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Incidence of exclusive extrapelvic skeletal metastasis in prostate carcinoma on bone scintigraphy
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作者 Parneet Singh Kanhaiyalal Agrawal +3 位作者 Ashique Rahman Tejasvini Singhal Girish Kumar Parida Gopinath Gnanasegaran 《World Journal of Radiology》 2024年第7期265-273,共9页
BACKGROUND Bone is one of the common sites of metastasis from prostate carcinoma.Bone scintigraphy(BS)is one of the most sensitive imaging modalities currently used for bone metastatic work-up.Skeletal metastasis in p... BACKGROUND Bone is one of the common sites of metastasis from prostate carcinoma.Bone scintigraphy(BS)is one of the most sensitive imaging modalities currently used for bone metastatic work-up.Skeletal metastasis in prostate carcinoma commonly involves pelvic bones but rarely involves extrapelvic-extraspinal sites.AIM To retrospectively analyze the BS data to determine the pattern of skeletal metastases in the prostate carcinoma.METHODS This retrospective observational study involves patients with biopsy-proven prostate carcinoma referred for BS for staging assessment.Patients with abnormal BS were evaluated for the pattern of skeletal involvement and data were pre-sented in descriptive format in the form of percentages.RESULTS A total of 150 patients with biopsy-proven prostate cancer who were referred for staging were included in the study.Thirteen of 150 patients(8.67%)had no abnormal uptake on planar images,ruling out metastatic disease.Twenty-four patients(16%)had heterogeneous uptake in the spine with distribution charac-teristic of degenerative disease and no scan pattern of metastatic disease.Thirty patients(20%)had multifocal uptake involving both pelvic and extra pelvic bones on planar images typical for skeletal metastasis and were considered metastatic.Eighty-three out of 150 patients(55.3%)had increased tracer uptake,which was indeterminate,thus,single photon emission computed tomography-computed tomography(SPECT-CT)was acquired,which showed 51 with metastatic disease,31 benign lesions,and one indeterminate finding.Seven of 150 patients had exclusive pelvic bone uptake,which was found to be metastatic in 4/7 patients in SPECT-CT.Fifty six out of 150 patients showed exclusive extrapelvic tracer uptake,of which only 3 had vertebral metastatic disease.None of the patients with increased uptake exclusively in the extrapelvic-extraspinal location was metastatic.CONCLUSION The incidence of exclusive extrapelvic skeletal metastatic disease in prostate carcinoma is 2%(excluding one patient with indeterminate findings).Further,none of the patients in the current study had exclusive extrapelvic-extraspinal metastasis.Thus,exclusive extrapelvic-extraspinal focal abnormality on planar BS carries a very low probability of metastatic disease and hence,further imaging or SPECT-CT can be safely avoided in such cases. 展开更多
关键词 pelvic Prostate cancer bone scan Single photon emission computed tomography-computed tomography Skeletal metastasis
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SOLITARY PLASMACYTOMA OF BONE AND EXTRAMEDULLARY PLASMACYTOMA
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作者 杨迪生 范顺武 +5 位作者 陶惠民 何荣新 叶招明 周方 詹文龙 黄宗坚 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1996年第4期276-279,共4页
Among plasma cell disorders, solitary plasmacytoma (solitany-plasmacytoma of bone, SPB and extramedullary plasmacytoma, EMP) is rare as compared with mulitiple myeloma (MM). Furthermore.the relationship between solita... Among plasma cell disorders, solitary plasmacytoma (solitany-plasmacytoma of bone, SPB and extramedullary plasmacytoma, EMP) is rare as compared with mulitiple myeloma (MM). Furthermore.the relationship between solitary plasmacytoma and MM remains unclear.Between 1960 and 1994, 24 patients with SPB and 20 with EMP were treated. The criteria for diagonosis were: (1) No evidence of other lesions based on clinical and radiologic examinations;(2) Biopsy evidence of a plasma cell neoplasm; (3) Bone marrow biopsy specimen with negative findings (less than 10% plasma cell); (4) No anemia, hypercalcemia or renal involvement. The average follow-up period was 112 months (from 6 to 360 months). Fifty-four percent of patients with SPB and 40% of patients with EMP developed MM, however, there was no significant statistical difference between SPB and EMP (P <0.05).We suggested that solitary plasmacytomas be classified as two types, latent and aggressive. The former was histologically well-differentiated plasmacytomas. The latter was poorly differentiated tumors which easily progress to MM. The treatment of choice is wide excision or thorough curettage, by cryogenic necrosis with liquid nitrogen or cautery of the bony wall with phenol and the cavity filled with bone grafts or cement. All patients with apparently isolated plasmacytoma should he given if the tumor turns out to be poorly differentiated, in order to delay their progression to MM. 展开更多
关键词 bone neoplasms plasmacytoma Multiple myeloma
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Adamantinoma of the pelvic bone, a difficult diagnosis with fatal outcome
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作者 Binesh F Abrisham J +3 位作者 Sobhan M Navabii H Vahidfar M R Ashrafi K 《The Chinese-German Journal of Clinical Oncology》 CAS 2012年第7期425-428,共4页
Adamantinoma is a primary low grade malignant bone tumor that is predominantly located in the mid-portion of the tibia. The tumor is of interest for two reasons: first, there still exists considerable dispute as to t... Adamantinoma is a primary low grade malignant bone tumor that is predominantly located in the mid-portion of the tibia. The tumor is of interest for two reasons: first, there still exists considerable dispute as to the origin of the lesion and recent reports reveal that the condition is more malignant than had previously been supposed. Although cases of adamanti- noma located to the axial skeleton have been reported, this is the first case of adamantinoma located to pelvic bone in Iran. Here we present the clinical, radiological & histopathological features of a 19 year-old male with painful lesion located to the right pelvic bone which was morphologically and immunohistochemically diagnosed as adamantinoma. In general, metastasis is seen in 15%-20% of patients. The spread can occur to regional nodes, lung and infrequently to skeleton, liver and brain . Several weeks after surgery, our patient's condition gradually worsened. A CT-scan of abdomen revealed widespread liver metastasis and the patient died due to acute liver failure. This case demonstrates that the mortality rate from adamantinoma is not always low. 展开更多
关键词 ADAMANTINOMA pelvic bone DIAGNOSIS
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Solitary bone plasmacytoma of the upper cervical spine: A case report
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作者 Ren-Jie Li Xue-Feng Li Wei-Min Jiang 《World Journal of Clinical Cases》 SCIE 2021年第10期2380-2385,共6页
BACKGROUND Solitary bone plasmacytoma(SBP)of the upper cervical spine is a rare diagnosis.The exact role of surgery for SBP remains unclear.CASE SUMMARY We present the first case of SBP of the C2.A 69-year-old Chinese... BACKGROUND Solitary bone plasmacytoma(SBP)of the upper cervical spine is a rare diagnosis.The exact role of surgery for SBP remains unclear.CASE SUMMARY We present the first case of SBP of the C2.A 69-year-old Chinese woman presented with severe neck pain and limitation of rotative activity for 2 mo.She underwent anterior one-stage debridement combined with cement augmentation in the C2 to reconstruct stability of the spine.The patient did not receive postoperative radiotherapy.She now remains disease free with no neck pain or neurological deficit after follow-up of 3 years.CONCLUSION Anterior one-stage debridement combined with cement augmentation of the upper cervical spine may be an alternative treatment for SBP. 展开更多
关键词 Solitary bone plasmacytoma Multiple myeloma Cervical spine Surgical treatment Mini-invasive surgery Case report
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Therapy-related acute promyelocytic leukemia with FMS-like tyrosine kinase 3-internal tandem duplication mutation in solitary bone plasmacytoma: A case report
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作者 Li-Li Hong Xian-Fu Sheng Hai-Feng Zhuang 《World Journal of Clinical Cases》 SCIE 2020年第19期4579-4587,共9页
BACKGROUND Therapy-related acute promyelocytic leukemia(t-APL)is a rare complication observed in solitary bone plasmacytoma(SBP),and SBP after radiotherapy evolving to APL harboring the FMS-like tyrosine kinase 3-inte... BACKGROUND Therapy-related acute promyelocytic leukemia(t-APL)is a rare complication observed in solitary bone plasmacytoma(SBP),and SBP after radiotherapy evolving to APL harboring the FMS-like tyrosine kinase 3-internal tandem duplication(FLT3-ITD)mutation has never been reported.Here,we present the first case reported until now.CASE SUMMARY We describe a 64-year-old woman who presented with lumbar pain and was initially diagnosed with SBP.However,after one year of radiotherapy treatment,this patient experienced a long-standing bone-marrow-suppressive period and finally developed APL harboring the FLT3-ITD mutation,as confirmed by analyses of clinical features,bone marrow morphology,flow cytometry,cytogenetic examination,and molecular biology.On admission,the patient had disseminated intravascular coagulation and intracranial hemorrhage,and the peripheral blood and bone marrow smear displayed abundant abnormal promyelocytes.Unfortunately,she died when the definite diagnosis was made.CONCLUSION The patient with t-APL harboring FLT3-ITD mutation evolving from SBP after radiotherapy had not been reported and had poor clinical outcomes.FLT3-ITD mutation in t-APL may be a potential pathogenesis of leukemogenesis.We should consider the potential risk of secondary neoplasms in SBP patients after radiotherapy. 展开更多
关键词 Solitary bone plasmacytoma Therapy-related acute promyelocytic Leukemia FMS-like tyrosine kinase 3-internal tandem duplication mutation Radiotherapy Cytopenia Disseminated intravascular coagulation Case report
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Sexual Dimorphism in Pelvic Bone Shape of the North Pacific Common Minke Whales (Balaenoptera acutorostrata)
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作者 Naoko Miyakawa Toshiya Kishiro +2 位作者 Yoshihiro Fujise Gen Nakamura Hidehiro Kato 《Open Journal of Animal Sciences》 2016年第2期131-136,共6页
Little is known about the morphology of the pelvic girdle of modern cetaceans, although many species have a vestigial pelvis (pelvic bone) and part of the hind limb bones inside the body. Previous studies have focused... Little is known about the morphology of the pelvic girdle of modern cetaceans, although many species have a vestigial pelvis (pelvic bone) and part of the hind limb bones inside the body. Previous studies have focused almost exclusively on hard tissues as well, despite the fact that the bones are comprised of cartilaginous tissue, especially in the case of femur. In the present study, we characterized the pelvic bones and searched for vestigial femurs among 43 North Pacific common minke whales (Balaenoptera acutorostrata), all of which were sexually mature individuals. The shape of the pelvic bones clearly differs depending on sex. Specifically, the pelvic bones of females were flat, but those of adult males consist of two types: one with a twisted caudal portion (Twisted type) and the other with a thickened caudal portion (Hypertrophied type). Those pelvic bone features in male are found only among North Pacific common minke whales. 98% of the individuals in this study had vestigial femur. The presence rate of vestigial femur may differ by subspecies. The shape of the pelvic and hind limb bones of modern cetaceans may vary between species and probably by region, at least at the Ocean basin scale. 展开更多
关键词 pelvic bone FEMUR CARTILAGE Common Minke Whale Sexual Dimorphism
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弯角椎体成形术与单侧椎体成形术治疗老年脊柱压缩骨折疗效比较
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作者 范小波 赵晨阳 +3 位作者 赵松涛 安彪 刘晖 刘睿鑫 《新乡医学院学报》 CAS 2024年第10期941-945,共5页
目的比较弯角椎体成形术与单侧椎体成形术治疗老年脊柱压缩骨折的疗效。方法选择2018年1月至2021年1月邯郸市第一医院骨科收治的122例老年脊柱压缩骨折患者为研究对象,按照手术方法将患者分为对照组和观察组,每组61例。对照组患者采用... 目的比较弯角椎体成形术与单侧椎体成形术治疗老年脊柱压缩骨折的疗效。方法选择2018年1月至2021年1月邯郸市第一医院骨科收治的122例老年脊柱压缩骨折患者为研究对象,按照手术方法将患者分为对照组和观察组,每组61例。对照组患者采用单侧椎体成形术,观察组患者采用弯角椎体成形术。比较2组患者手术时间、术中出血量和骨水泥注射量、骨水泥分布、骨水泥漏出情况、脊柱-骨盆参数、视觉模拟评分(VAS)、Barthel指数评分以及并发症发生情况。结果2组患者手术时间、术中出血量和骨水泥注射量比较差异无统计学意义(P>0.05)。2组患者Ⅰ级、Ⅱ级、Ⅲ级、Ⅳ级骨水泥分布占比比较差异无统计学意义(P>0.05);观察组患者Ⅰ级和Ⅱ级骨水泥分布总占比显著高于对照组(P<0.05)。观察组骨水泥漏出发生率显著低于对照组(P<0.05)。术前,2组患者矢状面平衡、胸椎后凸角、骨盆倾斜角、腰椎前凸角、骶骨倾斜角比较差异无统计学意义(P>0.05)。术后2组患者矢状面平衡、胸椎后凸角、骨盆倾斜角显著低于术前,且观察组患者矢状面平衡、胸椎后凸角、骨盆倾斜角显著低于对照组(P<0.05);2组患者腰椎前凸角、骶骨倾斜角显著高于术前,且观察组患者腰椎前凸角、骶骨倾斜角显著高于对照组(P<0.05)。术前,2组患者VAS评分、Barthel指数比较差异无统计学意义(P>0.05)。术后3个月,2组患者VAS评分显著低于术前,Barthel指数显著高于术前(P<0.05);观察组患者Barthel指数显著高于对照组(P<0.05),2组患者VAS评分比较差异无统计学意义(P>0.05)。治疗期间,观察组患者有1例发生椎管外血肿,并发症发生率为1.64%(1/61);对照组患者有2例发生椎管外血肿,1例发生切口感染,并发症发生率为4.92%(3/61)。2组患者的并发症发生率比较差异无统计学意义(χ^(2)=1.034,P=0.309)。结论与单侧椎体成形术比较,弯角椎体成形术用于治疗老年脊柱压缩骨折患者骨水泥分布效果较好,能够显著改善患者脊柱平衡状态,提高术后生活质量。 展开更多
关键词 脊柱 压缩骨折 弯角椎体成形术 单侧椎体成形术 脊柱-骨盆参数 骨水泥
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抗生素骨水泥被覆重建钢板治疗感染性骨盆前环骨折 被引量:1
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作者 厉孟 王克竞 +2 位作者 高振洋 谢云飞 郭涛 《中国骨伤》 CAS CSCD 2024年第5期451-457,共7页
目的:探讨抗生素骨水泥被覆重建钢板治疗感染性骨盆前环骨折的临床疗效。方法:自2017年1月至2022年3月应用抗生素骨水泥被覆重建钢板治疗感染性骨盆前环骨折患者11例,男7例,女4例;年龄27~49岁;骨盆骨折Tile分型:C1型4例,C2型4例,C3型3例... 目的:探讨抗生素骨水泥被覆重建钢板治疗感染性骨盆前环骨折的临床疗效。方法:自2017年1月至2022年3月应用抗生素骨水泥被覆重建钢板治疗感染性骨盆前环骨折患者11例,男7例,女4例;年龄27~49岁;骨盆骨折Tile分型:C1型4例,C2型4例,C3型3例。2例前环内固定术后感染,9例患者均因早期清创不彻底导致前环感染,按创伤严重度评分标准(injury severity score,ISS)评分为24~38分。前环经扩大清创、冲洗、抗生素骨水泥被覆重建钢板内固定,后环骨折均采用闭合复位,骶髂螺钉内固定。结果:11例均获得随访,时间13~20个月。2例术后感染复发,1例经再次清创更换抗生素骨水泥涂层内固定,1例感染较轻,未累计髓腔,清创后保留钢板仅更换抗生素骨水泥,感染得到控制。2例出现切口渗液,术后3个月取出内固定后愈合。所有患者在随访期内未见骨盆骨折再移位、再发感染。最终11例均骨性愈合。末次随访,按照Matta骨折复位标准,优6例,良4例,可1例;按照Majeed功能评分,优6例,良3例,可2例。结论:抗生素骨水泥被覆重建钢板有效治疗感染性骨盆前环骨折,具有术中安全性高和感染复发率低的特点,有利于术后早期康复锻炼,明显缩短病程。 展开更多
关键词 骨盆骨折 内固定 感染 抗生素骨水泥
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骨转移瘤治疗中骨盆假体的生物力学数值分析
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作者 何宜谦 钱程 +2 位作者 邱恩铎 于申 王玉名 《计算机辅助工程》 2024年第2期10-16,共7页
为研究骨盆骨肿瘤手术后骨盆假体的强度和稳定性,针对具体病例建立骨盆-假体结构系统的有限元模型,分别进行静力和动力问题计算。静力工况为双腿和单腿站立状态,动力工况为骨盆不同方向、不同高度跌落以及不同固定方式的跌落过程,通过... 为研究骨盆骨肿瘤手术后骨盆假体的强度和稳定性,针对具体病例建立骨盆-假体结构系统的有限元模型,分别进行静力和动力问题计算。静力工况为双腿和单腿站立状态,动力工况为骨盆不同方向、不同高度跌落以及不同固定方式的跌落过程,通过数值模型分析骨盆-假体结构系统不同工况的受力和变形。计算结果显示:在3种站立姿态下,结构最大应力均小于骨骼假体材料的强度极限,患侧的应力更大;骨盆从5 m高处跌落造成的最大应力可能超过骨骼和假体材料的屈服强度;螺钉固定方式对应力分布影响也较大。 展开更多
关键词 骨肿瘤 骨盆-假体结构 固定方式 生物力学 动力学 站立模拟 跌落模拟 有限元
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腰椎椎体骨强度综合指数预测骨质疏松性椎体的压缩骨折
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作者 张文胜 宋振杰 +4 位作者 吴春飞 李文超 刘洪江 杨晓光 原超 《中国组织工程研究》 CAS 北大核心 2024年第18期2871-2875,共5页
背景:骨质疏松性椎体压缩骨折是继发于骨质疏松症的常见骨折,目前尚缺乏有效的骨质疏松性椎体压缩骨折预测指标及方法。目的:探讨腰椎椎体骨强度综合指数对骨质疏松性椎体压缩骨折的预测作用。方法:纳入骨质疏松患者233例,根据是否发生... 背景:骨质疏松性椎体压缩骨折是继发于骨质疏松症的常见骨折,目前尚缺乏有效的骨质疏松性椎体压缩骨折预测指标及方法。目的:探讨腰椎椎体骨强度综合指数对骨质疏松性椎体压缩骨折的预测作用。方法:纳入骨质疏松患者233例,根据是否发生椎体骨折分为骨折组和非骨折组。收集患者人口统计学、体质量指数、椎体骨密度等详细信息,拍摄腰椎X射线侧位片,测量并计算椎体宽度、椎体长度、骶骨倾斜角、骨盆倾斜角、骨盆入射角、腰椎抗压强度指数及腰椎抗冲击强度指数,对以上参数进行单因素及多因素分析,并进行受试者操作特征曲线(ROC)分析,根据截断值进行生存分析。结果与结论:①所有患者皆获得随访,随访时间2-4年,平均3.1年。随访期间,99例(L1椎体38例,L2椎体61例)患者发生骨折(骨折组),134例(L1椎体52例,L2椎体82例)患者未发生骨折(非骨折组);单因素分析显示两组年龄、性别、身高、体质量、体质量指数、骨折节段比较均无统计学意义(P>0.05)。②骨折组腰椎抗压强度指数、腰椎抗冲击强度指数均低于非骨折组(P<0.05)。骨折组骨盆入射角、骨盆倾斜角大于非骨折组(P<0.05)。③多因素分析显示,腰椎抗压强度指数、腰椎抗冲击强度指数及骨盆倾斜角是患者发生骨质疏松性椎体压缩骨折的危险因素(P<0.05)。④ROC曲线分析显示椎体骨密度、腰椎抗压强度指数、腰椎抗冲击强度指数、骨盆倾斜角和骨盆入射角的截断值分别为0.9135 g/cm2,1.932,0.903,21.5°,55°;曲线下面积(AUC)分别为0.630,0.800,0.911,0.633,0.568。⑤根据生存分析(以骨质疏松性椎体压缩骨折为终点),腰椎抗冲击强度指数≥0.903椎体平均生存时间显著大于腰椎抗冲击强度指数<0.903者(P<0.05)。⑥结果说明,腰椎椎体骨强度综合指数比椎体骨密度和脊柱-骨盆矢状位参数对骨质疏松性椎体压缩骨折预测更加精准,有助于早期防治骨质疏松性椎体压缩骨折。 展开更多
关键词 腰椎椎体骨强度综合指数 骨质疏松 腰椎骨折 预测 骨密度 骨盆倾斜角
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经皮桥接钢板内固定与内置外固定支架治疗骨盆前环骨折的临床效果
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作者 梁海群 史志强 吕新智 《医学临床研究》 CAS 2024年第9期1327-1330,共4页
【目的】探讨经皮桥接钢板内固定与内置外固定支架治疗骨盆前环骨折的临床效果。【方法】选取2020年1月至2022年12月在本院接受手术治疗的72例骨盆前环骨折患者,按照随机数字表法分为内固定组(接受经皮桥接钢板内固定治疗)和外固定组(... 【目的】探讨经皮桥接钢板内固定与内置外固定支架治疗骨盆前环骨折的临床效果。【方法】选取2020年1月至2022年12月在本院接受手术治疗的72例骨盆前环骨折患者,按照随机数字表法分为内固定组(接受经皮桥接钢板内固定治疗)和外固定组(行内置外固定支架治疗),每组36例。比较两组手术相关指标、术后并发症发生率、骨折愈合时间、术后完全负重时间、骨折复位优良率、功能恢复状态及手术前后骨保护素(OPG)、骨钙素(BGP)水平。【结果】内固定组手术时间长于外固定组(P<0.05),术中出血量多于外固定组(P<0.05)。两组术中透视次数比较,差异无统计学意义(P>0.05)。内固定组骨折复位优良率高于外固定组(P<0.05),骨折愈合时间及术后完全负重时间均短于外固定组(P<0.05)。两组患者术后站、坐、工作、性功能、疼痛评分及总分比较,差异无统计学意义(P>0.05)。术后,两组OPG、BGP水平高于术前(P<0.05),但两组OPG、BGP水平比较,差异无统计学意义(P>0.05)。外固定组术后并发症发生率高于内固定组(P<0.05)。【结论】经皮桥接钢板内固定与内置外固定支架治疗骨盆前环骨折,均可促进患者术后肢体功能的恢复,但内置外固定支架术的手术时间更短、出血量更少,而经皮桥接钢板内固定术后骨折复位效果更优、愈合时间更短。 展开更多
关键词 骨盆骨/损伤 骨折/外科学 骨折固定术 治疗结果
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特发性中枢性性早熟与盆腔超声检查及骨龄情况分析
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作者 李丽莹 王岩 +2 位作者 周芸 干烨 冯伟 《医学影像学杂志》 2024年第9期88-91,共4页
目的探讨盆腔超声检查及骨龄指数(BAI)对特发性中枢性性早熟(ICPP)女童的诊断价值。方法选择我院收治的80例性早熟女童,根据Gn RH激发试验结果,将其分为ICPP组62例和单纯乳房早发育(PT组)18例,对两组行盆腔超声检查、BAI测定,并测定两... 目的探讨盆腔超声检查及骨龄指数(BAI)对特发性中枢性性早熟(ICPP)女童的诊断价值。方法选择我院收治的80例性早熟女童,根据Gn RH激发试验结果,将其分为ICPP组62例和单纯乳房早发育(PT组)18例,对两组行盆腔超声检查、BAI测定,并测定两组血清性激素雌二醇(E2)、卵泡雌激素(FSH)、黄体生成素(LH)水平,以Gn RH激发试验结果作为金标准,分析盆腔超声检查联合血清性激素以及联合BAI测定对ICPP的诊断效能,采用Kappa检验分析与金标准诊断结果的一致性。结果ICPP组患儿的子宫体积和长径、卵巢体积和长径以及最大卵泡直径均大于PT组,差异具有统计学意义(P<0.05);ICPP组BAI为0.25±0.06,PT组为0.08±0.02,差异具有统计学意义(t=11.785,P<0.05);ICPP组E2、FSH、LH水平以及LH/FSH均高于PT组,差异具有统计学意义(P<0.05);盆腔超声检查联合BAI诊断、盆腔超声检查联合激素诊断ICPP诊断效能差异无统计学意义(P>0.05),但二者均具有良好一致性。结论ICPP患儿盆腔超声检查指标及骨龄指数有明显改变,临床可将盆腔超声检查与骨龄指数作为诊断ICPP的重要依据,具有较高的应用价值。 展开更多
关键词 特发性中枢性性早熟 盆腔超声检查 骨龄指数 诊断效能 性激素
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微创经皮钢板内固定术与皮下内固定支架术治疗骨盆前环骨折患者的效果比较
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作者 王再军 王兴焱 陈州 《中国民康医学》 2024年第15期156-158,162,共4页
目的:比较微创经皮钢板内固定术与皮下内固定支架术治疗骨盆前环骨折患者的效果。方法:回顾性分析2020年6月至2022年6月该院收治的106例骨盆前环骨折患者的临床资料,根据术式不同将其分为观察组(n=53)、对照组(n=53)。对照组采用皮下内... 目的:比较微创经皮钢板内固定术与皮下内固定支架术治疗骨盆前环骨折患者的效果。方法:回顾性分析2020年6月至2022年6月该院收治的106例骨盆前环骨折患者的临床资料,根据术式不同将其分为观察组(n=53)、对照组(n=53)。对照组采用皮下内固定支架术治疗,观察组采用微创经皮钢板内固定术治疗,比较两组手术相关指标(住院时间、手术时间、骨折愈合时间、术中出血量)水平、血清骨转化状态指标[骨特异性碱性磷酸酶(BAP)、骨钙素(OCN)、总I型胶原氨基端延长肽(T-P1NP)]水平、骨盆垂直移位距离和并发症发生率。结果:观察组住院时间、手术时间、骨折愈合时间均短于对照组,术中出血量少于对照组,差异均有统计学意义(P<0.05);术后2周,两组血清BAP、OCN水平高于术前,且观察组高于对照组,两组血清T-P1NP水平低于术前,且观察组低于对照组,差异均有统计学意义(P<0.05);术后6个月,两组骨盆垂直移位距离均短于术前,且观察组短于对照组,差异有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:微创经皮钢板内固定术治疗骨盆前环骨折患者可改善骨转化状态指标水平,降低手术相关指标水平,缩短骨盆垂直移位距离,效果优于皮下内固定支架术治疗。 展开更多
关键词 骨盆前环骨折 微创经皮钢板内固定术 皮下内固定支架术 骨转化 骨盆垂直移位 并发症
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老年OVCF患者PKP术后脊柱骨盆矢状面参数和骨密度与继发骨折的关系研究
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作者 周庭捷 杨江 +1 位作者 杨军 洪杰 《全科医学临床与教育》 2024年第7期616-619,共4页
目的研究老年骨质疏松性椎体压缩性骨折(OVCF)患者经皮球囊扩张椎体后凸成形术(PKP)术后脊柱骨盆矢状面参数和骨密度与继发骨折的关系。方法回顾性分析200例接受PKP治疗的老年OVCF患者的病历资料,根据患者是否发生继发骨折分为继发组52... 目的研究老年骨质疏松性椎体压缩性骨折(OVCF)患者经皮球囊扩张椎体后凸成形术(PKP)术后脊柱骨盆矢状面参数和骨密度与继发骨折的关系。方法回顾性分析200例接受PKP治疗的老年OVCF患者的病历资料,根据患者是否发生继发骨折分为继发组52例和对照组148例。比较两组患者术后脊柱骨盆矢状面参数水平及骨密度水平,分析老年OVCF患者PKP术后脊柱骨盆矢状面参数和骨密度与继发骨折的关系。结果脊柱骨盆矢状面参数中骨盆入射角(PI)、骶骨倾斜角(SS)、腰椎前凸角(LL)水平以及骨密度水平与老年OVCF患者PKP术后继发骨折呈反比(rs分别=-0.32、-0.36、-0.33、-0.42,P均<0.05),脊柱骨盆矢状面参数中胸椎后凸角(TK)、矢状位轴向距离(SVA)水平与老年OVCF患者PKP术后继发骨折呈正比(rs分别=0.33、0.43,P均<0.05)。logistic回归分析显示,TK、SVA为影响老年OVCF患者PKP术后继发骨折的危险因素,脊柱骨盆矢状面参数PI、SS、LL及骨密度为影响老年OVCF患者PKP术后继发骨折的保护因素(OR分别=1.11、1.41、0.88、0.88、0.92、0.88,P均<0.05)。结论老年OVCF患者PKP术后脊柱骨盆矢状面参数中PI、SS、LL水平越高,TK、SVA水平越低,且患者骨密度越高,患者出现继发骨折的风险越低。 展开更多
关键词 骨质疏松性椎体压缩性骨折 老年 脊柱骨盆矢状面 骨密度 继发骨折
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龟鹿二仙胶在创伤性脊柱骨盆分离术后的应用效果分析
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作者 黄超 江加义 +2 位作者 李德福 张安定 吕维东 《中国烧伤创疡杂志》 2024年第2期134-138,共5页
目的探讨分析龟鹿二仙胶在创伤性脊柱骨盆分离术后的应用效果。方法选取2019年1月至2021年11月信阳一五四医院收治的70例创伤性脊柱骨盆分离患者作为研究对象,按照不同治疗方法将其分为研究组(35例)和对照组(35例),对照组患者经皮骶髂... 目的探讨分析龟鹿二仙胶在创伤性脊柱骨盆分离术后的应用效果。方法选取2019年1月至2021年11月信阳一五四医院收治的70例创伤性脊柱骨盆分离患者作为研究对象,按照不同治疗方法将其分为研究组(35例)和对照组(35例),对照组患者经皮骶髂螺钉内固定术后行抗感染、营养支持、预防下肢深静脉血栓形成等常规治疗,研究组患者经皮骶髂螺钉内固定术后在常规治疗的基础上联合应用龟鹿二仙胶治疗,对比观察两组患者骨盆功能、临床疗效、骨代谢指标水平以及不良事件发生情况。结果治疗6个月后,研究组患者Majeed评分中疼痛、工作、坐、站评分均明显高于对照组(t=2.633、3.089、4.408、2.594,P=0.011、P=0.003、P<0.001、P=0.012);研究组患者治疗总有效率为94.29%,明显高于对照组患者的治疗总有效率77.14%(χ^(2)=4.200,P=0.040);研究组患者血清骨钙素(OCN)、骨保护素(OPG)、Ⅰ型前胶原氨基端前肽(PⅠNP)、碱性磷酸酶(ALP)水平均明显高于对照组(t=4.059、2.762、7.346、2.955,P<0.001、P=0.007、P<0.001、P=0.004);研究组患者不良事件发生率为11.43%,与对照组患者的不良事件发生率20.00%无明显差异(χ^(2)=0.971,P=0.324)。结论创伤性脊柱骨盆分离术后采用龟鹿二仙胶治疗,能够明显改善患者骨代谢水平,促进骨盆功能恢复,效果显著。 展开更多
关键词 创伤性脊柱骨盆分离 经皮骶髂螺钉内固定 龟鹿二仙胶 Majeed评分 骨盆功能 骨代谢
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Non-secretory multiple myeloma expressed as multiple extramedullary plasmacytoma with an endobronchial lesion mimicking metastatic cancer:A case report 被引量:2
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作者 Seul Bi Lee Chi Young Park +3 位作者 Hee Jeong Lee Ran Hong Woo Shin Kim Sang-Gon Park 《World Journal of Clinical Cases》 SCIE 2022年第22期7899-7905,共7页
BACKGROUND Non-secretory multiple myeloma(MM)is a rare condition that accounts for only 3%of MM cases and is defined by normal serum and urine immunofixation and a normal serum free light chain ratio.Non-secretory MM ... BACKGROUND Non-secretory multiple myeloma(MM)is a rare condition that accounts for only 3%of MM cases and is defined by normal serum and urine immunofixation and a normal serum free light chain ratio.Non-secretory MM with multiple extramedullary plasmacytomas derived from endobronchial lesions is extremely rare and can be misdiagnosed as metastasis of solid cancer.CASE SUMMARY A 36-year-old man presented with progressive facial swelling and nasal congestion with cough.Various imaging studies revealed an endobronchial mass in the left bronchus and a large left maxillary mass with multiple destructive bone metastatic lesions.He initially presented with lung cancer and multiple metastases.However,pathologic reports showed multiple extramedullary plasmacytomas in the left maxilla and the left bronchus.There was no change in the serum and urine monoclonal protein levels,and no abnormalities were observed in laboratory examinations,including hemoglobin,calcium,and creatinine levels.The bone marrow was hypercellular,with 13.49%plasma cells.The patient was diagnosed with non-secretory MM expressed as multiple extramedullary plasmacytomas with endobronchial lesions in a rare location.Radiation therapy for symptomatic lesions with high-dose dexamethasone was started,and the size of the left maxillary sinus lesion dramatically decreased.In the future,chemotherapy will be administered to control lesions in other areas.CONCLUSION We present a rare case of non-secretory MM with multiple extramedullary plasmacytoma with an endobronchial lesion. 展开更多
关键词 Maxillary mass lesion Destructive bone metastatic lesion Multiple extramedullary plasmacytoma Endobronchial lesion Non-secretory multiple myeloma Case report
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Gastric cancer presenting with solitary gigantic pelvic metastasis
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作者 Qi Zheng Kejun Nan Yu Yao 《The Journal of Biomedical Research》 CAS 2012年第4期303-306,共4页
Bone metastasis of gastric cancer is relatively uncommon in clinical practice.Moreover,it is all the more unusual for the primary presentation of gastric malignancy to be bone metastasis.Here,we describe a male patien... Bone metastasis of gastric cancer is relatively uncommon in clinical practice.Moreover,it is all the more unusual for the primary presentation of gastric malignancy to be bone metastasis.Here,we describe a male patient who complained of pain and edema in his right lower extremity.Further assessment by computed tomography and positron emission tomography revealed an abnormally thickened gastric cardia and a giant neoplasm in the right pelvis with bone damage.Consequently,the finding of adenocarcinoma cells in pelvic and cardia biopsy specimens contributed to the diagnosis of pelvic metastasis from gastric cancer.This case report illustrates that stomach cancer has the potential,although far less than breast,prostate and lung cancers,to metastasize to bone.In addition,it highlights the peculiarity of this bone metastasis which is pelvic,solitary and huge. 展开更多
关键词 gastric cancer bone metastasis pelvic
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Solitary hyoid plasmacytoma with unicentric Castleman disease:A case report and review of literature
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作者 Yan-Hui Zhang Yi-Feng He +4 位作者 Hao Yue Yue-Ni Zhang Lei Shi Bin Jin Pin Dong 《World Journal of Clinical Cases》 SCIE 2022年第36期13364-13372,共9页
BACKGROUND Solitary plasmacytoma and unicentric Castleman disease(UCD)are rare lymphoproliferative disorders characterized by monoclonal plasma cells and a single set of locally enlarged lymph nodes,respectively.CASE ... BACKGROUND Solitary plasmacytoma and unicentric Castleman disease(UCD)are rare lymphoproliferative disorders characterized by monoclonal plasma cells and a single set of locally enlarged lymph nodes,respectively.CASE SUMMARY A 48-year-old Han Chinese man presented to our department with a neck mass and progressive foreign body sensation in his throat.18F-FDG positron emission tomography revealed focally increased radioactivity centered around the hyoid,and computed tomography(CT)revealed osteolytic lesions.Histopathology revealed Castleman-like features and CD138/CD38-positive mature plasma cells.Systemic work-up ruled out the possibility of POEMS syndrome,lymphoma,and multiple myeloma,leading to a final diagnosis of solitary hyoid plasmacytoma with UCD.The patient underwent partial hyoid resection and selective neck dissection,followed by intensity-modulated radiotherapy.99mTc-MDP singlephoton emission computed tomography/CT reevaluation showed neither local recurrence nor distant bone metastasis at the 40-mo follow-up.CONCLUSION The diagnostic process and differential diagnosis of this rare case provided valuable educational information to clinicians. 展开更多
关键词 18F-FDG Positron emission tomography/computed tomography plasmacytoma Hyoid bone Castleman disease Case report
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Atraumatic groin pain secondary to an aneurysmal bone cyst:A case report and literature review
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作者 Colum Downey Aisling Daly +1 位作者 Alan P Molloy Brendan J O’Daly 《World Journal of Orthopedics》 2020年第3期197-205,共9页
BACKGROUND Bone lesions can present the multi-displinary team with a challenge by way of diagnosis as some lesions share many radiological and histological characteristics.Giant cell tumours of the bone(GCTB)are relat... BACKGROUND Bone lesions can present the multi-displinary team with a challenge by way of diagnosis as some lesions share many radiological and histological characteristics.Giant cell tumours of the bone(GCTB)are relatively common,benign bone tumours.Aneurysmal bone cysts(ABC)are less common benign osteolytic lesions that are histologically similar to GCTBs but produce blood filled cavities.Both GCTBs and ABCs are locally aggressive and are typically found on meta-epiphyseal regions of long bones with pelvic tumours being less common.CASE SUMMARY A 17-year old female presented with atraumatic right groin pain and was initially diagnosed with a GCTB on the right superior pubic ramus of the pelvis.The patient was treated successfully with a wide excision,curettage and bone graft and underwent open reduction and internal fixation of the right hemi-pelvis.Following further intra-operative histological investigations,the lesion was diagnosed as an ABC.CONCLUSION This patient has had an uncomplicated post-operative course,has returned to comfortable weight bearing and will be reviewed for minimum 5 yr in the outpatient setting to monitor for reoccurrence. 展开更多
关键词 pelvic TUMOUR Aneurysmal bone cyst Giant cell tumour Open reduction internal fixation of pelvis Case report
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长链非编码RNA浆细胞瘤变异性易位基因1参与盆腔器官脱垂的机制
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作者 胡新明 乔艳华 +2 位作者 王肖帆 李林玉 赵冰 《中国组织工程研究》 CAS 北大核心 2023年第5期669-675,共7页
背景:作者所在课题组前期通过高通量测序结果发现长链非编码RNA浆细胞瘤变异性易位基因1在盆腔器官脱垂患者子宫主韧带中表达明显降低,转化生长因子β1信号通路也是相关通路之一。目的:观察长链非编码RNA浆细胞瘤变异性易位基因1对盆底... 背景:作者所在课题组前期通过高通量测序结果发现长链非编码RNA浆细胞瘤变异性易位基因1在盆腔器官脱垂患者子宫主韧带中表达明显降低,转化生长因子β1信号通路也是相关通路之一。目的:观察长链非编码RNA浆细胞瘤变异性易位基因1对盆底韧带成纤维细胞的影响,探讨其在盆腔器官脱垂疾病发病机制中的可能作用。方法:提取大鼠盆底韧带组织标本,分离成纤维细胞,进行原代培养。慢病毒构建长链非编码RNA浆细胞瘤变异性易位基因1干扰和过表达载体加入成纤维细胞中。通过免疫荧光、MTT、细胞划痕实验、流式细胞术来检测成纤维细胞的形态、增殖、迁移和凋亡情况;RT-PCR和Western-blot检测转化生长因子β1、smad2/3、c-Myc的mRNA及蛋白表达情况。结果与结论:①长链非编码RNA浆细胞瘤变异性易位基因1过表达时可显著促进成纤维细胞的增殖,提高细胞的迁移能力,抑制成纤维细胞凋亡;长链非编码RNA浆细胞瘤变异性易位基因1干扰时结果相反;②此外,长链非编码RNA浆细胞瘤变异性易位基因1过表达时细胞中的c-Myc、转化生长因子β1、smad2/3的mRNA和蛋白相对表达量均明显增加,其干扰时则显著抑制c-Myc和转化生长因子β1的表达;③提示长链非编码RNA浆细胞瘤变异性易位基因1能够影响成纤维细胞的形态和生物学功能,可能与转化生长因子β1/smad2/3/c-Myc通路有关;该研究可为盆腔器官脱垂患者的临床诊断和治疗提供新思路。 展开更多
关键词 长链非编码RNA 浆细胞瘤变异性易位基因1 盆腔器官脱垂 成纤维细胞 过表达 干扰
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