Effect of electroacupuncture at Jiaji (EX-B2) points on the expression of microRNA-21 and neuronal apoptosis in rats with acute spinal cord injury

Objective:To observe the effect of electroacupuncture at Jiaji (EX-B2) points on the expression of microRNA-21 and neuronal apoptosis in rats with acute spinal cord injury. Methods:SD rats were randomly divided into sham-operated group, model group, electro-acupuncture group and methylprednisolone group. The model of acute spinal cord injury was reproduced by modified Allen's method. Each group was given corresponding intervention treatment 2 hours after modeling. The electroacupuncture group was treated with electro-acupuncture at Jiaji (EX-B2) points in T8 to T12, the methylprednisolone group was given intraperitoneal injection of 30 mg/kg methylprednisolone sodium succinate, and the sham operation group and model group were not treated. After treatment, BBB scores were observed to evaluate the motor function of posterior limb in each group, and the injured spinal cord tissues were taken. The pathological changes of spinal cord neuropathy were observed by Nissl staining. The expression of microRNA-21 was detected by RT-qPCR, and the expression of apoptotic proteins (Bax, Bcl-2 and cleaved-Caspase-3) was detected by Western-Blot. Result:Compared with sham operation group, BBB, neuron survival rate and expression of microRNA-21 were significantly lower, apoptotic rate of neurons was significantly higher, expression of Bax, Bcl-2, cleaved Caspase-3 protein and Bax/Bcl-2 ratio were significantly increased in model group (P< 0.05). Electroacupuncture could significantly increase BBB score, neuron survival rate and expression of microRNA-21, reduce apoptotic rate of neurons and the ratio of Bax/Bcl-2, and inhibit the expression of Bax, Bcl-2 and cleaved Caspase-3 protein in tissues, which were significantly different from those of model group (P< 0.05). Conclusions: Electroacupuncture at Jiaji (EX-B2) points can significantly promote the recovery of neurological function in rats after ASCI, and its mechanism may be closely related to the up-regulation of the expression of microRNA-21 in tissues and the inhibition of the activation of Bax/Bcl-2/cleaved Caspase-3 signaling pathway.

THE TREATMENT OF CERVICAL SPONDYLOPATHY BY LASER ACUPUNCTURE AT THE CERVICAL JIAJI POINTS: AN ANALYSIS OF THERAPEUTIC EFFECT OF 102 CASES

Laser acupuncture therapy was employed in the treatment of spondylopathy.Thetherapeutic effect of the three types of the spondylopathy,nerve root type,vertebral artery type andspinal cord type were stuied and compared.The results indicate a significant difference between thethree types of spondylopathy.The best therapeutic effect was obtained in nerve root type with a remarkable effective rate of 98.5％;the effective rates for the vertebral artery type and the spinal cordtype were 92.3％and 25％,respectively.Combining laser irradiatlon with acupuncture,the therapyposseses the functions of acupuncture,heat effect and mild moxibustion action.Therefore,it showedeffect quickly and had the advantages of short treatment course and high therapeutic effect.Clinicalobservation has confirmed that laser acupuncture is more effective than single laser irradiation.Thistherapy offers another simple but effective method for the treatment of spondylopathy.

夹脊电针通过miR-128-3p/ATG12轴干预大鼠脊髓损伤后神经功能的机制研究

目的分析夹脊电针对大鼠脊髓损伤后神经功能的影响,并探讨其可能机制。方法将40只Wistar大鼠随机分为假手术组、模型组、夹脊电针组以及夹脊电针+anta-miR-128-3p组,每组10只。假手术组与模型组不做处理,夹脊电针组给予电针干预(每日1次,每次20 min,连续2周),夹脊电针+anta-miR-128-3p组在末次电针刺激后,尾静脉注射anta-miR-128-3p。干预结束后通过行为学(Basso Beattie Bresnahan,BBB)评分评估大鼠运动功能;苏木素-伊红染色与原位末端标记法染色观察大鼠脊髓病理改变以及凋亡情况;免疫荧光法测定脊髓组织神经元特异性核蛋白(neuron-specific nuclear protein,NeuN)阳性表达;qRT-PCR法检测脊髓组织miR-128-3p、自噬相关蛋白12(autophagy-related protein 12,ATG12)mRNA水平;Western blot法检测ATG12蛋白表达;双荧光素酶报告基因验证miR-128-3p与ATG12关系。结果假手术组脊髓结构完整,排列整齐;模型组大鼠脊髓结构紊乱,神经元数量减少,存在大量炎性浸润;夹脊电针组脊髓结构紊乱现象有所减轻,炎性浸润减少;与夹脊电针组比较,夹脊电针+anta-miR-128-3p组脊髓损伤加剧;与假手术组比较,模型组大鼠BBB评分、miR-128-3p水平、NeuN阳性神经元数量降低(P<0.05),凋亡率、ATG12 mRNA水平与ATG12蛋白表达升高(P<0.05);夹脊电针组大鼠BBB评分、miR-128-3p水平、NeuN阳性神经元数量高于模型组(P<0.05),凋亡率、ATG12 mRNA水平与ATG12蛋白表达低于模型组(P<0.05);与夹脊电针组比较,夹脊电针+anta-miR-128-3p组大鼠BBB评分、miR-128-3p水平、NeuN阳性神经元数量降低(P<0.05),凋亡率、ATG12 mRNA水平与ATG12蛋白表达升高(P<0.05);miR-128-3p与ATG12靶向结合。结论夹脊电针可能通过调控miR-128-3p/ATG12轴,改善脊髓损伤大鼠神经功能损伤。

电针夹脊穴联合祛风骨痛凝胶膏治疗2型糖尿病足气虚血瘀证临床研究

目的:观察电针夹脊穴联合祛风骨痛凝胶膏治疗2型糖尿病足气虚血瘀证患者的临床效果。方法:选择2型糖尿病足气虚血瘀证患者80例,以随机数字表法分为对照组(n=40)、治疗组(n=40)。治疗组采用电针夹脊穴联合祛风骨痛凝胶膏治疗;对照组应用电针夹脊穴治疗。比较两组患者临床症状积分、血液流变学指标、微循环血流情况。结果:治疗组的总有效率92.50%高于对照组的总有效率87.50%,差异有统计学意义(P<0.05)。治疗4周后,两组患者皮肤温度、疼痛程度、麻木程度、皮肤色泽、间歇性跛行距离的积分均较治疗前降低,且治疗组低于对照组,差异有统计学意义(均P<0.05)。治疗组血液流变学指标低于对照组,两组足背温度、温控血流、阻断后反应性充血、经皮氧分压均高于治疗前,且治疗组高于对照组,差异有统计学意义(均P<0.05)。结论:电针夹脊穴联合祛风骨痛凝胶膏能有效改善2型糖尿病足气虚血瘀证患者的临床症状,降低血液黏度,改善微循环血流状态,临床应用安全、作用持久。

针刺开音1号穴配合颈夹脊穴治疗声带小结25例临床观察

【目的】观察针刺开音1号穴配合颈夹脊穴治疗声带小结的临床疗效。【方法】将47例声带小结患者随机分为治疗组25例和对照组22例。治疗组以针刺开音1号穴配合颈夹脊穴3-5为主治疗,对照组以口服金嗓散结丸治疗。2组均以20 d为1个疗程。观察2组的临床疗效及安全性。【结果】治疗后治疗组愈显率为56.00%,对照组为36.36%,2组比较差异有显著性意义（P〈0.05）。治疗组患者治疗后的症状积分有明显改善（与治疗前比较,P〈0.05）;对照组治疗后的症状积分也有所改善,但与治疗前比较差异无显著性意义（P（0.05）。2组治疗后比较差异有显著性意义（P〈0.05）,说明治疗组对症状积分的改善作用明显优于对照组。2组病例均未出现任何不良反应。【结论】针刺开音1号穴配合颈夹脊穴为主治疗声带小结是临床安全有效的治法。

温针灸治疗稳定期慢性阻塞性肺疾病的疗效观察

目的基于冬病夏治理论,观察三伏天温针灸夹脊穴治疗稳定期慢性阻塞性肺疾病的临床疗效。方法将符合纳入标准的60例稳定期慢性阻塞性肺疾病患者随机分为对照组和治疗组,每组30例。对照组予穴位贴敷治疗,治疗组在对照组穴位贴敷治疗基础上予温针灸夹脊穴治疗。比较两组治疗后3个月和治疗后6个月的临床疗效和患者症状加重次数。观察两组治疗前、治疗后3个月和治疗后6个月慢阻肺评估测试问卷评分(chronic obstructive pulmonary disease assessment test,CAT)评分的变化。结果治疗后3个月,治疗组总有效率为93.3%,高于对照组的73.3%,差异具有统计学意义(P<0.05)。治疗后6个月,两组总有效率比较,差异无统计学意义(P>0.05)。治疗后3个月和治疗后6个月,两组CAT评分和患者症状加重次数均低于同组治疗前(P<0.05),且治疗组均低于对照组(P<0.05)。结论在穴位贴敷基础上,三伏天温针灸夹脊穴治疗稳定期慢性阻塞性肺疾病可降低患者6个月内症状加重次数,改善咳嗽、咳痰和胸闷症状,提高临床疗效。

皮肤针治疗带状疱疹后遗神经痛研究进展

带状疱疹后遗神经痛(postherpetic neuralgia,PHN)病位在皮部,主要累及肝、脾二脏,久则及肾。其发生涉及内、外两个因素,内因有年老体弱、素体亏虚、正气不足、情志内伤、饮食不节等,外因则与外感火毒湿热时邪有关。其病机有虚实两种,实为肝经湿热火毒蕴积与血气搏结,造成局部气血凝滞,经脉瘀阻不通,脏腑气机不畅则痛;虚为正气虚弱,无力抗邪,外感火毒之邪后,余邪未尽日久化火,耗伤阴血,阴血亏虚不能濡养肌肤经脉,不荣则痛。故该病治疗需要兼顾内外虚实,以扶正祛邪、理气活血、通络止痛为主。皮肤针治疗PHN可因势利导、诱邪外出,既能活血祛瘀、通络止痛,又可振奋经气、调节脏腑,常用治疗方法有:皮肤针放血、皮肤针联合普通针刺、皮肤针联合灸法、皮肤针联合中药、皮肤针联合西药等。皮肤针治疗PHN,临床叩刺部位选择主要为局部叩刺,其次是阿是穴、夹脊穴的穴位叩刺。目前,皮肤针治疗PHN的临床研究仍存在以下问题:观察的样本量较小,缺乏多中心、大样本研究;疗效评价以观察性指标为主,缺乏实验室指标观察,实验结果主观性较强,缺乏客观真实性;临床应用型研究多,基础理论型研究少;PHN易复发,病程迁延时间长,部分临床研究仅关注近期疗效,缺少后期随访;治疗主要以缓解疼痛为主,缺乏对患者的心理疏导。建议加强皮肤针治疗PHN的基础研究,注重客观疗效标准,同时注意后期随访及心理疏导,设计更为严谨的科研方案。

Effectiveness of electroacupuncture at Jiaji acupoints(EX-B 2), plus moxibustion and intermediate on postherpetic neuralgia: a randomized controlled trial

OBJECTIVE:To investigate the effectiveness of electroacupuncture at Jiaji acupoints(EX-B 2)plus moxibustion and intermediate frequency on postherpetic neuralgia(PHN).METHODS:A total of 140 outpatients who satisfied the inclusion criteria and volunteered for this treatment were randomly divided into treatment(n=70)and control(n=70)groups.Both groups received a localized lesion area and electroacupuncture treatment combined with moxibustion and intermediate frequency.The treatment group(TG)increased acupuncture at Jiaji acupoints(EX-B 2)and electroacupuncture.Pain and anxiety were assessed before and after 5,10,15,and 20 treatments by using visual pain simulation score(VAS)and Hamilton anxiety scale(HAMA),respectively.Clinical efficacy was also evaluated.RESULTS:The baseline between the two groups did not significantly differ(P>0.05).The VAS and HAMA scores of the two groups after treatment significantly decreased compared with those of various treatment stages(P>0.05).The HAMA score(P<0.01)of TG was lower than that of the control group(CG).The VAS score of TG was lower than that of CG in the 5th and 10th treatments(P<0.01).In the 15 th and 10 th scores,CG was also superior to TG(P<0.05).CONCLUSION:The combined treatment of electroacupuncture at Jiaji acupoints(EX-B 2),moxibustion,and intermediate frequency can relieve the pain and anxiety symptoms of PHN.The efficacy of the combined treatment was superior to traditional acupuncture.

Treatment of 100 Cases of Cervical Spondylotic Radiculopathy by Electroacupuncture of Jiaji(Ex-B2)plus Oblique Needling Ashi Point

Summary： One hundred patients were diagnosed with cervicalspondylotic radiculopathy definitely by symptoms, signs and Xray examination. The therapeutic method was acupuncture of Jiaji（Ex-B 2） on the affected segment and the upper and lower vertebrae close together. After the arrival of qi, the needles were connected to acupuncture therapeutic instrument. Meanwhile, the numb, heavy and uncomfortable area on the shoulder and upper limb, where something like cord could be touched, was selected as Ashi point. The needle was inserted perpendicularly into the skin on the place that the cord was most obvious and inserted obliquely and deeply along the cord. After 3 4 courses of treatment, 90 cases got marked effectiveness and 10 cases got effectiveness.

Clinical observation on acupuncture at Jiaji(EX-B 2) points plus tuina in treating thoracic facet joint disorder

Objective： To observe the clinical effects of acupuncture at Jiaji （EX-B 2） points plus tuina manipulation for thoracic facet joint disorder, and get new clinical evidence for treatment of thoracic facet joint disorder. Methods： Totally 106 patients with thoracic facet joint disorder were randomly allocated into an observation group and a control group based on the random number table. Patients in the control group were treated by tuina manipulation, while those in the observation group were treated by acupuncture at Jiaji （EX-B 2） points before tuina manipulation. Patients in the two groups were treated once a day. The improvements of signs and symptoms and the efficacy were observed after 3 treatments. Results： After treatment, there were intra-group statistical differences in scores of 8 signs and symptoms in both groups （P〈0.01}; the score of each item in the observation group was lower than that in the control group, and there was statistical significance in the inter-group difference （P〈0.05）. The cure rate of the observation group was 50.9%, versus 26.4% in the control group, and there was a significant difference between the two groups （P〈0.05）. Conclusion： In treating thoracic facet joint disorder, acupuncture plus tuina manipulation can restore the biomechanical balance of thoracic vertebrae, fully maximized the combined effect, and significantly improve the clinical efficacy.

Acupuncture-moxibustion at Jiaji(EX-B 2) points for intervertebral disc herniation: a systematic review

By organizing and classifying the literatures related to acupuncture-moxibustion at Jiaji （EX-B 2） points in treating intervertebral disc herniation （IDH） published before December 32, 2013, to summarize the application status and features of Jiaji （EX-B 2） points. It＇s found that its most favorable indication is IDH. It also further analyzed the action mechanism of acupuncture-moxibustion at Jiaji （EX-B 2） points in treating IDH, and brought up some ideas to highlight the further study.

Observation on Therapeutic Effects of Electroacupuncture at Jiaji (Ex-B 2) Points plus Herbal Medicine for Herpes Zoster

Objective： To observe the clinical effects of electroacupuncture （EA） at Jiaji （Ex-B 2） points plus herbal medicine for herpes zoster （HZ）. Methods： Sixty-two cases were randomly divided into a treatment group and a control group. The treatment group was treated with EA at Jiaji （Ex-B 2） points plus herbal medicine based upon the pattern differentiation. The control group was treated with oral administration of Aciclovir tablets for resisting virus, and Mecobalamin tablets for nourishing the nerves and Aciclovir cream for skin rash. The therapeutic effects were compared between the two groups, after two-week treatment Results： After 7 d of the treatment, the therapeutic effect was remarkably better in the treatment group than that in the control group （P〈0.01）. After two-week treatment, the therapeutic effects were still different between the two groups （P〈0.05）. Conclusion： The therapeutic effect of EA at Jiaji （Ex-B 2） points plus herbal medicine for HZ is better than that of Western medications in resisting virus and nourishing nerves.

夹脊穴电针治疗对急性脊髓损伤大鼠microRNA-21及其介导的神经元凋亡的影响

目的:观察夹脊穴电针治疗对急性脊髓损伤大鼠miR-21的表达及其介导的神经元凋亡的影响。方法:SD大鼠随机分为假手术组、模型组、电针组和甲强龙组,通过改良版Allen's打击法复制急性脊髓损伤大鼠模型。各组于造模后2 h给予相应的干预治疗,其中电针组予胸8~胸12夹脊穴电针治疗,甲强龙组给予甲泼尼龙琥珀酸钠30 mg/kg腹腔注射,假手术组和模型组不予处置。分别观察各组大鼠治疗后肢体运动功能评分,并取损伤节段脊髓组织,通过Nissl染色观察脊髓神经病理形态的改变,RT-qPCR法检测组织中miR-21的表达水平,Western-Blot法检测组织中凋亡蛋白(Bax、Bcl-2和cleaved-Caspase-3)的表达丰度。结果:与除假手术组相比,模型组术后BBB、神经元存活率和组织中miR-21的表达水平明显低,神经元凋亡率明显增高,组织中Bax、Bcl-2、cleaved Caspase-3蛋白的表达及Bax/Bcl-2的比值均明显增加,差异均具有统计学意义(P<0.05);夹脊穴电针治疗能够明显升高ASCI大鼠术后BBB评分、神经元存活率和组织中miR-21的表达,降低神经元凋亡率和Bax/Bcl-2的比值,抑制组织中Bax、Bcl-2、cleaved Caspase-3蛋白的表达,与模型组比较,差异均具有统计学意义(P<0.05)。结论:夹脊穴电针治疗可明显促进SCI后小鼠神经功能的恢复,其作用机制可能与其上调组织中miR-21的表达进而抑制Bax/Bcl-2/cleaved Caspase-3信号通路的活化密切相关。

针刺夹脊穴为主治疗2型糖尿病胃轻瘫的临床观察

目的:针刺夹脊穴为主治疗2型糖尿病胃轻瘫(DGP)的临床效果。方法:选取2015年3月至2016年2月汕头潮阳区大峰医院60例2型糖尿病胃轻瘫患者,随机分为观察组和对照组,每组各30例。对照组接受莫沙必利口服,观察组接受T5～T12夹脊穴为主穴的针刺治疗,疗程为30 d。以疗效指数、症状积分改善情况和不良反应为观察指标,并进行统计学处理。结果:(1)经治疗后,观察组总有效率达100.0%,对照组达93.3%,两组比较,差异具有统计学意义(P<0.05)。(2)两组患者治疗后餐后饱胀不适、早饱、上腹痛、上腹烧灼感的症状积分和症状总积分较治疗前显著改善,差异具有统计学意义(P<0.05);且治疗后两组患者上腹痛、上腹烧灼感症状积分和总症状积分比较,差异具有统计学意义(P<0.05)。(3)观察组中,3例患者先后出现针刺穴位处血肿,未经处理,血肿自行吸收,其余未见不良反应。结论:以夹脊穴为主穴的针刺疗法对DGP有较好的近期效果,可以明显减轻患者的症状,特别对症状上腹痛和上腹烧灼感的改善,优于莫沙必利。

TREATMENT OF 29 CASES OF LUMBAR INTERVETEBRAL DISC PROTRUSION WITH GINGER-SEPARATED MOXIBUSTION

: To observe the effect of ginger-separated moxibustion for treatment of lumbar intervertebral disc prolapse. Methods: 29 lumbar intervertebral disc protrusion patients including 21 males and 8 females were treated with ginger-separated moxibustion of Ashi-point and Jiaji (EX-B 2 , the affected region), 5-6 cones every time, once every other day, continuously for 5 times. Then the therapeutic effect was analyzed. Results: After treatment, of the 29 cases, 23(79.3%) were cured, and the rest 6(20.7%) experienced improvement. Conclusion: Ginger-separated moxibustion is fairly effective and safe in treatment of lumbar intervertebral disc protrusion.

Intractable post-herpetic neuralgia in the trunk treated with point injection at Jiájǐ(夹脊 EX-B 2)

ABSTRACT Objective To compare the efficacy difference between point injection at Jiiaji （夹脊 EX-B 2） and oral medication in the treatment of intractable post-herpetic neuralgia （PHN） in the trunk. Methods One hundred and thirty cases were randomly divided into an point injection group and an medication group, 65 cases in each one. In point injection group, according to the invasion site of herpes zoster, Jiiaji （夹脊 EX-B 2） of corresponding segments and the meridian points on skin lesion areas, such as Fengchi （风池GB 20）, Tianzhu （天柱 BL 10）, Feishu （肺俞 BL 13） and Geguan （膈关 BL 46） were selected and injected with the mixed solution of compound Betamethasone （administered only in the first injection）, Vitamin B12 and Lidoeaine Carbonate, 2 mL on each point, once per day. In medication group, Diclofenac Sodium sustained release tablets, 75 mg were administered, twice per day. The clinical efficacy was compared 10 days later between two groups. Results The total effective rate in point injection group was 100.0% （65/65）, which was better than 66.1% （43/65） in medication group （P〈0.01）. Conclusion Point injection mainly at Jiiaji （夹脊 EX-B 2） is effective significantly on intractable PHN in the trunk, which is superior to Diclofenac Sodium sustained release tablets.

针刺夹脊穴联合药物治疗脊髓型颈椎病的疗效观察及对颈椎曲度和矢状面参数的影响

目的观察针刺夹脊穴联合药物治疗脊髓型颈椎病的临床疗效及对患者颈椎曲度和矢状面参数的影响。方法回顾性选取行针刺夹脊穴联合常规西药治疗的脊髓型颈椎病患者50例作为观察组,另选取50例行单纯常规西药治疗的脊髓型颈椎病患者作为对照组。比较两组患者一般资料、临床疗效及并发症发生情况。比较两组治疗前和末次随访时疼痛视觉模拟量表(visualanalogscale,VAS)、日本骨科学会(JapaneseOrthopaedic Association,JOA)和颈椎功能障碍指数(neck disability index,NDI)的评分变化。根据影像学检查资料比较两组患者治疗前、治疗后3 d和末次随访时颈椎曲度和矢状面参数的变化。采用受试工作者特征曲线评估各矢状面参数对疗效的评估价值。用随机行走模型比较两组患者各指标改善情况。结果两组患者一般资料比较,差异无统计学意义(P>0.05)。两组末次随访时VAS、JOA和NDI评分较治疗前均有明显改善(P<0.05),且观察组末次随访时上述各项评分均优于对照组(P<0.05)。两组治疗后3 d和末次随访时椎间隙高度、C2~C7 Cobb角、T1倾斜角均较治疗前有明显增加(P<0.05),C2~C7矢状面垂直轴较治疗前明显降低(P<0.05);且观察组治疗后3d和末次随访时的上述指标均优于对照组(P<0.05)。颈椎曲度和矢状面参数联合预测疗效的曲线下面积为0.904[95%CI(0.842~0.923)],高于任何一项参数单独检测。观察组随机行走模型评价的各项指标均优于对照组(P<0.05)。观察组临床疗效优良率高于对照组(P<0.05),治疗后并发症发生率低于对照组(P<0.05)。结论针刺夹脊穴联合西药治疗能有效改善脊髓型颈椎病患者的颈椎曲度及矢状面参数,且临床疗效优于单纯常规西药治疗。

电针颈夹脊穴联合表面肌电生物反馈治疗脑卒中后吞咽障碍的临床观察

【目的】观察电针颈夹脊穴联合表面肌电生物反馈(sEMGBF)治疗脑卒中后吞咽障碍的临床疗效。【方法】将90例脑卒中后吞咽障碍患者随机分为观察组和对照组,每组各45例,对照组给予吞咽康复训练联合sEMGBF治疗,观察组在对照组治疗的基础上,联合电针颈夹脊穴治疗。疗程2个月。治疗2个月后,评价2组临床疗效,观察2组患者治疗前后吞咽障碍分级、舌骨喉复合体运动度的变化情况,以及食管上括约肌(UES)开放状态的情况,比较2组患者治疗前后标准吞咽功能评价量表(SSA)评分和功能性经口摄食量表(FOIS)评分的变化情况。【结果】(1)治疗后,观察组患者的吞咽障碍分级明显低于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的舌骨喉复合体运动度明显改善(P<0.05),且观察组在改善舌骨喉复合体运动度方面明显优于对照组,差异有统计学意义(P<0.05)。(3)观察组UES开放状态的完全开放率为66.67%(30/45),对照组为88.89%(40/45)。观察组完全开放率低于对照组,差异有统计学意义(P<0.05)。(4)治疗后,2组患者的SSA、FOIS评分明显改善(P<0.05),且观察组在改善SSA、FOIS评分方面明显优于对照组,差异有统计学意义(P<0.05)。【结论】电针颈夹脊穴联合sEMGBF治疗脑卒中后吞咽障碍,能够有效改善患者吞咽相关肌肉功能状态,改善患者吞咽功能与预后水平,临床效果显著。

夹脊盘龙针法联合多巴丝肼治疗肝肾不足型帕金森病运动障碍临床研究

目的:观察夹脊盘龙针法联合多巴丝肼治疗肝肾不足型帕金森病运动障碍的临床疗效。方法:采用随机数字表法将102例肝肾不足型帕金森病患者分为对照组、观察组各51例。对照组给予多巴丝肼治疗,观察组在对照组基础上联用夹脊盘龙针法治疗。比较2组治疗前后中医证候评分、Tinetti平衡与步态量表(POMA)评分、Barthel指数、运动神经电生理指标,并评估2组临床疗效及不良反应发生情况。结果:治疗期间,对照组脱落3例,完成研究48例;观察组脱落2例,完成研究49例。治疗后,观察组总有效率87.76%,高于对照组66.67%(P<0.05)。2组治疗后POMA(步态测试、平衡测试)评分、Barthel指数均较治疗前升高(P<0.05),中医证候评分降低(P<0.05);观察组治疗后POMA评分、Barthel指数高于对照组(P<0.05),中医证候评分低于对照组(P<0.05)。治疗后,对照组正中神经、尺神经、胫神经、腓总神经潜伏期较治疗前升高(P<0.05),观察组正中神经、尺神经、胫神经、腓总神经潜伏期降低(P<0.05),且观察组治疗后上述运动神经潜伏期低于对照组(P<0.05)。治疗后,对照组正中神经、尺神经、胫神经、腓总神经波幅较治疗前降低(P<0.05),观察组治疗后正中神经、尺神经、胫神经、腓总神经波幅升高(P<0.05);观察组治疗后上述运动神经波幅高于对照组(P<0.05)。2组均未发生严重不良反应。结论:夹脊盘龙针法联合多巴丝肼治疗肝肾不足型帕金森病疗效确切,能够提高患者运动功能,减轻周围神经损害,安全性高。

Effects of electroacupuncture at “Jiaji ” (EX-B 2) on myocardial apoptosis and the expression of Bcl-2 and Bax in rats with ischemia-reperfusion injury

Objective To explore the protective mechanism of acupuncture on myocardial ischemia-reperfusion injury.Methods Fifty Wistar rats were randomly divided into a sham-operation group,a model group,a Jiaji group,a Neiguan group and a Yanglingquan group,10-rats