For investigating the accelerated blood clearance(ABC) phenomenon of polyglycerin modified nanoemulsions upon cross administration with polyethylene glycol(PEG) covered nanoemulsion, we used the 1,2-distea-royl-sn-gly...For investigating the accelerated blood clearance(ABC) phenomenon of polyglycerin modified nanoemulsions upon cross administration with polyethylene glycol(PEG) covered nanoemulsion, we used the 1,2-distea-royl-sn-glycero-3-phosphoethanolamine-npolyglycerine-610 and the 1,2-distearoyl-n-glycero-3-phosphoethanolamine-n-[methoxy(polyethylene glycol)-2000] as modify materials, the dialkylcarbocyanines as fluorescence indicator. Exhausted macrophages rat model was established and new material containing polycarboxyl structure was synthesized. The microplate reader and the in vivo optical imaging system were applied to measure the concentration of nanoemulsions in tissues.The results show that the first dose of polyglycerin modified nanoemulsion can induce the ABC phenomenon of the second dose of PEGylated nanoemulsion. With the increase in the amount of the surface polyglycerin, the extent of the ABC phenomenon decreases. Liver accumulation has positive relationship with the ABC phenomenon. Furthermore, kupffer cells in liver can get more immune information from polyhydroxy structure than polycarboxyl group in the modify compound. The results of our work imply that the polycarboxyl structure has advantages to eliminate the ABC phenomenon.展开更多
According to the moisturizing mechanism,glyceryl glucoside,polyglycerin-10 and xylitylglucoside were compounded.The hygroscopicity and moisture-retention are rated by way of weighing.On such basis,the compound moistur...According to the moisturizing mechanism,glyceryl glucoside,polyglycerin-10 and xylitylglucoside were compounded.The hygroscopicity and moisture-retention are rated by way of weighing.On such basis,the compound moisturizing agent with better ratio is applied in the emulsion formulation.Skin moisture content and skin moisture loss test are adopted to evaluate its moisturizing performance.According to the result of experiment,glyceryl glucoside,polyglycerin-10 and xylitylglucoside humectants have synergistic effects,which can significantly increase the volume of skin moisture and enhance skin barrier function and the moisturizing capability.展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos.81072602,81373334)
文摘For investigating the accelerated blood clearance(ABC) phenomenon of polyglycerin modified nanoemulsions upon cross administration with polyethylene glycol(PEG) covered nanoemulsion, we used the 1,2-distea-royl-sn-glycero-3-phosphoethanolamine-npolyglycerine-610 and the 1,2-distearoyl-n-glycero-3-phosphoethanolamine-n-[methoxy(polyethylene glycol)-2000] as modify materials, the dialkylcarbocyanines as fluorescence indicator. Exhausted macrophages rat model was established and new material containing polycarboxyl structure was synthesized. The microplate reader and the in vivo optical imaging system were applied to measure the concentration of nanoemulsions in tissues.The results show that the first dose of polyglycerin modified nanoemulsion can induce the ABC phenomenon of the second dose of PEGylated nanoemulsion. With the increase in the amount of the surface polyglycerin, the extent of the ABC phenomenon decreases. Liver accumulation has positive relationship with the ABC phenomenon. Furthermore, kupffer cells in liver can get more immune information from polyhydroxy structure than polycarboxyl group in the modify compound. The results of our work imply that the polycarboxyl structure has advantages to eliminate the ABC phenomenon.
文摘According to the moisturizing mechanism,glyceryl glucoside,polyglycerin-10 and xylitylglucoside were compounded.The hygroscopicity and moisture-retention are rated by way of weighing.On such basis,the compound moisturizing agent with better ratio is applied in the emulsion formulation.Skin moisture content and skin moisture loss test are adopted to evaluate its moisturizing performance.According to the result of experiment,glyceryl glucoside,polyglycerin-10 and xylitylglucoside humectants have synergistic effects,which can significantly increase the volume of skin moisture and enhance skin barrier function and the moisturizing capability.
