Flavonoids with cytotoxicities from the seeds of Pongamia pinnata(L.)Pierre

Twenty-eight compounds,including flavones(2,4-5,7-11),flavonols(1,3,6,21,22),flavanones(12-18),isoflavones(19,20),chalcones(23,24),phenylpropanoids(25,26),and others(27,28)were isolated from the ethanol extract of the seeds of Pongamia pinnata(L.)Pierre and identified on the basis of physic-chemical constants and spectral analysis(NMR,ECD,[α]^20 D).Among them,compounds 16,18,21,23,25 and 26 were obtained from the genus for the first time.The cytotoxicities of the purified flavonoids against H292 cells were evaluated using MTT assays.As a result,compounds 14 and 15 displayed moderate cytotoxicities.

Evaluation of larvicidal activity of Pongamia pinnata extracts against three mosquito vectors

Objective:To evaluate the mosquito larvicidal activity of Pongamia pinnata(P.pinnata)extracts against three mosquito vectors.Methods:The methanol and hydroalcohol extracts of bark part of P.pinnata L were tested against fourth instar larvae of Culex quinqnefasciatus,Aedes aegypti and Anopheles stephensi.The mortality was observed 24 h and 48 h after treatment,data was subjected to probit analysis to determine lethal concentration(LC_(50)and LC_(90))to kill 50 and 90 percent of treated larvae of tested species.Results:The larval mortality was found in both methanol and hydroalcohol extracts of P.pinnata against Culex quinquefascialus,Aedes aegypti and Anopheles stephensi with LC_(50)values of 84.8,118.2 and 151.7 ppm;97.7,128.3 and 513 ppm.The highest larval mortality was found in methanol extract of P.pinnala when comparable to the hydroalcohol extract.Conclusions:These results suggest that both methanol and hyrdoalcohol extracts have the potential to be used as an ideal ecofriendly approach for the control of disease vectors.This could lead to isolation of novel natural larvicidal compounds.

值得开发利用的蛋白油料树种——水黄皮

随着人口不断增长,我国食用油及食用与饲用蛋白严重不足,迫切需要寻找木本蛋白油料资源。作为一种优良豆科多用途树种,水黄皮籽粒产量大,油酯与蛋白含量高,对环境适应性强,近些年,引起世界广泛关注。过去限于驯化改良与深加工技术,水黄皮主要作为工业原料及生物柴油资源开发利用。随着深加工技术发展,水黄皮籽粒已经被加工成食用油、食用与饲用蛋白。文章简要介绍水黄皮的研究进展,着重介绍水黄皮育种改良、栽培与食用开发进展,旨在为加快我国水黄皮产业发展提供参考。

半红树植物水黄皮的化学成分和药理作用研究进展

水黄皮是传统的半红树药用植物,印度对其的研究和应用历史悠久。从水黄皮中分离到的化学成分主要有黄酮、二氢黄酮、查耳酮、二氢查耳酮、三萜、生物碱及氨基酸等,其中黄酮类化合物占绝大多数,且多数黄酮的母核并有呋喃环或者吡喃环。现代药理研究表明水黄皮具有抗菌、抗炎、镇痛、抗病毒、抗溃疡和抗肿瘤等生物活性,是一种有开发潜力的半红树药用植物。在民间,人们多用水黄皮种子或叶子治疗肿瘤、痔疮、风湿等疾病。现对国内外有关水黄皮的化学成分、药理作用的研究成果进行综述,为全面开发利用水黄皮提供参考。

水黄皮的化学成分和药理作用研究进展

水黄皮Pongamia pinnata为豆科水黄皮属植物,广泛分布于东南亚国家的河堤与沿海地区。从中分离得到化学成分主要有黄酮类、三萜类、生物碱类、氨基酸等成分。现代药理学研究表明水黄皮具有抗菌、抗炎镇痛、抗溃疡和抗痢疾等作用。综述了近10年来水黄皮的化学成分和药理作用研究进展,为其药效物质基础、作用机制研究及开发利用提供理论依据。