Objective: To explore the specificity of Tongli(HT 5) and Xuanzhong(GB 39) paired acupionts in aspects of Deqi sensation and brain activation patterns during electroacupuncture. Methods: In this study, 15 healthy subj...Objective: To explore the specificity of Tongli(HT 5) and Xuanzhong(GB 39) paired acupionts in aspects of Deqi sensation and brain activation patterns during electroacupuncture. Methods: In this study, 15 healthy subjects were enrolled. All participants suffered two kinds of functional magnetic resonance imaging(f MRI) examinations randomly: Examination A received electro-acupuncture(EA) at the bilateral Tongli(HT5) and Xuanzhong(GB 39) acupoints(ACU), and examination B received EA at bilateral non-acupoints(NAP). The subjects reported the feeling of Deqi at each examination later respectively. A multi-voxel pattern analysis method and Statistical Program for Social Sciences were used to analyze the data. Results: The ACU group(Exam A) reported fullness, heaviness, numbness, soreness and throbbing of significantly greater intensity than the NAP group(Exam B). In addition, there was no statistical significance between two groups in aching, tingling, deep pressure, sharp pain, dull pain, warmness and cold. Meanwhile, f MRI data revealed differences between two groups in discriminating accuracy of brain somatosensory cortex and language-related cortices. Conclusion: Needling HT 5 and GB 39 may modulate language function through a complex brain network, suggesting that it may be beneficial to the recovery of language function in patients with aphasia.展开更多
Therapies that complement free radical scavenging are an important approach for treating aging in the brain. In the present study, two formulations of moxa cone moxibustion were applied at acupoints Zusanfi （ST 36） ...Therapies that complement free radical scavenging are an important approach for treating aging in the brain. In the present study, two formulations of moxa cone moxibustion were applied at acupoints Zusanfi （ST 36） and Xuanzhong （GB 39）, and at acupoints Baihui （DU 20） and Guanyuan （RN 4）, in D-galactose-induced senile mice. The results revealed that moxa cone moxibustion improved total superoxide dismutase and Cu/Zn-superoxide dismutase activity in the homogenates of the cerebral tissue, as well as ameliorating deficits in neuronal morphology and neuronal density in the cerebral cortex and hippocampal CA3. Moxa cone moxibustion also enhanced learning and memory functions of senile mice. Moxa cone moxibustion at Zusanli, Xuanzhong, Baihuiand Guanyuan acupoints can thus be used to complement free radical scavengers, with efficacy that is equal to that of electroacupuncture at Zusanliand Xuanzhong, and superior to that of nimodipine treatment.展开更多
基金Supported by the National Natural Science Foundation of China(No.81072768)the New Century Excellent Talents in University of the Ministry of Education of China(No.NCET-11-0603)Capital Featured Clinical Research of Beijing Municipal Science and Technology,China(No.Z131107002213094)
文摘Objective: To explore the specificity of Tongli(HT 5) and Xuanzhong(GB 39) paired acupionts in aspects of Deqi sensation and brain activation patterns during electroacupuncture. Methods: In this study, 15 healthy subjects were enrolled. All participants suffered two kinds of functional magnetic resonance imaging(f MRI) examinations randomly: Examination A received electro-acupuncture(EA) at the bilateral Tongli(HT5) and Xuanzhong(GB 39) acupoints(ACU), and examination B received EA at bilateral non-acupoints(NAP). The subjects reported the feeling of Deqi at each examination later respectively. A multi-voxel pattern analysis method and Statistical Program for Social Sciences were used to analyze the data. Results: The ACU group(Exam A) reported fullness, heaviness, numbness, soreness and throbbing of significantly greater intensity than the NAP group(Exam B). In addition, there was no statistical significance between two groups in aching, tingling, deep pressure, sharp pain, dull pain, warmness and cold. Meanwhile, f MRI data revealed differences between two groups in discriminating accuracy of brain somatosensory cortex and language-related cortices. Conclusion: Needling HT 5 and GB 39 may modulate language function through a complex brain network, suggesting that it may be beneficial to the recovery of language function in patients with aphasia.
文摘目的:探讨电针足少阳经穴在膝关节前交叉韧带(anterior cruciate ligament,ACL)损伤术后康复中的应用价值。方法:纳入膝关节ACL部分损伤患者50例。由同一组医生行膝关节镜下腓骨长肌腱单束ACL重建术,术后第2天开始电针患侧足少阳经的悬钟、阳陵泉、膝阳关、环跳4穴。每天1次,连续治疗6d为1个疗程,2个疗程间隔1d,共治疗6个疗程。比较治疗前及治疗开始后2周、4周、6周时双侧膝关节的被动活动察觉阈值(threshold to detection of passive motion,TTDPM)、关节位置觉(joint position sense,JPS)以及体感诱发电位(somatosensory evoked potentials,SEPs)P40起始潜伏期、波幅和运动神经传导速度(motor nerve conduction velocity,MCV)潜伏期、波幅。结果:①TTDPM。时间因素和分组因素存在交互效应(F=312.586,P=0.000)。双侧膝关节TTDPM总体比较,差异有统计学意义,即存在分组效应(F=406.942,P=0.000)。治疗前后不同时间点间膝关节TTDPM的差异有统计学意义,即存在时间效应(F=334.592,P=0.000)。患侧膝关节TTDPM随时间呈下降趋势(3.57°±0.53°,2.61°±0.47°,2.21°±0.39°,1.92°±0.28°,F=349.201,P=0.000),健侧随时间无明显变化(1.44°±0.10°,1.42°±0.12°,1.40°±0.10°,1.41°±0.07°,F=2.772,P=0.052)。治疗前后各时间点,患侧膝关节TTDPM均较健侧高(t=29.528,P=0.000;t=21.642,P=0.000;t=16.658,P=0.000;t=13.642,P=0.000)。②JPS。时间因素和分组因素存在交互效应(F=201.439,P=0.000)。双侧膝关节JPS总体比较,差异有统计学意义,即存在分组效应(F=532.141,P=0.000)。治疗前后不同时间点间膝关节JPS的差异有统计学意义,即存在时间效应(F=209.843,P=0.000)。患侧膝关节JPS随时间呈改善趋势(4.31°±0.71°,3.62°±0.65°,3.23°±0.60°,2.64°±0.54°,F=211.272,P=0.000),健侧随时间无明显变化(1.49°±0.13°,1.47°±0.11°,1.48°±0.10°,1.47°±0.10°,F=1.333,P=0.277)。治疗前后各时间点,患侧膝关节JPS均较健侧差(t=28.782,P=0.000;t=23.278,P=0.000;t=20.698,P=0.000;t=15.864,P=0.000)。③SEPsP40起始潜伏期。时间因素和分组因素存在交互效应(F=740.633,P=0.000)。双侧膝关节SEPsP40起始潜伏期总体比较,差异有统计学意义,即存在分组效应(F=12153.958,P=0.000)。治疗前后不同时间点间膝关节SEPsP40起始潜伏期的差异有统计学意义,即存在时间效应(F=817.474,P=0.000)。患侧膝关节SEPsP40起始潜伏期随时间呈缩短趋势[(49.23±1.95)ms,(43.87±1.81)ms,(38.33±1.91)ms,(34.68±1.39)ms,F=1406.798,P=0.000],健侧随时间无明显变化[(30.78±0.92)ms,(30.42±1.15)ms,(30.41±0.98)ms,(30.39±1.10)ms,F=1.680,P=0.173]。治疗前后各时间点,患侧膝关节SEPsP40起始潜伏期均较健侧长(t=64.829,P=0.000;t=51.154,P=0.000;t=26.471,P=0.000;t=18.256,P=0.000)。④SEPsP40波幅。时间因素和分组因素存在交互效应(F=540.382,P=0.000)。双侧膝关节SEPsP40波幅总体比较,差异有统计学意义,即存在分组效应(F=1309.833,P=0.000)。治疗前后不同时间点间膝关节SEPsP40波幅的差异有统计学意义,即存在时间效应(F=619.578,P=0.000)。患侧膝关节SEPsP40波幅随时间呈增高趋势[(1.36±0.10)mv,(1.67±0.11)mv,(1.83±0.10)mv,(1.97±0.09)mv,F=926.454,P=0.000],健侧随时间无明显变化[(2.27±0.08)mv,(2.29±0.09)mv,(2.28±0.06)mv,(2.29±0.07)mv,F=2.258,P=0.084]。治疗前后各时间点,患侧膝关节SEPsP40波幅均较健侧低(t=-69.500,P=0.000;t=-42.342,P=0.000;t=-30.748,P=0.000;t=-22.211,P=0.000)。⑤MCV潜伏期。时间因素和分组因素存在交互效应(F=647.733,P=0.000)。双侧膝关节MCV潜伏期总体比较,差异有统计学意义,即存在分组效应(F=828.428,P=0.000)。治疗前后不同时间点间膝关节MCV潜伏期的差异有统计学意义,即存在时间效应(F=673.718,P=0.000)。患侧膝关节MCV潜伏期随时间呈缩短趋势[(20.63±1.37)ms,(17.94±1.49)ms,(16.67±1.30)ms,(14.36±0.99)ms,F=866.063,P=0.000];健侧随时间无明显变化[(12.27±0.39)ms,(12.24±0.44)ms,(12.22±0.49)ms,(12.21±0.39)ms,F=0.282,P=0.839]。治疗前后各时间点,患侧膝关节MCV潜伏期均较健侧长(t=44.622,P=0.000;t=26.899,P=0.000;t=27.612,P=0.000;t=15.341,P=0.000)。⑥MCV波幅。时间因素和分组因素存在交互效应(F=2208.831,P=0.000)。双侧膝关节MCV波幅总体比较,差异有统计学意义,即存在分组效应(F=3582.216,P=0.000)。治疗前后不同时间点间膝关节MCV波幅的差异有统计学意义,即存在时间效应(F=2362.807,P=0.000)。患侧膝关节MCV波幅随时间呈增高趋势[(3.76±0.10)mv,(4.26±0.13)mv,(4.58±0.11)mv,(4.78±0.09)mv,F=4397.711,P=0.000],健侧随时间无明显变化[(5.23±0.07)mv,(5.24±0.06)mv,(5.23±0.06)mv,(5.24±0.05)mv,F=2.144,P=0.098]。治疗前后各时间点,患侧膝关节MCV波幅均较健侧低(t=-171.500,P=0.000;t=-63.024,P=0.000;t=-48.938,P=0.000;t=-40.251,P=0.000)。结论:对于膝关节ACL部分损伤患者,在ACL重建术后采用电针足少阳经穴,膝关节本体感觉可有一定程度的改善,但术后短期内并不能完全恢复。
基金Scientific Research Projects of Education Bureau of Guangxi Zhuang Autonomous Region,No.200710LX022the Natural Science Foundation of Guangxi Zhuang Autonomous Region,No.0832170
文摘Therapies that complement free radical scavenging are an important approach for treating aging in the brain. In the present study, two formulations of moxa cone moxibustion were applied at acupoints Zusanfi （ST 36） and Xuanzhong （GB 39）, and at acupoints Baihui （DU 20） and Guanyuan （RN 4）, in D-galactose-induced senile mice. The results revealed that moxa cone moxibustion improved total superoxide dismutase and Cu/Zn-superoxide dismutase activity in the homogenates of the cerebral tissue, as well as ameliorating deficits in neuronal morphology and neuronal density in the cerebral cortex and hippocampal CA3. Moxa cone moxibustion also enhanced learning and memory functions of senile mice. Moxa cone moxibustion at Zusanli, Xuanzhong, Baihuiand Guanyuan acupoints can thus be used to complement free radical scavengers, with efficacy that is equal to that of electroacupuncture at Zusanliand Xuanzhong, and superior to that of nimodipine treatment.
