Response surface methodology(RSM) was used to determine the optimum conditions of the methanolysis of crude poppy seed oil using Na OCH3 as catalyst. The experiments were run according to five levels, four variable ce...Response surface methodology(RSM) was used to determine the optimum conditions of the methanolysis of crude poppy seed oil using Na OCH3 as catalyst. The experiments were run according to five levels, four variable central composite rotatable design(CCRD) using RSM. The reaction variables, i.e., molar ratio of methanol/oil(3:1–9:1), catalyst concentration(0.5 wt%–1.25 wt% Na OCH3), reaction temperature(25–65 °C), and reaction time(20–90 min) were studied. We demonstrated that the molar ratio of methanol/oil, catalyst concentration,and reaction temperature were the significant parameters affecting the yield of poppy seed oil methyl esters(PSOMEs). The optimum transesterification reaction conditions, established using the RSM, which offered a89.35% PSOME yield, were found to be 7.5:1 molar ratio of methanol/oil, 0.75% catalyst concentration, 45 °C reaction temperature, and 90 min reaction time. The proposed process provided an average biodiesel yield of more than 85%. A linear correlation was constructed between the observed and predicted values of the yield.The gas chromatography(GC) analyses have shown that PSOMEs contain linoleic-, oleic-, palmitic-, and stearic-acids as main fatty acids. The FTIR spectrum of the PSOMEs was also analyzed to confirm the completion of the transesterification reaction. The fuel properties of the PSOMEs were discussed in light of biodiesel standards(ASTM D 6751 and EN 14214).展开更多
Concentration of cadmium in poppy seeds, semi-finished products and baked goods with poppy seeds was determined by graphite furnace atomic absorption spectrometry (GF-AAS). Homogenous samples of poppy seeds and prod...Concentration of cadmium in poppy seeds, semi-finished products and baked goods with poppy seeds was determined by graphite furnace atomic absorption spectrometry (GF-AAS). Homogenous samples of poppy seeds and products containing poppy seeds were digested by means of microwave digestion system by using of nitric acid and hydrogen peroxide as reagents. The measurements were carried out using an atomic absorption spectrometer with Zeeman background correction. Detection limit was 0.003 mg/kg. A total of 208 samples of poppy seeds (from years 2004-2009) and 17 samples of semi-finished and baked goods were analysed. The average content was 0.64 mg/kg (median 0.64 mg/kg) for poppy seeds and 0.079 mg/kg (median 0.069 mg/kg) for semi-finished and baked goods. The relative standard deviation was lower than 5% for all measurements.展开更多
Recently the cultivation of opium poppy in Afghanistan reached unprecedented levels.It is agreed that the complex and coupled interactions of social,economic and environmental drivers are crucial for understanding the...Recently the cultivation of opium poppy in Afghanistan reached unprecedented levels.It is agreed that the complex and coupled interactions of social,economic and environmental drivers are crucial for understanding the spatial and temporal dynamics of opium poppy cultivation in Afghanistan.In this context,we present an integrated risk concept,which considers environmental and socio-economic drivers of opium poppy cultivation.A set of spatially explicit indicators for the environmental suitability and socio-economic vulnerability was established and populated from a variety of databases.Subsequently,novel methods of modelling homogeneous and spatially explicit regions of opium poppy cultivation suitability,socio-economic vulnerability and risk are developed and applied.The risk assessment results demonstrate the complex nature of the illicit crops production in Afghanistan and prompt a more profound examination of the drivers of opium poppy cultivation in a spatial context.The study also confirms what has already been widely discussed in literature:that reasons for cultivation are spatially diverse and often distinct,meaning that any formulation of generalized explanations cannot be drawn without ignoring a more complex reality.Thus,an integrative spatial view of risk,which integrates the social dimension as well as environmental parameters,is required to better identify context-specific intervention measures.展开更多
Plants, as primary producers, have been playing an indispensable role in other organisms’ survival and the balance of whole ecosystem on Earth. Especially, they provide the main source of energy, food, and medicine f...Plants, as primary producers, have been playing an indispensable role in other organisms’ survival and the balance of whole ecosystem on Earth. Especially, they provide the main source of energy, food, and medicine for human beings, some of which are derived from the primary or secondary metabolites展开更多
Oripavine is the major alkaloid of Papaver orientale. It is an important intermediate in the biosynthesis of morphine alkaloids. Recently, new Papaver somniferum strains have been developed which accumulate thebaine a...Oripavine is the major alkaloid of Papaver orientale. It is an important intermediate in the biosynthesis of morphine alkaloids. Recently, new Papaver somniferum strains have been developed which accumulate thebaine and oripavine, but not morphine and codeine. Therefore, the chemistry of oripavine has been studied intensively to synthesize opioid pharmaceuticals such as oxymorphone, naloxone and buprenorphine.展开更多
Rubber plantation is the major land use type in Southeast Asia. Monitoring the spa- tial-temporal pattern of rubber plantation is significant for regional land resource development, eco-environmental protection, and m...Rubber plantation is the major land use type in Southeast Asia. Monitoring the spa- tial-temporal pattern of rubber plantation is significant for regional land resource development, eco-environmental protection, and maintaining border security. With remote sensing tech- nologies, we analyzed the rubber distribution pattern and spatial-temporal dynamic; with GIS and a newly proposed index of Planted Intensity (PI), we further quantified the impacts and limits of topographical factors on rubber plantation in the border region of China, Laos and Myanmar (BRCLM) between 1980 and 2010. The results showed that: (1) As the dominant land use type in this border region, the acreage of rubber plantation was 6014 km2 in 2010, accounting for 8.17% of the total area. Viewing from the rubber plantation structure, the ratio of mature- (〉10 year) and young rubber plantation (〈 10 year) was 5:7. (2) From 1980 to 2010, rubber plantation expanded significantly in BRCLM, from 705 km2 to 6014 km2, nearly nine times. The distribution characteristics of rubber plantation varied from concentrated toward dispersed, from border inside to outside, and expanded further in all directions with Jinghong City as the center. (3) Restricted by the topographical factors, more than 4/5 proportion of rubber plantation concentrated in the appropriate elevation gradients between 600 and 1000 m, rarely occurred in elevations beyond 1200 m in BRCLM. Nearly 2/3 of rubber plantation concentrated on slopes of 8^-25~, rarely distributed on slopes above 35~. Rubber plantation was primarily distributed in south and east aspects, relatively few in north and west aspects. Rubber planted intensity displayed the similar distribution trend. (4) Comparative studies of rubber plantation in different countries showed that there was a remarkable increase in area at higher elevations and steeper slopes in China, while there were large appropriate topog- raphical gradients for rubber plantation in Laos and Myanmar which benefited China for rubber trans-boundary expansion. (5) Rubber plantation in BRCLM will definitely expend cross borders of China to the territories of Laos and Myanmar, and the continuous expansion in the border region of China will be inevitable.展开更多
This paper analyzed forest land use change in Trans-Boundary Laos-China Biodiversity Conservation Area which is called Namha National Biodiversity Conservation Areas (Namha NBCAs), with 1992 and 2002 TM (ETM). Bas...This paper analyzed forest land use change in Trans-Boundary Laos-China Biodiversity Conservation Area which is called Namha National Biodiversity Conservation Areas (Namha NBCAs), with 1992 and 2002 TM (ETM). Based on GIS and statistical methods, the intensity, state index of land use change and transfer matrix were used to study spatio-temporal land use change in the region. The results showed that the area of forest land decreased greatly, also the area of bamboo and grassland decreased. The other way round, the area of unstocked forest, slash and burn and rice paddy land increased. As a whole, the intensity of forest land change was higher, but others were lower. From the transfer matrix, most of the forest land changed into unstocked forest and urban area, some to slash and burn The grassland and bamboo were mainly transferred to forest and unstocked forest. The unstocked forest land mostly came from forest land and grassland. It was showed there were three main causes of the land use change namely: opium poppy cultivation, rubber plantation and also ecotourism activities and finally some policies were developed in order to address the land use change in the study areas.展开更多
Chinese patent medicines(CPMs) are widely used across China, and they are differently administrated from chemical drugs. For traditional reasons, CPMs may contain opium-derived compounds, such as morphine, which may...Chinese patent medicines(CPMs) are widely used across China, and they are differently administrated from chemical drugs. For traditional reasons, CPMs may contain opium-derived compounds, such as morphine, which may pose the issues of drug abuse and addiction. In the present study, we aimed to evaluate the present risk of morphine-containing CPMs in causing drug abuse and addiction, based on a questionnaire-based approach and from a medicinal administrative perspective. We chose 76 CPMs containing morphine from government document and set them as the study group, and 10 chemical drugs containing morphine were set as the control group. Because there is no ready-made method, we created an evaluation sheet consisting of five questions to evaluate each drug and generate a risk-value score. Crosstabs analysis using SPSS 15.0 was conducted to obtain the influencing factors. We found that the study group obtained a mean score of 2.04 for the risk value, which was five times of that of the control group. Specifically, no maximum limit of morphine or codeine was set in product quality standards for more than four-fifth of the drugs. Moreover, 46.0% of package inserts failed to show any warning about addiction or prohibition over the long-term use of the drugs. The number of ingredients, as well as the functions of the drugs, was found to correlate with the risk value. Our findings suggested that CPMs were more risky in causing drug abuse and addiction than chemical drugs. Approaches, such as i) controlling the number of ingredients, ii) setting up maximum limit of morphine or codeine in quality standard, iii) providing more information on the package insert of drugs and iv) monitoring the drug containing both morphine and ephedrine, will be effective in reducing the risk of drug abuse and addiction.展开更多
基金the Deanship of Scientific Research at King Saud University for its funding of this research through the research group project RGP-VPP-048
文摘Response surface methodology(RSM) was used to determine the optimum conditions of the methanolysis of crude poppy seed oil using Na OCH3 as catalyst. The experiments were run according to five levels, four variable central composite rotatable design(CCRD) using RSM. The reaction variables, i.e., molar ratio of methanol/oil(3:1–9:1), catalyst concentration(0.5 wt%–1.25 wt% Na OCH3), reaction temperature(25–65 °C), and reaction time(20–90 min) were studied. We demonstrated that the molar ratio of methanol/oil, catalyst concentration,and reaction temperature were the significant parameters affecting the yield of poppy seed oil methyl esters(PSOMEs). The optimum transesterification reaction conditions, established using the RSM, which offered a89.35% PSOME yield, were found to be 7.5:1 molar ratio of methanol/oil, 0.75% catalyst concentration, 45 °C reaction temperature, and 90 min reaction time. The proposed process provided an average biodiesel yield of more than 85%. A linear correlation was constructed between the observed and predicted values of the yield.The gas chromatography(GC) analyses have shown that PSOMEs contain linoleic-, oleic-, palmitic-, and stearic-acids as main fatty acids. The FTIR spectrum of the PSOMEs was also analyzed to confirm the completion of the transesterification reaction. The fuel properties of the PSOMEs were discussed in light of biodiesel standards(ASTM D 6751 and EN 14214).
文摘Concentration of cadmium in poppy seeds, semi-finished products and baked goods with poppy seeds was determined by graphite furnace atomic absorption spectrometry (GF-AAS). Homogenous samples of poppy seeds and products containing poppy seeds were digested by means of microwave digestion system by using of nitric acid and hydrogen peroxide as reagents. The measurements were carried out using an atomic absorption spectrometer with Zeeman background correction. Detection limit was 0.003 mg/kg. A total of 208 samples of poppy seeds (from years 2004-2009) and 17 samples of semi-finished and baked goods were analysed. The average content was 0.64 mg/kg (median 0.64 mg/kg) for poppy seeds and 0.079 mg/kg (median 0.069 mg/kg) for semi-finished and baked goods. The relative standard deviation was lower than 5% for all measurements.
基金This work was supported by the Seventh Framework Programme[312912].
文摘Recently the cultivation of opium poppy in Afghanistan reached unprecedented levels.It is agreed that the complex and coupled interactions of social,economic and environmental drivers are crucial for understanding the spatial and temporal dynamics of opium poppy cultivation in Afghanistan.In this context,we present an integrated risk concept,which considers environmental and socio-economic drivers of opium poppy cultivation.A set of spatially explicit indicators for the environmental suitability and socio-economic vulnerability was established and populated from a variety of databases.Subsequently,novel methods of modelling homogeneous and spatially explicit regions of opium poppy cultivation suitability,socio-economic vulnerability and risk are developed and applied.The risk assessment results demonstrate the complex nature of the illicit crops production in Afghanistan and prompt a more profound examination of the drivers of opium poppy cultivation in a spatial context.The study also confirms what has already been widely discussed in literature:that reasons for cultivation are spatially diverse and often distinct,meaning that any formulation of generalized explanations cannot be drawn without ignoring a more complex reality.Thus,an integrative spatial view of risk,which integrates the social dimension as well as environmental parameters,is required to better identify context-specific intervention measures.
基金funding from the Thousand Youth Talents Program and Institute of Botany,CAS,China
文摘Plants, as primary producers, have been playing an indispensable role in other organisms’ survival and the balance of whole ecosystem on Earth. Especially, they provide the main source of energy, food, and medicine for human beings, some of which are derived from the primary or secondary metabolites
文摘Oripavine is the major alkaloid of Papaver orientale. It is an important intermediate in the biosynthesis of morphine alkaloids. Recently, new Papaver somniferum strains have been developed which accumulate thebaine and oripavine, but not morphine and codeine. Therefore, the chemistry of oripavine has been studied intensively to synthesize opioid pharmaceuticals such as oxymorphone, naloxone and buprenorphine.
基金National Natural Science Foundation of China, No.41271117 Strategy of Science and Technology Planning Project of Institute of Geographic Sciences and Natural Resources Research, CAS, No.2012SJ008
文摘Rubber plantation is the major land use type in Southeast Asia. Monitoring the spa- tial-temporal pattern of rubber plantation is significant for regional land resource development, eco-environmental protection, and maintaining border security. With remote sensing tech- nologies, we analyzed the rubber distribution pattern and spatial-temporal dynamic; with GIS and a newly proposed index of Planted Intensity (PI), we further quantified the impacts and limits of topographical factors on rubber plantation in the border region of China, Laos and Myanmar (BRCLM) between 1980 and 2010. The results showed that: (1) As the dominant land use type in this border region, the acreage of rubber plantation was 6014 km2 in 2010, accounting for 8.17% of the total area. Viewing from the rubber plantation structure, the ratio of mature- (〉10 year) and young rubber plantation (〈 10 year) was 5:7. (2) From 1980 to 2010, rubber plantation expanded significantly in BRCLM, from 705 km2 to 6014 km2, nearly nine times. The distribution characteristics of rubber plantation varied from concentrated toward dispersed, from border inside to outside, and expanded further in all directions with Jinghong City as the center. (3) Restricted by the topographical factors, more than 4/5 proportion of rubber plantation concentrated in the appropriate elevation gradients between 600 and 1000 m, rarely occurred in elevations beyond 1200 m in BRCLM. Nearly 2/3 of rubber plantation concentrated on slopes of 8^-25~, rarely distributed on slopes above 35~. Rubber plantation was primarily distributed in south and east aspects, relatively few in north and west aspects. Rubber planted intensity displayed the similar distribution trend. (4) Comparative studies of rubber plantation in different countries showed that there was a remarkable increase in area at higher elevations and steeper slopes in China, while there were large appropriate topog- raphical gradients for rubber plantation in Laos and Myanmar which benefited China for rubber trans-boundary expansion. (5) Rubber plantation in BRCLM will definitely expend cross borders of China to the territories of Laos and Myanmar, and the continuous expansion in the border region of China will be inevitable.
文摘This paper analyzed forest land use change in Trans-Boundary Laos-China Biodiversity Conservation Area which is called Namha National Biodiversity Conservation Areas (Namha NBCAs), with 1992 and 2002 TM (ETM). Based on GIS and statistical methods, the intensity, state index of land use change and transfer matrix were used to study spatio-temporal land use change in the region. The results showed that the area of forest land decreased greatly, also the area of bamboo and grassland decreased. The other way round, the area of unstocked forest, slash and burn and rice paddy land increased. As a whole, the intensity of forest land change was higher, but others were lower. From the transfer matrix, most of the forest land changed into unstocked forest and urban area, some to slash and burn The grassland and bamboo were mainly transferred to forest and unstocked forest. The unstocked forest land mostly came from forest land and grassland. It was showed there were three main causes of the land use change namely: opium poppy cultivation, rubber plantation and also ecotourism activities and finally some policies were developed in order to address the land use change in the study areas.
基金Funding Grants from University of Macao Research Grants(MYRG2015-00160-ICMS-QRCM and MYRG2014-00069-ICMS-QRCM)
文摘Chinese patent medicines(CPMs) are widely used across China, and they are differently administrated from chemical drugs. For traditional reasons, CPMs may contain opium-derived compounds, such as morphine, which may pose the issues of drug abuse and addiction. In the present study, we aimed to evaluate the present risk of morphine-containing CPMs in causing drug abuse and addiction, based on a questionnaire-based approach and from a medicinal administrative perspective. We chose 76 CPMs containing morphine from government document and set them as the study group, and 10 chemical drugs containing morphine were set as the control group. Because there is no ready-made method, we created an evaluation sheet consisting of five questions to evaluate each drug and generate a risk-value score. Crosstabs analysis using SPSS 15.0 was conducted to obtain the influencing factors. We found that the study group obtained a mean score of 2.04 for the risk value, which was five times of that of the control group. Specifically, no maximum limit of morphine or codeine was set in product quality standards for more than four-fifth of the drugs. Moreover, 46.0% of package inserts failed to show any warning about addiction or prohibition over the long-term use of the drugs. The number of ingredients, as well as the functions of the drugs, was found to correlate with the risk value. Our findings suggested that CPMs were more risky in causing drug abuse and addiction than chemical drugs. Approaches, such as i) controlling the number of ingredients, ii) setting up maximum limit of morphine or codeine in quality standard, iii) providing more information on the package insert of drugs and iv) monitoring the drug containing both morphine and ephedrine, will be effective in reducing the risk of drug abuse and addiction.