It has been extensively proved that electro-acupuncture elicit analgesia in bothextensive areas and local region via supraspinal structures and spinal cord.The present investigationwas to study the role of P<sub>...It has been extensively proved that electro-acupuncture elicit analgesia in bothextensive areas and local region via supraspinal structures and spinal cord.The present investigationwas to study the role of P<sub>1</sub>-purinergic receptors in the spinal mechanisms of weak electroacupuncture-induced analgesia.Leg withdrawal latency（LWL）to noxious radiant heat focused on the ankle regionwas used to assess the effects of acupuncture and that of P<sub>1</sub>-purinergic（adenosine）receptor antago-nists,theophylline and caffeine on the electro-acupuncture（EA）analgesia.EA prolonged the LWLby 16.7%±20.3%,with an after-effect lasting about 15 min.Both theophylline and caffeineblocked the EA-induced prolongation of LWL in a dose-dependent manner at the doses of 1.6-16 mg/kg.These results suggest that P<sub>1</sub>-purinegic receptor is involved in the spinal mechanisms of weak EAproduced analgesia in the rat.展开更多
文摘It has been extensively proved that electro-acupuncture elicit analgesia in bothextensive areas and local region via supraspinal structures and spinal cord.The present investigationwas to study the role of P<sub>1</sub>-purinergic receptors in the spinal mechanisms of weak electroacupuncture-induced analgesia.Leg withdrawal latency（LWL）to noxious radiant heat focused on the ankle regionwas used to assess the effects of acupuncture and that of P<sub>1</sub>-purinergic（adenosine）receptor antago-nists,theophylline and caffeine on the electro-acupuncture（EA）analgesia.EA prolonged the LWLby 16.7%±20.3%,with an after-effect lasting about 15 min.Both theophylline and caffeineblocked the EA-induced prolongation of LWL in a dose-dependent manner at the doses of 1.6-16 mg/kg.These results suggest that P<sub>1</sub>-purinegic receptor is involved in the spinal mechanisms of weak EAproduced analgesia in the rat.
