Zinc(Zn)alloys have demonstrated significant potential in healing critical-sized bone defects.However,the clinical application of Zn alloys implants is still hindered by challenges including excessive release of zinc ...Zinc(Zn)alloys have demonstrated significant potential in healing critical-sized bone defects.However,the clinical application of Zn alloys implants is still hindered by challenges including excessive release of zinc ions(Zn^(2+)),particularly in the early stage of implantation,and absence of bio-functions related to complex bone repair processes.Herein,a biodegradable aliphatic polycarbonate drug-eluting coating was fabricated on zinc-lithium(Zn-Li)alloys to inhibit Zn^(2+)release and enhance the osteogenesis,angiogenesis,and bacteriostasis of Zn alloys.Specifically,the photo-curable aliphatic polycarbonates were co-assembled with simvastatin and deposited onto Zn alloys to produce a drug-loaded coating,which was crosslinked by subsequent UV light irradiation.During the 60 days long-term immersion test,the coating showed distinguished stable drug release and Zn^(2+)release inhibition properties.Benefiting from the regulated release of Zn^(2+)and simvastatin,the coating facilitated the adhesion,proliferation,and differentiation of MC3T3-E1 cells,as well as the migration and tube formation of EA.hy926 cells.Astonishingly,the coating also showed remarkable antibacterial properties against both S.aureus and E.coli.The in vivo rabbit critical-size femur bone defects model demonstrated that the drug-eluting coating could efficiently promote new bone formation and the expression of platelet endothelial cell adhesion molecule-1(CD31)and osteocalcin(OCN).The enhancement of osteogenesis,angiogenesis,and bacteriostasis is achieved by precisely controlling of the released Zn^(2+)at an appropriate level,as well as the stable release profile of simvastatin.This tailored aliphatic polycarbonate drug-eluting coating provides significant potential for clinical applications of Zn alloys implants.展开更多
通过熔体流动速率、热变形温度和力学性能等指标变化评价了ASA胶含量及用量对PC/ASA合金性能的影响。结果表明,随着ASA用量的增加,合金的热变形温度下降;可以通过ASA胶含量和用量调节合金的流动性;不论合金的组成,ASA胶含量为30%的PC/AS...通过熔体流动速率、热变形温度和力学性能等指标变化评价了ASA胶含量及用量对PC/ASA合金性能的影响。结果表明,随着ASA用量的增加,合金的热变形温度下降;可以通过ASA胶含量和用量调节合金的流动性;不论合金的组成,ASA胶含量为30%的PC/ASA合金的低温冲击强度最高;当PC/ASA比例为7∶3,ASA胶含量为30%时,PC/ASA合金的低温冲击强度最高为36 k J/m^(2)。展开更多
基金support for this work from the National Natural Science Foundation of China,China (52173127).
文摘Zinc(Zn)alloys have demonstrated significant potential in healing critical-sized bone defects.However,the clinical application of Zn alloys implants is still hindered by challenges including excessive release of zinc ions(Zn^(2+)),particularly in the early stage of implantation,and absence of bio-functions related to complex bone repair processes.Herein,a biodegradable aliphatic polycarbonate drug-eluting coating was fabricated on zinc-lithium(Zn-Li)alloys to inhibit Zn^(2+)release and enhance the osteogenesis,angiogenesis,and bacteriostasis of Zn alloys.Specifically,the photo-curable aliphatic polycarbonates were co-assembled with simvastatin and deposited onto Zn alloys to produce a drug-loaded coating,which was crosslinked by subsequent UV light irradiation.During the 60 days long-term immersion test,the coating showed distinguished stable drug release and Zn^(2+)release inhibition properties.Benefiting from the regulated release of Zn^(2+)and simvastatin,the coating facilitated the adhesion,proliferation,and differentiation of MC3T3-E1 cells,as well as the migration and tube formation of EA.hy926 cells.Astonishingly,the coating also showed remarkable antibacterial properties against both S.aureus and E.coli.The in vivo rabbit critical-size femur bone defects model demonstrated that the drug-eluting coating could efficiently promote new bone formation and the expression of platelet endothelial cell adhesion molecule-1(CD31)and osteocalcin(OCN).The enhancement of osteogenesis,angiogenesis,and bacteriostasis is achieved by precisely controlling of the released Zn^(2+)at an appropriate level,as well as the stable release profile of simvastatin.This tailored aliphatic polycarbonate drug-eluting coating provides significant potential for clinical applications of Zn alloys implants.
文摘通过熔体流动速率、热变形温度和力学性能等指标变化评价了ASA胶含量及用量对PC/ASA合金性能的影响。结果表明,随着ASA用量的增加,合金的热变形温度下降;可以通过ASA胶含量和用量调节合金的流动性;不论合金的组成,ASA胶含量为30%的PC/ASA合金的低温冲击强度最高;当PC/ASA比例为7∶3,ASA胶含量为30%时,PC/ASA合金的低温冲击强度最高为36 k J/m^(2)。
