Mechanism of disintegrant action of polacrilin potassium: Swelling or wicking?

The effect of particle size,pH of medium,and presence of lubricant on the swelling behaviour,water uptake properties and disintegrant performance of polacrilin potassium was examined.Particle size did not affect the bulk swelling of disintegrant particles when measured as settling volume,but increased the water uptake and decreased the disintegration time of tablets containing this disintegrant.An increase in the pH of the medium from acidic to neutral increased the bulk swelling of the particles,whereas it decreased water uptake and disintegrant performance.Addition of lubricant had no effect on settling volume,but decreased the water uptake rate and the disintegrant performance significantly.It is concluded that wicking,i.e.capillary action,rather than swelling,is the major factor that contributes to the disintegration behaviour of polacrilin potassium.

药用辅料聚克立林钾质量标准研究

目的建立我国药用辅料聚克立林钾质量标准。方法参考我国药用辅料编写要求及USP标准,进行研究。结果在USP标准的基础上,对铁盐、钠、含量测定(钾)方法进行改进,各元素在各自浓度范围内线性关系良好(r均>0.999);平均回收率为100.33%~105.18%;增加了甲基苯烯酸及重金属控制项。结论拟定的药用辅料聚克立林钾质量标准能更好的控制聚克立林钾质量。