In this work, two new diacids, di（m-carboxyphenyl） succinate （m-dCPS） and di（o-carboxyphenyl） succinate （o- dCPS）, were synthesized by reaction of m-, o-hydroxy benzoic acid with succinic chloride, respectivel...In this work, two new diacids, di（m-carboxyphenyl） succinate （m-dCPS） and di（o-carboxyphenyl） succinate （o- dCPS）, were synthesized by reaction of m-, o-hydroxy benzoic acid with succinic chloride, respectively. Their corresponding copolymers with sebacic acid （SA）, P（m-dCPS：SA） and P（o-dCPS：SA）, were prepared by melt copolycondensation and characterized by NMR, UV and DSC methods. Compared with inherently fluorescent poly[di（p-carboxyphenyl） succinate- co-sebacic anhydride] （P（p-dCPS：SA））, P（m-dCPS：SA） and P（o-dCPS：SA） displayed different luminescent properties. P（m- dCPS：SA） could emit fluorescence under the excitation of both visible and UV light, while P（o-dCPS：SA） could only emit fluorescence when excited with UV light. Degradation rate of the two new copolyanhydrides increased with the increase of SA fraction in the copolymers. In addition, P（o-dCPS：SA） degraded more rapidly than P（m-dCPS：SA） with the same composition. Typical surface-degradation characteristics of these copolyanhydrides were observed.展开更多
The in vitro degradation rate of polyanhydride （poly（sebacic acid）, diacetoxy terminated）, also known as PSADT, was investigated. PSADT tablets with a circular cross-section were formed using a compression molding...The in vitro degradation rate of polyanhydride （poly（sebacic acid）, diacetoxy terminated）, also known as PSADT, was investigated. PSADT tablets with a circular cross-section were formed using a compression molding device, and then immersed into phosphate buffer saline （PBS） for in vitro degradation experiments. The mechanisms of degradation and the degradation rate were characterized by the change in molecular weight and reduction in specimen mass. In addition, the effects of processing temperature and the geometry of the formed PSADT tablets on the rate of degradation were studied. The surface morphology at different degradation times was observed by scanning electron microscopy （SEM）. The experimental results showed that PSADT exhibited sur^hce erosion due to the fact that near zero-order degradation kinetics was observed during its degradation process. Moreover, it is found that the geometry of tablets played an important role on the rate of degradation, while the processing temperature had no significant effect on the PSADT degradation rate.展开更多
基金This work was financially supported by the National Natural Science Foundation of China (No. 20274038)partially by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry.
文摘In this work, two new diacids, di（m-carboxyphenyl） succinate （m-dCPS） and di（o-carboxyphenyl） succinate （o- dCPS）, were synthesized by reaction of m-, o-hydroxy benzoic acid with succinic chloride, respectively. Their corresponding copolymers with sebacic acid （SA）, P（m-dCPS：SA） and P（o-dCPS：SA）, were prepared by melt copolycondensation and characterized by NMR, UV and DSC methods. Compared with inherently fluorescent poly[di（p-carboxyphenyl） succinate- co-sebacic anhydride] （P（p-dCPS：SA））, P（m-dCPS：SA） and P（o-dCPS：SA） displayed different luminescent properties. P（m- dCPS：SA） could emit fluorescence under the excitation of both visible and UV light, while P（o-dCPS：SA） could only emit fluorescence when excited with UV light. Degradation rate of the two new copolyanhydrides increased with the increase of SA fraction in the copolymers. In addition, P（o-dCPS：SA） degraded more rapidly than P（m-dCPS：SA） with the same composition. Typical surface-degradation characteristics of these copolyanhydrides were observed.
基金Funded by the China Scholarship Council and Wisconsin Institute for Discovery(WID)the Scientific Research Staring Foundation,Fujian University of Technology,China(No.GY-Z13028)+1 种基金the Programfor New Century Excellent Talents in Fujian Province University(NCETFJ-2010)the Research Fund for Fujian Provincial University(JK-2010038)
文摘The in vitro degradation rate of polyanhydride （poly（sebacic acid）, diacetoxy terminated）, also known as PSADT, was investigated. PSADT tablets with a circular cross-section were formed using a compression molding device, and then immersed into phosphate buffer saline （PBS） for in vitro degradation experiments. The mechanisms of degradation and the degradation rate were characterized by the change in molecular weight and reduction in specimen mass. In addition, the effects of processing temperature and the geometry of the formed PSADT tablets on the rate of degradation were studied. The surface morphology at different degradation times was observed by scanning electron microscopy （SEM）. The experimental results showed that PSADT exhibited sur^hce erosion due to the fact that near zero-order degradation kinetics was observed during its degradation process. Moreover, it is found that the geometry of tablets played an important role on the rate of degradation, while the processing temperature had no significant effect on the PSADT degradation rate.
