The synthesis and characterization of a series of metal porphyrins, MII(Por), {Por=dianionic of 5, 10, 15, 20-tetrakis [4-(4′-bromobutyloxy) phenyl]porphyrinato and 5, 10, 15, 20-tetrakis [4-(4′-butyloxypyridine bro...The synthesis and characterization of a series of metal porphyrins, MII(Por), {Por=dianionic of 5, 10, 15, 20-tetrakis [4-(4′-bromobutyloxy) phenyl]porphyrinato and 5, 10, 15, 20-tetrakis [4-(4′-butyloxypyridine bromide)phenyl]porphyrinato, M=Zn, Cu, Mn, Co, Ni, Ru-CO} were described. The complexes 3a-3e were prepared from the reactions of compound 2 with metal acetates in chloroform, and the treatment of 3a-3f with excess of pyridine gave corresponding complexes 4a-4f. These new compounds were identified by absorption spectroscopies,1H-NMR and elemental analyses. The results of biological activity testing for 4a-4f revealed that 4a and 4c had stronger inhibiting action on the growth metabolism ofEsche richia coli.展开更多
The synthesis, characterization, and biological activities of a series of metal porphyrins were described. The complexes 3a similar to 3e were prepared from the reaction of compound 2 with M(OAc)(2) in CHCl3, and the ...The synthesis, characterization, and biological activities of a series of metal porphyrins were described. The complexes 3a similar to 3e were prepared from the reaction of compound 2 with M(OAc)(2) in CHCl3, and the treatment of 3a similar to 3f with pyridine gave corresponding complexes 4a similar to 4f. These new compounds were identified by absorption spectroscopies, H-1 NMR and elemental analysis. The results of biological activity,testing revealed that 4a and 4c had stronger inhibiting action for Escherichia coli (CCTCC AB91115).展开更多
A novel series of quaternary ammonium cationic derivatives based on tetrapyridyl-porphyrin was synthesized. All the compounds were evaluated for their in vitro antibacterial activities against S. aureus, E. coli and P...A novel series of quaternary ammonium cationic derivatives based on tetrapyridyl-porphyrin was synthesized. All the compounds were evaluated for their in vitro antibacterial activities against S. aureus, E. coli and P. aeruginosa, and antifungal activities against C. albicans, where microorganisms were exposed and unexposed to the irradiation. The results revealed that some of these compounds, especially, 3a and 4a displayed satisfactory antibacterial activity against Gram-positive bacteria S. aureus and moderate antifungal activity against C. albicans. Unfortunately, Gram-negative bacteria P aeruginasa was resistant to all compounds. The antimicrobial activity was found to be sensitive to the functional groups attached on the aromatic ring and the complex metal in the porphyrin ring, and decreased with the increase of electron-withdrawing capability of the functional groups. These preliminary results suggested that the remarkable antibacterial efficiency against S. aureus makes these substances promising antimicrobial agents.展开更多
The four cobalt porphyrins [Co (3, 4, 5 MeO TPP) (1) ; Co (TTP) (2) ; Co (4 CI TPP) (3);Co (4 HSO 3 TPP) (4)] were synthesized and considered as two mimic of superoxide dismutaes (SOD) and catalase (CAT). The ...The four cobalt porphyrins [Co (3, 4, 5 MeO TPP) (1) ; Co (TTP) (2) ; Co (4 CI TPP) (3);Co (4 HSO 3 TPP) (4)] were synthesized and considered as two mimic of superoxide dismutaes (SOD) and catalase (CAT). The catalytic efficiency of them on deplete the harmful radical have been proved using riboflavin methionine photoreduction method in the concentration range of 10 6 ~10 5 mol/L. The catalytic efficiency of them at decomposing H 2O 2 has been performed by spectrophotometer. The percentage of decomposing H 2O 2 while the increasing the concentration of the imitating compounds. The lipid peroxidationproduced in liver homogenatcd of mice was determined by spectrophotometer detecting the content of MDA.展开更多
A synthetic method of porphyrins tailed with salicylic substituents is described. Reaction of bromoalkoxyphenyl porphyrin 1 with salicylic acid gave porphyrins 2~5. These new compounds were confirmed by 1H NMR, IR, ...A synthetic method of porphyrins tailed with salicylic substituents is described. Reaction of bromoalkoxyphenyl porphyrin 1 with salicylic acid gave porphyrins 2~5. These new compounds were confirmed by 1H NMR, IR, UV-vis, MS and elemental analysis, and observed their interaction with bovine serum albumin (BSA) in fluorescence spectrum.展开更多
6-Deoxy- 6-iodo-β-cyclodextrin (1) reacted with 5-(p-aminophenyl)-10, 15,20-triphenyl porphyrin(2), 5-(p-aminophenyl)-10,15,20-triphenyl nickel(Ⅱ) porphyrin [NiⅡTPPNH2P](3),5-(p-aminophenyl)-10,15,20-triphenyl mang...6-Deoxy- 6-iodo-β-cyclodextrin (1) reacted with 5-(p-aminophenyl)-10, 15,20-triphenyl porphyrin(2), 5-(p-aminophenyl)-10,15,20-triphenyl nickel(Ⅱ) porphyrin [NiⅡTPPNH2P](3),5-(p-aminophenyl)-10,15,20-triphenyl manganese(Ⅲ) porphyrin [MnⅢTPPNH2P] (4) and 5-(p-aminophenyl)-10,l5,20-triphenyl carbonyl ruthenium porphyrin [RuⅡ (CO)TPPNH2P] (5) to generate the compounds 6-9, respectively. Those new compound 5-9 have been identified by 1H NMR, IR, MS and UV-visible spectra and elemental analysis.展开更多
The reaction of 5-(p-hydroxyphenyl)-10, 15, 20- (p-methoxy phenyl) porphyrin with Br(CH2)4 Br produced monobromo substituted porphyrin 1. The tailed porphyrins 2–4 were synthesized by the reactions of 1 with small mo...The reaction of 5-(p-hydroxyphenyl)-10, 15, 20- (p-methoxy phenyl) porphyrin with Br(CH2)4 Br produced monobromo substituted porphyrin 1. The tailed porphyrins 2–4 were synthesized by the reactions of 1 with small molecular offering biological activities such as D-glucose, D-glucuronic acid. These new compounds were confirmed by1H NMR, IR, UV-vis and element analyses.展开更多
The reactions of 5,10,15,20-tetrakis(p-hydroxyphenyl) porphyrin 1 and 5-(p-hydroxyphenyl)-10,15,20-tris(p-methoxyphenyl) porphyrin 2 with 1-bromo-2,3,4,6-O-acetyl-alpha -D- glucoside 3 respectively afforded 5,10,15,20...The reactions of 5,10,15,20-tetrakis(p-hydroxyphenyl) porphyrin 1 and 5-(p-hydroxyphenyl)-10,15,20-tris(p-methoxyphenyl) porphyrin 2 with 1-bromo-2,3,4,6-O-acetyl-alpha -D- glucoside 3 respectively afforded 5,10,15,20-tetrakis[p-(2,3,4,6-O-acetyl-glucoside)-1-O-phenyl]porphyrin 4 and 5,10,15-tris(p-methoxyphenyl)-20-[p-(2,3,4,6-O-acetyl-glucoside)-1-O-phenyl] porphyrin 5. Their metal complexes Co-II(4), Mn-II (4) and Co-II(5), Mn-II'(5) also have been prepared. These new compounds have been identified by IR, UV-visible,H-1 NMR spectra and elemental analysis.展开更多
The reactions of 5- (p-hydroxyphenyl)-10, 15, 20-tris (p-methoxyphenyl) porphyrin(H2Por) 1 respectively with triruthenium dodecacarbonyl [Ru3 (CO)12] and triosmiumdodecacarbonyl [Os3 (CO)12] under N2 gave complexes 2 ...The reactions of 5- (p-hydroxyphenyl)-10, 15, 20-tris (p-methoxyphenyl) porphyrin(H2Por) 1 respectively with triruthenium dodecacarbonyl [Ru3 (CO)12] and triosmiumdodecacarbonyl [Os3 (CO)12] under N2 gave complexes 2 and 3. Treatment of 2 (and 3) withMerrifield' peptide resin gave 4 (and 5) respectively.展开更多
The reaction of 5, 10, 15, 20-tetra-(4-pyridyl) porphyrin 1 with triruthenium dodecacarbonyl [Ru3(CO)12], zinc(II) acetate, copper(II) acetate, cobalt(II) acetate afforded complexes 2a?2d respectively. Treatment of 2a...The reaction of 5, 10, 15, 20-tetra-(4-pyridyl) porphyrin 1 with triruthenium dodecacarbonyl [Ru3(CO)12], zinc(II) acetate, copper(II) acetate, cobalt(II) acetate afforded complexes 2a?2d respectively. Treatment of 2a?2d with Merrifield’s peptide resin obtained 3a?3d. The compounds 3a?3d reacted with methyl iodide respectively gave 4a?4d. New complexes 4a?4d have been identified by IR, UV-visible spectra, and AES.展开更多
The novel diporphyrin ligands in which the two porphyrin ring units attached via a rigid aromatic linker were prepared. Their structures have been identified by IR, UV visible, 1 H NMR spectra and elemental ana...The novel diporphyrin ligands in which the two porphyrin ring units attached via a rigid aromatic linker were prepared. Their structures have been identified by IR, UV visible, 1 H NMR spectra and elemental analysis.展开更多
A novel series of unsymmetrical porphyrins with aldehyde group at the terminal of the linkage which connected to meso-phenyl through acylamide bond have been synthesized and structurally characterized by IR, (1)H NMR,...A novel series of unsymmetrical porphyrins with aldehyde group at the terminal of the linkage which connected to meso-phenyl through acylamide bond have been synthesized and structurally characterized by IR, (1)H NMR, MS, UV–vis, fluorescence.展开更多
The reaction of 5-(4-hydroxyphenyl)-10,15,20-triphenyl porphyrin with 2,6-dibromomethylpyridine and 4,4′-dicarboxyl-2,2′-bipyridine respectively gave 2,6-bis-[5,10,15-triphenyl-20-(4-phenoxymethyl)-porphyrin-yl]-pyr...The reaction of 5-(4-hydroxyphenyl)-10,15,20-triphenyl porphyrin with 2,6-dibromomethylpyridine and 4,4′-dicarboxyl-2,2′-bipyridine respectively gave 2,6-bis-[5,10,15-triphenyl-20-(4-phenoxymethyl)-porphyrin-yl]-pyridine(3) and 4,4′-di-[5,10,15-triphenyl-20-(p-phenoxycarbonyl)-porphyrin-yl]-2,2′-bipyridine (4). 5-[4-(4′- Bromobutoxy) phenyl]-10,15,20-triphenyl porphyrin reacted with 2,6-dihydroxymethylpyridine to give 2,6-bis-[5,10,15-triphenyl-20-(4-(p-phenoxy)-butoxymethyl)-porphyrin-yl]-pyridine(5). Those new compounds have been identified by1H NMR, IR, MS and UV-visible spectra, and elemental analysis. Key words bridged porphyrin - synthesis - structure characterization CLC number O 626.13 Foundation item: Supported by the National Natural Science Foundation of China (29972035)Biography: FU Shi-tao (1979-), male, Ph. D candidate, research direction: porphyrin chemistry.展开更多
The reaction of pyrrole with 4-hydroxybenzaldehyde and 4-pyridinecarboxaldehyde afforded new porphyrin ligand 1. Treatment of 1 with copper( II ) acetate, cobalt ( II ) acetate gave complexes 2-3 respectively. 2 and 3...The reaction of pyrrole with 4-hydroxybenzaldehyde and 4-pyridinecarboxaldehyde afforded new porphyrin ligand 1. Treatment of 1 with copper( II ) acetate, cobalt ( II ) acetate gave complexes 2-3 respectively. 2 and 3 reacted with Merrifield's peptide resin produced 4 and 5. Complexes 4 and 5 reacted with methyl iodide respectively gave 6-7. The new compounds 1-7 have been identified by H-1 NMR, IR, MS and UV-visible spectra, elemental analysis and AES.展开更多
Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy(APDT)is one of the most promising and innovative approaches for the destruction of pathogenic microorganisms.Among the photosensi...Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy(APDT)is one of the most promising and innovative approaches for the destruction of pathogenic microorganisms.Among the photosensitizers(PSs),compounds based on cationic porphyrins/metalloporphyrins are most successfully used to inactivate microorganisms.Series of meso-substituted cationic pyridylporphyrins and metalloporphyrins with various peripheral groups in the third and fourth positions of the pyrrole ring have been synthesized in Armenia.The aim of this work was to determine and test the most e®ective cationic porphyrins and metalloporphyrins with high photoactivity against Gram negative and Gram positive microorganisms.It was shown that the synthesized cationic pyridylporphyrins/metalloporphyrins exhibit a high degree of phototoxicity towards both types of bacteria,including the methicillinresistant S.aureus strain.Zinc complexes of porphyrins are more phototoxic than metal-free porphyrin analogs.The e®ectiveness of these Zn–metalloporphyrins on bacteria is consistent with the level of singlet oxygen generation.It was found that the high antibacterial activity of the studied cationic porphyrins/metalloporphyrins depends on four factors:the presence in the porphyrin macrocycle of a positive charge(+4),a central metal atom(Zn2þÞand hydrophobic peripheral functional groups as well as high values of quantum yields of singlet oxygen.The results indicate that meso-substituted cationic pyridylporphyrins/metalloporphyrins cannd wider application in photoinactivation of bacteria than anionic or neutral PSs usually used in APDT.展开更多
The synthesis of polyfluoroalkoxyl substituted tetrakisphenylporphyrin is reported.The reaction is carrying out using Lewis acid BF_3·OEt_2 as catalyst and p-chloranil as oxidant.The yields of the porphyrins are ...The synthesis of polyfluoroalkoxyl substituted tetrakisphenylporphyrin is reported.The reaction is carrying out using Lewis acid BF_3·OEt_2 as catalyst and p-chloranil as oxidant.The yields of the porphyrins are about 30—40%.展开更多
Reaction of tetrakis(p-allyloxyphenyl)porphyrin and perfluoroalkanesulfonyl bromides gives tetrakis(p-polyfluoroalkoxylphenyl)substituted porphyrins.The yields are over 90%.The synthesis of the metal ion complexes of ...Reaction of tetrakis(p-allyloxyphenyl)porphyrin and perfluoroalkanesulfonyl bromides gives tetrakis(p-polyfluoroalkoxylphenyl)substituted porphyrins.The yields are over 90%.The synthesis of the metal ion complexes of these F-containing porphyrins is also reported.Preliminary results on the study of the catalytic activity of the manganese(Ⅲ)complexes of various fluorinated porphyrins on oxidation of cyclohexene indicate that the introduction of R_F group into porphyrin contributes to the stability of the catalysts.展开更多
A novel complex ZnTPPL1·3DMF 1(TPP = tetraphenylporphyrin,L1 = N-(4-(9-carbazolyl) phenyl)-N,N-di(4-pyridyl)amine) was prepared by a hydrothermal method and characterized by elemental analysis,IR,and sing...A novel complex ZnTPPL1·3DMF 1(TPP = tetraphenylporphyrin,L1 = N-(4-(9-carbazolyl) phenyl)-N,N-di(4-pyridyl)amine) was prepared by a hydrothermal method and characterized by elemental analysis,IR,and single-crystal X-ray diffraction analysis.Compound 1 crystallizes in triclinic,space group P1 with a = 13.3082(2),b = 14.3276(2),c = 18.6120(3) ,α = 109.853(1),β = 95.054(1),γ = 98.832(1)°,V = 3260.57(9) 3,Z = 2,Dc = 1.334 g/cm3,C81H69N11O3Zn,Mr = 1309.84,μ(MoKα) = 0.438 mm-1,F(000) = 1372,GOF = 1.159,the final R = 0.0482 and wR = 0.1479 for 12091 observed reflections(Ⅰ 〉 2σ(Ⅰ)).Crystal structure analyses revealed that L1 utilizes one pyridyl N atom to bind Zn via axial coordination,affording a 1:1 complex.The binding constant was estimated to be 1.74(7) × 10^4 M^-1 from electronic spectra measurements.展开更多
The attractive and impertan complexes, manganese porphyrin aromatic thiolates, are prepared directly by the reaction of chloro(5, 10, 15, 20-tetraphenylporphyrinato) manganese Mn(TPP)Cl with PhSNa and (p-NO2)PhSNa und...The attractive and impertan complexes, manganese porphyrin aromatic thiolates, are prepared directly by the reaction of chloro(5, 10, 15, 20-tetraphenylporphyrinato) manganese Mn(TPP)Cl with PhSNa and (p-NO2)PhSNa under extremely simple and mild reaction展开更多
基金Supported by the National Natural Science Foundation of China( No:2 9972 0 35 ) and the Zi-Qiang Science Foundationof Wuhan University2 0 0 0
文摘The synthesis and characterization of a series of metal porphyrins, MII(Por), {Por=dianionic of 5, 10, 15, 20-tetrakis [4-(4′-bromobutyloxy) phenyl]porphyrinato and 5, 10, 15, 20-tetrakis [4-(4′-butyloxypyridine bromide)phenyl]porphyrinato, M=Zn, Cu, Mn, Co, Ni, Ru-CO} were described. The complexes 3a-3e were prepared from the reactions of compound 2 with metal acetates in chloroform, and the treatment of 3a-3f with excess of pyridine gave corresponding complexes 4a-4f. These new compounds were identified by absorption spectroscopies,1H-NMR and elemental analyses. The results of biological activity testing for 4a-4f revealed that 4a and 4c had stronger inhibiting action on the growth metabolism ofEsche richia coli.
基金the National Natural Science Foundation of China is gratefully acknowledged (No. 29972035).
文摘The synthesis, characterization, and biological activities of a series of metal porphyrins were described. The complexes 3a similar to 3e were prepared from the reaction of compound 2 with M(OAc)(2) in CHCl3, and the treatment of 3a similar to 3f with pyridine gave corresponding complexes 4a similar to 4f. These new compounds were identified by absorption spectroscopies, H-1 NMR and elemental analysis. The results of biological activity,testing revealed that 4a and 4c had stronger inhibiting action for Escherichia coli (CCTCC AB91115).
基金the School of Pharmacy of Southwest University for their partial support to this work.
文摘A novel series of quaternary ammonium cationic derivatives based on tetrapyridyl-porphyrin was synthesized. All the compounds were evaluated for their in vitro antibacterial activities against S. aureus, E. coli and P. aeruginosa, and antifungal activities against C. albicans, where microorganisms were exposed and unexposed to the irradiation. The results revealed that some of these compounds, especially, 3a and 4a displayed satisfactory antibacterial activity against Gram-positive bacteria S. aureus and moderate antifungal activity against C. albicans. Unfortunately, Gram-negative bacteria P aeruginasa was resistant to all compounds. The antimicrobial activity was found to be sensitive to the functional groups attached on the aromatic ring and the complex metal in the porphyrin ring, and decreased with the increase of electron-withdrawing capability of the functional groups. These preliminary results suggested that the remarkable antibacterial efficiency against S. aureus makes these substances promising antimicrobial agents.
文摘The four cobalt porphyrins [Co (3, 4, 5 MeO TPP) (1) ; Co (TTP) (2) ; Co (4 CI TPP) (3);Co (4 HSO 3 TPP) (4)] were synthesized and considered as two mimic of superoxide dismutaes (SOD) and catalase (CAT). The catalytic efficiency of them on deplete the harmful radical have been proved using riboflavin methionine photoreduction method in the concentration range of 10 6 ~10 5 mol/L. The catalytic efficiency of them at decomposing H 2O 2 has been performed by spectrophotometer. The percentage of decomposing H 2O 2 while the increasing the concentration of the imitating compounds. The lipid peroxidationproduced in liver homogenatcd of mice was determined by spectrophotometer detecting the content of MDA.
文摘A synthetic method of porphyrins tailed with salicylic substituents is described. Reaction of bromoalkoxyphenyl porphyrin 1 with salicylic acid gave porphyrins 2~5. These new compounds were confirmed by 1H NMR, IR, UV-vis, MS and elemental analysis, and observed their interaction with bovine serum albumin (BSA) in fluorescence spectrum.
文摘6-Deoxy- 6-iodo-β-cyclodextrin (1) reacted with 5-(p-aminophenyl)-10, 15,20-triphenyl porphyrin(2), 5-(p-aminophenyl)-10,15,20-triphenyl nickel(Ⅱ) porphyrin [NiⅡTPPNH2P](3),5-(p-aminophenyl)-10,15,20-triphenyl manganese(Ⅲ) porphyrin [MnⅢTPPNH2P] (4) and 5-(p-aminophenyl)-10,l5,20-triphenyl carbonyl ruthenium porphyrin [RuⅡ (CO)TPPNH2P] (5) to generate the compounds 6-9, respectively. Those new compound 5-9 have been identified by 1H NMR, IR, MS and UV-visible spectra and elemental analysis.
文摘The reaction of 5-(p-hydroxyphenyl)-10, 15, 20- (p-methoxy phenyl) porphyrin with Br(CH2)4 Br produced monobromo substituted porphyrin 1. The tailed porphyrins 2–4 were synthesized by the reactions of 1 with small molecular offering biological activities such as D-glucose, D-glucuronic acid. These new compounds were confirmed by1H NMR, IR, UV-vis and element analyses.
基金This work was supported by the National Natural Science Foundation of China(projects No.29972035).
文摘The reactions of 5,10,15,20-tetrakis(p-hydroxyphenyl) porphyrin 1 and 5-(p-hydroxyphenyl)-10,15,20-tris(p-methoxyphenyl) porphyrin 2 with 1-bromo-2,3,4,6-O-acetyl-alpha -D- glucoside 3 respectively afforded 5,10,15,20-tetrakis[p-(2,3,4,6-O-acetyl-glucoside)-1-O-phenyl]porphyrin 4 and 5,10,15-tris(p-methoxyphenyl)-20-[p-(2,3,4,6-O-acetyl-glucoside)-1-O-phenyl] porphyrin 5. Their metal complexes Co-II(4), Mn-II (4) and Co-II(5), Mn-II'(5) also have been prepared. These new compounds have been identified by IR, UV-visible,H-1 NMR spectra and elemental analysis.
文摘The reactions of 5- (p-hydroxyphenyl)-10, 15, 20-tris (p-methoxyphenyl) porphyrin(H2Por) 1 respectively with triruthenium dodecacarbonyl [Ru3 (CO)12] and triosmiumdodecacarbonyl [Os3 (CO)12] under N2 gave complexes 2 and 3. Treatment of 2 (and 3) withMerrifield' peptide resin gave 4 (and 5) respectively.
文摘The reaction of 5, 10, 15, 20-tetra-(4-pyridyl) porphyrin 1 with triruthenium dodecacarbonyl [Ru3(CO)12], zinc(II) acetate, copper(II) acetate, cobalt(II) acetate afforded complexes 2a?2d respectively. Treatment of 2a?2d with Merrifield’s peptide resin obtained 3a?3d. The compounds 3a?3d reacted with methyl iodide respectively gave 4a?4d. New complexes 4a?4d have been identified by IR, UV-visible spectra, and AES.
文摘The novel diporphyrin ligands in which the two porphyrin ring units attached via a rigid aromatic linker were prepared. Their structures have been identified by IR, UV visible, 1 H NMR spectra and elemental analysis.
文摘A novel series of unsymmetrical porphyrins with aldehyde group at the terminal of the linkage which connected to meso-phenyl through acylamide bond have been synthesized and structurally characterized by IR, (1)H NMR, MS, UV–vis, fluorescence.
文摘The reaction of 5-(4-hydroxyphenyl)-10,15,20-triphenyl porphyrin with 2,6-dibromomethylpyridine and 4,4′-dicarboxyl-2,2′-bipyridine respectively gave 2,6-bis-[5,10,15-triphenyl-20-(4-phenoxymethyl)-porphyrin-yl]-pyridine(3) and 4,4′-di-[5,10,15-triphenyl-20-(p-phenoxycarbonyl)-porphyrin-yl]-2,2′-bipyridine (4). 5-[4-(4′- Bromobutoxy) phenyl]-10,15,20-triphenyl porphyrin reacted with 2,6-dihydroxymethylpyridine to give 2,6-bis-[5,10,15-triphenyl-20-(4-(p-phenoxy)-butoxymethyl)-porphyrin-yl]-pyridine(5). Those new compounds have been identified by1H NMR, IR, MS and UV-visible spectra, and elemental analysis. Key words bridged porphyrin - synthesis - structure characterization CLC number O 626.13 Foundation item: Supported by the National Natural Science Foundation of China (29972035)Biography: FU Shi-tao (1979-), male, Ph. D candidate, research direction: porphyrin chemistry.
文摘The reaction of pyrrole with 4-hydroxybenzaldehyde and 4-pyridinecarboxaldehyde afforded new porphyrin ligand 1. Treatment of 1 with copper( II ) acetate, cobalt ( II ) acetate gave complexes 2-3 respectively. 2 and 3 reacted with Merrifield's peptide resin produced 4 and 5. Complexes 4 and 5 reacted with methyl iodide respectively gave 6-7. The new compounds 1-7 have been identified by H-1 NMR, IR, MS and UV-visible spectra, elemental analysis and AES.
基金the Decree of the Government of the Russian Federation No.220 of April 9,2010(Agreement No.075-15-2021-615 of June 4,2021).
文摘Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy(APDT)is one of the most promising and innovative approaches for the destruction of pathogenic microorganisms.Among the photosensitizers(PSs),compounds based on cationic porphyrins/metalloporphyrins are most successfully used to inactivate microorganisms.Series of meso-substituted cationic pyridylporphyrins and metalloporphyrins with various peripheral groups in the third and fourth positions of the pyrrole ring have been synthesized in Armenia.The aim of this work was to determine and test the most e®ective cationic porphyrins and metalloporphyrins with high photoactivity against Gram negative and Gram positive microorganisms.It was shown that the synthesized cationic pyridylporphyrins/metalloporphyrins exhibit a high degree of phototoxicity towards both types of bacteria,including the methicillinresistant S.aureus strain.Zinc complexes of porphyrins are more phototoxic than metal-free porphyrin analogs.The e®ectiveness of these Zn–metalloporphyrins on bacteria is consistent with the level of singlet oxygen generation.It was found that the high antibacterial activity of the studied cationic porphyrins/metalloporphyrins depends on four factors:the presence in the porphyrin macrocycle of a positive charge(+4),a central metal atom(Zn2þÞand hydrophobic peripheral functional groups as well as high values of quantum yields of singlet oxygen.The results indicate that meso-substituted cationic pyridylporphyrins/metalloporphyrins cannd wider application in photoinactivation of bacteria than anionic or neutral PSs usually used in APDT.
文摘The synthesis of polyfluoroalkoxyl substituted tetrakisphenylporphyrin is reported.The reaction is carrying out using Lewis acid BF_3·OEt_2 as catalyst and p-chloranil as oxidant.The yields of the porphyrins are about 30—40%.
文摘Reaction of tetrakis(p-allyloxyphenyl)porphyrin and perfluoroalkanesulfonyl bromides gives tetrakis(p-polyfluoroalkoxylphenyl)substituted porphyrins.The yields are over 90%.The synthesis of the metal ion complexes of these F-containing porphyrins is also reported.Preliminary results on the study of the catalytic activity of the manganese(Ⅲ)complexes of various fluorinated porphyrins on oxidation of cyclohexene indicate that the introduction of R_F group into porphyrin contributes to the stability of the catalysts.
基金Supported by the Shanghai Pujiang Program (08PJ14037),NNSFC,SRF for ROCS,and SEM
文摘A novel complex ZnTPPL1·3DMF 1(TPP = tetraphenylporphyrin,L1 = N-(4-(9-carbazolyl) phenyl)-N,N-di(4-pyridyl)amine) was prepared by a hydrothermal method and characterized by elemental analysis,IR,and single-crystal X-ray diffraction analysis.Compound 1 crystallizes in triclinic,space group P1 with a = 13.3082(2),b = 14.3276(2),c = 18.6120(3) ,α = 109.853(1),β = 95.054(1),γ = 98.832(1)°,V = 3260.57(9) 3,Z = 2,Dc = 1.334 g/cm3,C81H69N11O3Zn,Mr = 1309.84,μ(MoKα) = 0.438 mm-1,F(000) = 1372,GOF = 1.159,the final R = 0.0482 and wR = 0.1479 for 12091 observed reflections(Ⅰ 〉 2σ(Ⅰ)).Crystal structure analyses revealed that L1 utilizes one pyridyl N atom to bind Zn via axial coordination,affording a 1:1 complex.The binding constant was estimated to be 1.74(7) × 10^4 M^-1 from electronic spectra measurements.
文摘The attractive and impertan complexes, manganese porphyrin aromatic thiolates, are prepared directly by the reaction of chloro(5, 10, 15, 20-tetraphenylporphyrinato) manganese Mn(TPP)Cl with PhSNa and (p-NO2)PhSNa under extremely simple and mild reaction