Several studies have suggested a pathogenetic role of paraproteinaemias in PNS damage. Over the few last years, the presence of symptomatic or subclinical PNS lesions in CNS diseases like multiple sclerosis has been d...Several studies have suggested a pathogenetic role of paraproteinaemias in PNS damage. Over the few last years, the presence of symptomatic or subclinical PNS lesions in CNS diseases like multiple sclerosis has been described. On the other hand, CNS demyelinating lesions and cervical atrophy have been re- ported in patients affected by chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Very few cases of MGUS associated with CNS disease alone or with both CNS and PNS disease have been re- ported. Since 1999, we have been studying 16 patients (8 M, 8 F), with a mean age 60.2 ± 13.4, affected by MGUS associated with symptomatic neurological central and/or peripheral diseases. Patients affected with lymphomas, lupus erithematosus and other immunological diseases were excluded. Involvement of both PNS and CNS was not associated to a particular type of paraproteinemia: monoclonal IgM were found in 8 patients;monoclonal IgG in 6 patients and mono- clonal IgA in 1 patient and Igl in 1 patient. High anti- nervous system autoantibodies were found in 10/16 patients and antiMAG antibodies were detected in patients with paraproteinemic demyelinating neuropathy (PDN). High reactivity anti-nervous system might support the hypothesis of a pathogenetic role of MGUS in these neurological diseases. Nevertheless, at present, we cannot exclude that there is only a circumstantial association between MGUS and neurological damages, particularly concerning CNS.展开更多
Graphitic carbon nitride(g-C3N4,CN)has attracted increasing interests in the field of photocatalysis due to its high visible-light-response.However,its photocatalytic activity is still lower for degradation of refract...Graphitic carbon nitride(g-C3N4,CN)has attracted increasing interests in the field of photocatalysis due to its high visible-light-response.However,its photocatalytic activity is still lower for degradation of refractory contaminants such as Cr(Ⅵ)and Rhodamine B(RhB)etc.Herein,we report a facile method to synthesize a novel sulfur(S)-doped CN/reduced graphene oxide(rGO)porous nanosheet(S-CN/rGO PNs)via a supramolecular self-assembling followed by a solvothermal treatment.The as-prepared porous SCN/rGO PNs are stable with high specific surface area^188.5 m2 g-1 and exhibit a significantly enhanced photocatalytic activity of^17-fold and 15-fold higher than that of bulk CN for the degradation of RhB and Cr(Ⅵ)under visible light irradiation,respectively.Typically,50 mL of 15 mg/mL RhB can be degraded within 20 min by 10 mg S-CN/rGO PNs.The mechanism can be explained by the synergistic effect of S doping and porous structure which can effectively reduce the band gap of CN and increase the specific surface area to promote the separation and transfer of photo-generated charge carriers.The results have provided a new way to significantly enhance the photocatalytic activity of g-C3N4 for degradation of refractory contaminants.展开更多
文摘Several studies have suggested a pathogenetic role of paraproteinaemias in PNS damage. Over the few last years, the presence of symptomatic or subclinical PNS lesions in CNS diseases like multiple sclerosis has been described. On the other hand, CNS demyelinating lesions and cervical atrophy have been re- ported in patients affected by chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Very few cases of MGUS associated with CNS disease alone or with both CNS and PNS disease have been re- ported. Since 1999, we have been studying 16 patients (8 M, 8 F), with a mean age 60.2 ± 13.4, affected by MGUS associated with symptomatic neurological central and/or peripheral diseases. Patients affected with lymphomas, lupus erithematosus and other immunological diseases were excluded. Involvement of both PNS and CNS was not associated to a particular type of paraproteinemia: monoclonal IgM were found in 8 patients;monoclonal IgG in 6 patients and mono- clonal IgA in 1 patient and Igl in 1 patient. High anti- nervous system autoantibodies were found in 10/16 patients and antiMAG antibodies were detected in patients with paraproteinemic demyelinating neuropathy (PDN). High reactivity anti-nervous system might support the hypothesis of a pathogenetic role of MGUS in these neurological diseases. Nevertheless, at present, we cannot exclude that there is only a circumstantial association between MGUS and neurological damages, particularly concerning CNS.
基金the Science and Technology Major Project of Shanxi Province(Grant Numbers MC2016-06)National Natural Science Foundation of China(21173041)the Opening Project of Jiangsu Key Laboratory of Advanced Metallic Materials,China.
文摘Graphitic carbon nitride(g-C3N4,CN)has attracted increasing interests in the field of photocatalysis due to its high visible-light-response.However,its photocatalytic activity is still lower for degradation of refractory contaminants such as Cr(Ⅵ)and Rhodamine B(RhB)etc.Herein,we report a facile method to synthesize a novel sulfur(S)-doped CN/reduced graphene oxide(rGO)porous nanosheet(S-CN/rGO PNs)via a supramolecular self-assembling followed by a solvothermal treatment.The as-prepared porous SCN/rGO PNs are stable with high specific surface area^188.5 m2 g-1 and exhibit a significantly enhanced photocatalytic activity of^17-fold and 15-fold higher than that of bulk CN for the degradation of RhB and Cr(Ⅵ)under visible light irradiation,respectively.Typically,50 mL of 15 mg/mL RhB can be degraded within 20 min by 10 mg S-CN/rGO PNs.The mechanism can be explained by the synergistic effect of S doping and porous structure which can effectively reduce the band gap of CN and increase the specific surface area to promote the separation and transfer of photo-generated charge carriers.The results have provided a new way to significantly enhance the photocatalytic activity of g-C3N4 for degradation of refractory contaminants.
