Plasma Metabonomics of Human Adenovirus-infected Patients with Pneumonia and Upper Respiratory Tract Infection

Objective Human adenovirus(HAdV)infection is common and can develop to serious conditions with high mortality,yet the mechanism of HAdV infection remains unclear.In the present study,the serum metabolite profiles of HAdV-7-infected patients with pneumonia or upper respiratory tract infection(URTI)were explored.Methods In total,35 patients were enrolled in the study following an outbreak of HAdV-7 in the army,of whom 14 had pneumonia and 21 had URTI.Blood samples were collected at the acute stage and at the recovery stage and were analyzed by untargeted metabolomics.Results Over 90% of the differential metabolites identified between the pneumonia patients and URTI patients were lipids and lipid-like molecules,including glycerophospholipids,fatty acyls,and sphingolipids.The metabolic pathways that were significantly enriched were primarily the lipid metabolism pathways,including sphingolipid metabolism,glycerophospholipid metabolism,and linoleic acid metabolism.The sphingolipid metabolism was identified as a significantly differential pathway between the pneumonia patients and URTI patients and between the acute and recovery stages for the pneumonia patients,but not between the acute and recovery stages for the URTI patients.Ceramide and lactosylceramide,involved in sphingolipid metabolism,were significantly higher in the pneumonia patients than in the URTI patients with good discrimination abilities[area under curve(AUC)0.742 and 0.716,respectively;combination AUC 0.801].Conclusion Our results suggested that HAdV modulated lipid metabolism for both the patients with URTI and pneumonia,especially the sphingolipid metabolism involving ceramide and lactosylceramide,which might thus be a potential intervention target in the treatment of HAdV infection.

Prevalence and Antibiotic Resistance of Urinary Tract Pathogens, with Molecular Identification of Klebsiella pneumoniae, Klebsiella oxytoca, and Acinetobacter spp., Using Multiplex Real-Time PCR

Urinary tract infections (UTIs) caused by uropathogens are a significant public health problem, and their treatment primarily relies on antibiotic therapy. However, the increasing global development of antibiotic resistance necessitates updating diagnostic techniques to ensure higher sensitivity and specificity, especially with advancements in science and medicine. This study aimed to evaluate the prevalence of UTIs and antibiotic resistance profiles through urine culture, as well as to identify Klebsiella pneumoniae, Klebsiella oxytoca, and Acinetobacter spp. in urine samples using a molecular approach with multiplex real-time PCR. From May 3 to July 25, 2023, at the Pietro Annigoni Biomolecular Research Center (CERBA) and Saint Camille Hospital of Ouagadougou (HOSCO), 209 urine samples collected from patients with suspected UTIs were analyzed using both urine culture and multiplex real-time PCR. Among the 209 patients, 52.15% were male and 47.85% female, with an average age of 46.87 ± 21.33 years. Urine cultures revealed an overall UTI prevalence of 23.44%, with a prevalence of 8.13% in men versus 15.31% in women (P = 0.023). The bacterial prevalence rates were as follows: Escherichia coli (12.92%), Klebsiella spp. (7.18%), Enterobacter cloacae (1.44%), Staphylococcus aureus (0.96%), and other bacteria. Klebsiella spp. demonstrated 100% resistance to Amoxicillin and Amoxicillin/Clavulanic Acid, while Escherichia coli showed 96.2% and 65.4% resistance to Amoxicillin and Amoxicillin/Clavulanic Acid, respectively. PCR analysis of the target bacteria revealed mono-infection prevalence rates of Klebsiella pneumoniae (10.39%), Klebsiella oxytoca (7.79%), and Acinetobacter spp. (7.79%), along with a co-infection prevalence rate of Klebsiella pneumoniae/Acinetobacter spp. (1.30%). This study demonstrated that PCR, with its high sensitivity and specificity, could effectively distinguish Klebsiella pneumoniae from Klebsiella oxytoca and detect Acinetobacter spp. in less than 24 hours—something urine culture alone could not achieve. The relative ease of automating urine PCR testing, combined with its diagnostic accuracy and rapid turnaround time, makes it a valuable addition to modern medical practice for the laboratory diagnosis of UTIs.

度伐利尤单抗联合PP化疗方案治疗Ⅲ期非小细胞肺癌患者的效果

目的:观察度伐利尤单抗联合PP化疗方案治疗Ⅲ期非小细胞肺癌(NSCLC)患者的效果。方法:回顾性分析2021年5月至2023年5月该院收治的66例Ⅲ期NSCLC患者临床资料,按治疗方案不同将其分为观察组和对照组各33例。对照组采用PP化疗方案治疗,观察组在对照组基础上联合度伐利尤单抗注射液治疗,比较两组疾病缓解率、KPS评分、癌症治疗功能评价系统-肺癌模块(FACT-L)评分、血清生化因子[Ⅳ型胶原蛋白α3(COL4A3)、G蛋白偶联受体相关分选蛋白1(GASP-1)]水平和不良反应发生率。结果:观察组疾病缓解率为60.61%,明显高于对照组的36.36%,差异有统计学意义(P<0.05);治疗后,两组KPS评分高于治疗前,且观察组高于对照组,两组FACT-L评分和血清COL4A3、GASP-1水平低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05);治疗期间,两组腹泻、脱发、骨髓抑制、恶心等不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:度伐利尤单抗联合PP化疗方案治疗Ⅲ期NSCLC患者可提高疾病缓解率和KPS评分,降低FACT-L评分及血清COL4A3、GASP-1水平,效果优于单纯PP化疗方案治疗。

枳PtrPP2C51基因克隆与非生物胁迫表达分析

克隆枳PP2C基因家族的PtrPP2C51基因,分析其在低温、高温和干旱等胁迫下的表达规律,探究其在非生物胁迫中的功能。以1年生枳苗为试材,从嫩叶克隆到PtrPP2C51基因cDNA序列,采用生物信息学方法对其进行分析,利用实时荧光定量PCR仪(qRT-PCR)检测枳苗在低温、高温和干旱(15%PEG-6000)处理下的PtrPP2C51基因表达模式。克隆获得PtrPP2C51基因编码区CDS序列长度为879 bp,编码292个氨基酸,其蛋白分子量为31.36 ku,理论等电点4.9,脂肪系数79.52,不稳定系数39.57,亲水性平均值-0.279。PtrPP2C51蛋白的二级结构中α-螺旋、β-转角、延伸链和无规则卷曲占比分别为40.07%、7.88%、18.15%和33.90%。PtrPP2C51蛋白与克里曼丁橘的PP2C蛋白在同一小分支上,亲缘关系最近。经低温(0℃)、高温(38℃)和干旱(15%PEG-6000)3种不同胁迫处理,PtrPP2C51基因的相对表达量均表现持续上调趋势,并且均在处理12 h时表达量达到最高值。PtrPP2C51基因可能参与枳的抗逆胁迫调控机制。

支气管镜介入治疗对RMPP患儿的疗效及其对外周血CRP、SF、IL-8水平及CD4^(+)/CD8^(+)比值的影响

目的探讨支气管镜介入治疗对难治性肺炎支原体肺炎(RMPP)患儿的疗效及其对外周血C反应蛋白(CRP)、铁蛋白(SF)、白细胞介素(IL)-8水平及CD4^(+)/CD8^(+)比值的影响。方法选取2020年12月至2022年12月河北省儿童医院收治的195例确诊为RMPP患儿作为研究对象,采用随机数字表法分为对照组和介入组(病程≥14 d归为晚期介入组、病程<14 d归为早期介入组)。根据临床疗效将130例接受支气管镜介入治疗的患儿分为有效组和无效组。对照组进行常规治疗,晚期介入组和早期介入组在对照组的基础上实施支气管镜介入治疗。比较对照组、晚期介入组和早期介入组临床疗效、临床症状与体征改善情况;检测并比较对照组、晚期介入组和早期介入组外周血CRP、SF、IL-8水平及CD4^(+)/CD8^(+)比值;比较对照组、晚期介入组和早期介入组不良反应发生率;比较有效组和无效组外周血CRP、SF、IL-8水平及CD4^(+)/CD8^(+)比值。采用受试者工作特征(ROC)曲线分析外周血CRP、SF、IL-8、CD4^(+)/CD8^(+)比值对支气管镜介入治疗RMPP疗效的预测价值。结果早期介入组总有效率高于对照组和晚期介入组,差异均有统计学意义(P<0.05);对照组和晚期介入组总有效率比较,差异无统计学意义(P>0.05)。早期介入组咳嗽持续时间、发热持续时间、住院时间均短于对照组和晚期介入组,差异均有统计学意义(P<0.05)。对照组、晚期介入组和早期介入组治疗后外周血CD4^(+)/CD8^(+)比值均高于治疗前,CRP、SF、IL-8水平均低于治疗前,差异均有统计学意义(P<0.05);早期介入组治疗后外周血CD4^(+)/CD8^(+)比值均高于对照组和晚期介入组,CRP、SF、IL-8水平均低于对照组和晚期介入组,差异均有统计学意义(P<0.05)。早期介入组出现不良反应8例,晚期介入组出现不良反应10例,均暂停灌洗操作后很快恢复。对照组未出现上述不良反应。无效组外周血CRP、SF、IL-8水平均高于有效组,CD4^(+)/CD8^(+)比值低于有效组,差异均有统计学意义(P<0.05)。ROC曲线分析结果显示,CRP、SF、IL-8、CD4^(+)/CD8^(+)比值联合检测预测支气管镜介入治疗RMPP无效的曲线下面积、灵敏度、特异度分别为0.871、81.81%、83.80%。结论早期应用支气管镜介入治疗对RMPP的疗效较好,可改善患儿外周血CRP、SF、IL-8水平及CD4^(+)/CD8^(+)比值,且外周血CRP、SF、IL-8、CD4^(+)/CD8^(+)比值联合检测有助于预测支气管镜介入治疗RMPP的疗效。

RCEP与CPTPP的比较和融合之道

当前,竞争政策在自由贸易协定中的地位愈发重要,约有五分之四的自由贸易协定涉及竞争条款。发达国家对于竞争法和区域自由贸易协定中的竞争条款都具有先进性,中国作为发展中国家对于竞争条款仍处于起步阶段,因此要在研究CPTPP等发达国家竞争条款的基础上,制定和完善符合发展中国家利益的竞争政策。

废弃PP纤维再生混凝土基本力学性能试验

目的 针对纤维体积掺量、长径比、再生骨料取代率等因素,探究废弃PP纤维对再生混凝土力学性能的影响,提高废弃纤维利用率。方法 以废弃PP打包带制成不同长径比的纤维作为筋材,以不同体积掺量与不同再生骨料取代率的再生混凝土混合制成11组废弃PP纤维再生混凝土试块,对其进行抗压和抗拉试验。结果 立方体抗压、抗拉强度最佳时的废弃PP纤维体积掺量为1.5%,长径比为47.85;废弃PP纤维再生混凝土的立方体抗压、抗拉强度与再生骨料取代率有关,其强度与再生骨料取代率近似呈线性关系。结论 废弃PP纤维的掺入可以提高再生混凝土的立方体抗压强度和抗拉强度。

An unusual case of severe pneumonia caused by Tropheryma whipplei combined with Legionella pneumophila

Community-acquired pneumonia is a common disease caused by a variety of pathogens.Tropheryma whipplei (T.whipplei) is a rare pathogenic bacterium,few cases have been reported.George Hoyt Whipple described Whipple’s disease as a chronic infectious disease affecting multiple organ systems for the first time in 1907.

自成核行为在CF/PPS复合材料中的差异性与普适性

以半结晶高分子为基体的碳纤维增强热塑性复合材料,其基体的结晶行为将受到碳纤维表面性质与热历史的共同影响。当这种材料在经历反复加热冷却的热循环过程时,基体会产生自成核行为,其结晶过程变得更加复杂。通过三种T300级碳纤维分别制备了碳纤维增强聚苯硫醚(CF/PPS)复合材料,并探究了二次熔融温度与CF/PPS复合材料结晶行为的关系,揭示了不同碳纤维表面性质对CF/PPS复合材料自成核行为的影响。在此基础上阐明了CF/PPS复合材料基体自成核与CF异相成核的竞争关系。最后,通过冲压成型制得具有自成核行为的CF/PPS复合材料角片,验证了自成核对于CF/PPS复合材料二次热成型技术的有效性与重要性。

不同时期RMPP患儿支气管肺泡灌洗液SPA表达及与肺功能的关系

目的探讨不同时期难治性支原体肺炎(refractory mycoplasma pneumoniae pneumonia,RMPP)患儿支气管肺泡灌洗液中表面活性物质相关蛋白-A(surfactant protein A,SPA)的表达水平及与肺功能的关系。方法选取2021年1月—2023年1月南通市第一人民医院收治的62例RMPP患儿为对象,以同期行支气管镜异物取出术且无肺部感染的50例患儿为对照组。RMPP患儿于急性期、恢复期行支气管肺泡灌洗液中SPA检测以及肺功能指标检测[第1秒用力呼气容积(forced expiratory volume in one second,FEV_(1))、用力肺活量(forced vital capacity,FVC)、FEV_(1)/FVC],对照组同样如此。比较三者检测结果差异,使用Pearson分析RMPP患儿支气管肺泡灌洗液中SPA水平与肺功能指标的相关性。结果RMPP患儿肺泡灌洗液中的SPA急性期(59.82±12.64)μg/L、恢复期(129.91±24.86)μg/L高于对照组,差异有统计学意义(P<0.05)。RMPP急性期、RMPP恢复期的FEV_(1)、FVC、FEV_(1)/FVC(80.95±6.88)%、(88.41±5.75)%较对照组低,差异有统计学意义(P<0.05);RMPP患儿于急性期时肺泡灌洗液中的SPA较恢复期低,FEV_(1)、FVC、FEV_(1)/FVC较恢复期低,差异有统计学意义(P<0.05);RMPP患儿肺泡灌洗液中SPA水平与FEV_(1)、FVC、FEV_(1)/FVC呈正相关(P<0.05)。结论RMPP患儿病情处于急性发展阶段的情况下其支气管肺泡灌洗液中的SPA表达相较病情恢复阶段更低,同时RMPP患儿支气管肺泡灌洗液中SPA水平与其肺功能指标呈正相关性。

高岭土对APP/PER/PP复合材料性能的影响

以PP废玩具料(W-PP)为主材,高岭土(Kaol)、聚磷酸铵(APP)和季戊四醇(PER)为阻燃剂,通过熔融挤出制备一系列Kaol/APP/PER/W-PP复合材料,对复合材料的极限氧指数(LOI)、UL 94阻燃等级、力学性能和热变形温度(HDT)进行测试,并用锥形量热仪进行分析,结果表明,APP/PER添加后,复合材料的阻燃性能和HDT明显提高,力学强度逐渐降低;适量的Kaol和APP/PER具有较好的协同阻燃效果,而且,添加Kaol后,复合材料的力学性能和HDT明显提升,当在W-PP中同时加入3%的Kaol和25%的APP/PER时,复合材料的LOI为32.1%,阻燃达到UL 94(1.6 mm)V-0级,与单独添加相比,拉伸强度、弯曲模量、弯曲强度和缺口冲击强度均提高了28%APP/PER的性能分别提高了16.9%、15.0%、27.4%和31.3%。

PE/PP混杂纤维应变硬化碱激发复合材料力学性能研究

应变硬化碱激发复合材料(SHAAC)兼具低碳环保和高韧性的优点,但高昂的成本限制了其工程应用。为降低成本,研究采用PP纤维替代PE纤维,开发了一种混杂PE/PP纤维SHAAC,并通过轴压与轴拉试验及成本分析,探讨了不同PP纤维替代率(0%、25%、50%、75%和100%,体积分数)对混杂PE/PP纤维SHAAC的轴压、轴拉性能和成本的影响。结果表明:采用PP纤维替代PE纤维时,SHAAC的轴压、轴拉强度及裂缝控制能力随着纤维替代率的增加而降低,但在PP纤维替代率低于75%时,SHAAC仍可呈现伪应变硬化和多缝开裂现象;当PP纤维替代率为50%时,SHAAC极限拉伸应变最高(8.40%),且能保持较高的轴压和轴拉性能,同时成本可降低29.00%,且综合性能与成本比值最高。

Klebsiella pneumoniae infections after liver transplantation:Drug resistance and distribution of pathogens,risk factors,and influence on outcomes

BACKGROUND Liver transplantation(LT)is the only curative treatment for end-stage liver disease.However,LT recipients are susceptible to infection,which is the leading cause of early mortality after LT.Klebsiella pneumoniae infections(KPIs)in the bloodstream are common in LT recipients.We hypothesized that KPIs and carbapenemresistant Klebsiella pneumoniae(CRKP)infections may affect the outcomes of LT recipients.AIM To assess KPI incidence,timing,distribution,drug resistance,and risk factors following LT and its association with outcomes.METHODS This retrospective study included 406 patients undergoing LT at The Third Xiangya Hospital of Central South University,a tertiary hospital,from January 2015 to January 2023.We investigated the risk factors for KPIs and assessed the impact of KPIs and CRKP infections on the prognosis of LT recipients using logistic regression analysis.RESULTS KPI incidence was 7.9%(n=32),with lung/thoracic cavity the most frequent site of infection;the median time from LT to KPI onset was 7.5 d.Of 44 Klebsiella pneumoniae isolates,43(97.7%)and 34(77.3%)were susceptible to polymyxin B or ceftazidime/avibactam and tigecycline,respectively;>70%were resistant to piperacillin/tazobactam,ceftazidime,cefepime,aztreonam,meropenem,and levofloxacin.Female sex[odds ratio(OR)=2.827,95%confidence interval(CI):1.256-6.364;P=0.012],pre-LT diabetes(OR=2.794,95%CI:1.070-7.294;P=0.036),day 1 post-LT alanine aminotransferase(ALT)levels≥1500 U/L(OR=3.645,95%CI:1.671-7.950;P=0.001),and post-LT urethral catheter duration over 4 d(OR=2.266,95%CI:1.016-5.054;P=0.046)were risk factors for KPI.CRKP infections,but not KPIs,were risk factors for 6-month all-cause mortality post-LT.CONCLUSION KPIs occur frequently and rapidly after LT.Risk factors include female sex,pre-LT diabetes,increased post-LT ALT levels,and urethral catheter duration.CRKP infections,and not KPIs,affect mortality.

Clinical analysis of colistin sulfate in the treatment of pneumonia caused by carbapenem-resistant Gram-negative bacteria

BACKGROUND Multidrug-resistant Gram-negative bacteria,exacerbated by excessive use of antimicrobials and immunosuppressants,are a major health threat.AIM To study the clinical efficacy and safety of colistin sulfate in the treatment of carbapenem-resistant Gram-negative bacilli-induced pneumonia,and to provide theoretical reference for clinical diagnosis and treatment.METHODS This retrospective analysis involved 54 patients with Gram-negative bacilli pneumonia admitted to intensive care unit of The General Hospital of the Northern Theater Command of the People's Liberation Army of China from August 2020 to June 2022.After bacteriological culture,the patients'airway secretions were collected to confirm the presence of Gram-negative bacilli.The patients were divided into the experimental and control groups according to the medication used.The research group consisted of 28 patients who received polymyxin sulfate combined with other drugs through intravenous,nebulization,or intravenous combined with nebulization,with a daily dosage of 1.5–3.0 million units.The control group consisted of 26 patients who received standard dosages of other antibiotics(including sulbactam sodium for injection,cefoperazone sodium sulbactam for injection,tigecycline,meropenem,or vaborbactam).RESULTS Of the 28 patients included in the research group,26 patients showed improvement,treatment was ineffective for two patients,and one patient died,with the treatment efficacy rate of 92.82%.Of the 26 patients in the control group,18 patients improved,treatment was ineffective for eight patients,and two patients died,with the treatment efficacy rate of 54.9%;significant difference was observed between the two groups(P<0.05).The levels of white blood cell(WBC),procalcitonin(PCT),and C-reactive protein(CRP)in both groups were significantly lower after treatment than before treatment(P<0.05),and the levels of WBC,PCT,and CRP in the research group were significantly lower than those in the control group(P<0.05).Compared with before treatment,there were no significant changes in aspartate aminotransferase,creatinine,and glomerular filtration rate in both groups,while total bilirubin and alanine aminotransferase decreased after treatment(P<0.05)with no difference between the groups.In patients with good clinical outcomes,the sequential organ failure assessment(SOFA)score was low when treated with inhaled polymyxin sulfate,and specific antibiotic treatment did not improve the outcome.Sepsis and septic shock as well as a low SOFA score were independent factors associated with good clinical outcomes.CONCLUSION Polymyxin sulfate has a significant effect on the treatment of patients with multiple drug-resistant Gram-negative bacilli pneumonia and other infections in the lungs and is safe and reliable.Moreover,the administration route of low-dose intravenous injection combined with nebulization shows better therapeutic effects and lower adverse reactions,providing new ideas for clinical administration.

PP1A与GSDME介导的结直肠癌细胞焦亡的临床意义

目的检测PP1A与GSDME在结直肠癌组织中的表达与CD8^(+)T淋巴细胞丰度,探讨PP1A与GSDME介导焦亡的相关性和临床意义。方法应用GEPIA数据库分析PP1A与GSDME在结直肠癌组织与正常组织中mRNA的表达。采用Western blot法检测结直肠癌组织与对应癌旁正常黏膜中PP1A蛋白表达水平,运用免疫组化法检测107例结直肠癌与癌旁正常黏膜中PP1A、GSDME蛋白的表达和CD8^(+)T淋巴细胞丰度。利用Spearman等级相关性分析PP1A、GSDME和CD8^(+)T淋巴细胞丰度的相关性。结果GEPIA数据库检索显示,PP1A与GSDME的mRNA在结直肠癌组织和正常组织中的表达差异有统计学意义(P<0.05)。Western blot法检测结果显示,结直肠癌组织中PP1A相对表达量明显高于癌旁组织(0.937 vs 0.643,P<0.001)。免疫组化结果显示,结直肠癌组织中PP1A的表达明显高于正常黏膜,而GSDME的表达明显低于正常黏膜(P<0.05),GSDME表达与结直肠癌患者年龄、临床分期和错配修复蛋白密切相关(P<0.05);CD8^(+)T细胞在癌浸润前沿的分布明显高于癌旁正常黏膜,且CD8^(+)T细胞在癌组织中的分布与pT分期、临床分期及淋巴结转移相关。Spearman相关性分析显示,PP1A与GSDME表达呈负相关(r=-0.196,P<0.05)。PP1A阳性结直肠癌患者的总生存期低于PP1A阴性患者(P<0.05),患者预后与分化程度、淋巴结转移、pT分期和临床分期相关。PP1A表达、肿瘤分化程度、临床分期、pT分期和淋巴结转移均是影响结直肠癌患者预后的独立危险因素。结论PP1A在结直肠癌中高表达,与GSDME介导的细胞焦亡呈负相关,两者表达差异性与结直肠癌的发生、发展及预后均密切相关,可作为判断结直肠癌患者预后的潜在指标,CD8^(+)T细胞的差异性分布可能与GSDME介导的细胞焦亡及肿瘤的发展相关。

Effects of the 23-Valent Pneumococcal Polysaccharide Vaccine on the Mortality of Pneumonia among Elderly over 70 Years Old after the Great East Japan Earthquake—PPV Vaccination Program in Iwate Prefecture, Japan

Objective: To estimate the efficacy of 23-valent pneumococcal polysaccharide vaccine (PPSV23) among the elderly, we analyzed the relationship between the mortality of the elderly for pneumonia and the vaccination rate of PPSV23 from 2008 to 2016 in Iwate Prefecture, Japan. Study Design: The present study was a retrospective, observational, database study adopting an ecological design. The mortality for pneumonia among the elderly over 70 years old from 2006 to 2016 in Iwate Prefecture was calculated based on the data from the Japanese Vital Statistics. We compared the mortality rate (MR) of pneumonia among the elderly over 70 years old between the low-vaccinated period (LVP) (2006-2010) and high-vaccinated period (HVP) (2012-2016) using a Poisson regression model. Results: While the vaccination rate of PPSV23 among the elderly over 65 years old was 3.3% in 2010, it increased rapidly up to 40.7% in 2012 and reached 66.4% in 2016. The MR ratio of the total population during HVP to the average MR during LVP was 0.749. The MR of the total population during HVP was significantly lower than that during LVP (p Conclusion: The increase in vaccination rate of PPSV23 during HVP (2012-2016) may contribute to the decrease in mortality for pneumonia among the elderly over 70 years old in Iwate Prefecture.

PP/SEBS/HDPE复合材料的制备及性能研究

将氢化聚苯乙烯-丁二烯-聚苯乙烯(SEBS)与聚丙烯(PP)和聚乙烯(PE)通过双螺杆挤出机进行熔融共混后,制备得到PP/SEBS/HDPE三元共混物,采用冲击试验机、热重分析仪(TGA)、红外光谱仪、差示扫描量热仪(DSC)等手段对共混物的流动性能、力学性能、热性能、结晶行为、相容性等进行研究分析。结果表明,在PP/PE体系中,随着PE的增加,共混物的流动性逐渐变好,当PE含量为20%时,共混物的拉伸强度、冲击强度、断裂伸长率达到最高,此时其力学性能最优;在三元共混体系中,随着SEBS含量的增加,共混物的悬臂梁冲击强度大幅提高,当SEBS添加量为8%时,共混物的力学性能最优,因此最优体系为PP/20%HDPE/8%SEBS,此时共混物的相容性最好。

PPS+PTFE混纺针刺滤袋在燃煤电厂的应用分析

针对某燃煤电厂使用聚苯硫醚(PPS)滤袋不足一年时间即发生大面积破损的问题,制备面层不同PPS和聚四氟乙烯(PTFE)纤维质量比的PPS+PTFE混纺针刺滤袋,对其进行挂袋试验,并从面密度、透气性、拉伸性能、粉尘渗透情况、材质变化及微观形貌等方面分析使用前后PPS+PTFE混纺针刺滤袋的性能。根据试验数据进行PPS+PTFE混纺针刺滤袋使用寿命的预估分析,推算其剩余使用寿命。研究结果显示,制备的PPS+PTFE混纺针刺滤袋满足粉尘排放质量浓度长期低于10 mg/m3的要求;面层PPS和PTFE纤维质量比为50∶50时,制备的PPS+PTFE混纺针刺滤袋的整体使用寿命可达74个月。研究为燃煤电厂滤袋除尘器的超低排放及滤袋选型提供参考。

MDEV Model:A Novel Ensemble-Based Transfer Learning Approach for Pneumonia Classification Using CXR Images

Pneumonia is a dangerous respiratory disease due to which breathing becomes incredibly difficult and painful;thus,catching it early is crucial.Medical physicians’time is limited in outdoor situations due to many patients;therefore,automated systems can be a rescue.The input images from the X-ray equipment are also highly unpredictable due to variances in radiologists’experience.Therefore,radiologists require an automated system that can swiftly and accurately detect pneumonic lungs from chest x-rays.In medical classifications,deep convolution neural networks are commonly used.This research aims to use deep pretrained transfer learning models to accurately categorize CXR images into binary classes,i.e.,Normal and Pneumonia.The MDEV is a proposed novel ensemble approach that concatenates four heterogeneous transfer learning models:Mobile-Net,DenseNet-201,EfficientNet-B0,and VGG-16,which have been finetuned and trained on 5,856 CXR images.The evaluation matrices used in this research to contrast different deep transfer learning architectures include precision,accuracy,recall,AUC-roc,and f1-score.The model effectively decreases training loss while increasing accuracy.The findings conclude that the proposed MDEV model outperformed cutting-edge deep transfer learning models and obtains an overall precision of 92.26%,an accuracy of 92.15%,a recall of 90.90%,an auc-roc score of 90.9%,and f-score of 91.49%with minimal data pre-processing,data augmentation,finetuning and hyperparameter adjustment in classifying Normal and Pneumonia chests.

Acute Eosinophilic Pneumonia (AEP) Due to Daptomycin: Is Autoimmunity a Clinico-Pathophysiologic Bridge to AEP?

Daptomycin induced acute eosinophilic pneumonia is a rare and potentially life threatening condition characterized by rapid respiratory failure, pulmonary infiltrates and eosinophilia. Risk factors for acute eosinophilic pneumonia include smoking, environmental irritants or inhalants and certain medications such as Daptomycin [1]. In this review of literature, we aim to explore the potential triggers for developing acute eosinophilic pneumonia in patients exposed to Daptomycin. The exact immune mechanism for daptomycin induced AEP is unknown, however the current proposed mechanism describes a T helper 2 lymphocyte response to inactivated daptomycin in the pulmonary surfactant, which leads to eosinophilia. Disordered T regulatory cell function is seen in patients with certain cancers, allergies and autoimmune conditions. We propose that patients with these underlying risk factors may be at increased risk of developing AEP after becoming exposed to Daptomycin. Understanding potential risk factors is crucial for health care workers as it allows them to identify susceptible populations, explore preventative measures and treat accordingly.