Closed-loop control of epileptiform activities in a neural population model using a proportional-derivative controller

Epilepsy is believed to be caused by a lack of balance between excitation and inhibitation in the brain. A promising strategy for the control of the disease is closed-loop brain stimulation. How to determine the stimulation control parameters for effective and safe treatment protocols remains, however, an unsolved question. To constrain the complex dynamics of the biological brain, we use a neural population model（NPM）. We propose that a proportional-derivative（PD） type closed-loop control can successfully suppress epileptiform activities. First, we determine the stability of root loci, which reveals that the dynamical mechanism underlying epilepsy in the NPM is the loss of homeostatic control caused by the lack of balance between excitation and inhibition. Then, we design a PD type closed-loop controller to stabilize the unstable NPM such that the homeostatic equilibriums are maintained; we show that epileptiform activities are successfully suppressed. A graphical approach is employed to determine the stabilizing region of the PD controller in the parameter space, providing a theoretical guideline for the selection of the PD control parameters. Furthermore, we establish the relationship between the control parameters and the model parameters in the form of stabilizing regions to help understand the mechanism of suppressing epileptiform activities in the NPM. Simulations show that the PD-type closed-loop control strategy can effectively suppress epileptiform activities in the NPM.

THE PERIODIC SOLUTIONS FOR TIME DEPENDENT AGE-STRUCTURED POPULATION MODELS

In this paper, the existence of periodic solutions for a time dependent age-structured population model is studied. The averaged net reproductive number is introduced as the main parameter to determine the dynamical behaviors of the model. The existence of a global parameterized branch of periodic solutions of the model is obtained by using the contracting mapping theorem in a periodic and continuous function space. The global stability of the trivial equilibrium is studied and a very practical stability criteria for the model is obtained. The dynamics of the linear time-periodic model is similar to that of the linear model.

QUALITATIVE ANALYSIS OF BOBWHITE QUAIL POPULATION MODEL

In this paper, the qualitative behavior of solutions of the bobwhite quail pop-ulation modelwhere 0<a < 1 < a + 6,p, c ∈ (0, ∞) and k is a nonnegative integer, is investigated. Some necessary and sufficient as well as sufficient conditions for all solutions of the model to oscillate and some sufficient conditions for all positive solutions of the model to be nonoscillatory and the convergence of nonoscillatory solutions are derived. Furthermore, the permanence of every positive solution of the model is also showed. Many known results are improved and extended and some new results are obtained for G. Ladas' open problems.

QUALITATIVE ANALYSIS OF A DICRETE POPULATION MODEL

In this paper, authors study the qualitative behavior of solutions of the discrete population model xn-xn-1=xn (a+bxn-k-cx2n-k),where a ∈ (0, 1), b ∈ (-∞, 0),c ∈ (0,∞ ), and k is a positive integer. They hot only obtain necessary as well as sufficient and necessary conditions for the oscillation of ail eventually positive solutions about the positive equilibrium, but also obtain some sufficient conditions for the convergence of eventually positive solutions. Furthermore, authors also show that such model is uniformly persistent, and that all its eventually positive solutions are bounded.

Nonlinear dynamical wave structures of Zoomeron equation for population models

The nonlinear dynamical exact wave solutions to the non-fractional order and the time-fractional order of the biological population models are achieved for the first time in the framwork of the Paul-Painlevéapproach method(PPAM).When the variables appearing in the exact solutions take specific values,the solitary wave solutions will be easily obtained.The realized results prove the efficiency of this technique.

A Guide to Population Modelling for Simulation

This paper outlines the fundamentals of a consistent theory of numerical modelling of a population system under study. The focus is on the systematic work to construct an executable simulation model. There are six fundamental choices of model category and model constituents to make. These choices have a profound impact on how the model is structured, what can be studied, possible introduction of bias, lucidity and comprehensibility, size, expandability, performance of the model, required information about the system studied and its range of validity. The first choice concerns a discrete versus a continuous description of the population system under study—a choice that leads to different model categories. The second choice is the model representation (based on agents, entities, compartments or situations) used to describe the properties and behaviours of the objects in the studied population. Third, incomplete information about structure, transitions, signals, initial conditions or parameter values in the system under study must be addressed by alternative structures and statistical means. Fourth, the purpose of the study must be explicitly formulated in terms of the quantities used in the model. Fifth, irrespective of the choice of representation, there are three possible types of time handling: Event Scheduling, Time Slicing or Micro Time Slicing. Sixth, start and termination criteria for the simulation must be stated. The termination can be at a fixed end time or determined by a logical condition. Population models can thereby be classified within a unified framework, and population models of one type can be translated into another type in a consistent way. Understanding the pros and cons for different choices of model category, representation, time handling etc. will help the modeller to select the most appropriate type of model for a given purpose and population system under study. By understanding the rules for consistent population modelling, an appropriate model can be created in a systematic way and a number of pitfalls can be avoided.

Spreading speed of a food-limited population model with delay

This paper is concerned with the spreading speed of a food-limited population model with delay.First,the existence of the solution of Cauchy problem is proved.Then,the spreading speed of solutions with compactly supported initial data is investigated by using the general Harnack inequality.Finally,we present some numerical simulations and investigate the dynamical behavior of the solution.

Exact Solutions of Fractional-Order Biological Population Model

In this paper, the Adomian＇s decomposition method （ADM） is presented for finding the exact solutions of a more general biological population models. A new solution is constructed in power series. The fractional derivatives are described in the Caputo sense. To illustrate the reliability of the method, some examples are provided.

Homotopy Analysis Method for Solving Biological Population Model

In this paper,the homotopy analysis method (HAM) is applied to solve generalized biological populationmodels.The fractional derivatives are described by Caputo's sense.The method introduces a significant improvementin this field over existing techniques.Results obtained using the scheme presented here agree well with the analyticalsolutions and the numerical results presented in Ref.[6].However,the fundamental solutions of these equations stillexhibit useful scaling properties that make them attractive for applications.

SPATIALIZATION MODEL OF POPULATION BASED ON DATASET OF LAND USE AND LAND COVER CHANGE IN CHINA

The spatialization of population of counties in China is significant. Firstly, we can gain the estimated values of population density adaptive to different kinds of regions. Secondly, we can integrate effectively population data with other data including natural resources, environment, society and economy, build 1km GRIDs of natural resources reserves per person, population density and other economic and environmental data, which are necessary to the national management and macro adjustment and control of natural resources and dynamic monitoring of population. In order to establish population information system serving national decision making, three steps ought to be followed:1) establishing complete geographical spatial data foundation infrastructure including the establishment of electric map of residence with high resolution using topographical map with large scale and high resolution satellite remote sensing data, the determination of attribute information of housing and office buildings, and creating complete set of attribute database and rapid data updating; 2) establishing complete census systems including improving the transformation efficiency from census data to digital database and strengthening the link of census database and geographical spatial database, meanwhile, the government should attach great importance to the establishment and integration of population migration database; 3) considering there is no GIS software specially serving the analysis and management of population data, a practical approach is to add special modules to present software system, which works as a bridge actualizing the digitization and spatialization of population geography research.

An efficient technique for two-dimensional fractional order biological population model

In this paper,we find the solutions for two-dimensional biological population model having fractional order using fractional natural decomposition method(FNDM).The proposed method is a graceful blend of decomposition scheme with natural transform,and three examples are considered to validate and illustrate its efficiency.The nature of FNDM solution has been captured for distinct arbitrary order.In order to illustrate the proficiency and reliability of the considered scheme,the numerical simulation has been presented.The obtained results illuminate that the considered method is easy to apply and more effective to examine the nature of multi-dimensional differential equations of fractional order arisen in connected areas of science and technology.

Multiple positive periodic solutions for a generalized delayed population model with an exploited term

In this paper, the existence of two positive periodic solutions for a generalized delayed population model with an exploited term is established by using the continuation theorem of the coincidence degree theory.

A study of nonlinear age-structured population models

This paper presents a novel analysis for the solution of nonlinear age-structured prob- lem which is of extreme importance in biological sciences. The presented model is very useful but quite complicated. Modified variational iteration method （MVIM） coupled with auxiliary parameter is used to cope with the complexity of the model which subse- quently shows better results as compared to some existing results available in literature. Furthermore, an appropriate way is used for the identification of auxiliary parameter by means of residual function. Numerical examples are presented for the analysis of the pro- posed algorithm. Graphical results along with the discussions re-confirm the efficiency of proposed algorithm. The work proposes a new algorithm where He＇s polynomials and an auxiliary parameter are merged with correction functional. The suggested scheme is implemented on nonlinear age-structured population models. Graphs are plotted for the residual function that reflects the accuracy and convergence of the presented algorithm.

Mathematical study of fractional-order biological population model using optimal homotopy asymptotic method

In this paper, we study the fractional-order biological population models （FI3PMs） with Malthusian~ Verhulst, and porous media laws. The fractional derivative is defined in Caputo sense. The optimal homotopy asymptotic method （OHAM） for partial differ- ential equations （PDEs） is extended and successfully implemented to solve FBPMs. Third-order approximate solutions are obtained and compared with the exact solutions. The numerical results unveil that the proposed extension in the OHAM for fractional- order differential problems is very effective and simple in computation. The results reveal the effectiveness with high accuracy and extremely efficient to handle most complicated biological population models.

On biological population model of fractional order

In this paper, we extensively studied a mathematical model of biology. It helps us to understand the dynamical procedure of population changes in biological population model and provides valuable predictions. In this model, we establish a variety of exact solutions. To study the exact solutions, we used a fractional complex transform to convert the particular partial differential equation of fractional order into corresponding partial differential equation and modified exp-function method is implemented to investigate the nonlinear equation. Graphical demonstrations along with the numerical data reinforce the efficacy of the used procedure. The specified idea is very effective, unfailing, well-organized and pragmatic for fractional PDEs and could be protracted to further physical happenings.

A collocation method for numerical solutions of fractional-order logistic population model

In this study, a collocation technique is presented for approximate solution of the fractional-order logistic population model. Actually, we develop the Bessel collocation method by using the fractional derivative in the Caputo sense to obtain the approximate solutions of this model problem. By means of the fractional derivative in the Caputo sense, the collocation points, the Bessel functions of the first kind, the method transforms the model problem into a system of nonlinear algebraic equations. Numerical applications are given to demonstrate efficiency and accuracy of the method. In applications, the reliability of the scheme is shown by the error function based on the accuracy of the approximate solution.

Investigating biological population model using exp-function method

This paper is the spectator of the arrangement of an efficient transformation and exfunction technique to build up generalized exact solutions of the biological population model equation. Computational work and subsequent numerical results re-identify the effectiveness of proposed algorithm. It is pragmatic that recommended plan is greatly consistent and may be comprehensive to other nonlinear differential equations of fractional order.

Haar wavelet method for solving nonlinear age-structured population models

In this study, Haar wavelet method is implemented for solving the nonlinear age- structured population model which is the nonclassic type of partial differential equation associated with boundary integral equation. This paper develops the flexibility of Haar wavelet method for reduction of the partial differential equation with nonlocal boundary conditions to an algebraic system. In fact, the simple structure of piecewise orthogonM Haar basis functions which leads to sparse matrices causes the convergence and com- putational efficiency. Some illustrative results show the reliability and accuracy of the presented method.

GLOBAL ATTRACTIVITY OF POPULATION MODELS WITH DELAYS AND DIFFUSION

In this paper, the asymptotic behavior of three types of population models with delays and diffusion is studied. The first represents one species growth in the patch Ω and periodic environment and with delays recruitment, the second models a single species dispersal among the m patches of a heterogeneous environment, and the third models the spread of bacterial infections. Sufficient conditions for the global attractivity of periodic solution are obtained by the method of monotone theory and strongly concave operators. Some earlier results are extended to population models with delays and diffusion.

Analysis and control of a non-smooth population model with impulsive effects

In this paper, a non-smooth population model with impulsive effects is proposed by combining discontinuity and non-smoothness. According to the qualitative theory of differential equations, the global analysis of the model is discussed. Using the theory of impulsive differential equations, the existence conditions of order one periodic solution are obtained. And the impulsive controllers are designed to make the pest populations stay at the refuge level. Some simulations are carried out to prove the results.