damping.展开更多
The low-frequency oscillation(LFO)has occurred in the train-network system due to the introduction of the power electronics of the trains.The modeling and analyzing method in current researches based on electrified ra...The low-frequency oscillation(LFO)has occurred in the train-network system due to the introduction of the power electronics of the trains.The modeling and analyzing method in current researches based on electrified railway unilateral power supply system are not suitable for the LFO analysis in a bilateral power supply system,where the trains are supplied by two traction substations.In this work,based on the single-input and single-output impedance model of China CRH5 trains,the node admittance matrices of the train-network system both in unilateral and bilateral power supply modes are established,including three-phase power grid,traction transformers and traction network.Then the modal analysis is used to study the oscillation modes and propagation characteristics of the unilateral and bilateral power supply systems.Moreover,the influence of the equivalent inductance of the power grid,the length of the transmission line,and the length of the traction network are analyzed on the critical oscillation mode of the bilateral power supply system.Finally,the theoretical analysis results are verified by the time-domain simulation model in MATLAB/Simulink.展开更多
Oscillation detection has been a hot research topic in industries due to the high incidence of oscillation loops and their negative impact on plant profitability.Although numerous automatic detection techniques have b...Oscillation detection has been a hot research topic in industries due to the high incidence of oscillation loops and their negative impact on plant profitability.Although numerous automatic detection techniques have been proposed,most of them can only address part of the practical difficulties.An oscillation is heuristically defined as a visually apparent periodic variation.However,manual visual inspection is labor-intensive and prone to missed detection.Convolutional neural networks(CNNs),inspired by animal visual systems,have been raised with powerful feature extraction capabilities.In this work,an exploration of the typical CNN models for visual oscillation detection is performed.Specifically,we tested MobileNet-V1,ShuffleNet-V2,Efficient Net-B0,and GhostNet models,and found that such a visual framework is well-suited for oscillation detection.The feasibility and validity of this framework are verified utilizing extensive numerical and industrial cases.Compared with state-of-theart oscillation detectors,the suggested framework is more straightforward and more robust to noise and mean-nonstationarity.In addition,this framework generalizes well and is capable of handling features that are not present in the training data,such as multiple oscillations and outliers.展开更多
In this paper,we consider a class of third-order nonlinear delay dynamic equations.First,we establish a Kiguradze-type lemma and some useful estimates.Second,we give a sufficient and necessary condition for the existe...In this paper,we consider a class of third-order nonlinear delay dynamic equations.First,we establish a Kiguradze-type lemma and some useful estimates.Second,we give a sufficient and necessary condition for the existence of eventually positive solutions having upper bounds and tending to zero.Third,we obtain new oscillation criteria by employing the Potzsche chain rule.Then,using the generalized Riccati transformation technique and averaging method,we establish the Philos-type oscillation criteria.Surprisingly,the integral value of the Philos-type oscillation criteria,which guarantees that all unbounded solutions oscillate,is greater than θ_(4)(t_(1),T).The results of Theorem 3.5 and Remark 3.6 are novel.Finally,we offer four examples to illustrate our results.展开更多
The penetration of new energy sources such as wind power is increasing,which consequently increases the occurrence rate of subsynchronous oscillation events.However,existing subsynchronous oscillation source-identific...The penetration of new energy sources such as wind power is increasing,which consequently increases the occurrence rate of subsynchronous oscillation events.However,existing subsynchronous oscillation source-identification methods primarily analyze fixed-mode oscillations and rarely consider time-varying features,such as frequency drift,caused by the random volatility of wind farms when oscillations occur.This paper proposes a subsynchronous oscillation sourcelocalization method that involves an enhanced short-time Fourier transform and a convolutional neural network(CNN).First,an enhanced STFT is performed to secure high-resolution time-frequency distribution(TFD)images from the measured data of the generation unit ports.Next,these TFD images are amalgamated to form a subsynchronous oscillation feature map that serves as input to the CNN to train the localization model.Ultimately,the trained CNN model realizes the online localization of subsynchronous oscillation sources.The effectiveness and accuracy of the proposed method are validated via multimachine system models simulating forced and natural oscillation events using the Power Systems Computer Aided Design platform.Test results show that the proposed method can localize subsynchronous oscillation sources online while considering unpredictable fluctuations in wind farms,thus providing a foundation for oscillation suppression in practical engineering scenarios.展开更多
This investigation aims to study the El-Niño-Southern Oscillation (ENSO) events in these three phases: El Niño, La Niña, and neutral. Warm and cold events relate to the Spring/Summer seasons. This paper...This investigation aims to study the El-Niño-Southern Oscillation (ENSO) events in these three phases: El Niño, La Niña, and neutral. Warm and cold events relate to the Spring/Summer seasons. This paper will search for connections between the ENSO events and climate anomalies worldwide. There is some speculation that those events would be necessary for the climate anomalies observed worldwide. After analyzing the data from the reports to the ENSO, it shows almost periodicity from 1950-2023. We emphasized the occurrence of El Niño two years, when it was most prominent, and the climate anomalies (following NOAA maps), 2015 and 2023. The results indicated that the observed climate anomalies couldn’t be linked to the abnormal events observed. The worldwide temperatures in those years enhanced mostly in 2023. It shows an abnormal behavior compared with all the years scrutinized and analyzed since the records began. Therefore, there must be unknown factors beyond ENSO that rule the worldwide temperatures and the climate anomalies observed.展开更多
As a general feature, the electric field of a localized electric charge distribution diminishes as the distance from the distribution increases;there are exceptions to this feature. For instance, the electric field of...As a general feature, the electric field of a localized electric charge distribution diminishes as the distance from the distribution increases;there are exceptions to this feature. For instance, the electric field of a charged ring (being a localized charge distribution) along its symmetry axis perpendicular to the ring through its center rather than as expected being a diminishing field encounters a local maximum bump. It is the objective of this research-oriented study to analyze the impact of this bump on the characteristics of a massive point-like charged particle oscillating along the symmetry axis. Two scenarios with and without gravity along the symmetry axis are considered. In addition to standard kinematic diagrams, various phase diagrams conducive to a better understanding are constructed. Applying Computer Algebra System (CAS), [1] [2] most calculations are carried out symbolically. Finally, by assigning a set of reasonable numeric parameters to the symbolic quantities various 3D animations are crafted. All the CAS codes are included.展开更多
The initial idea for baryonic acoustic oscillations (BAO) came about during early efforts to understand the origin of galaxies by studying perturbed versions of the Friedmann-Robertson-Walker (FRW) model. In more rece...The initial idea for baryonic acoustic oscillations (BAO) came about during early efforts to understand the origin of galaxies by studying perturbed versions of the Friedmann-Robertson-Walker (FRW) model. In more recent times, the emphasis has shifted to the idea that 2-point galaxy correlations embedded in the distribution of matter by the BAO could be used as a standard ruler to fix the parameters of cosmological models. In this paper, we first consider the actual business of extracting the correlation length from large data sets of measured galaxy locations. To facilitate this process, we introduce a much-improved method for extracting the correlation peak from the data set. Fundamental to this process in any model is the use of a fiducial cosmological model to transition from redshift space to comoving coordinate space where the correlations actually exist. The belief is that the correlation length so determined can then be reverted to redshift space to fix the parameters of cosmological models. We show, however, that this process is circular and hence of no value whatsoever for fixing model parameters. All one obtains are the parameters of the model used to transition to comoving space in the first place. Finally, we present simple arguments that show that the idea of BAO being responsible for the structure of the universe, i.e. the cosmic web, is unworkable.展开更多
Understanding the relationship between rainfall anomalies and large-scale systems is critical for driving adaptation and mitigation strategies in socioeconomic sectors. This study therefore aims primarily to investiga...Understanding the relationship between rainfall anomalies and large-scale systems is critical for driving adaptation and mitigation strategies in socioeconomic sectors. This study therefore aims primarily to investigate the correlation between rainfall anomalies in Rwanda during the months of September to December (SOND) with the occurrences of Indian Ocean Dipole (IOD) and El Nino Southern Oscillation (ENSO) events. The study is useful for early warning and forecasting of negative effects associated with extreme rainfall anomalies across the country, using Climate Hazards Group InfraRed Precipitation with Station (CHIRPS), the National Centers for Environmental Prediction (NCEP) National Center for Atmospheric Research (NCAR) reanalysis sea surface temperature and ERA5 reanalysis datasets, during the period of 1983-2021. Both empirical orthogonal function (EOF), correlation analysis and composite analysis were used to delineate variability, relationship and the related atmospheric circulation between Rwanda seasonal rainfall September to December (SOND) with Indian Ocean Dipole (IOD) and El-Nino Southern Oscillation (ENSO). The results for Empirical Orthogonal Function (EOF) for the reconstructed rainfall data set showed three modes. EOF-1, EOF-2 and EOF-3 with their total variance of 63.6%, 16.5% and 4.8%, Indian ocean dipole (IOD) events resulted to a strong positive correlation of rainfall anomalies and Dipole model index (DMI) (r = 0.42, p value = 0.001, DF = 37) significant at 95% confidence level. The composite analysis for the reanalysis dataset was carried out to show the circulation patterns during four different events correlated with September to December seasonal rainfall in Rwanda using T-test at 95% confidence level. Wind anomaly revealed that there was a convergence of south westerly winds and easterly wind over the study area during positive Indian Ocean Diploe (PIOD) and PIOD with El Nino concurrence event years. The finding of this study will contribute to the enhancement of SOND seasonal rainfall forecasting and the reduction of vulnerability during IOD (ENSO) event years.展开更多
Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Cu...Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.展开更多
基金co-supported by the Fundamental Research Funds for the Central Universities of China(No.YWF-23-SDHK-L-005)the 1912 Project,China and the Aeronautical Science Foundation of China(No.20220048051001).
文摘This paper presents a Shared Control Architecture(SCA)between a human pilot and a smart inceptor for nonlinear Pilot Induced Oscillations(PIOs),e.g.,category II or III PIOs.One innovation of this paper is that an intelligent shared control architecture is developed based on the intelligent active inceptor technique,i.e.,Smart Adaptive Flight Effective Cue(SAFE-Cue).A deep reinforcement learning approach namely Deep Deterministic Policy Gradient(DDPG)method is chosen to design a gain adaptation mechanism for the SAFE-Cue module.By doing this,the gains of the SAFE-Cue will be intelligently tuned once nonlinear PIOs triggered;meanwhile,the human pilot will receive a force cue from the SAFE-Cue,and will consequently adapting his/her control policy.The second innovation of this paper is that the reward function of the DDPG based gain adaptation approach is constructed according to flying qualities.Under the premise of considering failure situation,task completion qualities and pilot workload are also taken into account.Finally,the proposed approach is validated using numerical simulation experiments with two types of scenarios:lower actuator rate limits and airframe damages.The Inceptor Peak Power-Phase(IPPP)metric is adopted to analyze the human-vehicle system simulation results.Results and analysis show that the DDPG based sharing control approach can well address nonlinear PIO problems consisting of Categories Ⅱ and Ⅲ PIO events.
基金co-supported by the National Natural Science Foundation of China (No. 11502008)the Aeronautical Science Foundation of China (No. 2017ZA51002)
文摘This paper proposes a method to predict nonlinear Pilot-Induced Oscillation(PIO)using an intelligent human pilot model.This method is based on a scalogram-based PIO metric,which uses wavelet transforms to analyze the nonlinear characteristics of a time-varying system.The intelligent human pilot model includes three modules:perception module,decision and adaptive module,and execution module.Intelligent and adaptive features,including a neural network receptor,fuzzy decision and adaptation,are also introduced into the human pilot model to describe the behavior of the human pilot accommodating the nonlinear events.Furthermore,an algorithm is proposed to describe the procedure of the PIO prediction method with nonlinear evaluation cases.The prediction results obtained by numerical simulation are compared with the assessments of flight test data to validate the utility of the method.The flight test data were generated in the evaluation of the Smart-Cue/Smart-Gain,which is capable of reducing the PIO tendencies considerably.The results show that the method can be applied to predict the nonlinear PIO events by human pilot model simulation.
基金the National Natural Science Foundation of China(Grant Numbers 42374195 and 42188101)a fellowship from the China National Postdoctoral Program for Innovative Talents(Grant Number BX20230273).
文摘The vertically integrated emission rate,centroid altitude,peak emission rate,and peak height of the hydroxyl(OH)airglow were calculated from Thermosphere Ionosphere Mesosphere Energetics and Dynamics(TIMED)/Sounding of the Atmosphere using Broadband Emission Radiometry(SABER)observations to study the seasonal and interannual variations in the intensity and location of the OH emission.The emission rate is inversely proportional to the height of the emission,with the semiannual oscillation dominating at low latitudes and the annual oscillation dominating at higher latitudes.The OH emission is modulated by the quasibiennial oscillation at the equator,and the quasibiennial oscillation signal is weak at other latitudes.We represented the vertical transport of atomic oxygen by using atomic oxygen concentrations obtained from a global atmospheric model,the Specified Dynamics Whole Atmosphere Community Climate Model with thermosphere and ionosphere eXtension simulations.Compared with the amplitudes of the migrating diurnal tide(DW1)calculated from temperature data observed by TIMED/SABER,we found that both the vertical transport of atomic oxygen and DW1 amplitudes in the equatorial region exhibit semiannual oscillation and quasibiennial oscillation,which have a strong correlation with the variations in the amplitude and phase of semiannual oscillation and quasibiennial oscillation in OH emission.It is likely that the DW1 affects the vertical transport of atomic oxygen that is involved in the reaction to produce O3,thus affecting the OH emission.We analyzed the relationship between OH emission and solar activity by using the solar radio flux at 10.7 cm as a proxy for solar activity.The results showed that the OH emission is well correlated with solar activity,and the modulation of OH emission by solar activity has a significant latitudinal variation.The small correlation between emission height and solar activity indicates that solar activity modulates OH emission mainly through chemical rather than dynamic processes.
文摘This paper focuses on the characteristics of solutions of nonlinear oscillatory systems in the limit of very high oscillation energy, E;specifically, systems, in which the nonlinear driving force grows with energy much faster for x(t) close to the turning point, a(E), than at any position, x(t), that is not too close to a(E). This behavior dominates important aspects of the solutions. It will be called “nonlinear violence”. In the vicinity of a turning point, the solution of a nonlinear oscillatory systems that is affected by nonlinear violence exhibits the characteristics of boundary-layer behavior (independently of whether the equation of motion of the system can or cannot be cast in the traditional form of a boundary-layer problem.): close to a(E), x(t) varies very rapidly over a short time interval (which vanishes for E → ∞). In traditional boundary layer systems this would be called the “inner” solution. Outside this interval, x(t) soon evolves into a moderate profile (e.g. linear in time, or constant)—the “outer” solution. In (1 + 1)-dimensional nonlinear energy-conserving oscillators, if the solution is reflection-invariant, nonlinear violence determines the characteristics of the whole solution. For large families of nonlinear oscillatory systems, as E → ∞, the solutions for x(t) tend to common, indistinguishable profiles, such as periodic saw-tooth profiles or step-functions. If such profiles are observed experimentally in high-energy oscillations, it may be difficult to decipher the dynamical equations that govern the motion. The solution of motion in a central field with a non-zero angular momentum exhibits extremely fast rotation around a turning point that is affected by nonlinear violence. This provides an example for the possibility of interesting phenomena in (1 + 2)-dimensional oscillatory systems.
文摘In this paper, we study the second-order nonlinear differential systems of Liénard-type x˙=1a(x)[ h(y)−F(x) ], y˙=−a(x)g(x). Necessary and sufficient conditions to ensure that all nontrivial solutions are oscillatory are established by using a new nonlinear integral inequality. Our results substantially extend and improve previous results known in the literature.
基金supported by the National Key Research and Development Program of China(Grant No.2023YFA1406500)the National Natural Science Foundation of China(Grant Nos.12174454,U2130101,and 92165204)+2 种基金the Guangdong Basic and Applied Basic Research Funds(Grant Nos.2024B1515020040 and 2022A1515010035)Guangzhou Basic and Applied Basic Research Funds(Grant No.2024A04J6417)Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices(Grant No.2022B1212010008).
文摘The kagome system has attracted great interest in condensed matter physics due to its unique structure that canhost various exotic states such as superconductivity(SC),charge density waves(CDWs)and nontrivial topological states.The topological semimetal RbTi_(3)Bi_(5)consisting of a Ti kagome layer shares a similar crystal structure to the topologicalcorrelated materials AV_(3)Sb_(5)(A=K,Rb,Cs)but without the absence of CDW and SC.Systematic de Haas-van Alphenoscillation measurements are performed on single crystals of RbTi_(3)Bi_(5)to pursue nontrivial topological physics and exoticstates.Combining this with theoretical calculations,the detailed Fermi surface topology and band structure are investigated.A two-dimensional Fermi pocket b is revealed with a light effective mass,consistent with the semimetal predictions.TheLandau fan diagram of RbTi_(3)Bi_(5)reveals a zero Berry phase for the b oscillation in contrast to that of CsTi_(3)Bi_(5).Theseresults suggest that kagome RbTi_(3)Bi_(5)is a good candidate for exploring nontrivial topological exotic states and topologicalcorrelated physics.
基金The National Natural Science Foundation of China under contract No.41976221the National Key Scientific and Technological Infrastructure Project“Earth System Numerical Simulation Facility”(EarthLab).
文摘The importance of the Atlantic Multidecadal Oscillation(AMO)and Interdecadal Pacific Oscillation(IPO)in influencing zonally asymmetric changes in Antarctic surface air temperature(SAT)has been established.However,previous studies have primarily concentrated on examining the combined impact of the contrasting phases of the AMO and IPO,which have been dominant since the advent of satellite observations in 1979.This study utilizes long-term reanalysis data to investigate the impact of four combinations of+AMO+IPO,–AMO–IPO,+AMO–IPO,and–AMO+IPO on Antarctic SAT over the past 115 years.The+AMO phase is characterized by a spatial mean temperature amplitude of up to 0.5℃over the North Atlantic Ocean,accompanied by positive sea surface temperature(SST)anomalies in the tropical eastern Pacific and negative SST anomalies in the extratropical-mid-latitude western Pacific,which are indicative of the+IPO phase.The Antarctic SAT exhibits contrasting spatial patterns during the+AMO+IPO and+AMO–IPO periods.However,during the–AMO+IPO period,apart from the Antarctic Peninsula and the vicinity of the Weddell Sea,the entire Antarctic region experiences a warming trend.The most pronounced signal in the SAT anomalies is observed during the austral autumn,whereas the combination of–AMO and–IPO exhibits the smallest magnitude across all the combinations.The wavetrain excited by the SST anomalies associated with the AMO and IPO induces upper-level and surface atmospheric circulation anomalies,which alter the SAT anomalies.Furthermore,downward longwave radiation anomalies related to anomalous cloud cover play a crucial role.In the future,if the phases of AMO and IPO were to reverse(AMO transitioning to a negative phase and IPO transitioning to a positive phase),Antarctica could potentially face more pronounced warming and accelerated melting compared to the current observations.
基金Supported by the National Natural Science Foundation of China(No.42030410)the Laoshan Laboratory(No.LSKJ 202202403)supported by the Startup Foundation for Introducing Talent of NUIST。
文摘A 110-year ensemble simulation of an ocean general circulation model(OGCM)was analyzed to identify the modulation of salinity interdecadal variability on El Niño-Southern Oscillation(ENSO)amplitude in the tropical Pacific during 1901-2010.The simulating results show that sea surface salinity(SSS)variation in the region exhibits notable and coherent interdecadal variability signal,which is closely associated with the Interdecadal Pacific Oscillation(IPO).As salinity increases or reduces,the SSS modulations on ENSO amplitude during its warm/cold events vary asymmetrically with positive/negative IPO phases.Physically,salinity interdecadal variability can enhance or reduce ENSO-related conditions in upper-ocean stratification,contributing noticeably to ENSO variability.Salinity anomalies associated with the mixed layer depth and barrier layer thickness can modulate ENSO amplitude during positive and negative IPO phases,resulting in the asymmetry of sea surface temperature(SST)anomaly in the tropical Pacific.During positive IPO phases,SSS interdecadal variability contributes positively to El Niño amplitude but negatively to La Niña amplitude by enhancing or reducing SSS interannual variability,and vice versa during negative IPO phases.Quantitatively,the results indicate that the modulation of the ENSO amplitude by the SSS interdecadal variability is 15%-28%during negative IPO phases and 30%-20%during positive IPO phases,respectively.Evidently,the SSS interdecadal variability associated with IPO and its modulation on ENSO amplitude in the tropical Pacific are among factors essentially contributing ENSO diversity.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12004405,12334008,and 12374148)the Double First-Class Initiative Fund of Shanghai Tech University+2 种基金the Analytical Instrumentation Center of Shanghai Tech University(Grant No.SPST-AIC10112914)the research fund from the Shanghai Sailing Program(Grant No.23YF1426900)the fund from the National Key R&D Program of China(Grant Nos.2022YFA1402702 and 2021YFA1401600)。
文摘The REAgSb_(2)(RE = rare earth and Y) family has drawn considerable research interest because the two-dimensional Sb net in their crystal structures hosts topological fermions and hence rich topological properties. We report herein the magnetization and magnetotransport measurements of SmAgSb_(2) single crystal, which unveil very large magnetoresistance and high carrier mobility up to 6.2 × 10^(3)% and 5.58 × 10^(3)cm^(2)·V^(-1)·s^(-1), respectively. The analysis of both Shubnikov–de Haas and de Haas–van Alphen quantum oscillations indicates nontrivial Berry phases in the paramagnetic state while trivial Berry curvature in the antiferromagnetic state, indicating a topological phase transition induced by the antiferromagnetic order. It is also supported by the first-principles calculations. The results not only provide a new interesting topological material but also offer valuable insights into the correlation between magnetism and nontrivial topological states.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.42088101 and 41875099)。
文摘Changes in the activities of the Boreal Summer Intraseasonal Oscillation(BSISO)at the end of 21st century under the SSP5-8.5 scenario are assessed by adopting 17 CMIP6 models and the weak-temperature-gradient assumption.Results show that the intraseasonal variations become more structured.The BSISO-related precipitation anomaly shows a larger zonal scale and propagates further northward.However,there is no broad agreement among models on the changes in the eastward and northward propagation speeds and the frequency of individual phases.In the western North Pacific(WNP),the BSISO precipitation variance is significantly increased,at 4.62%K^(−1),due to the significantly increased efficiency of vertical moisture transport per unit of BSISO apparent heating.The vertical velocity variance is significantly decreased,at−3.51%K^(−1),in the middle troposphere,due to the significantly increased mean-state static stability.Changes in the lower-level zonal wind variance are relatively complex,with a significant increase stretching from the northwestern to southeastern WNP,but the opposite in other regions.This is probably due to the combined impacts of the northeastward shift of the BSISO signals and the reduced BSISO vertical velocity variance under global warming.Changes in strong and normal BSISO events in the WNP are also compared.They show same-signed changes in precipitation and large-scale circulation anomalies but opposite changes in the vertical velocity anomalies.This is probably because the precipitation anomaly of strong(normal)events changes at a rate much larger(smaller)than that of the meanstate static stability,causing enhanced(reduced)vertical motion.
基金supported in part by the Fundamental Research Funds for the Central Universities under Grant 2682023CX019National Natural Science Foundation of China under Grant U23B6007 and Grant 52307141Sichuan Science and Technology Program under Grant 2024NSFSC0115。
文摘High-frequency oscillation(HFO)of gridconnected wind power generation systems(WPGS)is one of the most critical issues in recent years that threaten the safe access of WPGS to the grid.Ensuring the WPGS can damp HFO is becoming more and more vital for the development of wind power.The HFO phenomenon of wind turbines under different scenarios usually has different mechanisms.Hence,engineers need to acquire the working mechanisms of the different HFO damping technologies and select the appropriate one to ensure the effective implementation of oscillation damping in practical engineering.This paper introduces the general assumptions of WPGS when analyzing HFO,systematically summarizes the reasons for the occurrence of HFO in different scenarios,deeply analyses the key points and difficulties of HFO damping under different scenarios,and then compares the technical performances of various types of HFO suppression methods to provide adequate references for engineers in the application of technology.Finally,this paper discusses possible future research difficulties in the problem of HFO,as well as the possible future trends in the demand for HFO damping.
基金This work was supported by the Applied Basic Research Program of Science and Technology Plan Project of Sichuan Province of China(No.2020YJ0252).
文摘The low-frequency oscillation(LFO)has occurred in the train-network system due to the introduction of the power electronics of the trains.The modeling and analyzing method in current researches based on electrified railway unilateral power supply system are not suitable for the LFO analysis in a bilateral power supply system,where the trains are supplied by two traction substations.In this work,based on the single-input and single-output impedance model of China CRH5 trains,the node admittance matrices of the train-network system both in unilateral and bilateral power supply modes are established,including three-phase power grid,traction transformers and traction network.Then the modal analysis is used to study the oscillation modes and propagation characteristics of the unilateral and bilateral power supply systems.Moreover,the influence of the equivalent inductance of the power grid,the length of the transmission line,and the length of the traction network are analyzed on the critical oscillation mode of the bilateral power supply system.Finally,the theoretical analysis results are verified by the time-domain simulation model in MATLAB/Simulink.
基金the National Natural Science Foundation of China(62003298,62163036)the Major Project of Science and Technology of Yunnan Province(202202AD080005,202202AH080009)the Yunnan University Professional Degree Graduate Practice Innovation Fund Project(ZC-22222770)。
文摘Oscillation detection has been a hot research topic in industries due to the high incidence of oscillation loops and their negative impact on plant profitability.Although numerous automatic detection techniques have been proposed,most of them can only address part of the practical difficulties.An oscillation is heuristically defined as a visually apparent periodic variation.However,manual visual inspection is labor-intensive and prone to missed detection.Convolutional neural networks(CNNs),inspired by animal visual systems,have been raised with powerful feature extraction capabilities.In this work,an exploration of the typical CNN models for visual oscillation detection is performed.Specifically,we tested MobileNet-V1,ShuffleNet-V2,Efficient Net-B0,and GhostNet models,and found that such a visual framework is well-suited for oscillation detection.The feasibility and validity of this framework are verified utilizing extensive numerical and industrial cases.Compared with state-of-theart oscillation detectors,the suggested framework is more straightforward and more robust to noise and mean-nonstationarity.In addition,this framework generalizes well and is capable of handling features that are not present in the training data,such as multiple oscillations and outliers.
基金supported by the National Natural Science Foundation of China(12071491,12001113)。
文摘In this paper,we consider a class of third-order nonlinear delay dynamic equations.First,we establish a Kiguradze-type lemma and some useful estimates.Second,we give a sufficient and necessary condition for the existence of eventually positive solutions having upper bounds and tending to zero.Third,we obtain new oscillation criteria by employing the Potzsche chain rule.Then,using the generalized Riccati transformation technique and averaging method,we establish the Philos-type oscillation criteria.Surprisingly,the integral value of the Philos-type oscillation criteria,which guarantees that all unbounded solutions oscillate,is greater than θ_(4)(t_(1),T).The results of Theorem 3.5 and Remark 3.6 are novel.Finally,we offer four examples to illustrate our results.
基金supported by the Science and Technology Project of State Grid Corporation of China(5100202199536A-0-5-ZN)。
文摘The penetration of new energy sources such as wind power is increasing,which consequently increases the occurrence rate of subsynchronous oscillation events.However,existing subsynchronous oscillation source-identification methods primarily analyze fixed-mode oscillations and rarely consider time-varying features,such as frequency drift,caused by the random volatility of wind farms when oscillations occur.This paper proposes a subsynchronous oscillation sourcelocalization method that involves an enhanced short-time Fourier transform and a convolutional neural network(CNN).First,an enhanced STFT is performed to secure high-resolution time-frequency distribution(TFD)images from the measured data of the generation unit ports.Next,these TFD images are amalgamated to form a subsynchronous oscillation feature map that serves as input to the CNN to train the localization model.Ultimately,the trained CNN model realizes the online localization of subsynchronous oscillation sources.The effectiveness and accuracy of the proposed method are validated via multimachine system models simulating forced and natural oscillation events using the Power Systems Computer Aided Design platform.Test results show that the proposed method can localize subsynchronous oscillation sources online while considering unpredictable fluctuations in wind farms,thus providing a foundation for oscillation suppression in practical engineering scenarios.
文摘This investigation aims to study the El-Niño-Southern Oscillation (ENSO) events in these three phases: El Niño, La Niña, and neutral. Warm and cold events relate to the Spring/Summer seasons. This paper will search for connections between the ENSO events and climate anomalies worldwide. There is some speculation that those events would be necessary for the climate anomalies observed worldwide. After analyzing the data from the reports to the ENSO, it shows almost periodicity from 1950-2023. We emphasized the occurrence of El Niño two years, when it was most prominent, and the climate anomalies (following NOAA maps), 2015 and 2023. The results indicated that the observed climate anomalies couldn’t be linked to the abnormal events observed. The worldwide temperatures in those years enhanced mostly in 2023. It shows an abnormal behavior compared with all the years scrutinized and analyzed since the records began. Therefore, there must be unknown factors beyond ENSO that rule the worldwide temperatures and the climate anomalies observed.
文摘As a general feature, the electric field of a localized electric charge distribution diminishes as the distance from the distribution increases;there are exceptions to this feature. For instance, the electric field of a charged ring (being a localized charge distribution) along its symmetry axis perpendicular to the ring through its center rather than as expected being a diminishing field encounters a local maximum bump. It is the objective of this research-oriented study to analyze the impact of this bump on the characteristics of a massive point-like charged particle oscillating along the symmetry axis. Two scenarios with and without gravity along the symmetry axis are considered. In addition to standard kinematic diagrams, various phase diagrams conducive to a better understanding are constructed. Applying Computer Algebra System (CAS), [1] [2] most calculations are carried out symbolically. Finally, by assigning a set of reasonable numeric parameters to the symbolic quantities various 3D animations are crafted. All the CAS codes are included.
文摘The initial idea for baryonic acoustic oscillations (BAO) came about during early efforts to understand the origin of galaxies by studying perturbed versions of the Friedmann-Robertson-Walker (FRW) model. In more recent times, the emphasis has shifted to the idea that 2-point galaxy correlations embedded in the distribution of matter by the BAO could be used as a standard ruler to fix the parameters of cosmological models. In this paper, we first consider the actual business of extracting the correlation length from large data sets of measured galaxy locations. To facilitate this process, we introduce a much-improved method for extracting the correlation peak from the data set. Fundamental to this process in any model is the use of a fiducial cosmological model to transition from redshift space to comoving coordinate space where the correlations actually exist. The belief is that the correlation length so determined can then be reverted to redshift space to fix the parameters of cosmological models. We show, however, that this process is circular and hence of no value whatsoever for fixing model parameters. All one obtains are the parameters of the model used to transition to comoving space in the first place. Finally, we present simple arguments that show that the idea of BAO being responsible for the structure of the universe, i.e. the cosmic web, is unworkable.
文摘Understanding the relationship between rainfall anomalies and large-scale systems is critical for driving adaptation and mitigation strategies in socioeconomic sectors. This study therefore aims primarily to investigate the correlation between rainfall anomalies in Rwanda during the months of September to December (SOND) with the occurrences of Indian Ocean Dipole (IOD) and El Nino Southern Oscillation (ENSO) events. The study is useful for early warning and forecasting of negative effects associated with extreme rainfall anomalies across the country, using Climate Hazards Group InfraRed Precipitation with Station (CHIRPS), the National Centers for Environmental Prediction (NCEP) National Center for Atmospheric Research (NCAR) reanalysis sea surface temperature and ERA5 reanalysis datasets, during the period of 1983-2021. Both empirical orthogonal function (EOF), correlation analysis and composite analysis were used to delineate variability, relationship and the related atmospheric circulation between Rwanda seasonal rainfall September to December (SOND) with Indian Ocean Dipole (IOD) and El-Nino Southern Oscillation (ENSO). The results for Empirical Orthogonal Function (EOF) for the reconstructed rainfall data set showed three modes. EOF-1, EOF-2 and EOF-3 with their total variance of 63.6%, 16.5% and 4.8%, Indian ocean dipole (IOD) events resulted to a strong positive correlation of rainfall anomalies and Dipole model index (DMI) (r = 0.42, p value = 0.001, DF = 37) significant at 95% confidence level. The composite analysis for the reanalysis dataset was carried out to show the circulation patterns during four different events correlated with September to December seasonal rainfall in Rwanda using T-test at 95% confidence level. Wind anomaly revealed that there was a convergence of south westerly winds and easterly wind over the study area during positive Indian Ocean Diploe (PIOD) and PIOD with El Nino concurrence event years. The finding of this study will contribute to the enhancement of SOND seasonal rainfall forecasting and the reduction of vulnerability during IOD (ENSO) event years.
基金supported by the National Natural Science Foundation of China,No.82071254(to WZ).
文摘Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.