Background:Pituicytoma is an extremely rare low-grade glial tumor that is closely related to the neurohypophysis axis.Most studies of pituicytomas include only several cases.To better understand this disease,we review...Background:Pituicytoma is an extremely rare low-grade glial tumor that is closely related to the neurohypophysis axis.Most studies of pituicytomas include only several cases.To better understand this disease,we reviewed a series of cases of pituicytomas.The diagnosis and treatment of pituicytoma must be further elucidated.Methods:Eleven patients with pituicytoma admitted to Beijing Tiantan Hospital from 2012 to 2019 were selected.The clinical features,including radiological and histological examination,surgical records and prognosis were reviewed.Sixty-eight other previously published cases of pituicytoma also were used to analyze the predictive factors for the results.The Cox regression model was used for univariate and multivariate analyses.Results:Our patients included 5 males(45.5%)and 6 females(54.5%),with a mean age of 49.3 years.The tumor was located in the suprasellar region in 5 patients(45.5%),intrasellar region in 4 patients(36.4%),and intrasellarsuprasellar region in 2 patients(18.2%).All patients were misdiagnosed with other common tumors in the sellar region before the operation.During the operation,gross total resection(GTR)of the tumor was achieved in 6 patients(54.5%),and subtotal resection(STR)was achieved in 5 patients(45.5%).The mean progression-free survival(PFS)time was 29.82 months.Tumor progression after surgical resection occurred in 4 patients(36.4%).Among them,60.0%of the patients(cases 4,5,7)with STR experienced progression,while 16.7%of the patients(case 2)with GTR experienced progression.Combined with the 68 cases in the literature,GTR was an independent risk factor for PFS time(P<0.05).Conclusions:Pituicytomas are more common in middle-aged people and the sellar region.The clinical manifestations of pituicytomas are different,but no diagnostic clinical features have been identified other than an abnormally abundant blood supply.Currently,GTR is the best approach for the treatment of pituicytomas.More patients and longer follow-up periods were needed to further elucidate the biological features of pituicytomas.展开更多
Background: Pituicytoma is a rare benign tumor of the neurohypophysis or hypophyseal stalk. Endocrinological abnormalities derived from this tumor are even rarer. Although three cases of pituicytoma with elevated plas...Background: Pituicytoma is a rare benign tumor of the neurohypophysis or hypophyseal stalk. Endocrinological abnormalities derived from this tumor are even rarer. Although three cases of pituicytoma with elevated plasma adrenocorticotropic hormone (ACTH) have been reported previously, the etiological mechanisms remain unknown. Case Description: We present a 47-year-old woman who was referred to a hospital complaining of headache. On investigation using magnetic resonance imaging (MRI), a tumor was detected in the sellar region. Elevation of basal ACTH and serum cortisol was identified, suggesting an ACTH-producing pituitary adenoma. However, physical findings and results of other hormonal examination showed no evidence of Cushing disease. The tumor had been detected incidentally eight years earlier when MRI was performed, and showed considerable enlargement on this consultation. Endoscopic endonasal transsphenoidal surgery was performed in order to remove the tumor completely. The histopathological diagnosis was pituicytoma. The patient’s postoperative clinical course was excellent, and both ACTH and cortisol levels returned to normal following surgery. Conclusions: It appears that ACTH was being secreted from the tumor cells. We discuss the possible mechanism of ACTH elevation in cases of pituicytoma.展开更多
Pituicytoma is a distinct low-grade glioma arising from pituicytes of the neurohypophysis and infundibulum. Due to the rarity of this tumor, most of the reported cases in the literature were originally misdiagnosed as...Pituicytoma is a distinct low-grade glioma arising from pituicytes of the neurohypophysis and infundibulum. Due to the rarity of this tumor, most of the reported cases in the literature were originally misdiagnosed as pituitary adenoma, meningiomas, and craniopharyngioma. It is of vital importance to accurately identify this tumor because this tumor, unlike pituitary adenomas, is prone to heavy bleeding during the surgical resection.展开更多
文摘Background:Pituicytoma is an extremely rare low-grade glial tumor that is closely related to the neurohypophysis axis.Most studies of pituicytomas include only several cases.To better understand this disease,we reviewed a series of cases of pituicytomas.The diagnosis and treatment of pituicytoma must be further elucidated.Methods:Eleven patients with pituicytoma admitted to Beijing Tiantan Hospital from 2012 to 2019 were selected.The clinical features,including radiological and histological examination,surgical records and prognosis were reviewed.Sixty-eight other previously published cases of pituicytoma also were used to analyze the predictive factors for the results.The Cox regression model was used for univariate and multivariate analyses.Results:Our patients included 5 males(45.5%)and 6 females(54.5%),with a mean age of 49.3 years.The tumor was located in the suprasellar region in 5 patients(45.5%),intrasellar region in 4 patients(36.4%),and intrasellarsuprasellar region in 2 patients(18.2%).All patients were misdiagnosed with other common tumors in the sellar region before the operation.During the operation,gross total resection(GTR)of the tumor was achieved in 6 patients(54.5%),and subtotal resection(STR)was achieved in 5 patients(45.5%).The mean progression-free survival(PFS)time was 29.82 months.Tumor progression after surgical resection occurred in 4 patients(36.4%).Among them,60.0%of the patients(cases 4,5,7)with STR experienced progression,while 16.7%of the patients(case 2)with GTR experienced progression.Combined with the 68 cases in the literature,GTR was an independent risk factor for PFS time(P<0.05).Conclusions:Pituicytomas are more common in middle-aged people and the sellar region.The clinical manifestations of pituicytomas are different,but no diagnostic clinical features have been identified other than an abnormally abundant blood supply.Currently,GTR is the best approach for the treatment of pituicytomas.More patients and longer follow-up periods were needed to further elucidate the biological features of pituicytomas.
文摘Background: Pituicytoma is a rare benign tumor of the neurohypophysis or hypophyseal stalk. Endocrinological abnormalities derived from this tumor are even rarer. Although three cases of pituicytoma with elevated plasma adrenocorticotropic hormone (ACTH) have been reported previously, the etiological mechanisms remain unknown. Case Description: We present a 47-year-old woman who was referred to a hospital complaining of headache. On investigation using magnetic resonance imaging (MRI), a tumor was detected in the sellar region. Elevation of basal ACTH and serum cortisol was identified, suggesting an ACTH-producing pituitary adenoma. However, physical findings and results of other hormonal examination showed no evidence of Cushing disease. The tumor had been detected incidentally eight years earlier when MRI was performed, and showed considerable enlargement on this consultation. Endoscopic endonasal transsphenoidal surgery was performed in order to remove the tumor completely. The histopathological diagnosis was pituicytoma. The patient’s postoperative clinical course was excellent, and both ACTH and cortisol levels returned to normal following surgery. Conclusions: It appears that ACTH was being secreted from the tumor cells. We discuss the possible mechanism of ACTH elevation in cases of pituicytoma.
文摘Pituicytoma is a distinct low-grade glioma arising from pituicytes of the neurohypophysis and infundibulum. Due to the rarity of this tumor, most of the reported cases in the literature were originally misdiagnosed as pituitary adenoma, meningiomas, and craniopharyngioma. It is of vital importance to accurately identify this tumor because this tumor, unlike pituitary adenomas, is prone to heavy bleeding during the surgical resection.
