Katherine Anne Porter is a prominent figure in American literary history,particularly excelling in the realm of short stories as a novelist and stylist.This paper studies her short stories,combined with her growth and...Katherine Anne Porter is a prominent figure in American literary history,particularly excelling in the realm of short stories as a novelist and stylist.This paper studies her short stories,combined with her growth and life experience,from the revolutionary independence of youth to middle-aged female consciousness to the old age of home-sick and miss to relatives,Katherine Anne Porter reveals a sense of loneliness and desire.Her exquisite writing style,agile language,psychological character portrait,gives a picture of the specific history and social changes under her thoughts and life insight.展开更多
In the first half of the 20th century, a great number of modernism literary works emerged. Katherine Ann Porter,a famous short story writer and stylist, has positive thoughts and keen insights, and her unique artistic...In the first half of the 20th century, a great number of modernism literary works emerged. Katherine Ann Porter,a famous short story writer and stylist, has positive thoughts and keen insights, and her unique artistic features inher works are innovative and attractive. Her works also have a good reputation both at home and abroad. This paperselects Porter’s famous collection Pale Horse, Pale Rider including Old Morality and Noon Wine to analyze andexplore their narrative technique.展开更多
AIM:To evaluate the correlation between the level of 18 F-fluoro-2-deoxyglucose (18 F-FDG) uptake and glucose transporter 1 (GLUT1) expression in colorectal adenocarcinoma (CRA).METHODS:Forty four patients with resect...AIM:To evaluate the correlation between the level of 18 F-fluoro-2-deoxyglucose (18 F-FDG) uptake and glucose transporter 1 (GLUT1) expression in colorectal adenocarcinoma (CRA).METHODS:Forty four patients with resected CRA and preoperative 18 F-FDG positron emission tomography computed tomography data were investigated in this study.Comparison of maximum standardized uptake value (SUVmax) of the lesion was made with GLUT1 expression by immunohistochemistry and various clinicopathologic factors including tumor volume,invasion depth,gross finding,and lymph node metastasis.RESULTS:SUVmax was 14.45 ± 7.0 in negative GLUT1 expression cases,15.51 ± 5.7 in weak GLUT1 expression cases,and 16.52 ± 6.8 in strong GLUT1 expression cases,and there was no correlation between between GLUT1 expression and SUVmax.SUVmax was significantly correlated with tumor volume (P < 0.001).However,there was no significant differences in SUVmax and GLUT1 expression among other clinicopathologic factors.CONCLUSION:GLUT1 expression does not correlates significantly with 18 F-FDG uptake in CRA.18 F-FDG uptake was increased with tumor volume,which is statistically significant.展开更多
This paper will define the scope of hotel industry,specifically use Michael Porter 's five forces to explain the natural environment and competitive situation in this field.The porter's theory would significan...This paper will define the scope of hotel industry,specifically use Michael Porter 's five forces to explain the natural environment and competitive situation in this field.The porter's theory would significantly help hotel managers to apply key marketing strategies and gain more competitive advantages.展开更多
AIM: To evaluate the inhibitory effects of apigenin and kaempferol on the uptake of several important solute carrier(SLC) transporters.METHODS: Various SLC transporters including the essential human organic anion tran...AIM: To evaluate the inhibitory effects of apigenin and kaempferol on the uptake of several important solute carrier(SLC) transporters.METHODS: Various SLC transporters including the essential human organic anion transporter 1(OAT1), OAT2, OAT3 and OAT4 as well as the important organic cation transporter 1(OCTN1) and OCTN2, were overexpressed in human embryonic kidney(HEK)-293 cells, a well-established cell model of transporter studies. Transport uptake assay was performed 24 h after the transfection. The transport activity was assessed with the uptake of previously determined transporter model substrates and the inhibitory effect of apigenin and kaempferol was evaluated with the substrate uptake in the presence of 10 μmol/L of each compound. Uptakemeasurements with varying concentrations of inhibitors(ranged from 0.0001 to 50 μmol/L) were performed to further characterize the inhibitory potency of apigenin and kaempferol. The IC50 value(the concentration that inhibits 50% of the transporter function) of each compound was then calculated by the nonlinear regression model of Graphpad Prism 6.0 software.RESULTS: Our data indicated that apigenin could potently inhibit the uptake of estrone-3-sulfate(ES) mediated by the HEK-293 cells expressing OAT2, OAT3 and OAT4 as well as the L-ergothioneine uptake via OCTN1-expressing HEK-293 cells. Among these transporters, the most prominent inhibition of apigenin was observed in the case of OAT3. Kaempferol showed significant inhibitory effects on the uptake of ES mediated through OAT2 and OAT3. Impaired L-ergothioneine uptake due to the presence of kaempferol was also observed in OCTN1-expressing HEK-293 cells. Similar to apigenin, kaempferol showed the most potent inhibitory effect on OAT3 as well. To further assess the inhibitory potencies of these two compounds on the uptake of ES mediated by OAT3-expressing HEK-293 cells, their IC50 values were then determined. Both chemicals showed pronounced inhibitory potencies on OAT3 with the IC50 values of 1.7 ± 0.1 and 1.0 ± 0.1 μmol/L(P < 0.01) for apigenin and kaempferol, respectively. CONCLUSION: Both apigenin and kaempferol are potent inhibitors of OAT3; precautions will be necessary when co-administrating them with drugs that are substrates of OAT3.展开更多
Based on theoretical derivation,this paper aims to analyse the internal relationship between Porter Hypothesis and Environmental Kuznets Curve.Conclusions were made:(1)In terms of theoretical analysis and empirical re...Based on theoretical derivation,this paper aims to analyse the internal relationship between Porter Hypothesis and Environmental Kuznets Curve.Conclusions were made:(1)In terms of theoretical analysis and empirical researches,the existence of inverted U-shaped EKC and U-shaped Porter Curve has its rationality,most of the controversy come from the misuse and diversity of empirical methods;(2)The progress of Porter Hypothesis also relys on economic growth,which is compatible with EKC;(3)Similar to EKC,a threshold effect exist in the process of technological progress.Environmental regulation is a driving force to promote the widespread use of green technology and reach the threshold.(4)In the process of speeding up economic development,government should gradually increase the intensity of environmental regulation.展开更多
文摘Katherine Anne Porter is a prominent figure in American literary history,particularly excelling in the realm of short stories as a novelist and stylist.This paper studies her short stories,combined with her growth and life experience,from the revolutionary independence of youth to middle-aged female consciousness to the old age of home-sick and miss to relatives,Katherine Anne Porter reveals a sense of loneliness and desire.Her exquisite writing style,agile language,psychological character portrait,gives a picture of the specific history and social changes under her thoughts and life insight.
文摘In the first half of the 20th century, a great number of modernism literary works emerged. Katherine Ann Porter,a famous short story writer and stylist, has positive thoughts and keen insights, and her unique artistic features inher works are innovative and attractive. Her works also have a good reputation both at home and abroad. This paperselects Porter’s famous collection Pale Horse, Pale Rider including Old Morality and Noon Wine to analyze andexplore their narrative technique.
基金Supported by National Research Foundation of Korea Grant funded by the Ministry of Education,Science and Technology through the Research Center for Resistant Cells,No.R13-2003-009
文摘AIM:To evaluate the correlation between the level of 18 F-fluoro-2-deoxyglucose (18 F-FDG) uptake and glucose transporter 1 (GLUT1) expression in colorectal adenocarcinoma (CRA).METHODS:Forty four patients with resected CRA and preoperative 18 F-FDG positron emission tomography computed tomography data were investigated in this study.Comparison of maximum standardized uptake value (SUVmax) of the lesion was made with GLUT1 expression by immunohistochemistry and various clinicopathologic factors including tumor volume,invasion depth,gross finding,and lymph node metastasis.RESULTS:SUVmax was 14.45 ± 7.0 in negative GLUT1 expression cases,15.51 ± 5.7 in weak GLUT1 expression cases,and 16.52 ± 6.8 in strong GLUT1 expression cases,and there was no correlation between between GLUT1 expression and SUVmax.SUVmax was significantly correlated with tumor volume (P < 0.001).However,there was no significant differences in SUVmax and GLUT1 expression among other clinicopathologic factors.CONCLUSION:GLUT1 expression does not correlates significantly with 18 F-FDG uptake in CRA.18 F-FDG uptake was increased with tumor volume,which is statistically significant.
文摘This paper will define the scope of hotel industry,specifically use Michael Porter 's five forces to explain the natural environment and competitive situation in this field.The porter's theory would significantly help hotel managers to apply key marketing strategies and gain more competitive advantages.
基金Supported by Internal funding from Faculty of Pharmacy,the University of Sydney,Australia
文摘AIM: To evaluate the inhibitory effects of apigenin and kaempferol on the uptake of several important solute carrier(SLC) transporters.METHODS: Various SLC transporters including the essential human organic anion transporter 1(OAT1), OAT2, OAT3 and OAT4 as well as the important organic cation transporter 1(OCTN1) and OCTN2, were overexpressed in human embryonic kidney(HEK)-293 cells, a well-established cell model of transporter studies. Transport uptake assay was performed 24 h after the transfection. The transport activity was assessed with the uptake of previously determined transporter model substrates and the inhibitory effect of apigenin and kaempferol was evaluated with the substrate uptake in the presence of 10 μmol/L of each compound. Uptakemeasurements with varying concentrations of inhibitors(ranged from 0.0001 to 50 μmol/L) were performed to further characterize the inhibitory potency of apigenin and kaempferol. The IC50 value(the concentration that inhibits 50% of the transporter function) of each compound was then calculated by the nonlinear regression model of Graphpad Prism 6.0 software.RESULTS: Our data indicated that apigenin could potently inhibit the uptake of estrone-3-sulfate(ES) mediated by the HEK-293 cells expressing OAT2, OAT3 and OAT4 as well as the L-ergothioneine uptake via OCTN1-expressing HEK-293 cells. Among these transporters, the most prominent inhibition of apigenin was observed in the case of OAT3. Kaempferol showed significant inhibitory effects on the uptake of ES mediated through OAT2 and OAT3. Impaired L-ergothioneine uptake due to the presence of kaempferol was also observed in OCTN1-expressing HEK-293 cells. Similar to apigenin, kaempferol showed the most potent inhibitory effect on OAT3 as well. To further assess the inhibitory potencies of these two compounds on the uptake of ES mediated by OAT3-expressing HEK-293 cells, their IC50 values were then determined. Both chemicals showed pronounced inhibitory potencies on OAT3 with the IC50 values of 1.7 ± 0.1 and 1.0 ± 0.1 μmol/L(P < 0.01) for apigenin and kaempferol, respectively. CONCLUSION: Both apigenin and kaempferol are potent inhibitors of OAT3; precautions will be necessary when co-administrating them with drugs that are substrates of OAT3.
文摘Based on theoretical derivation,this paper aims to analyse the internal relationship between Porter Hypothesis and Environmental Kuznets Curve.Conclusions were made:(1)In terms of theoretical analysis and empirical researches,the existence of inverted U-shaped EKC and U-shaped Porter Curve has its rationality,most of the controversy come from the misuse and diversity of empirical methods;(2)The progress of Porter Hypothesis also relys on economic growth,which is compatible with EKC;(3)Similar to EKC,a threshold effect exist in the process of technological progress.Environmental regulation is a driving force to promote the widespread use of green technology and reach the threshold.(4)In the process of speeding up economic development,government should gradually increase the intensity of environmental regulation.
