OBJECTIVE: To investigate the mechanism of Ping-wei capsules(PWC) in improving gastrointestinal m otility in rats with functional dyspepsia(FD).METHODS: We established an FD model by stimu-lating semi-starvation rats ...OBJECTIVE: To investigate the mechanism of Ping-wei capsules(PWC) in improving gastrointestinal m otility in rats with functional dyspepsia(FD).METHODS: We established an FD model by stimu-lating semi-starvation rats via tail damping, provo-cation, and forced exercise fatigue. The FD model group was further divided into five groups accord-ing to the treatment received: normal saline, dom-peridone, low-dose PWC, mid-dose PWC, or highdose PWC. The effect of PWC on FD was evaluated by measuring gastrointestinal motility. Changes in leptin and cholecystokinin(CCK) were detected through enzyme-linked immunosorbent assay, re-verse transcription-polymerase chain reaction, and immunohistochemistry.RESULTS: PWC significantly increased gastrointesti-nal m otility in FD rats. Furthermore, PWC signifi-cantly increased CCK m RNA and protein concentra-tions in the duodenum and antrum, decreased leptin protein concentrations in the duodenum, an-trum, and hypothalamus, and decreased CCK pro-tein concentration in the hypothalamus.CONCLUSION: PWC improves gastrointestinal mo-tor function in FD rats by decreasing the leptin con-centration in serum and the brain-gut axis, and by increasing the CCK concentration in gastrointesti-nal tissue. Our findings help to elucidate the mech-anism of FD and provide further insight into the pharmacokinetics of PWC.展开更多
目的:观察二陈平胃散和三子养亲汤加减治疗痰湿蕴肺型咳嗽的临床疗效。方法:将痰湿蕴肺型咳嗽患者90例随机分为对照组(西药治疗)和试验组(加用二陈平胃散和三子养亲汤加减)各45例。观察两组患者肺机能恢复情况、呼吸困难程度、咳嗽症状...目的:观察二陈平胃散和三子养亲汤加减治疗痰湿蕴肺型咳嗽的临床疗效。方法:将痰湿蕴肺型咳嗽患者90例随机分为对照组(西药治疗)和试验组(加用二陈平胃散和三子养亲汤加减)各45例。观察两组患者肺机能恢复情况、呼吸困难程度、咳嗽症状、视觉模拟量表(visual analog scale,VAS)评分、生活质量及唾液分泌型免疫球蛋白A(secreted immunoglobulin A,SIgA)水平。结果:治疗后试验组、对照组显效率分别为82.2%、60.0%,差异有统计学意义(P<0.05)。两组患者治疗后呼吸困难程度、生存质量、VAS评分、咳嗽症状评分与治疗前比较差异有统计学意义(P<0.05),试验组低于对照组(P<0.05)。治疗后两组患者唾液sIgA水平与治疗前比较差异有统计学意义(P<0.05),试验组高于对照组(P<0.05)。结论:二陈平胃散和三子养亲汤加减联合西药能改善痰湿蕴肺型咳嗽患者临床症状、呼吸困难、生存质量及免疫功能,效果优于单纯西药治疗。展开更多
基金Supported by the Natural Science Foundation of China(Based on Brain-Gut Axis to Study Peptidomics of Liver Stag-nation and Spleen Deficiency with Functional Dyspepsia and Its Intervention of Shugan Jianpi Method,No.8136-0540)the Administration of Gansu Traditional Chinese Medicine and Chinese Herbs(A Study about Intervening Ef-fects of a Chinese Herbal Preparation w ith Resveratrol on In-sulin Resistance of Type 2 Diabetes Mellitus,No.GZK-2015-23)
文摘OBJECTIVE: To investigate the mechanism of Ping-wei capsules(PWC) in improving gastrointestinal m otility in rats with functional dyspepsia(FD).METHODS: We established an FD model by stimu-lating semi-starvation rats via tail damping, provo-cation, and forced exercise fatigue. The FD model group was further divided into five groups accord-ing to the treatment received: normal saline, dom-peridone, low-dose PWC, mid-dose PWC, or highdose PWC. The effect of PWC on FD was evaluated by measuring gastrointestinal motility. Changes in leptin and cholecystokinin(CCK) were detected through enzyme-linked immunosorbent assay, re-verse transcription-polymerase chain reaction, and immunohistochemistry.RESULTS: PWC significantly increased gastrointesti-nal m otility in FD rats. Furthermore, PWC signifi-cantly increased CCK m RNA and protein concentra-tions in the duodenum and antrum, decreased leptin protein concentrations in the duodenum, an-trum, and hypothalamus, and decreased CCK pro-tein concentration in the hypothalamus.CONCLUSION: PWC improves gastrointestinal mo-tor function in FD rats by decreasing the leptin con-centration in serum and the brain-gut axis, and by increasing the CCK concentration in gastrointesti-nal tissue. Our findings help to elucidate the mech-anism of FD and provide further insight into the pharmacokinetics of PWC.
文摘目的:观察二陈平胃散和三子养亲汤加减治疗痰湿蕴肺型咳嗽的临床疗效。方法:将痰湿蕴肺型咳嗽患者90例随机分为对照组(西药治疗)和试验组(加用二陈平胃散和三子养亲汤加减)各45例。观察两组患者肺机能恢复情况、呼吸困难程度、咳嗽症状、视觉模拟量表(visual analog scale,VAS)评分、生活质量及唾液分泌型免疫球蛋白A(secreted immunoglobulin A,SIgA)水平。结果:治疗后试验组、对照组显效率分别为82.2%、60.0%,差异有统计学意义(P<0.05)。两组患者治疗后呼吸困难程度、生存质量、VAS评分、咳嗽症状评分与治疗前比较差异有统计学意义(P<0.05),试验组低于对照组(P<0.05)。治疗后两组患者唾液sIgA水平与治疗前比较差异有统计学意义(P<0.05),试验组高于对照组(P<0.05)。结论:二陈平胃散和三子养亲汤加减联合西药能改善痰湿蕴肺型咳嗽患者临床症状、呼吸困难、生存质量及免疫功能,效果优于单纯西药治疗。
