Comparison of clinical efficacy of neddle knife at acupoints selected from recent regions along meridians and according to anatomical structures in treating early and middle stage knee osteoarthritis

Objective:To stimulate tenderness points around knee joint in two metholds-corresponding acupoints selected from recent regions along meridians and anatomical structures,to compare the clinical efficacy of neddle knife of to cure early and middle stage knee osteoarthritis.Method:70 patients were randomly(Random Number Tables)divided into test group(acupoints selected from recent regions along meridians,n=35)and control group(anatomical structures,n=35),who were diagnosed as knee osteoarthritis.Observe the VAS(visual analogue scale),Lysholm,WOMAC(the Western Ontario and McMaster Unive rsities Osteoarthritis Index)and ROM(rang of motion)between two groups in first week,first month,third month after treatment.Recording the degree of improvement of knee joint’s pain,dysfunction and symptoms of osteoarthritis and rang of motion.Results:Within groups,the VAS,Lysholm,WOMAC and ROM were obviously different from pre-therapy scores in the third,sixth and twelfth week post-therapy(P<0.05).Between groups no significant difference were observed in the third week post-therapy about VAS,Lysholm,WOMAC scores(P>0.05).However,there were differences in the sixth,twelfth weeks post-therapy(P<0.05);compared with control group,the ROM of test group were difference in the third,sixth,twelfth weeks post-therapy(P<0.05).Conclusion:The clinical efficacy of stimulating corresponding acupoints tenderness points selected from recent regions along meridians to treat early and middle stage knee osteoarthritis was superior to anatomical structures,which can effectively relieve pain,dysfunction,symptoms of osteoarthritis of knee joint and rang of motion.

Similarities and differences between the trigger point of myofascial pain and the traditional meridian points

In recent years,the treatment of myofascial pain trigger point is a relatively popular technology,many people regard it as"Ashi point"in meridian theory,but compared with the traditional meridian theory,the description of myofascial pain trigger point is more intuitive and easier to master.This paper expounds the similarities and differences between myofascial pain trigger point and traditional meridian theory from the aspects of theory,basic research and clinical application,in order to provide a specific idea for the scientific interpretation of meridian phenomenon in traditional Chinese medicine.

Forty-five Cases of Apoplexy Treated by Electroacupuncture at the Points of Yin Meridians

Forty-five cases of apoplexy were treated by electroacupuncture only at the points of Yin Meridians (i.e. the Hand- and Foot-Taiyin Meridians), and the other 30 cases as the controls were treated only at the points of Yang Meridians (i.e. the Hand- and Foot-Yangming Meridians). The total effective rate was 91.1% in the former and 86.7% in the latter, with no statistically significant difference between the two groups, indicating that acupuncture only at the points of Yin-Meridians is also an effective therapy for apoplexy.

Effect of electroacupuncture at pericardium meridian on D‑ser and NMDAR in acute phase of MCAO rats

Objective :To observe the effect of electroacupuncture at pericardium meridian on neurological deficit, D-serine ( D-Ser ) content and NMDAR expression in ischemic brain tissue of rats with middle cerebral artery occlusion ( MCAO ). Methods:A total of 36 SD rats were randomly divided into normal group, sham operation group, model group, EA pericardium meridian group, model+D-Ser group,and EA pericardium meridian+D-Ser group. The MCAO model was prepared by Zea Longa method. The model+D-Ser group and the EA pericardium meridian+D-Ser group were given exogenous D-Ser reagent(160 mg/kg i.p.) 30 minutes after the success of the insertion of the suture. EA pericardium meridian group and EA pericardium meridian+D-Ser group were treated with electroacupuncture for 30 min on the next day. The remaining groups were only bound for 30 min.Behavioral evaluation was performed at 6 h after successful modeling and 2 d after intervention, and then the rats were sacrificed. The content of D-Ser in ischemic brain tissue was measured by liquid chromatography tandem mass spectrometry, and the protein expression of NR1, NR2A and NR2B was detected by Western Blot. Results : Before treatment, compared with the normal group and the sham operation group, the behavioral scores of each group increased after modeling (P<0.05 );Compared with the model group, the behavioral scores of the model+D-Ser group and the EA pericardium meridian+D-Ser group were increased (P<0.05).After treatment, compared with the model group, there was no significant difference in the EA pericardium meridian group (P>0.05),The behavioral scores of the model+D-Ser group and the EA pericardium meridian+D-Ser group were still increased (P<0.05);Compared with the model+D-Ser group, the behavioral score of the EA pericardium meridian+D-Ser group was not statistically significant (P>0.05).Comparison before and after treatment in the group,except for the normal group and the sham operation group, the behavioral scores of each group were slightly increased, and the difference was not statistically significant (P>0.05).Compared with the model group, the content of D-Ser and the protein expression of NR1, NR2A and NR2B in the brain tissue of the model+D-Ser group were significantly increased (P<0.05);The protein expression of NR1, NR2A and NR2B decreased in EA pericardium meridian group (P<0.05);Compared with the model+ D-Ser group, the D-Ser content and the protein expression of NR1, NR2A and NR2B in the EA pericardium meridian+D-Ser group were decreased (P<0.05). Conclusion : EA at pericardium meridian points can reduce the D-Ser content in brain tissue of rats with acute MCAO, regulate the decrease of NR1, NR2A and NR2B protein expression, inhibit the NMDA receptor activity, and play a neuroprotective role.

RESEARCH INTO THE LOW RESISTANCE OF MERIDIAN POINTS AND CLINICAL EXPERIMENTAL OBSERVATION

This thesis has further studied the low resistance of meridian points with a new in-strument called Model TZ-03 of resistance detector for Acupoints. Through experiments and clinicalobservation, the author found that the changes of skin resistances of points are closely related to thechanges of human physiology and pathology. The experiments also show that the factors which influ-ence the results are complicated and changeable in many ways. Therefore, the absolute values of theresistances of points are not precise and stahle f and the ratio of the resistance of bilateral point of thesame name is more re1iable. In healthy people, the resistances of the sarne points on two sides of thebody are similar, and there is much difference of these resistances among people with diseases.

Purines Change at Acupoints along the Pericardium Meridian in Healthy and Myocardial Ischemic Rats

Objective: To quantify the purine concentrations of the acupoints along the pericardium and nonpericardium meridians under healthy and myocardial ischemia conditions to investigate the relationship between acupoint purine change and body functional status in rats.Methods: A total of 70 rats underwent an operation for myocardial ischemia,while 40 of them survived.They were randomly assigned to the following 5 subgroups:Neiguan(PC 6),Quze(PC 3),Tianquan(PC 2),Quchi(LI 11),and Jianyu(LI 15).Simultaneously,another40 healthy rats were also randomized into the same 5 subgroups as the control group.The tissue ?uids at the acupoints were collected by microdialysis for 30 min.Subsequently,the concentration of adenosine triphosphate(ATP),adenosine diphosphate(ADP),adenosine monophosphate(AMP),and adenosine(ADO) were quanti?ed using the high-performance liquid chromatography method.Results: Compared with the healthy group,the ADO at PC 6(P=0.012),PC 3(P=0.038),PC 2(P=0.024),and LI 15(P=0.042) obviously increased in the model group,while no signi?cant difference was observed at LI 11(P=0.201).However,ATP,ADP,and AMP manifested no significant changes in these areas,except for ATP at LI 15(P=0.036).Conclusions: Myocardial ischemia could induce an increase in ADO at acupoints of the upper arm and shoulder area,suggesting that the body functional status could affect the responsiveness of acupoints.The status of these acupoints could be pathogenically activated by disease,and distribution following some speci?c courses.

Treatment of Migraine with Acupuncture at Points Pertaining to the Liver and Gallbladder Channels

In studying the syndrome of yang-hyperactivity, we found that most migraine patients were with hyperactivity of the liver-yang, stagnation of the liver-qiand blood stasis, and stagnation of the liverqi and deficiency of the spleen. To evaluate the needling effects on migraine and to approach its mechanism, we have launched a study in 207 cases since 1997. The results were satisfactory and reported as follows.

Activities of Liquid Crystals in Acupuncture Points

The theory of Meridians is an important part of Traditional Chinese Medicine. Modern science should play its role in analysing and making clear the mystique of the theory. The relation between the activities of liquid crystals in acupuncture points and the regulative actions of Meridians was studied in this paper. The results showed the intimate intrinsic association between them.

Comparative observation of scapulohumeral periarthritis treated with kinetic acupuncture on the distal points of the affected meridians

Objective To compare the clinical therapeutic effects on scapulohumeral periarthritis between kinetic acupuncture on the distal points of the affected meridians and shoulder three-needle therapy.Methods Fifty cases of scapulohumeral periarthritis were randomly divided into an observation group and a control group,25 cases for each.The cases in observation group were treated with kinetic acupuncture on the distal points of the affected meridians.For example,the case of Hand-Taiyin type was treated with Yújì （鱼际 LU 10） and the case of Hand-Yangming type was treated with Hégǔ （合谷 LI 4）,etc.The cases in control group were treated with shoulder three-needle therapy,in which,Jiānqián （肩前 Extral）,Jiānyú （肩髃 LI 15） and Jiānliáo （肩髎 TE 14） were selected;7 days of treatment made one session,totally 2 sessions were required.Results In observation group,the curative rate based on ROM of shoulder joint was 72.0% （18/25）,which was superior to that of 40.0% （10/25） in control group （P0.05）.After treatment,the improvements of McGill SF-MPQ score,VAS and PPI in observation group were all superior to those in control group （all P0.05）.Conclusion The kinetic acupuncture on the distal points of the affected meridians is advantageous at analgesia and motor improvements of shoulder joint in treatment of scapulohumeral periarthritis as compared with shoulder three-needle therapy.

Research on the body surface resistance imbalance degree at yuan-source points of three yin meridians of foot in the patients with primary dysmenorrhea

Objective:To explore whether or not the changes in body surface resistance at yuan-source points of three yin meridians of foot can specifically responds the onset of primary dysmenorrhea(PD) in females of menstrual period and the before and after,so as to provide the evidence for acupoint selection in clinic.Methods:A total of 90 cases of PD were recruited in a PD group and 90 healthy female undergraduates were recruited in a normal group.The yuan-source of points of three yin meridians of foot were selected,i.e.Taibai(太白SP3),Taichong(太冲LR3) and Taixi(太溪KI3).The acupoints for control were Xuehai(血海SP10),the non-special acupoint,Xuanzhong(悬钟GB39),the acupoint not on the relevant meridian,as well as a non-meridian point.Successively,before menstruation,on Day 1 during menstruation and on Day 3 after menstruation,the body surface resistance at the above-mentioned test sites was detected in the participants of two groups each day.The resistance imbalance degree(RID) of the bilateral acupoints was taken as the outcome indicator.The observation lasted one menstrual cycle.Results:(1) Intra-group comparison:at LR3,the RID was lower on Day 1 during menstruation than that before menstruation significantly in the normal group(P ≤0.05).There was no significant change in RID at the same time points,but RID on Day 3 after menstruation was lower significantly than that before menstruation in the PD group(P ≤0.05).At SP3,KI3,SP10,GB39 and sham acupoint,there were no significant differences in RID among different time points within the same group(all P> 0.05).(2) Intergroup comparison:there were no significant differences in RID among different time points at the same point.(all P> 0.05).Conclusion:RID at yuan-source points of three yin meridians of foot cannot specifically respond to PD.However,at LR3,before and after menstruation,RID changes are different between PD patients and healthy female undergraduates,which needs a further study in the future.

Influence of Acupuncture on Microcirculation Perfusion of Pericardium Meridian and Heart in Acute Myocardial Ischemia Model Rats

Objective: To observe the influence of acupuncture on microcirculation perfusion of the pericardium meridian and heart in acute myocardial ischemia(AMI) rats and evaluate whether acupuncture can simultaneously affect the meridians and corresponding viscera. Additionally, acupoints at different meridians were compared and whether they exert the same effects was discussed. Methods: Totally 32 Sprague-Dawley rats were subjected to left anterior descending(LAD) ligation to develop an AMI model.Rats were divided into 4 groups, including AMI, acupuncture Neiguan(PC 6), Lieque(LU 7) and Qiansanli(LI 10) groups(n=8). Eight rats received only thoracotomy(sham-operated group). The rats in the acupuncture groups received manual acupuncture at PC 6, LU 7 and LI 10 acupoints for 15 min, respectively. The microcirculation perfusion of pericardium meridian and heart was monitored by laser speckle perfusion imager(LSPI) before, during and after acupuncture manipulation for 15 min. Subsequently, the perfusion unit(PU)was calculated and analyzed by PSI System. Results: After LAD, compared to pre-acupuncture stage, the heart microcirculation perfusion(HMP) in the AMI group decreased continuously at during-acupuncture(P>0.05) and post-acupuncture stages(P<0.05), and the pericardium meridian microcirculation perfusion(PMP) showed no significant differences at 3 stages(P>0.05). Compared to pre-acupuncture stage, the PMP and HMP in PC 6 group significantly increased during acupuncture manipulation(both P<0.05), and PMP decreased obviously after acupuncture(P<0.05). The PMP in the LU 7 and LI 10 groups were slightly elevated(both P>0.05);however, they were significantly reduced after acupuncture manipulation(both P<0.05). Additionally, HMP of LI 10 group was decreased significantly during acupuncture, especially compared to pre-acupuncture stage(P<0.05). Conclusions: Acupuncture at PC 6 obviously increased the PMP and HMP in AMI rats, and the effects were superior to at LU 7 and LI 10 acupoints. It was further confirmed that acupuncture promoted qi and blood circulation, indicating that acupoint specificity exists and features a meridian-propagated effect.

Mechanism of the acupoints of the governor vessel in treatment of post-stroke depression on the base of the specificity of meridian points

Focusing on the effect specificity of meridian points along the running course of meridian,by taking the treatment of post-stroke depression(PSD)with the acupoints of the governor vessel as an example,the correlation between meridian points and disease was explored.The specific regulatory effect of governor vessel,Baihui(百会GV20)and Shenting(神庭GV24)in physiology and pathology in PSD and the material basis of the specificity effect were analyzed.Finally,the specific relationship between the acupoints of the governor vessel and PSD was explained.

Reflections on the calculation methods of the imbalance degree in the biophysical properties of meridian points

Objective To analyze and compare the features and strengths of different methods for calculating the biophysical properties of meridian points,and thus propose corresponding suggestions to fully achieve the research and application value of biophysical properties of meridian points.Methods We searched and collected the literature on the imbalance of biophysical properties of meridian points between January 1,2005 and March 1,2020 in China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP)and PubMed database,and then analyzed,compared,and summarized the applied methods for calculating the imbalance degree of the biophysical properties of meridian points.Results The current methods for calculating the imbalance degree of the biophysical properties of meridian points are diverse and can be summarized as the following three:direct comparison of the measured values of the left and right namesake points,difference method,and ratio method.The low uniformity of the calculation methods has limited the promotion and application of its research results.Conclusion In future research on the biophysical properties of meridian points,multidisciplinary cooperation in terms of imbalance degree calculation methods,detection instruments,and health data models is necessary to achieve more widely applicable scientific conclusions and more generalized experimental results.

Effect of electroacupuncture at the Pericardium Meridian on the heart function of volunteers with acute hypoxia

Objective： To study the effect of electroacupuncture （EA） at the Pericardium Meridian on the heart function of volunteers with acute hypoxia, and to provide scientific evidence for the acupoints selection along the affected meridian in acupuncture-moxibustion therapy. Methods： Based on a self-control design, eighteen healthy volunteers were recruited in the study. Points from the Pericardium Meridian [Neiguan （PC 6）, Ximen （PC 4）, Quze （PC 3） and Tianquan （PC 2）], non-Pericardium Meridian point [Shousanli （LI 10）], non-meridian and non-acupoint points [1.0-1.5 cm lateral to Neiguan （PC 6） and Ximen （PC 4）, respectively on both sides], and a blank control （only inhaling low-oxygen gas without EA stimulation] were selected to observe, once every week, 10 sessions in total, and only 1 acupoint was observed once. The volunteers inhaled low-oxygen gas mixture （10.8% 02 and 89.2% N2] for 30 min to imitate acute hypoxia. EA was conducted when the gas mixture was inhaled for 10 min and then lasted for 20 min; meanwhile, hemodynamic indexes such as cardiac output （CO）, cardiac index （Cl）, systemic vascular resistance （SVR）, systemic vascular resistance index （SVRI], left cardiac work （LCW], left cardiac work index （LCWl） and heart rate （HR） were recorded on a hemodynamic monitor. Results： EA at the acupoints of Pericardium Meridian significantly down-regulated the increased CO/CI, LCW/LCWl, and HR （P〈0.05）, and significantly up-regulated the decreased SVR/SVRI in hypoxia （P〈0.05）; EA at other meridian acupoints or at non-meridian and non-acupoint points didn＇t produce such effects. Conclusion： EA at the Pericardium Meridian can obviously improve the cardiac hyper-activation caused by acute hypoxia in healthy volunteers.

Mechanisms on Correlation between the Pericardium Meridian and Heart Effects of Electroacupuncture at Neiguan and Other Acupo

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Influence of Different Acupuncture Method on Points Transcutaneous CO_2 Emission

Objective： To observe the influence of transcutaneous CO2 emission （TCE） at points on the meridian or beside the meridian after different stimulations like acupuncture De-qi, sham acupuncture, study the correlation between acupuncture De-qi and local energy metabolism through TCE. Methods： Twenty healthy volunteers （male 8, female 12, average age 29 years old） were selected. Before, during and after five different acupuncture Neiguan （PC 6）, the TCE was measured at Quze （PC 3）, point A [at the lower one fourth of line between Tianquan （PC 2） and Quze （PC 3）] , point B [at the middle of line between Ximen （PC 4） and Quze （PC 3）], point C （2 cm ulnar side point A） and point D （2 cm ulnar side point B） with a high sensitive CO2 instrument （Frewil-Q.F., made in China）. The measure results were compared. Results： The comparison on value of TCE before and after the acupuncture, in Sham acupuncture and shallow acupuncture groups, it increased in all five points; in De-qi acupuncture group, there are significant increase on point A, point B, and Quze （PC 3）, it has statistic significance, but there are no significant increase on point C and D. After Ximen （PC 4） or Daling （PC 7） were pressed to block Neiguan （PC 6）, the value of TCE on Quze （PC 3）, point A and point B were decreased during acupuncture Neignan （PC 6）, and increased after the block was removed, but there was no significant difference. Conclusion： Sham acupuncture has also some effects on body, it can increase energy metabolism of local skin, it may be the reason that shallow acupuncture without qi arriving can obtain clinical efficacy. The operation method of traditional qi arriving acupuncture can increase energy metabolism of relevant meridian skin, mechanical press can reduce this effect.

Comparative study on skin temperature response to menstruation at acupuncture points in healthy volunteers and primary dysmenorrhea patients

OBJECTIVE:To assess skin temperature response to menstruation at acupuncture points in primary dysmenorrhea(PD) patients and healthy volunteers so as to explore acupuncture point specificity in reflecting diseases in the light of skin temperature.METHODS:Fifty-two PD patients and 49 healthy volunteers were recruited.Skin temperature measurements were performed with a skin temperature assessment device at 10 points.Absolute difference between skin temperature of the same point on the left and right side is used as main outcome measure.RESULTS:On the first day of menstruation, when menstrual pain attacking in PD patients, a significant increase in skin temperature difference was detected at Taixi(KI 3) compared with the healthy group(P < 0.01).A significant reduction in skin temperature difference was detected at Taixi(KI 3) in the first day of menstruation compared with those values in the third day after menstruation(P < 0.01)in the healthy group.On the third day after menstruation, a significant reduction in skin temperature difference was found at Zhongdu(LR 6) in PD group compared with the healthy group(P < 0.05).No significant differences of skin temperature were detected at other points(P > 0.05).CONCLUSION:The skin temperature difference at menstruation-relevant points in PD patients did not all change significantly more than those in women without PD.Significant difference was only found in Taixi(KI 3), the Yuan-source point of Kidney meridian.

基于“经脉所过,主治所及”理论探讨阿尔茨海默病的辨经论治

阿尔茨海默病(alzheimer’s disease,AD)是一种中枢神经系统退行性疾病,其治疗是现阶段的研究热点。中医对AD的发病机制和治疗有独到的见解,文章从五脏角度阐述了它的病因病机,从针刺作用方面解释了其治疗原则。针灸在AD的治疗上具有独特的优势和效果,针刺通过调节脏腑经脉的阴阳气血平衡,达到治疗效果,穴位的选择和针法的选取是针灸治疗中的重中之重。文章从“经脉所过,主治所及”理论出发,通过回顾针灸治疗AD的基础和临床研究,探讨了在AD的治疗中所选取的经脉、经脉中的穴位,分析了经脉及穴位的作用机制,同时讨论了在临床AD治疗中各家针法的选穴及中、西医作用原理。希冀通过文章为广大科研工作者提供研究思路,进一步揭示针刺在AD治疗中的深层作用原理,以期为临床治疗AD提供一定的参考依据,寻找可能具有真正改善疾病的治疗方法。

经筋透刺法联合穴位注射治疗顽固性面瘫60例临床观察

目的探讨经筋透刺法联合穴位注射治疗顽固性面瘫的临床疗效。方法选取2020年5月至2021年10月在遂宁市中医院接受治疗的120例顽固性面瘫病人,采用随机数字表法随机分为单一组(60例)和联合组(60例),两组病人均给予常规西药治疗,单一组在此基础上给予穴位注射,联合组在此基础上给予经筋透刺法联合穴位注射,比较两组病人治疗前后面神经功能、神经生长因子(NGF)和胶质细胞源性神经营养因子(GDNF)水平、神经功能分级(H-B)评分、面瘫Portmann评分、Sunnybrook量表、复发率及临床疗效。结果单一组和联合组治疗后面神经功能明显改善,且联合组面神经功能改善情况明显优于单一组(P<0.05);单一组H-B评分治疗后较治疗前降低(2.63±0.54)分比(4.01±0.73)分,联合组(1.67±0.49)分比(4.03±0.71)分(P<0.05),且联合组H-B评分低于单一组(P<0.05),单一组和联合组GDNF(12.16±3.33)mg/L比(8.92±1.35)mg/L、(15.54±3.42)mg/L比(8.89±1.37)mg/L、NGF水平(12.16±3.33)mg/L比(8.92±1.35)mg/L、(15.54±3.42)mg/L比(8.89±1.37)mg/L、面瘫Portmann评分(15.31±1.03)分比(6.69±0.68)分、(17.24±1.16)分比(6.72±0.71)分、Sunnybrook量表评分(69.16±10.67)分比(36.42±10.17)分、(78.64±11.56)分比(36.17±10.13)分治疗后较治疗前升高,且联合组GDNF、NGF水平、面瘫Portmann评分、Sunnybrook量表评分高于单一组(P<0.05);联合组总复发率(3.33%)低于单一组(13.33%)(P<0.05);联合组总有效率(90.00%)明显高于单一组(75.00%)(P<0.05)。结论经筋透刺法联合穴位注射可改善顽固性面瘫病人临床症状及面神经功能,疗效较好且复发率较低。

电针心经/心包经对阿尔茨海默病模型大鼠记忆能力及Aβ1-42蛋白表达的影响

目的:探讨电针心经/心包经对阿尔茨海默病大鼠学习记忆能力及心脏HO-1、Aβ1-42表达的影响。方法:选用SD大鼠35只,随机分为正常组、假手术组、模型组、心包经组、心经组,每组7只。分别对模型组、心包经组、心经组大鼠采用双侧海马内注射0.9%氯化钠溶液和Aβ1-42法建立AD模型。成模后对心包经组、心经组进行电针干预,正常组、假手术组、模型组捆绑处理,不进行电针刺激。治疗结束后运用Morris水迷宫检测大鼠学习记忆能力、HE染色法观察大鼠心肌组织病理改变、免疫组化法和免疫印迹法检测大鼠心肌HO-1和Aβ1-42蛋白表达情况。结果:假手术组各项指标与正常组比较,差异无统计学意义(均P>0.05)。与假手术组比较,模型组大鼠的逃避潜伏期明显延长,第二象限百分比、跨越平台次数减少,差异有统计学意义(均P<0.05)。心肌纤维排列紊乱,炎症反应明显,HO-1蛋白表达下调,而Aβ1-42蛋白表达增加,差异有统计学意义(均P<0.05)。与模型组比较,心经组、心包经组大鼠各项异常指标均得到改善,差异有统计学意义(均P<0.05)。与心经组比较,心包经组的逃避潜伏期缩短,第二象限百分比和跨越平台次数增加,差异有统计学意义(均P<0.05)。心经组HO-1与Aβ1-42蛋白表达与心包经组比较,差异无统计学意义(P>0.05)。结论:电针心经/心包经可改善阿尔茨海默病大鼠空间学习记忆能力,其作用机制可能与上调HO-1表达,减轻Aβ1-42神经毒性损伤有关。