抗病毒药物普来可那利的合成

Starting from 2,6-dimethyl phenol,antiviral agent pleconaril was synthesized via bromination,cyanidation and etherification followed by reaction with acetaldehyde oxime,hydroxylamine hydrochloride and trifluoroacetic anhydride respectively.Its structure was confirmed by IR,MS, 1 HNMR and elemental analysis.

A perspective on picornavirus inhibitors and concrete evolution of WIN compounds

The family Picornaviridae is one of the largest families of human viral pathogens,causing an extensive range of clinical manifestations from mild fever,common cold to serious paralytic poliomyelitis,COPD,etc.,some of which can even be life-threatening.Picornaviruses also cause zoonotic epidemics that result in dramatic social and economical losses.Although no efficient antivirus agent for prophylaxis or treatment of picornarivus infections has been officially approved yet,a large number of anti-picornavirus compounds with potent activity have been developed and investigated,through which further information about picornavirus has been revealed as well.Viral mRNA translation,viral mRNA replication and especially the viral capsid are the three main targets of these compounds having been extensively studied.The typical one is the WIN series of compounds that bind to the viral capsid and inhibit rival attachment or uncoating.Herein,a perspective on picornavirus inhibitors and a concrete evolution of WIN compounds will be presented in this paper.

柯萨奇病毒B感染性心肌炎的治疗选择

病毒性心肌炎是扩张型心肌病的常见原因，柯萨奇病毒B对心肌所致损害的确切机制尚不清楚。其中可能的机制包括免疫介导的损伤和病毒的直接细胞毒性作用。美国罗格斯大学Brunetti等针对心肌炎向心肌病进展的特殊靶点，提出了几项治疗措施。鉴于心肌自身免疫性损害观点，应用免疫抑制剂（咪唑硫嘌呤、强的松、环孢素）似为合理。另一治疗选择是静脉内注射免疫球蛋白，可抑制免疫反应；免疫球蛋白还可替代抗体，增加对病毒的清除，中和病原体，以及减少炎性细胞因子对心肌的损害。针对病原微生物，应使用抗病毒制剂，如干扰素、pleconaril和阿昔洛韦，这可能阻止心肌损害的级联反应。天然产物黄芪和小紫金牛也被用于治疗病毒性心肌炎。然而，以上治疗措施的疗效尚未确立，对病毒性心肌炎仍无特异性治疗方法。