The lethal dose LD<sub>50</sub> represents the most important experimental value for acute toxicity. The simple logarithmic calculation of -log<sub>10</sub> LD<sub>50</sub> = value ...The lethal dose LD<sub>50</sub> represents the most important experimental value for acute toxicity. The simple logarithmic calculation of -log<sub>10</sub> LD<sub>50</sub> = value leads to the possible poison power pLD. As with the pH or pK value, respectively, for acid or the scale of earthquake intensities the logarithm helps making large differences of orders of magnitude easier to understand since they are more comparable. The higher the pLD value, the higher is the power of poison. An increase of the pLD value by 1 stands for a tenfold increase in toxicity. The lethal acute dose for water, one of the most important and at the same time non-toxic substances of all, is about one tenth of the body weight. This leads to a possible pLD value for water of 1, an ideal starting value for a logarithmic poison scale.展开更多
Objective:To study the value of some biochemical indicators and Peradeniya Organophosphate Poisoning scale in prediction and prognosis of organophosphorus poisoning.Methods:This was a hospital-based prospective,observ...Objective:To study the value of some biochemical indicators and Peradeniya Organophosphate Poisoning scale in prediction and prognosis of organophosphorus poisoning.Methods:This was a hospital-based prospective,observational study.Various biochemical tests viz.complete blood count,random blood sugar,liver and renal function tests,creatine phosphokinase,and electrolytes were performed.Patients were assessed based on the Peradeniya Organophosphate Poisoning scale.All the patients were followed till the end point like recovery/death.Results:Out of the 100 patients,72%were males and 28%were females.The majority of the patients were farmers and 21 to 30 years of age.Suicidal was the most common manner(92,92%).Based on the Peradeniya Organophosphate Poisoning scale,47%were mild,34%moderate,and 19%severe.Serum creatinine,creatine phosphokinase,serum glutamic-oxaloacetic transaminase,serum glutamic pyruvic transaminase,and alkaline phosphatase levels showed a significant correlation with severity.Conclusions:Some biochemical indicators such as creatine phosphokinase,alkaline phosphatase can be used as prognostic markers of organophosphorus poisoning.The Peradeniya Organophosphate Poisoning scale can be used for assessing severity of the poisoning.展开更多
It has been shown that farmers with limited knowledge of the use and safe handling of pesticides may suffer exposure which results in adverse health effects. In Buea, Cameroon, small-scale tomato farmers commonly use ...It has been shown that farmers with limited knowledge of the use and safe handling of pesticides may suffer exposure which results in adverse health effects. In Buea, Cameroon, small-scale tomato farmers commonly use pesticides for pest control. Information was obtained from these tomato farmers to determine the extent and types of their pesticide use, their knowledge of pesticide use and effectiveness, and their perception of potential harm resulting from pesticide use. A standardized questionnaire, interviews, field observations and an analytical ranking game were used to describe the pesticide use of 93 tomato farmers. Many farmers (47.6%) used pyrethiod and organophosphorus insecticides and identified these chemicals as the most effective in pesticide control;these are WHO Class II pesticides which are the most hazardous to humans. Most farmers (83.8%) used knapsack sprayers to apply pesticides, with 76.3% using no or partial personal protective equipment (PPE). It was notable that 55.5% of farmers expressed no concern regarding the wind direction (pesticide drift) during spraying. The results showed a significant association between the method of pesticides application and farm size (P < 0.001). Most farmers (85.0%) reported at least one symptom of acute pesticide poisoning following spraying. This study revealed that the tomato farmers have a high exposure to pesticides secondary to inadequate knowledge of the safe and judicious use of pesticides. Strategies that provide training on the appropriate use of pesticides, how to reduce exposure to and health risks of pesticides and alternative options of pest management and control are required. The study also raised concerns that further control of the sale and distribution of pesticides may be indicated.展开更多
目的探讨医用三氧自体血回输治疗急性一氧化碳中毒迟发性脑病(delayed encephalopathy after acute carbon monoxide poisoning DEACMP)的临床疗效。方法将符合入组标准的46例DEACMP患者随机分为两组,分别为治疗组(医用三氧自体血回输疗...目的探讨医用三氧自体血回输治疗急性一氧化碳中毒迟发性脑病(delayed encephalopathy after acute carbon monoxide poisoning DEACMP)的临床疗效。方法将符合入组标准的46例DEACMP患者随机分为两组,分别为治疗组(医用三氧自体血回输疗法+传统治疗方法)和对照组(传统治疗方法),各23例。对两组患者治疗前、治疗2周及3个月进行脑电图检查、简易智能状态检查量表(Mini-mental State Examination MMSE)评分和日常生活能力评定量表(Acticity of Daily Living Scale ADL)评分。结果入院时,两组患者的脑电图评分、MMSE评分、ADL评分差异无统计学意义(P>0.05)。入院后2周、3个月,治疗组较对照组的脑电图评分减低,MMSE评分和ADL评分增高,且差异有统计学意义(P<0.05)。结论三氧自体血回输疗法有助于提高DEACMP患者认知能力及日常生活能力,可减轻脑电图的异常程度。展开更多
文摘The lethal dose LD<sub>50</sub> represents the most important experimental value for acute toxicity. The simple logarithmic calculation of -log<sub>10</sub> LD<sub>50</sub> = value leads to the possible poison power pLD. As with the pH or pK value, respectively, for acid or the scale of earthquake intensities the logarithm helps making large differences of orders of magnitude easier to understand since they are more comparable. The higher the pLD value, the higher is the power of poison. An increase of the pLD value by 1 stands for a tenfold increase in toxicity. The lethal acute dose for water, one of the most important and at the same time non-toxic substances of all, is about one tenth of the body weight. This leads to a possible pLD value for water of 1, an ideal starting value for a logarithmic poison scale.
文摘Objective:To study the value of some biochemical indicators and Peradeniya Organophosphate Poisoning scale in prediction and prognosis of organophosphorus poisoning.Methods:This was a hospital-based prospective,observational study.Various biochemical tests viz.complete blood count,random blood sugar,liver and renal function tests,creatine phosphokinase,and electrolytes were performed.Patients were assessed based on the Peradeniya Organophosphate Poisoning scale.All the patients were followed till the end point like recovery/death.Results:Out of the 100 patients,72%were males and 28%were females.The majority of the patients were farmers and 21 to 30 years of age.Suicidal was the most common manner(92,92%).Based on the Peradeniya Organophosphate Poisoning scale,47%were mild,34%moderate,and 19%severe.Serum creatinine,creatine phosphokinase,serum glutamic-oxaloacetic transaminase,serum glutamic pyruvic transaminase,and alkaline phosphatase levels showed a significant correlation with severity.Conclusions:Some biochemical indicators such as creatine phosphokinase,alkaline phosphatase can be used as prognostic markers of organophosphorus poisoning.The Peradeniya Organophosphate Poisoning scale can be used for assessing severity of the poisoning.
文摘It has been shown that farmers with limited knowledge of the use and safe handling of pesticides may suffer exposure which results in adverse health effects. In Buea, Cameroon, small-scale tomato farmers commonly use pesticides for pest control. Information was obtained from these tomato farmers to determine the extent and types of their pesticide use, their knowledge of pesticide use and effectiveness, and their perception of potential harm resulting from pesticide use. A standardized questionnaire, interviews, field observations and an analytical ranking game were used to describe the pesticide use of 93 tomato farmers. Many farmers (47.6%) used pyrethiod and organophosphorus insecticides and identified these chemicals as the most effective in pesticide control;these are WHO Class II pesticides which are the most hazardous to humans. Most farmers (83.8%) used knapsack sprayers to apply pesticides, with 76.3% using no or partial personal protective equipment (PPE). It was notable that 55.5% of farmers expressed no concern regarding the wind direction (pesticide drift) during spraying. The results showed a significant association between the method of pesticides application and farm size (P < 0.001). Most farmers (85.0%) reported at least one symptom of acute pesticide poisoning following spraying. This study revealed that the tomato farmers have a high exposure to pesticides secondary to inadequate knowledge of the safe and judicious use of pesticides. Strategies that provide training on the appropriate use of pesticides, how to reduce exposure to and health risks of pesticides and alternative options of pest management and control are required. The study also raised concerns that further control of the sale and distribution of pesticides may be indicated.
文摘目的探讨医用三氧自体血回输治疗急性一氧化碳中毒迟发性脑病(delayed encephalopathy after acute carbon monoxide poisoning DEACMP)的临床疗效。方法将符合入组标准的46例DEACMP患者随机分为两组,分别为治疗组(医用三氧自体血回输疗法+传统治疗方法)和对照组(传统治疗方法),各23例。对两组患者治疗前、治疗2周及3个月进行脑电图检查、简易智能状态检查量表(Mini-mental State Examination MMSE)评分和日常生活能力评定量表(Acticity of Daily Living Scale ADL)评分。结果入院时,两组患者的脑电图评分、MMSE评分、ADL评分差异无统计学意义(P>0.05)。入院后2周、3个月,治疗组较对照组的脑电图评分减低,MMSE评分和ADL评分增高,且差异有统计学意义(P<0.05)。结论三氧自体血回输疗法有助于提高DEACMP患者认知能力及日常生活能力,可减轻脑电图的异常程度。
