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血清NT-proBNP、HMGB1及sTREM-1水平在脓毒症急性肺损伤预后评估中的价值 被引量:1
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作者 王晓林 李静 +2 位作者 范志强 佟庆 黄艳丽 《川北医学院学报》 CAS 2024年第2期222-225,共4页
目的:分析血清N末端脑钠肽前体(NT-proBNP)、高迁移率族蛋白B1(HMGB1)、可溶性髓系细胞触发受体-1(sICAM-1)水平与在脓毒症急性肺损伤(ALI)预后评估中的价值。方法:选取104例脓毒症ALI患者为研究对象(ALI组),以肺部超声评分(LUS)将其分... 目的:分析血清N末端脑钠肽前体(NT-proBNP)、高迁移率族蛋白B1(HMGB1)、可溶性髓系细胞触发受体-1(sICAM-1)水平与在脓毒症急性肺损伤(ALI)预后评估中的价值。方法:选取104例脓毒症ALI患者为研究对象(ALI组),以肺部超声评分(LUS)将其分为轻度组(n=50)、中度组(n=36)、重度组(n=18);另选取80例单纯性脓毒症患者为对照组。采用酶联免疫吸附法检测血清NT-proBNP、HMGB1、sICAM-1水平,以脓毒症ALI患者28 d预后情况将其分为生存组和死亡组,绘制受试者工作特征曲线(ROC)评估NT-proBNP、HMGB1、sICAM-1及联合预测预后的价值。结果:脓毒症ALI组NT-proBNP、HMGB1、sTREM-1水平均高于对照组(P<0.05);不同严重程度的脓毒症ALI组患者NT-proBNP、HMGB1、sTREM-1值比较,差异均有统计学意义(P<0.05),且均表现为脓毒症ALI轻度组患者<中度组<重度组(P<0.05);Spearman相关性分析显示,NT-proBNP、HMGB1、sTREM-1与严重程度正相关(P<0.05);生存组NT-proBNP、HMGB1、sTREM-1水平均低于死亡组(P<0.05),三者联合检测预测预后的曲线下面积高于单一指标预测。结论:脓毒症ALI患者血清NT-proBNP、HMGB1、sTREM-1水平较高,三者联合检测对于预后有较高的评估价值。 展开更多
关键词 脓毒症 急性肺损伤 nt-probnp HMGB1 STREM-1 预后
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慢性心力衰竭患者血清Ⅲ型前胶原氨基末端前肽、高迁移率族蛋白B1、NT-proBNP的表达及临床意义
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作者 郭丽 王雪 《黑龙江医药科学》 2024年第1期29-32,共4页
目的:检测慢性心力衰竭(CHF)患者血清Ⅲ型前胶原氨基末端前肽(N-terminal peptide of typeⅢprocollagen,PⅢNP)、高迁移率族蛋白B1(high mobility group box-1,HMGB1)的表达水平,探讨二者与左室射血分数(LVEF)的相关性以及对CHF的诊断... 目的:检测慢性心力衰竭(CHF)患者血清Ⅲ型前胶原氨基末端前肽(N-terminal peptide of typeⅢprocollagen,PⅢNP)、高迁移率族蛋白B1(high mobility group box-1,HMGB1)的表达水平,探讨二者与左室射血分数(LVEF)的相关性以及对CHF的诊断价值。方法:收集2021年12月至2022年11月期间于佳木斯大学附属第一医院心内科住院治疗的慢性心力衰竭患者90例为实验组,按照LVEF将其分为HFrEF组(n=33)、HFmrEF组(n=27)和HFpEF组(n=30)。此外选取排除心功能不全诊断的同期住院患者30例为对照组。对比各组患者血清中氨基末端脑钠肽前体(NT-proBNP)、PⅢNP、HMGB1水平的差异,分析PⅢNP、HMGB1水平与心功能指标的相关性,并借助ROC曲线评估NT-proBNP、HMGB1、PⅢNP单独以及联合应用对不同表型CHF患者的诊断价值。结果:HFrEF组PⅢNP、HMGB1及NT-proBNP水平均高于HFpEF组和对照组,差异有统计学意义(P<0.05)。PⅢNP与HMGB1呈正相关(P<0.05);PⅢNP、HMGB1均与NT-proBNP、LVEDD呈正相关,与LVEF呈明显负相关(P<0.05);HMGB1与LAD呈正相关(P<0.05),PⅢNP与LAD无明显相关性(P>0.05)。血清NT-proBNP、HMGB1、PⅢNP水平诊断HFrEF患者的AUC分别为0.867、0.871、0.779;诊断HFmrEF患者的AUC分别为0.840、0.804、0.760;诊断HFpEF患者的AUC分别为0.851、0.728、0.769。多生物标志物模型NT-proBNP+PⅢNP、NT-proBNP+HMGB1、NT-proBNP+PⅢNP+HMGB1诊断HFrEF患者的AUC分别为0.887、0.954、0.954;诊断HFmrEF患者的AUC分别为0.942、0.937、0.951;诊断HFpEF患者的AUC分别为0.904、0.910、0.914。结论:CHF患者血清PⅢNP、HMGB1明显升高,并且,CHF患者血清PⅢNP、HMGB1水平与心脏功能指标具有良好的相关性,说明PⅢNP、HMGB1可反映疾病的严重程度。PⅢNP、HMGB1对各表型CHF患者均具有诊断价值,并且,多生物标志物联合检测能提高对CHF患者诊断的敏感性。 展开更多
关键词 慢性心力衰竭 左室射血分数 nt-probnp PⅢNP HMGB1
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沙库巴曲缬沙坦联合冻干重组人脑利钠肽治疗心力衰竭的疗效及对NT-proBNP的影响
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作者 陈吉丽 王艳飞 吕彩萍 《生命科学仪器》 2024年第1期53-55,58,共4页
目的探讨沙库巴曲缬沙坦联合冻干重组人脑利钠肽治疗心力衰竭的疗效及对NT-proBNP的影响。方法选取2022年4月至2023年5月云南省昆明市第一人民医院心内科收治的150例心力衰竭患者为研究对象,根据就诊时间分为两组。参照组采用沙库巴曲... 目的探讨沙库巴曲缬沙坦联合冻干重组人脑利钠肽治疗心力衰竭的疗效及对NT-proBNP的影响。方法选取2022年4月至2023年5月云南省昆明市第一人民医院心内科收治的150例心力衰竭患者为研究对象,根据就诊时间分为两组。参照组采用沙库巴曲缬沙坦治疗,实验组在参照组基础上使用冻干重组人脑利钠肽治疗。对比两组治疗效果、心功能、血浆BNP、NT-proBNP水平及不良反应发生情况。结果实验组治疗总有效率高于参照组,差异有统计学意义(P<0.05)。实验组干预后心率低于参照组,每搏量及LVEF均高于参照组,差异有统计学意义(P<0.05)。实验组干预后血浆BNP、NT-proBNP水平均低于参照组,差异有统计学意义(P<0.05)。实验组不良反应发生率低于参照组,差异有统计学意义(P<0.05)。结论沙库巴曲缬沙坦联合冻干重组人脑利钠肽治疗心力衰竭可显著提高疗效,降低血浆BNP及NT-proBNP水平,改善患者心功能,减少不良反应。 展开更多
关键词 沙库巴曲缬沙坦 冻干重组人脑利钠肽 心力衰竭 nt-probnp
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D-二聚体、NT-proBNP、TNF-α水平在COPD合并肺心病中的表达及诊断价值 被引量:3
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作者 张咪 孙婧婷 +1 位作者 孔田田 盛辉 《中国老年学杂志》 CAS 北大核心 2024年第1期38-41,共4页
目的分析D-二聚体、B型利钠肽原(NT-proBNP)、肿瘤坏死因子(TNF)-α水平在COPD合并肺心病患者中的表达及诊断价值。方法选取COPD患者80例,其中42例合并肺心病者为COPD合并肺心病(合并)组,38例未合并肺心病者为单纯COPD组,选择30例健康... 目的分析D-二聚体、B型利钠肽原(NT-proBNP)、肿瘤坏死因子(TNF)-α水平在COPD合并肺心病患者中的表达及诊断价值。方法选取COPD患者80例,其中42例合并肺心病者为COPD合并肺心病(合并)组,38例未合并肺心病者为单纯COPD组,选择30例健康志愿者为对照组,按照纽约心脏病协会(NYHA)心功能分级标准将患者分为Ⅰ、Ⅱ、Ⅲ、Ⅳ级,对比各组D-二聚体、NT-proBNP、TNF-α表达水平,采用受试者工作特征(ROC)曲线预测D-二聚体、NT-proBNP、TNF-α水平联合对COPD合并肺心病患者的预测价值。结果合并组D-二聚体、NT-proBNP、TNF-α水平均高于对照组、单纯COPD组,且单纯COPD组高于对照组,差异有统计学意义(P<0.05)。Ⅳ级组D-二聚体、NT-proBNP、TNF-α水平均高于Ⅰ、Ⅱ、Ⅲ级;Ⅲ级组均高于Ⅰ、Ⅱ级;Ⅱ级组均高于Ⅰ级,差异有统计学意义(P<0.05);经Pearson相关性分析,D-二聚体、NT-proBNP、TNF-α之间呈正相关;D-二聚体、NT-proBNP、TNF-α联合预测的曲线下面积(AUC)显著高于单独预测(P<0.05)。结论COPD合并肺心病患者应用D-二聚体、NT-proBNP、TNF-α检测的临床价值明显,有利于评估患者心功能和肺动脉高压的严重程度,随着心功能恶化和肺动脉高压程度的加重,D-二聚体、NT-proBNP、TNF-α水平均升高。且三者检测方便,对COPD合并肺心病的诊断和病情评估及指导治疗、判断预后都有帮助。 展开更多
关键词 D-二聚体 B型利钠肽原(nt-probnp) 肿瘤坏死因子(TNF)-α 慢性阻塞性肺疾病(COPD)合并肺心病
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HbA1c联合NT-proBNP检测在急性心力衰竭近期死亡风险中的预测作用
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作者 郏红静 丁延魁 +1 位作者 高峰 过高峰 《分子诊断与治疗杂志》 2024年第7期1359-1362,1367,共5页
目的 探析糖化血红蛋白(HbA1c)联合B型脑钠钛前体生物标志物(NT-proBNP)检测在急性心力衰竭患者近期死亡风险中的预测价值。方法 选取2020年2月至2023年2月蒙城县第一人民医院收治的103例急性心力衰竭患者为观察组,选取同期在本院体检... 目的 探析糖化血红蛋白(HbA1c)联合B型脑钠钛前体生物标志物(NT-proBNP)检测在急性心力衰竭患者近期死亡风险中的预测价值。方法 选取2020年2月至2023年2月蒙城县第一人民医院收治的103例急性心力衰竭患者为观察组,选取同期在本院体检中心体检且各项指标均显示正常的健康者共计101名为对照组。比较不同人群HbA1c、NT-proBNP表达差异;分析HbA1c、NT-proBNP与急性心力衰竭患者近期死亡风险的相关性及诊断价值,并分析影响急性心力衰竭患者死亡的危险因素。结果 观察组血清HbA1c、NT-proBNP表达均显著高于对照组,差异有统计学意义(P<0.05)。观察组HbA1c、NT-proBNP与心功能分级呈正相关(r=0.587,0.536,P<0.05)。死亡组NYAH分级Ⅳ级占比、HbA1c、NT-proBNP表达均高于存活组,差异有统计学意义(P<0.05)。经Logistic回归分析可知,NYAH分级为Ⅳ级、HbA1c及NT-proBNP表达上升是急性心力衰竭患者死亡的危险因素(OR>1,P<0.05)。森林图显示,在与急性心力衰竭患者死亡风险增加的相关因素中,NT-proBNP是关联强度最大的因素(OR=2.491,95%CI 1.414~4.390)。急性心力衰竭死亡患者实施联合检测(HbA1c与NT-proBNP)的AUC值与单独HbA1c、NT-proBNP检测相比更高(P<0.05)。结论 HbA1c、NT-proBNP表达水平随急性心力衰竭死亡患者的心力衰竭严重程度的增加而升高,两指标联合检测可提高预测急性心力衰竭死亡患者的死亡风险效能,可指导临床早期及时干预。 展开更多
关键词 急性心力衰竭 HBA1C nt-probnp 近期死亡风险
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miR-21、NT-proBNP、CTGF在心房颤动患者中的表达及对预后的预测价值分析
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作者 张丽莉 马蕊 +1 位作者 朱玫玉 蔡静波 《中国处方药》 2024年第6期181-185,共5页
目的分析miR-21、氨基末端B型利钠肽前体(NT-proBNP)、结缔组织生长因子(Connective tissue growth factor,CTGF)在心房颤动(Atrial fibrillation,AF)患者中的表达及对预后的预测价值。方法纳入2020年1月~2022年1月100例治疗的AF患者为... 目的分析miR-21、氨基末端B型利钠肽前体(NT-proBNP)、结缔组织生长因子(Connective tissue growth factor,CTGF)在心房颤动(Atrial fibrillation,AF)患者中的表达及对预后的预测价值。方法纳入2020年1月~2022年1月100例治疗的AF患者为研究对象,作为房颤组,另选取50例健康人作为对照组。对比2组研究对象miR-21、NT-proBNP、CTGF水平,比较miR-21、NT-proBNP、CTGF在房颤未复发与复发患者中的表达情况;绘制ROC曲线评价3者联合检测对AF患者复发情况的预测价值。结果2组研究对象基线资料对比,高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、Cr、hs-CRP、D-二聚体对比,差异具有统计学意义(P<0.05)。房颤组miR-21、NT-proBNP、CTGF水平显著高于对照组,差异具有统计学意义(P<0.05)。持续性房颤患者miR-21、NT-proBNP、CTGF水平显著升高,差异具有统计学意义(P<0.05)。1年内复发患者miR-21、NT-proBNP、CTGF水平显著升高,差异具有统计学意义(P<0.05)。ROC曲线显示:3者联合检测预测AF患者1年复发的灵敏度(94.2%)、特异度(91.8%)、AUC(93.4%)均高于单一指标检测。结论miR-21、NT-proBNP、CTGF在AF患者中表达明显增加,与AF持续时间呈正相关;miR-21、NT-proBNP、CTGF在AF复发组患者中表达水平明显升高,且三者联合对AF患者术后复发有预测价值。 展开更多
关键词 MIR-21 nt-probnp CTGF 心房颤动 预后
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Plasma‐oxidized 2D MXenes subnanochannel membrane for high‐performance osmotic energy conversion 被引量:2
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作者 Zhengmao Ding Tiancheng Gu +5 位作者 Rui Zhang Shouyi Sun Kaiqiang Wang Hanli Zhang Jinjin Li Yunjun Luo 《Carbon Energy》 SCIE EI CAS CSCD 2024年第8期178-191,共14页
Nanofluidic channels inspired by electric eels open a new era of efficient harvesting of clean blue osmotic energy from salinity gradients.Limited by less charge and weak ion selectivity of the raw material itself,ene... Nanofluidic channels inspired by electric eels open a new era of efficient harvesting of clean blue osmotic energy from salinity gradients.Limited by less charge and weak ion selectivity of the raw material itself,energy conversion through nanofluidic channels is still facing considerable challenges.Here,a facile and efficient strategy to enhance osmotic energy harvesting based on drastically increasing surface charge density of MXenes subnanochannels via oxygen plasma is proposed.This plasma could break Ti–C bonds in the MXenes subnanochannels and effectively facilitate the formation of more Ti–O,C═O,O–OH,and rutile with a stronger negative charge and work function,which leads the surface potential of MXenes membrane to increase from 205 to 430 mV.This significant rise of surface charge endows the MXenes membrane with high cation selectivity,which could make the output power density of the MXenes membrane increase by 248.2%,reaching a high value of 5.92Wm^(−2) in the artificial sea‐river water system.Furthermore,with the assistance of low‐quality heat at 50℃,the osmotic power is enhanced to an ultrahigh value of 9.68Wm^(−2),which outperforms those of the state‐of‐the‐art two‐dimensional(2D)nanochannel membranes.This exciting breakthrough demonstrates the enormous potential of the facile plasma‐treated 2D membranes for osmotic energy harvesting. 展开更多
关键词 ion transport MXenes membranes osmotic energy harvesting plasma two‐dimensional nanochannels
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Spark Plasma Sintering of Mg-based Alloys:Microstructure,Mechanical Properties,Corrosion Behavior,and Tribological Performance 被引量:1
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作者 Alessandro M.Ralls Mohammadreza Daroonparvar Pradeep L.Menezes 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第2期405-442,共38页
Within the past ten years,spark plasma sintering(SPS)has become an increasingly popular process for Mg manufacturing.In the SPS process,interparticle diffusion of compressed particles is rapidly achieved due to the co... Within the past ten years,spark plasma sintering(SPS)has become an increasingly popular process for Mg manufacturing.In the SPS process,interparticle diffusion of compressed particles is rapidly achieved due to the concept of Joule heating.Compared to traditional and additive manufacturing(AM)techniques,SPS gives unique control of the structural and microstructural features of Mg components.By doing so,their mechanical,tribological,and corrosion properties can be tailored.Although great advancements in this field have been made,these pieces of knowledge are scattered and have not been contextualized into a single work.The motivation of this work is to address this scientific gap and to provide a groundwork for understanding the basics of SPS manufacturing for Mg.To do so,the existing body of SPS Mg literature was first surveyed,with a focus on their structural formation and degradation mechanisms.It was found that successful Mg SPS fabrication highly depended on the processing temperature,particle size,and particle crystallinity.The addition of metal and ceramic composites also affected their microstructural features due to the Zener pinning effect.In degradative environments,their performance depends on their structural features and whether they have secondary phased composites.In industrial applications,SPS'd Mg was found to have great potential in biomedical,hydrogen storage,battery,automotive,and recycling sectors.The prospects to advance the field include using Mg as a doping agent for crystallite size refinement and using bulk metallic Mg-based glass powders for amorphous SPS components.Despite these findings,the interactions of multi-composites on the processing-structure-property relationships of SPS Mg is not well understood.In total,this work will provide a useful direction in the SPS field and serve as a milestone for future Mg-based SPS manufacturing. 展开更多
关键词 Spark plasma sintering Magnesium alloys NANOCRYSTALLINE TRIBOLOGY Mechanical properties Corrosion
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急性心肌梗死时超过检测上限的NT-proBNP的临床意义及其预测指标
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作者 刘江红 范继红 +1 位作者 王刚 刘锐锋 《医学研究杂志》 2024年第7期32-37,21,共7页
目的分析急性心肌梗死时超过检测上限的N-末端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNP)的临床意义及其预测指标。方法选取急性心肌梗死患者669例,根据NT-proBNP峰值水平分为超检测范围组(n=50)和可检测组(n=61... 目的分析急性心肌梗死时超过检测上限的N-末端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNP)的临床意义及其预测指标。方法选取急性心肌梗死患者669例,根据NT-proBNP峰值水平分为超检测范围组(n=50)和可检测组(n=619),同时使用倾向评分进行匹配(1∶2),比较两组的临床和实验室指标、冠状动脉特征、院内预后等,并采用多因素Logistic回归分析探索早期预测NT-proBNP超过检测上限指标。结果NT-proBNP超检测范围组中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)、超敏C反应蛋白水平、纤维蛋白原含量均较高;在倾向评分匹配后结果一致。院内预后方面,NT-proBNP超检测范围组的心功能Killip 2级以上的患者比例高、住院天数长、左心室射血分数低、主要不良心脑血管事件发生率高;在倾向评分匹配之后,仍然是相同的结果;但两组的心肌酶峰值差异在倾向评分匹配前后均无统计学意义。多因素Logistic回归分析结果显示,早期预测NT-proBNP超检测范围的指标有:NLR高、抗血小板药应用率低、纤维蛋白原含量高、左前降支闭塞、年龄高。倾向评分匹配后,预测NT-proBNP超检测范围组的指标有右冠状动脉闭塞、NLR高、纤维蛋白原含量高、左前降支闭塞。结论急性心肌梗死时NT-proBNP峰值超检测范围的患者院内预后更差;入院时的NLR、纤维蛋白原可作为NT-proBNP峰值水平超检测范围的早期预测指标。 展开更多
关键词 nt-probnp 急性心肌梗死 检测上限 预后
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慢性心力衰竭患者阳虚血瘀证与心功能及血清NT-proBNP表达的相关性及二者对预后的影响 被引量:2
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作者 高晨 李劼 冯伟 《广州中医药大学学报》 CAS 2024年第5期1097-1103,共7页
【目的】探究慢性心力衰竭患者阳虚血瘀证与心功能及血清B型氨基端利钠肽原(NT-proBNP)表达的相关性以及二者对患者预后的影响。【方法】选取2019年1月至2021年1月期间唐山市中医医院收治的320例慢性心力衰竭患者作为研究对象,根据中医... 【目的】探究慢性心力衰竭患者阳虚血瘀证与心功能及血清B型氨基端利钠肽原(NT-proBNP)表达的相关性以及二者对患者预后的影响。【方法】选取2019年1月至2021年1月期间唐山市中医医院收治的320例慢性心力衰竭患者作为研究对象,根据中医辨证分型结果,将辨证为阳虚血瘀证的160例患者作为观察组,将辨证为气虚血瘀证或气阴两虚证的160例患者作为对照组;并对慢性心力衰竭阳虚血瘀证患者出院后进行为期1年的随访,根据随访结果,将患者分为良好预后组104例和不良预后组56例。采用Spearman相关性分析患者中医证型与血清NT-proBNP水平及心功能指标左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、每分钟搏出量(SV)、心排血量(CO)之间的相关性;采用多因素Logistic回归分析探讨影响患者不良预后的危险因素。【结果】(1)观察组患者的血清NT-proBNP水平及LVEDD值均明显高于对照组,LVEF、SV、CO值均低于对照组,差异均有统计学意义(P<0.05或P<0.01)。(2)Pearson相关性分析结果显示,慢性心力衰竭患者中医证型与血清NT-proBNP水平及LVEDD值呈正相关,与LVEF、SV、CO值呈负相关,差异均有统计学意义(P<0.01)。(3)慢性心力衰竭阳虚血瘀证患者不良预后组血清NT-proBNP水平及LVEDD值均明显高于良好预后组,LVEF、SV、CO值均低于良好预后组,差异均有统计学意义(P<0.01)。(4)血清NT-proBNP联合心功能指标对预后不良评估的曲线下面积(AUC)为0.942。Logistic回归分析结果显示,血清NT-proBNP高水平、LVEDD高水平均为影响慢性心力衰竭阳虚血瘀证患者发生不良预后的危险因素(P<0.01),而LVEF高水平、SV高水平、CO高水平均为保护因素(P<0.05或P<0.01)。【结论】慢性心力衰竭阳虚血瘀证患者血清NT-proBNP水平升高,阳虚血瘀证与血清NT-proBNP水平及心功能关系密切,且NT-proBNP水平及心功能与患者预后有关。 展开更多
关键词 慢性心力衰竭 阳虚血瘀证 心功能 B型氨基端利钠肽原(nt-probnp) 预后
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利伐沙班、华法林对ACS患者介入治疗后NT-proBNP、D-D及Fg水平的影响
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作者 夏俊涛 李峰 +4 位作者 余快 胡丽 陈黎 周乐玲 田林 《分子诊断与治疗杂志》 2024年第6期1130-1133,1142,共5页
目的 分析利伐沙班、华法林对急性冠脉综合征(ACS)患者介入治疗后N端B型脑钠肽前体(NT-proBNP)、D-二聚体(D-D)及纤维蛋白原(Fg)水平的影响。方法 选取武胜县人民医院2020年7月至2023年2月期间收治的行经皮冠状动脉介入治疗的ACS患者142... 目的 分析利伐沙班、华法林对急性冠脉综合征(ACS)患者介入治疗后N端B型脑钠肽前体(NT-proBNP)、D-二聚体(D-D)及纤维蛋白原(Fg)水平的影响。方法 选取武胜县人民医院2020年7月至2023年2月期间收治的行经皮冠状动脉介入治疗的ACS患者142例,遵循单盲法原则,根据治疗方案不同分为对照组70例(予以华法林治疗)与观察组72例(予以利伐沙班治疗)。对比两组临床疗效、血脂水平[甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、NT-proBNP、D-D、Fg水平,比较两组随访期间出现的心血管不良事件以及用药期间的不良反应发生情况。结果 观察组治疗后的临床有效率高于对照组,差异有统计学意义(P<0.05);治疗3个月后,两组TG、TC、LDL-C、HDL-C水平均下降,且观察组低于对照组,差异有统计学意义(P<0.05);治疗3个月后,两组NT-proBNP、D-D、Fg水平均下降,且观察组低于对照组,差异有统计学意义(P<0.05);观察组在治疗期间出现的心血管不良事件的总发生率低于对照组,差异有统计学意义(P<0.05);观察组在用药期间出现的不良反应的总发生率低于对照组,差异有统计学意义(P<0.05)。结论 在ACS患者介入治疗后,应用利伐沙班的治疗效果相对更为显著,其可有效改善患者血脂水平、凝血功能,减少心血管不良事件的发生风险,且具有一定的安全性。 展开更多
关键词 利伐沙班 华法林 ACS 介入治疗 nt-probnp D-D FG
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NT-proBNP及NT-proBNP/Crea用于鉴别心源性呼吸困难和肺源性呼吸困难的诊断截点研究
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作者 冯彩滑 王有秀 宋昊岚 《内蒙古医学杂志》 2024年第7期876-879,共4页
目的建立适合中国人群不同年龄段的诊断和鉴别诊断以急诊呼吸困难为主诉的心力衰竭的NT-proBNP和NT-proBNP/Crea的cut off值。方法将133例急性呼吸困难患者分为心源性呼吸困难组(n=55)和肺源性呼吸困难组(n=78),根据年龄、性别、基本生... 目的建立适合中国人群不同年龄段的诊断和鉴别诊断以急诊呼吸困难为主诉的心力衰竭的NT-proBNP和NT-proBNP/Crea的cut off值。方法将133例急性呼吸困难患者分为心源性呼吸困难组(n=55)和肺源性呼吸困难组(n=78),根据年龄、性别、基本生化指标NT-proBNP及Crea水平,绘制ROC曲线,并进行统计学分析。结果心源性呼吸困难组中NT-proBNP为2744(1076,7329)pg/mL,而在肺源性呼吸困难组中NT-proBNP水平为268(80,918)pg/mL,差异具有统计学意义。心源性呼吸困难组NT-proBNP/Crea为31.3(12.02,61.21),肺源性呼吸困难组NT-proBNP/Crea为4.48(1.13,12.24),两组间差异具有统计学意义。NT-proBNP/Crea诊断心源性呼吸困难的能力是0.822(95%可信区间),最佳诊断截点是15.45。结论NT-proBNP和NT-proBNP/Crea在鉴别心源性呼吸困难和肺源性呼吸困难上有不同的诊断截点,且中国人群不同年龄段亦有不同的诊断截点。可以帮助急诊医生快速、准确诊断和鉴别诊断心源性呼吸困难及肺源性呼吸困难。 展开更多
关键词 nt-probnp nt-probnp/Crea 心源性呼吸困难 肺源性呼吸困难 诊断截点
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达格列净对射血分数降低的心力衰竭患者心功能及血清NT-proBNP、cTnⅠ水平的影响 被引量:1
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作者 龚庆平 游倩 王鸿权 《临床医学工程》 2024年第2期197-198,共2页
目的探讨达格列净对射血分数降低的心力衰竭(HFrEF)患者心功能以及血清NT-proBNP、cTnⅠ水平的影响。方法120例HFrEF患者随机分为两组。对照组采用标准心力衰竭药物治疗方案进行治疗,观察组在对照组基础上采用达格列净治疗。比较两组的... 目的探讨达格列净对射血分数降低的心力衰竭(HFrEF)患者心功能以及血清NT-proBNP、cTnⅠ水平的影响。方法120例HFrEF患者随机分为两组。对照组采用标准心力衰竭药物治疗方案进行治疗,观察组在对照组基础上采用达格列净治疗。比较两组的心功能、不良事件以及血清NT-proBNP、cTnⅠ水平。结果治疗后,观察组的LVEF高于对照组,LVESD、LVEDD以及血清NT-proBNP、cTnⅠ水平均低于对照组(P<0.05)。观察组的不良事件总发生率为11.67%,低于对照组的30.00%(P<0.05)。结论达格列净可明显改善HFrEF患者的心功能,降低NT-proBNP、cTnⅠ水平,减少不良事件的发生。 展开更多
关键词 心力衰竭 射血分数降低 达格列净 心功能 不良事件 nt-probnp cTnⅠ
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Study of plasma parameters of coaxial plasma source using triple Langmuir probe and Faraday cup diagnostics
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作者 Sunil KANCHI Rohit SHUKLA Archana SHARMA 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第4期94-100,共7页
Coaxial plasma guns are a type of plasma source that produces plasma which propagates radially and axially controlled by the shape of the ground electrode, which has attracted much interest in several applications. In... Coaxial plasma guns are a type of plasma source that produces plasma which propagates radially and axially controlled by the shape of the ground electrode, which has attracted much interest in several applications. In this work, a 120° opening angle of CPG nozzle is used as a plasma gun configuration that operates at the energy of 150 J. The ionization of polyethylene insulator between the electrodes of the gun produces a cloud of hydrogen and carbon plasma.The triple Langmuir probe and Faraday cup are used to measure plasma density and plasma temperature. These methods are used to measure the on-axis and off-axis plasma divergence of the coaxial plasma gun. The peak values of ion densities measured at a distance of 25 mm on-axis from the plasma gun are(1.6±0.5)×10^(19)m^(-3)and(2.8±0.6)×10^(19)m^(-3)for hydrogen and carbon plasma respectively and the peak temperature is 3.02±0.5 eV. The mean propagation velocity of plasma is calculated using the transit times of plasma at different distances from the plasma gun and is found to be 4.54±0.25 cm/μs and 1.81±0.18 cm/μs for hydrogen and carbon plasma respectively. The Debye radius is obtained from the measured experimental data that satisfies the thin sheath approximation. The shot-to-shot stability of plasma parameters facilitates the use of plasma guns in laboratory experiments. These types of plasma sources can be used in many applications like plasma opening switches, plasma devices, and as plasma sources. 展开更多
关键词 coaxial plasma source triple Langmuir probe Faraday cup plasma density plasma temperature
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Effects of external parameters on plasma characteristics and uniformity in a dual cylindrical inductively coupled plasma
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作者 Pengyu WANG Siyu XING +5 位作者 Daoman HAN Yuru ZHANG Yong LI Cheng ZHOU Fei GAO Younian WANG 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第12期63-74,共12页
The dual cylindrical inductively coupled plasma source,compared to the conventional structure of inductively coupled plasma source,can significantly improve the uniformity of plasma.It has an enhanced potential for ap... The dual cylindrical inductively coupled plasma source,compared to the conventional structure of inductively coupled plasma source,can significantly improve the uniformity of plasma.It has an enhanced potential for application in processes,such as etching and ashing.A uniform plasma can be obtained by allowing the remote plasma from the upper chamber modulate the main plasma generated in the lower chamber.In this study,a fluid model was employed to investigate a dual cylindrical inductively coupled Ar/O_(2)discharge.The effects of external parameters on electron density,electron temperature,O atomic density,and plasma uniformity in the main chamber were studied,and the reasons were analyzed.The results of this study show that remote power can control the plasma uniformity and increase the plasma density in the main chamber.As the remote power increased,plasma uniformity improved initially and then deteriorated.The main power affected the plasma density at the edge of the main chamber and can modulate the plasma density in the main chamber.The gas pressure affected both the uniformity and density of the plasma.As the gas pressure increased,the plasma uniformity deteriorated,but the free radical density improved. 展开更多
关键词 dual inductively coupled plasma remote plasma plasma uniformity fluid model
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The multi-peak point phenomenon of broadband microwave reflection caused by inhomogeneous plasma
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作者 杨敏 齐凯旋 +5 位作者 杨玖文 贾飒 刘浩岩 陈燕扬 李瑾 李小平 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第7期1-11,共11页
During spacecraft re-entry,the challenge of measuring plasma sheath parameters directly contributes to difficulties in addressing communication blackout.In this work,we have discovered a phenomenon of multiple peaks i... During spacecraft re-entry,the challenge of measuring plasma sheath parameters directly contributes to difficulties in addressing communication blackout.In this work,we have discovered a phenomenon of multiple peaks in reflection data caused by the inhomogeneous plasma.Simulation results show that the multi-peak points fade away as the characteristic frequency is approached,resembling a series of gradually decreasing peaks.The positions and quantities of these points are positively correlated with electron density,yet they show no relation to collision frequency.This phenomenon is of significant reference value for future studies on the spatial distribution of plasmas,particularly for using microwave reflection signals in diagnosing the plasma sheath. 展开更多
关键词 plasma sheath microwave reflection inhomogeneous plasma
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Final results of the first phase of the PROTO-SPHERA experiment: obtainment of the full current stable screw pinch and first evidences of the jet + torus combined plasma configuration
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作者 Paolo MICOZZI Franco ALLADIO +21 位作者 Alessandro MANCUSO Vincenzo ZANZA Gerarda APRUZZESE Francesca BOMBARDA Luca BONCAGNI Paolo BURATTI Francesco FILIPPI Giuseppe GALATOLA TEKA Francesco GIAMMANCO Edmondo GIOVANNOZZI Andrea GROSSO Matteo IAFRATI Alessandro LAMPASI Violeta LAZIC Simone MAGAGNINO Simone MANNORI Paolo MARSILI Valerio PIERGOTTI Giuliano ROCCHI Alessandro SIBIO Benedetto TILIA Onofrio TUDISCO 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第2期31-43,共13页
In astrophysics, the boundary conditions for plasma phenomena are provided by nature and the astronomer faces the problem of understanding them from a variety of observations [Hester J J et al 1996 Astrophys. J. 456 2... In astrophysics, the boundary conditions for plasma phenomena are provided by nature and the astronomer faces the problem of understanding them from a variety of observations [Hester J J et al 1996 Astrophys. J. 456 225], on the other hand, in laboratory plasma experiments the electromagnetic boundary conditions become a major problem in the set-up of the machine that produces the plasma, an issue that has to be investigated step by step and to be modified and adapted with great patience, in particular in the case of an innovative plasma confinement experiment. The PROTO-SPHERA machine [Alladio F et al 2006 Nucl. Fusion 46 S613] is a magnetic confinement experiment, that emulates in the laboratory the jet + torus plasma configurations often observed in astrophysics: an inner magnetized jet of plasma centered on the(approximate) axis of symmetry and surrounded by a magnetized plasma torus orthogonal to this jet. The PROTO-SPHERA plasma is simply connected, i.e., no metal current conducting rod is linked to the plasma torus, while instead it is the inner magnetized plasma jet(in the following always called the plasma centerpost) that is linked to the torus. It is mandatory that no spurious plasma current path modifies the optimal shape of the plasma centerpost. Moreover, as the plasma torus is produced and sustained, in absence of any applied inductive electric field, by the inner plasma centerpost through magnetic reconnections [Taylor J B and Turner M F 1989 Nucl.Fusion 29 219], it is required as well that spurious current paths do not surround the torus on its outboard, in order not to lower the efficiency of the magnetic reconnections that maintain the plasma torus at the expense of the plasma centerpost. Boundary conditions have been corrected,up to the point that the first sustainment in steady state has been achieved for the combined plasma. 展开更多
关键词 laboratory plasmas magnetic confinement astrophysical plasmas
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Experimental confirmation of the linear relation between plasma current and external vertical magnetic field in EXL-50 spherical torus energetic electron plasmas
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作者 董力立 王明远 +9 位作者 刘文军 石跃江 董家齐 郭栋 孙恬恬 顾翔 宋显明 袁保山 彭元凯 the ENN Team 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第8期32-36,共5页
A three-fluid equilibrium plasma with bulk plasma and energetic electrons has been observed on the Xuanlong-50(EXL-50) spherical torus, where the energetic electrons play a crucial role in sustaining the plasma curren... A three-fluid equilibrium plasma with bulk plasma and energetic electrons has been observed on the Xuanlong-50(EXL-50) spherical torus, where the energetic electrons play a crucial role in sustaining the plasma current and pressure. In this study, the equilibrium of a multi-fluid plasma was investigated by analyzing the relationship between the external vertical magnetic field(B_(V)),plasma current(I_(p)), the poloidal ratio(β_(p)) and the Shafranov formula. Remarkably, our research demonstrates some validity of the Shafranov formula in the presence of multi-fluid plasma in EXL-50 spherical torus. This finding holds significant importance for future reactors as it allows for differentiation between alpha particles and background plasma. The study of multi-fluid plasma provides a significant reference value for the equilibrium reconstruction of burning plasma involving alpha particles. 展开更多
关键词 plasma equilibrium Shafranov formula multi-fluid plasma
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Effect of matrix thermal properties on laser-induced plasma
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作者 Yuheng Shan An Li +4 位作者 Xinyu Zhang Wen Yi Ying Zhang Xiaodong Liu Ruibin Liu 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第10期331-336,共6页
The matrix thermal properties have an important impact on laser-induced plasma,as the thermal effect dominates the interaction between ns-pulsed laser and matter,especially in metals.We used a series of pure metals an... The matrix thermal properties have an important impact on laser-induced plasma,as the thermal effect dominates the interaction between ns-pulsed laser and matter,especially in metals.We used a series of pure metals and aluminum alloys to measure plasma temperature and electron density through laser-induced breakdown spectroscopy,in order to investigate the effect of matrix thermal properties on laser-induced plasma.In pure metals,a significant negative linear correlation was observed between the matrix thermal storage coefficient and plasma temperature,while a weak correlation was observed with electron density.The results indicate that metals with low thermal conductivity or specific heat capacity require less laser energy for thermal diffusion or melting and evaporation,resulting in higher ablation rates and higher plasma temperatures.However,considering ionization energy,thermal effects may be a secondary factor affecting electron density.The experiment of aluminum alloy further confirms the influence of thermal conductivity on plasma temperature and its mechanism explanation. 展开更多
关键词 laser-induced plasma thermal properties matrix effect thermal storage coefficient plasma temperature
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Customized modulation on plasma uniformity by non-uniform magnetic field in capacitively coupled plasma
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作者 王森 张权治 +2 位作者 马方方 Maksudbek YUSUPOV 王友年 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第6期79-87,共9页
A two-dimensional fluid model based on COMSOL Multiphysics is developed to investigate the modulation of static magnetic field on plasma homogeneity in a capacitively coupled plasma(CCP)chamber. To generate a static m... A two-dimensional fluid model based on COMSOL Multiphysics is developed to investigate the modulation of static magnetic field on plasma homogeneity in a capacitively coupled plasma(CCP)chamber. To generate a static magnetic field, direct current is applied to a circular coil located at the top of the chamber. By adjusting the magnetic field's configuration, which is done by altering the coil current and position, both the plasma uniformity and density can be significantly modulated. In the absence of the magnetic field, the plasma density exhibits an inhomogeneous distribution characterized by higher values at the plasma edge and lower values at the center. The introduction of a magnetic field generated by coils results in a significant increase in electron density near the coils. Furthermore, an increase in the sets of coils improves the uniformity of the plasma. By flexibly adjusting the positions of the coils and the applied current,a substantial enhancement in overall uniformity can be achieved. These findings demonstrate the feasibility of using this method for achieving uniform plasma densities in industrial applications. 展开更多
关键词 COMSOL capacitively coupled plasma plasma uniformity magnetic field
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