Alzheimer’s disease（AD）is the most common form of dementia among the elderly.It currently affects approximately 5.1 million Americans,a number predicted to triple by 2050.AD is clinically manifested as progressive ...Alzheimer’s disease（AD）is the most common form of dementia among the elderly.It currently affects approximately 5.1 million Americans,a number predicted to triple by 2050.AD is clinically manifested as progressive loss of memory and cognitive function,and is characterized pathologically by the formation of amyloid-beta（Aβ）plaques and neurofibrillary tangles（NFT）.Since its discovery in 1906,展开更多
Alzheimer’s disease（AD）is broadly defined by dementia and the presence of specific neuropathological features in the brain（amyloid plaques,neurofibrillary tangles（NFTs）and congophilic amyloid angiopathy）.Howeve...Alzheimer’s disease（AD）is broadly defined by dementia and the presence of specific neuropathological features in the brain（amyloid plaques,neurofibrillary tangles（NFTs）and congophilic amyloid angiopathy）.However,the rate of disease progression,type of cognitive impairment,and extent of neuropathology vary widely in patients with AD（Murray et al.,2011）.展开更多
基金supported by the Alzheimer’s Association Investigator-Initiated Research Grant(IIRG-10-172459)the NIH-funded Institutional Development Award(P20GM103418)+2 种基金the NIH-funded University of Kansas Alzheimer’s Disease Center(P30AG035982)the University of Kansas Institute for Reproductive Health and Regenerative Medicinethe University of Kansas general research and startup funds to LZ
文摘Alzheimer’s disease（AD）is the most common form of dementia among the elderly.It currently affects approximately 5.1 million Americans,a number predicted to triple by 2050.AD is clinically manifested as progressive loss of memory and cognitive function,and is characterized pathologically by the formation of amyloid-beta（Aβ）plaques and neurofibrillary tangles（NFT）.Since its discovery in 1906,
文摘Alzheimer’s disease（AD）is broadly defined by dementia and the presence of specific neuropathological features in the brain（amyloid plaques,neurofibrillary tangles（NFTs）and congophilic amyloid angiopathy）.However,the rate of disease progression,type of cognitive impairment,and extent of neuropathology vary widely in patients with AD（Murray et al.,2011）.
