BACKGROUND A well-recognized class effect of immune checkpoint inhibitors(ICI)is immune-related adverse events(IrAEs)ranging from low grade toxicities to life-threatening end organ damage requiring permanent discontin...BACKGROUND A well-recognized class effect of immune checkpoint inhibitors(ICI)is immune-related adverse events(IrAEs)ranging from low grade toxicities to life-threatening end organ damage requiring permanent discontinuation of ICI.Deaths are reported in<5%of patients treated with ICI.There are,however,no reliable markers to predict the onset and severity of IrAEs.We tested the association between neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLR)at baseline with development of clinically significant IrAEs(grade≥2)in hepatocellular carcinoma(HCC)patients treated with ICI.AIM To test the association between NLR and PLR at baseline with development of clinically significant IrAEs(grade≥2)in HCC patients treated with ICI.METHODS Data was extracted from an international database from a consortium of 11 tertiary-care referral centers.NLR=absolute neutrophil count/absolute lymphocyte count(ALC)and PLR=platelet count/ALC.Cutoff of 5 was used for NLR and 300 for PLR based on literature.We also tested the association between RESULTS Data was collected from 361 patients treated between 2016-2020 across the United States(67%),Asia(14%)and Europe(19%).Most patients received Nivolumab(n=255,71%).One hundred sixty-seven(46%)patients developed at least one IrAE,highest grade 1 in 80(48%),grade≥2 in 87(52%)patients.In a univariable regression model PLR>300 was significantly associated with a lower incidence of grade≥2 IrAEs(OR=0.40;P=0.044).Similarly,a trend was observed between NLR>5 and lower incidence of grade≥2 IrAEs(OR=0.58;P=0.097).Multivariate analyses confirmed PLR>300 as an independent predictive marker of grade≥2 IrAEs(OR=0.26;P=0.011),in addition to treatment with programmed cell death ligand 1(PD-1)/cytotoxic T lymphocyte-associated protein-4(OR=2.57;P=0.037)and PD-1/tyrosine kinase inhibitor(OR=3.39;P=0.01)combinations.Antibiotic use was not associated with IrAE incidence(OR=1.02;P=0.954).Patients treated with steroids had a>2-fold higher incidence of grade≥2 IrAEs(OR=2.74;P<0.001),although 74%were prescribed steroids for the treatment of IrAEs.CONCLUSION Given that high baseline NLR and PLR are associated with a decreased incidence of IrAEs,lower baseline NLR and PLR may be predictive biomarkers for the appearance of IrAEs in HCC treated with ICI.This finding is in keeping with several studies in solid tumors that have shown that baseline NLR and PLR appear predictive of IrAEs.展开更多
Inflammation has been shown to be a factor in tumorigenesis. The circulating platelet to lymphocyte ratio (PLR) is a representative index of systemic inflammation. In this study, we analyzed the association between pr...Inflammation has been shown to be a factor in tumorigenesis. The circulating platelet to lymphocyte ratio (PLR) is a representative index of systemic inflammation. In this study, we analyzed the association between preoperative PLR levels and clinicopathological variables in two hundred sixty-four Japanese patients with localized breast carcinoma. We also evaluated the prognostic significance of preoperative PLR levels using the Cox proportional hazard model. Seventy-five patients (28.4%) had elevated PLR values, whereas 189 (71.6%) had depressed PLR values. The PLR correlated significantly with venous invasion (P < 0.05). Disease-free survival rates were significantly worse among patients with elevated PLR values than among those with lower PLR value (5-year survival, 81.6% vs. 90.7%, respectively;P < 0.05). In multivariate analysis, elevated PLR, nuclear grade, and lymph node involvement were significant prognostic factors for disease-free survival in patients with breast carcinoma (P < 0.05). Preoperative PLR levels may be an independent prognostic factor in patients with breast carcinoma.展开更多
<strong>Introduction: </strong>Breast cancer had become top leading cause of death in Taiwan and endangered women’s health worldwide. Therefore, we try to invest the peripheral inflammatory cell counts an...<strong>Introduction: </strong>Breast cancer had become top leading cause of death in Taiwan and endangered women’s health worldwide. Therefore, we try to invest the peripheral inflammatory cell counts and neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) from our routine practice for the predictor of prognosis of breast cancer after resection. <strong>Patients and</strong> <strong>Methods: </strong>There were 574 breast cancer patients accepted surgical resection and registered in Cancer Registry Center of our hospital. Patient’s basic profiles, peripheral neutophil, lymphocyte and platelet count were measured for study. The scales of NLR and PLR were derived from the lower and higher normal range in cell count from neutrophil, lymphocyte and platelet respectively. Therefore, the scales for NLR and PLR were ≤1.62, 1.63 - 2.57, ≥2.58 and ≤224, 225 - 253, ≥254 respectively for analysis. <strong>Results: </strong>Poor 5-yr survival rate was found if higher cell counts of neutrophil and platelet (p ≤ 0.05). Three scales of NLR were ≤1.62, 1.63 - 2.57, ≥2.58, and their 5-year survival rates were 94%, 91% and 84% respectively (p = 0.019). In the subgroup of HER-2 (negative), and 3-Negative breast patients had a higher NLR of poor prognosis. But higher PLR was found less in 3-Negative and non in 3-Positive patients (p = 0.039). The PLR was ≤224, 225 - 253, ≥254 and their 5-year survival rates were 92%, 87%, and 64% respectively (p = 0.001);Multivariate Cox regression model for predictor of breast cancer patients who have 3.39 (PLR ≥ 254) and 2.45 (NLR ≥ 2.58 ) times risk (p = 0.02 and p = 0.002) of poor prognosis respectively. <strong>Conclusion: </strong>Peripheral inflammatory cell counts are easily to take in our clinical practice and have a potential role as predictors of prognosis. We have to pay attention to the trends of peripheral inflammatory cell count and their ratio in our clinical practice where possible.展开更多
目的探讨人外周血早期中性粒细胞-淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、血小板-淋巴细胞比值(platelet to lymphocyte ratio,PLR)和中性粒细胞-淋巴细胞和血小板比值(neutrophils to lymphocytes and platelets ratio,N/...目的探讨人外周血早期中性粒细胞-淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、血小板-淋巴细胞比值(platelet to lymphocyte ratio,PLR)和中性粒细胞-淋巴细胞和血小板比值(neutrophils to lymphocytes and platelets ratio,N/LP)在重度创伤性颅脑损伤(severe traumatic brain injury,sTBI)患者早期结果中的预测价值。方法回顾性分析2014年6月-2016年12月中国医科大学第七临床学院神经外科收治的95例sTBI患者的临床资料。比较预后良好组(n=36)和预后不良组(n=59)患者的早期NLR、PLR和N/LP差异,分析影响预后相关危险因素并绘制森林图,采用多因素logsitic回归确定独立危险因素并构建临床预测模型;绘制出受试者工作特征曲线(receiver operating characteristic curve,ROC),分析并比较NLR、PLR和N/LP单独或联合其他指标构建出的不同临床预测模型的差异。结果sTBI预后良好组和预后不良组早期NLR、PLR和N/LP比较,差异均有统计学意义(P<0.05);多因素logsitic回归分析提示,年龄、入院格拉斯哥昏迷评分(Glasgow coma scale,GCS)、NLR、PLR和N/LP是影响sTBI患者早期结果的独立危险因素,差异有统计学意义(P<0.05)。根据多因素logstic回归分析构建出19个临床预后预测模型,其中NLR+PLR+N/LP及其联合指标(年龄和GCS)模型曲线下面积(area under curve,AUC)均高于同组其他模型,分别为0.912、0.935、0.933和0.954;Age+GCS+NLR+PLR+N/LP预测模型在所有组别中AUC最大,表明该模型预测患者预后的价值最高。结论NLR、PLR和N/LP的升高与sTBI不良预后相关;早期NLR、PLR及N/LP联合年龄和GCS评分在sTBI早期结果预测中具有重要价值。展开更多
Objective:To evaluate the prognostic value of platelet-to-lymphocyte ratio(PLR)in upper tract urothelial carcinoma(UTUC)patients treated with radical nephroureterectomy.Methods:This study was pre-registered in PROSPER...Objective:To evaluate the prognostic value of platelet-to-lymphocyte ratio(PLR)in upper tract urothelial carcinoma(UTUC)patients treated with radical nephroureterectomy.Methods:This study was pre-registered in PROSPERO(No.CRD42020186645).Two reviewers independently performed a comprehensive literature search on PubMed,Web of Science,EMBASE,Cochrane Library databases,China Biology Medicine disc(CBM),Wanfang database,and China National Knowledge Infrastructure(CNKI)from inception to May 2021 for prospective or retrospective cohort studies evaluating the prognostic value of PLR.Literature was analyzed with inclusion and exclusion criteria.Data and other useful clinicopathological features were extracted and analyzed with fixed or random-effect models when applicable.Heterogeneity was assessed on the basis of Cochran’s Q test and I2 statistic.Publication bias was assessed with funnel plots and precisely assessed by Egger's tests.Results:A total of ten studies involving 3287 UTUC patients were included.Meta-analysis showed that elevated preoperative PLR was associated with worse overall survival(HR=1.51,95%CI 1.17-1.94,P=0.001),cancer specific survival(HR=1.52,95%CI 1.21-1.90,P<0.001),disease free survival(HR=1.32,95%CI 1.12-1.56,P=0.001),and progression free survival(HR=1.88,95%CI 1.41-2.52,P<0.001).Furthermore,the sensitivity analyses validated the stability and reliability of the results.Conclusion:The present meta-analysis demonstrates a significant association between elevated preoperative PLR and poor prognosis of UTUC patients treated with radical nephroureterectomy.Hence,PLR could be helpful as a potential prognostic biomarker to guide clinical decision-making and select individualized treatment strategies for UTUC patients.However,more prospective and large-scale trials are needed to provide more evidence.展开更多
The short-term impacts of urban air pollution on the platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) remain obscure.In this study,we included 3487 urban adults from the Wuhan-Zhuhai cohort.Indivi...The short-term impacts of urban air pollution on the platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) remain obscure.In this study,we included 3487 urban adults from the Wuhan-Zhuhai cohort.Individual inhalation exposure to air pollutants was estimated by combining participants’daily breath volume and ambient concentrations of six air pollutants (includingfine particulate matter (PM_(2.5)),inhalable particulate matter(PM_(10)),nitrogen dioxide (NO_(2)),sulfur dioxide (SO_(2)),carbon monoxide (CO) and ozone (O_(3))).The cumulative impacts were assessed by applying lag structures of up to 7 days before the survey date.Associations of air pollutants with PLR and NLR were assessed using a linear mixed model and Bayesian kernel machine regression (BKMR) model.We found that PLR was negatively related to PM_(2.5)(lag02-lag06),PM_(10)(lag02-lag07),NO_(2)(lag02-lag07),and SO_(2)(lag03-lag05) and NLR was negatively related to PM_(10)(lag05 and lag07).In the BKMR model,a negative joint association between the six-air-pollutant mixture and PLR and NLR was observed,whereas PM_(10)and NO_(2)appeared to be more important than the other pollutants in the mixture.The negative impact of air pollutants was stronger in males,participants with lower body mass index (<24 kg/m^(2)),those cooking meals at home,drinkers,and nonexercisers.In conclusion,short-term exposure to air pollutants is significantly related to PLR and NLR in peripheral blood.PLR and NLR may provide new insight into the molecular mechanism underlying the adverse health impact of air pollutants.展开更多
目的探讨接受早期宫颈癌根治术患者术前外周血中中性粒/淋巴细胞(neutrophil to lymphocyte ratio,NLR)、血小板/淋巴细胞(platelet to lymphocyte ratio,PLR)及单核/淋巴细胞(Lymphocyte to monocyte ratio,LMR)与预后的关系。方法分析...目的探讨接受早期宫颈癌根治术患者术前外周血中中性粒/淋巴细胞(neutrophil to lymphocyte ratio,NLR)、血小板/淋巴细胞(platelet to lymphocyte ratio,PLR)及单核/淋巴细胞(Lymphocyte to monocyte ratio,LMR)与预后的关系。方法分析2012-2018年新疆医科大学第一附属医院妇科确诊为宫颈癌(I-IIa期)并接受早期根治术的116例患者的相关资料并计算NLR、PLR、LMR,讨论高、低比值组与临床资料的相关性及其对预后的影响。结果高、低NLR组在年龄、肿块大小方面的差异有统计学意义(P<0.05);高低PLR组在年龄、淋巴结转移、肿块大小、脉管浸润方面的差异有统计学意义(P<0.05);高、低LMR组在年龄、脉管浸润方面的差异有统计学意义(P<0.05)。高NLR组患者5年生存率(34.4%)低于低NLR组(63.3%),高PLR组患者5年生存率(45.6%)低于低PLR组(55.8%),高LMR组患者5年生存率(57.6%)高于低LMR组(37.6%),差异均有统计学意义(P<0.05)。单因素分析显示,浸润深度≥1/2、NLR≥2.77、PLR≥133.57、LMR<4.04、临床分期为II期、有淋巴结转移是影响患者生存情况的危险因素。多因素分析显示,NLR≥2.77、浸润深度≥1/2、临床分期为II期是影响患者生存率的独立危险因素。结论宫颈癌患者术前高NLR、高PLR及低LMR是提示预后不良的指标,NLR较其他2个比值对预后的预测更具意义。展开更多
文摘BACKGROUND A well-recognized class effect of immune checkpoint inhibitors(ICI)is immune-related adverse events(IrAEs)ranging from low grade toxicities to life-threatening end organ damage requiring permanent discontinuation of ICI.Deaths are reported in<5%of patients treated with ICI.There are,however,no reliable markers to predict the onset and severity of IrAEs.We tested the association between neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLR)at baseline with development of clinically significant IrAEs(grade≥2)in hepatocellular carcinoma(HCC)patients treated with ICI.AIM To test the association between NLR and PLR at baseline with development of clinically significant IrAEs(grade≥2)in HCC patients treated with ICI.METHODS Data was extracted from an international database from a consortium of 11 tertiary-care referral centers.NLR=absolute neutrophil count/absolute lymphocyte count(ALC)and PLR=platelet count/ALC.Cutoff of 5 was used for NLR and 300 for PLR based on literature.We also tested the association between RESULTS Data was collected from 361 patients treated between 2016-2020 across the United States(67%),Asia(14%)and Europe(19%).Most patients received Nivolumab(n=255,71%).One hundred sixty-seven(46%)patients developed at least one IrAE,highest grade 1 in 80(48%),grade≥2 in 87(52%)patients.In a univariable regression model PLR>300 was significantly associated with a lower incidence of grade≥2 IrAEs(OR=0.40;P=0.044).Similarly,a trend was observed between NLR>5 and lower incidence of grade≥2 IrAEs(OR=0.58;P=0.097).Multivariate analyses confirmed PLR>300 as an independent predictive marker of grade≥2 IrAEs(OR=0.26;P=0.011),in addition to treatment with programmed cell death ligand 1(PD-1)/cytotoxic T lymphocyte-associated protein-4(OR=2.57;P=0.037)and PD-1/tyrosine kinase inhibitor(OR=3.39;P=0.01)combinations.Antibiotic use was not associated with IrAE incidence(OR=1.02;P=0.954).Patients treated with steroids had a>2-fold higher incidence of grade≥2 IrAEs(OR=2.74;P<0.001),although 74%were prescribed steroids for the treatment of IrAEs.CONCLUSION Given that high baseline NLR and PLR are associated with a decreased incidence of IrAEs,lower baseline NLR and PLR may be predictive biomarkers for the appearance of IrAEs in HCC treated with ICI.This finding is in keeping with several studies in solid tumors that have shown that baseline NLR and PLR appear predictive of IrAEs.
文摘Inflammation has been shown to be a factor in tumorigenesis. The circulating platelet to lymphocyte ratio (PLR) is a representative index of systemic inflammation. In this study, we analyzed the association between preoperative PLR levels and clinicopathological variables in two hundred sixty-four Japanese patients with localized breast carcinoma. We also evaluated the prognostic significance of preoperative PLR levels using the Cox proportional hazard model. Seventy-five patients (28.4%) had elevated PLR values, whereas 189 (71.6%) had depressed PLR values. The PLR correlated significantly with venous invasion (P < 0.05). Disease-free survival rates were significantly worse among patients with elevated PLR values than among those with lower PLR value (5-year survival, 81.6% vs. 90.7%, respectively;P < 0.05). In multivariate analysis, elevated PLR, nuclear grade, and lymph node involvement were significant prognostic factors for disease-free survival in patients with breast carcinoma (P < 0.05). Preoperative PLR levels may be an independent prognostic factor in patients with breast carcinoma.
文摘<strong>Introduction: </strong>Breast cancer had become top leading cause of death in Taiwan and endangered women’s health worldwide. Therefore, we try to invest the peripheral inflammatory cell counts and neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) from our routine practice for the predictor of prognosis of breast cancer after resection. <strong>Patients and</strong> <strong>Methods: </strong>There were 574 breast cancer patients accepted surgical resection and registered in Cancer Registry Center of our hospital. Patient’s basic profiles, peripheral neutophil, lymphocyte and platelet count were measured for study. The scales of NLR and PLR were derived from the lower and higher normal range in cell count from neutrophil, lymphocyte and platelet respectively. Therefore, the scales for NLR and PLR were ≤1.62, 1.63 - 2.57, ≥2.58 and ≤224, 225 - 253, ≥254 respectively for analysis. <strong>Results: </strong>Poor 5-yr survival rate was found if higher cell counts of neutrophil and platelet (p ≤ 0.05). Three scales of NLR were ≤1.62, 1.63 - 2.57, ≥2.58, and their 5-year survival rates were 94%, 91% and 84% respectively (p = 0.019). In the subgroup of HER-2 (negative), and 3-Negative breast patients had a higher NLR of poor prognosis. But higher PLR was found less in 3-Negative and non in 3-Positive patients (p = 0.039). The PLR was ≤224, 225 - 253, ≥254 and their 5-year survival rates were 92%, 87%, and 64% respectively (p = 0.001);Multivariate Cox regression model for predictor of breast cancer patients who have 3.39 (PLR ≥ 254) and 2.45 (NLR ≥ 2.58 ) times risk (p = 0.02 and p = 0.002) of poor prognosis respectively. <strong>Conclusion: </strong>Peripheral inflammatory cell counts are easily to take in our clinical practice and have a potential role as predictors of prognosis. We have to pay attention to the trends of peripheral inflammatory cell count and their ratio in our clinical practice where possible.
文摘目的探讨人外周血早期中性粒细胞-淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、血小板-淋巴细胞比值(platelet to lymphocyte ratio,PLR)和中性粒细胞-淋巴细胞和血小板比值(neutrophils to lymphocytes and platelets ratio,N/LP)在重度创伤性颅脑损伤(severe traumatic brain injury,sTBI)患者早期结果中的预测价值。方法回顾性分析2014年6月-2016年12月中国医科大学第七临床学院神经外科收治的95例sTBI患者的临床资料。比较预后良好组(n=36)和预后不良组(n=59)患者的早期NLR、PLR和N/LP差异,分析影响预后相关危险因素并绘制森林图,采用多因素logsitic回归确定独立危险因素并构建临床预测模型;绘制出受试者工作特征曲线(receiver operating characteristic curve,ROC),分析并比较NLR、PLR和N/LP单独或联合其他指标构建出的不同临床预测模型的差异。结果sTBI预后良好组和预后不良组早期NLR、PLR和N/LP比较,差异均有统计学意义(P<0.05);多因素logsitic回归分析提示,年龄、入院格拉斯哥昏迷评分(Glasgow coma scale,GCS)、NLR、PLR和N/LP是影响sTBI患者早期结果的独立危险因素,差异有统计学意义(P<0.05)。根据多因素logstic回归分析构建出19个临床预后预测模型,其中NLR+PLR+N/LP及其联合指标(年龄和GCS)模型曲线下面积(area under curve,AUC)均高于同组其他模型,分别为0.912、0.935、0.933和0.954;Age+GCS+NLR+PLR+N/LP预测模型在所有组别中AUC最大,表明该模型预测患者预后的价值最高。结论NLR、PLR和N/LP的升高与sTBI不良预后相关;早期NLR、PLR及N/LP联合年龄和GCS评分在sTBI早期结果预测中具有重要价值。
基金National Natural Science Foundation of China(81970662)Key Research and Development of Shanxi Province(201803D31110)the Shanxi‘1331 Project’key Innovation Team Construction Plan(3c332019001)。
文摘Objective:To evaluate the prognostic value of platelet-to-lymphocyte ratio(PLR)in upper tract urothelial carcinoma(UTUC)patients treated with radical nephroureterectomy.Methods:This study was pre-registered in PROSPERO(No.CRD42020186645).Two reviewers independently performed a comprehensive literature search on PubMed,Web of Science,EMBASE,Cochrane Library databases,China Biology Medicine disc(CBM),Wanfang database,and China National Knowledge Infrastructure(CNKI)from inception to May 2021 for prospective or retrospective cohort studies evaluating the prognostic value of PLR.Literature was analyzed with inclusion and exclusion criteria.Data and other useful clinicopathological features were extracted and analyzed with fixed or random-effect models when applicable.Heterogeneity was assessed on the basis of Cochran’s Q test and I2 statistic.Publication bias was assessed with funnel plots and precisely assessed by Egger's tests.Results:A total of ten studies involving 3287 UTUC patients were included.Meta-analysis showed that elevated preoperative PLR was associated with worse overall survival(HR=1.51,95%CI 1.17-1.94,P=0.001),cancer specific survival(HR=1.52,95%CI 1.21-1.90,P<0.001),disease free survival(HR=1.32,95%CI 1.12-1.56,P=0.001),and progression free survival(HR=1.88,95%CI 1.41-2.52,P<0.001).Furthermore,the sensitivity analyses validated the stability and reliability of the results.Conclusion:The present meta-analysis demonstrates a significant association between elevated preoperative PLR and poor prognosis of UTUC patients treated with radical nephroureterectomy.Hence,PLR could be helpful as a potential prognostic biomarker to guide clinical decision-making and select individualized treatment strategies for UTUC patients.However,more prospective and large-scale trials are needed to provide more evidence.
文摘目的探讨经手术治疗的宫颈鳞癌患者治疗前中性粒细胞与淋巴细胞比(neutrophil-tolymphocyte ratio,NLR)及血小板与淋巴细胞比(platelet-to-lymphocyteratio,PLR)与总生存期(overall survival,OS)、无病生存期(disease-free survival,DFS)和各临床病理因素的相关性。方法回顾性分析中山大学附属第一医院于2005年1月1日至2009年12月31日期间初治的并且经过手术治疗的143例宫颈鳞癌患者的临床病理资料,根据统计学方法选取NLR和PLR截断值,将患者根据截断值分组,分析NLR和PLR与患者生存、复发情况的相关性以及与临床病理因素的相关性。结果选取NLR=2.8和PLR=125分别作为截断值,高NLR组5年生存率为30.3%,低NLR组5年生存率为80%,差异有统计学意义(P=0.000)。高NLR组复发率为69.7%,低NLR组复发率为24.5%,差异有统计学意义(P=0.000)。高PLR组5年生存率为53.7%,低PLR组5年生存率为81.6%,差异有统计学意义(P=0.000)。高PLR组复发率为50%,低PLR组复发率为22.4%,差异有统计学意义(P=0.000)。经过单因素和多因素分析,国际妇产科联盟(International Federation of Gynecology and Obstetrics,FIGO)分期、术前化疗、病灶大小、外周血血小板计数(platelet,PLT),NLR值和PLR值是影响宫颈鳞癌患者总生存率和无病生存率的独立危险因素。结论治疗前NLR及PLR均是影响宫颈鳞癌患者总生存时间和无病生存时间的独立危险因素。
基金supported by the Key Program of the National Natural Science Foundation of China (No. 91543207)the Major Research Program of the National Natural Science Foundation of China (No. 91843302)。
文摘The short-term impacts of urban air pollution on the platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) remain obscure.In this study,we included 3487 urban adults from the Wuhan-Zhuhai cohort.Individual inhalation exposure to air pollutants was estimated by combining participants’daily breath volume and ambient concentrations of six air pollutants (includingfine particulate matter (PM_(2.5)),inhalable particulate matter(PM_(10)),nitrogen dioxide (NO_(2)),sulfur dioxide (SO_(2)),carbon monoxide (CO) and ozone (O_(3))).The cumulative impacts were assessed by applying lag structures of up to 7 days before the survey date.Associations of air pollutants with PLR and NLR were assessed using a linear mixed model and Bayesian kernel machine regression (BKMR) model.We found that PLR was negatively related to PM_(2.5)(lag02-lag06),PM_(10)(lag02-lag07),NO_(2)(lag02-lag07),and SO_(2)(lag03-lag05) and NLR was negatively related to PM_(10)(lag05 and lag07).In the BKMR model,a negative joint association between the six-air-pollutant mixture and PLR and NLR was observed,whereas PM_(10)and NO_(2)appeared to be more important than the other pollutants in the mixture.The negative impact of air pollutants was stronger in males,participants with lower body mass index (<24 kg/m^(2)),those cooking meals at home,drinkers,and nonexercisers.In conclusion,short-term exposure to air pollutants is significantly related to PLR and NLR in peripheral blood.PLR and NLR may provide new insight into the molecular mechanism underlying the adverse health impact of air pollutants.
文摘目的探讨接受早期宫颈癌根治术患者术前外周血中中性粒/淋巴细胞(neutrophil to lymphocyte ratio,NLR)、血小板/淋巴细胞(platelet to lymphocyte ratio,PLR)及单核/淋巴细胞(Lymphocyte to monocyte ratio,LMR)与预后的关系。方法分析2012-2018年新疆医科大学第一附属医院妇科确诊为宫颈癌(I-IIa期)并接受早期根治术的116例患者的相关资料并计算NLR、PLR、LMR,讨论高、低比值组与临床资料的相关性及其对预后的影响。结果高、低NLR组在年龄、肿块大小方面的差异有统计学意义(P<0.05);高低PLR组在年龄、淋巴结转移、肿块大小、脉管浸润方面的差异有统计学意义(P<0.05);高、低LMR组在年龄、脉管浸润方面的差异有统计学意义(P<0.05)。高NLR组患者5年生存率(34.4%)低于低NLR组(63.3%),高PLR组患者5年生存率(45.6%)低于低PLR组(55.8%),高LMR组患者5年生存率(57.6%)高于低LMR组(37.6%),差异均有统计学意义(P<0.05)。单因素分析显示,浸润深度≥1/2、NLR≥2.77、PLR≥133.57、LMR<4.04、临床分期为II期、有淋巴结转移是影响患者生存情况的危险因素。多因素分析显示,NLR≥2.77、浸润深度≥1/2、临床分期为II期是影响患者生存率的独立危险因素。结论宫颈癌患者术前高NLR、高PLR及低LMR是提示预后不良的指标,NLR较其他2个比值对预后的预测更具意义。
