Xianyang Lake is the abbreviation of Weihe River(Xianyang Urban Area Section) Comprehensive Treatment Project,which is to build a partition wall in the middle of the 500 wide Weihe River Valley,then a 270 m wide water...Xianyang Lake is the abbreviation of Weihe River(Xianyang Urban Area Section) Comprehensive Treatment Project,which is to build a partition wall in the middle of the 500 wide Weihe River Valley,then a 270 m wide water storage channel on the north side and a 230 m wide muddy water floodway channel on the south side will be formed.Two rubber dams are constructed in the water storage channels to form a 'Xianyang Lake' with an area of 1.24×106 m2,meanwhile,along both sides of Weihe River in this section,slope protection and flood prevention as well as a series of greening and cultural landscape projects are to be constructed.This project,with flood prevention as the core,aims to improve the living environment and protect ecological environment,and realize the comprehensive treatment of river way flood-proofing,desilting,sewage purification,greening and beautification.The construction of Xianyang Lake greatly improves the image of Xianyang City and generates considerable economic,social and ecological benefits,however,it also has negative effects,such as insufficient lake water supply,original ecology being intervened by human activities,aggravating local fiscal burden,and potential threats to the flood-proofing in the lower reaches of Weihe River.The author puts forwards that 'creating a lake by damming the river' in the process of urbanization and solving the conflicts between sectional interests and integrated interests should follow natural laws and go along the track of sustainable development,which is also the orientation of future work,and the concrete reform scheme is to be further studied.展开更多
The Loess positive and negative terrains (P-N terrains), which are widely distributed on the Loess Plateau, are discussed for the first time by introducing its characteristic, demarcation as well as extraction metho...The Loess positive and negative terrains (P-N terrains), which are widely distributed on the Loess Plateau, are discussed for the first time by introducing its characteristic, demarcation as well as extraction method from high-resolution Digital Elevation Models. Using 5 m-resolution DEMs as original test data, P-N terrains of 48 geomorphological units in different parts of Shaanxi Loess Plateau are extracted accurately. Then six indicators for depicting the geomorphologic landscape and spatial configuration characteristic of P-N terrains are proposed. The spatial distribution rules of these indicators and the relationship between the P-N terrains and Loess relief are discussed for further understanding of Loess landforms. Finally, with the integration of P-N terrains and traditional terrain indices, a series of un-supervised classification methods are applied to make a proper landform classification in northern Shaanxi. Results show that P-N terrains are an effect clue to reveal energy and substance distribution rules on the Loess Plateau. A continuous change of P-N terrains from south to north in Shaanxi Loess Plateau shows an obvious spatial difference of Loess land-forms and the positive terrain area only accounted for 60.5% in this region. The P-N terrains participant landform classification method increases validity of the result, especially in the Loess tableland, Loess tableland-ridge and the Loess low-hill area. This research is significant on the study of Loess landforms with the Digital Terrains Analysis methods.展开更多
Vegetative insecticidal proteins (VIPs), produced during the vegetative stage of their growth in Bacillus thuringiensis, are a group of insecticidal proteins and represent the second generation of insecticidal trans...Vegetative insecticidal proteins (VIPs), produced during the vegetative stage of their growth in Bacillus thuringiensis, are a group of insecticidal proteins and represent the second generation of insecticidal trans-genes that will complement the novel δendotoxins in future. Fewer structural and functional relationships of Vip proteins are known in comparison with those of δ-endotoxins. In this study, both the maximum-likelihood methods and the maximum parsimony based sliding window analysis were used to evaluate the molecular evolution of Vip proteins. As a result, strong evidence was found that Vip proteins are subject to the high rates of positive selection, and 16 sites are identified to be under positive selection using the Bayes Empirical Bayesian method. Interestingly, all these positively selected sites are located from site-705 to site-809 in the C-terminus of the Vip proteins. Most of these sites are exposed and clustered in the loop regions when mapped onto its computational predicted secondary tertiary and a part of the tertiary structure. It has been postulated that the high divergence in the C-terminal of Vip proteins may not result from the lack of functional constraints, but rather from the rapid mutation to adapt their targeted insects, driven by positive selection. The potential positive selection pressures may be an attempt to adapt for the "arm race" between Vip proteins and the targeted insects, or to enlarge their target's host range. Sites identified to be under positive selection may be related to the insect host range, which may shed a light on the investigation of the Vip proteins' structural and functional relationships.展开更多
The positive and negative terrains(P-N terrains) widely distributed across China's Loess Plateau constitute the dual structure characteristic of loess landforms. Analysis of loess P-N terrains at the watershed sca...The positive and negative terrains(P-N terrains) widely distributed across China's Loess Plateau constitute the dual structure characteristic of loess landforms. Analysis of loess P-N terrains at the watershed scale can serve to elucidate the structural characteristics and spatial patterns of P-N terrains, which benefits a better understanding of watershed evolution and suitable scales for loess landform research. The Two-Term Local Quadrat Variance Analysis(TTLQV) is calculated as the average of the square of the difference between the block totals of all possible adjacent pairs of block size, which can be used to detect both the scale and the intensity of landscape patches(e.g., plant/animal communities and gully networks). In this study, we determined the latitudinal and longitudinal spatial scale of P-N terrain patterns within 104 uniformly distributed watersheds in our target soil and water conservation region. The results showed that TTLQV is very effective for examining the scale of P-N terrain patterns. There were apparently three types of P-N terrain pattern in latitudinal direction(i.e., Loess Tableland type, Loess Hill type, and Transitional Form between Sand and Loess type), whereas there were both lower and higher values for P-N terrain pattern scales in all loess landforms in the longitudinal direction. The P-N terrain pattern alsoclearly presented anisotropy, suggesting that gully networks in the main direction were well-developed while others were relatively undeveloped. In addition, the relationships between the first scales and controlling factors(i.e., gully density, nibble degree, watershed area, mean watershed slope, NDVI, precipitation, loess thickness, and loess landforms) revealed that the first scales are primarily controlled by watershed area and loess landforms. This may indicate that the current spatial pattern of P-N terrains is characterized by internal force. In selecting suitable study areas in China' Loess Plateau, it is crucial to understand four control variables: the spatial scale of the P-N terrain pattern, the watershed area, the main direction of the watershed, and the loess landforms.展开更多
The oscillatory behavior of neutral differential equation with positive and negative coefficients is investigated by mathematics analysis technique and the fixed point principle. Some sufficient conditions for oscilla...The oscillatory behavior of neutral differential equation with positive and negative coefficients is investigated by mathematics analysis technique and the fixed point principle. Some sufficient conditions for oscillation of neutral differential equation with positive and negative coefficients are obtained.展开更多
Human enterovirus 71 viruses have been long circulating throughout the world. In this study, we performed a positive selection analysis of the VP1 genes of capsid proteins from Enterovirus 71 viruses. Our results show...Human enterovirus 71 viruses have been long circulating throughout the world. In this study, we performed a positive selection analysis of the VP1 genes of capsid proteins from Enterovirus 71 viruses. Our results showed that although most sites were under negative or neutral evolution, four positions of the VP1 genes were under positive selection pressure. This might account for the spread and frequent outbreaks of the viruses and the enhanced neurovirulence. In particular, position 98 might be involved in neutralizing antibodies, modulating the virus-receptor interaction and enhancing the virulence of the viruses. Moreover, both positions 145 and 241 might correlate to determine the receptor specificity. However, these positions did not display much difference in amino acid polymorphism. In addition, no position in the VP1 genes of viruses isolated from China was under positive selection.展开更多
To overcome the limitations of traditional monitoring methods, based on vibration parameter image of rotating machinery, this paper presents an abnormality online monitoring method suitable for rotating machinery usin...To overcome the limitations of traditional monitoring methods, based on vibration parameter image of rotating machinery, this paper presents an abnormality online monitoring method suitable for rotating machinery using the negative selection mechanism of biology immune system. This method uses techniques of biology clone and learning mechanism to improve the negative selection algorithm to generate detectors possessing different monitoring radius, covers the abnormality space effectively, and avoids such problems as the low efficiency of generating detectors, etc. The result of an example applying the presented monitoring method shows that this method can solve the difficulty of obtaining fault samples preferably and extract the turbine state character effectively, it also can detect abnormality by causing various fault of the turbine and obtain the degree of abnormality accurately. The exact monitoring precision of abnormality indicates that this method is feasible and has better on-line quality, accuracy and robustness.展开更多
T cells are derived from progenitor thymocytes, of which only a minority receive the appropriate TCR signal, undergo positive selection and mature. Owing to the very short lifespan of thymocytes, the prerequisite for ...T cells are derived from progenitor thymocytes, of which only a minority receive the appropriate TCR signal, undergo positive selection and mature. Owing to the very short lifespan of thymocytes, the prerequisite for posi- tive selection is survival. TCR signal-induced Bcl-2 expression is believed to play a dominant role in the survival of positively selecting thymocytes, but how Bcl-2 is directly regulated is unknown. Here we report that the immediate early gene (IEG) c-Fos can stimulate the expression of Bcl-2, depending on a specific AP-l-binding site in the Bcl-2 promoter. In c-Fos transgenic (Fos-Tg) mice, c-Fos binds to this site and promotes the expression of Bcl-2. As a result, Fos-Tg thymocytes exhibited enhanced survival, and more mature single-positive (SP) thymocytes were generated, even on a unique TCR background. The TCR repertoire remained normal in Fos-Tg mice. Our results identified c-Fos as the mediator of the stimulatory effect of TCR signaling on Bcl-2 expression. Therefore, c-Fos, as an IEG, because of its early response ability, can quickly rescue the survival of short-lived thymocytes during positive selection. Our results provide novel insight into the mechanism regulating the survival of positively selecting thymocytes.展开更多
Leader propagation is a fundamental issue in lightning physics. The propagation characteristics of positive leaders and negative leaders are summarized and compared based on data from high-speed camera and electromagn...Leader propagation is a fundamental issue in lightning physics. The propagation characteristics of positive leaders and negative leaders are summarized and compared based on data from high-speed camera and electromagnetic field in rocket-triggered lightning and tower-initiated lightning discharges; available channel base current data recorded in rocket-triggered lightning are also used. The negative leaders propagate in a stepped fashion accompanied by many branches. The stems ahead of the negative leader tip determine the manner and direction of the leader propagation, and even the branching and winding of the lightning channel. The impulsive current, electromagnetic field, and related optical images suggest that the positive leader may develop in a step-like fashion at its initial stage of triggered lightning. However, the stepping processes of the positive leader are obviously different from those of the negative leader. Tower-initiated lightning revealed that the most conspicuous characteristics of the stepwise positive leader involve the intermittent brush-like corona zone in front of the leader tip and the luminosity enhancement of the channel behind the tip. In rockettriggered lightning flashes, the charge transferred during an individual step for the negative leader was nearly an order greater than for the positive counterpart. The successive streamers ahead of the leader tip are essential for both negative and positive leader propagation, and the stems could be formed from one or more streamers in the previous negative streamer zone with the main leader channel dim. High-resolution observation of tower lightning also revealed a new type of bidirectional recoil leader, with polarity contrary to the traditional one, traversing in negative channels associated with tower-initiated and rocket-triggered lightning.展开更多
A neutral difference equation with positive and negative coefficientsΔ(x n-c nx n-k )+p nx n-l -q nx n-r =0, n=0,1,2,...,is considered and a sufficient condition for the global attractivity of the ze...A neutral difference equation with positive and negative coefficientsΔ(x n-c nx n-k )+p nx n-l -q nx n-r =0, n=0,1,2,...,is considered and a sufficient condition for the global attractivity of the zero solution of this equation is obtained, which improves and extends the all known results in the literature.展开更多
In this paper the sufficient conditions for the existence of positive solutions of the neutral difference equations with positive and negative coefficients are established. The results improve some known conclusions i...In this paper the sufficient conditions for the existence of positive solutions of the neutral difference equations with positive and negative coefficients are established. The results improve some known conclusions in the literature.展开更多
People living on the high plateaus of the world have long fascinated biological anthropologists and geneticists because they live in "thin air" and epitomize an extreme of human biological adaptation.
This paper proposes a negative selection with neighborhood representation named as neighborhood negative selection algorithm.This algorithm employs a new representation method which uses the fully adjacent but mutuall...This paper proposes a negative selection with neighborhood representation named as neighborhood negative selection algorithm.This algorithm employs a new representation method which uses the fully adjacent but mutually disjoint neighborhoods to present the self samples and detectors.After normalizing the normal samples into neighborhood shape space,the algorithm uses a special matching rule similar as Hamming distance to train mature detectors at the training stage and detect anomaly at the detection stage.The neighborhood negative selection algorithm is tested using KDD CUP 1999 dataset.Experimental results show that the algorithm can prevent the negative effect of the dimension of shape space,and provide a more accuracy and stable detection performance.展开更多
In this paper,we consider the forced neutral advanced dynamic equations with positive and negative coeffcients[x(t)-R(t)x(t+r)]+P(t)x(t+τ)△Q(t)x(t+δ)= f(t),t≥t0 on a time scale T.Several suffcient conditions are o...In this paper,we consider the forced neutral advanced dynamic equations with positive and negative coeffcients[x(t)-R(t)x(t+r)]+P(t)x(t+τ)△Q(t)x(t+δ)= f(t),t≥t0 on a time scale T.Several suffcient conditions are obtained for the oscillation of the dynamic equations.The main result is illustrated by an example.展开更多
Point-wise negative selection algorithms,which generate their detector sets based on point of self data,have lower training efficiency and detection rate.To solve this problem,a self region based real-valued negative ...Point-wise negative selection algorithms,which generate their detector sets based on point of self data,have lower training efficiency and detection rate.To solve this problem,a self region based real-valued negative selection algorithm is presented.In this new approach,the continuous self region is defined by the collection of self data,the partial training takes place at the training stage according to both the radius of self region and the cosine distance between gravity of the self region and detector candidate,and variable detectors in the self region are deployed.The algorithm is tested using the triangle shape of self region in the 2-D complement space and KDD CUP 1999 data set.Results show that,more information can be provided when the training self points are used together as a whole,and compared with the point-wise negative selection algorithm,the new approach can improve the training efficiency of system and the detection rate significantly.展开更多
Objective:To determine the effect of an immunosuppressive active component (periploside A) isolated from the stem bark of Periplocae Cortex (Periploca sepium Bge.),a Chinese medicinal herb used in the treatment of rhe...Objective:To determine the effect of an immunosuppressive active component (periploside A) isolated from the stem bark of Periplocae Cortex (Periploca sepium Bge.),a Chinese medicinal herb used in the treatment of rheumatoid arthritis for centuries in China,on positive selection of thymocytes in vitro.Methods:Female C57BL/6 mice at 6 weeks of age were housed in specific pathogen-free conditions.Double-positive thymocytes from C57BL/6 mice were induced into positive selection in vitro with or without periploside A treatment.Cell viability and expression of CD69,CD4,and CD8 were analyzed by flow cytometry.Results:Flow cytometric examination of thymocyte populations revealed that the percentage of CD8+ single-positive thymocytes was decreased by periploside A upon differentiation induced by an anti-CD3 antibody.However,the percentage of CD4+ single-positive thymocytes was decreased by periploside A upon differentiation induced by phorbol 12-myristate 13-acetate/ionomycin.Expression of CD69 plays a major role in prohibiting differentiation of thymocytes.Treatment with periploside A decreased CD69 expression in thymocytes.Conclusion:These results demonstrate that periploside A influences positive selection of thymocytes in vitro.展开更多
In this paper,negative selection and genetic algorithms are combined and an improved bi-objective optimization scheme is presented to achieve optimized negative selection algorithm detectors.The main aim of the optima...In this paper,negative selection and genetic algorithms are combined and an improved bi-objective optimization scheme is presented to achieve optimized negative selection algorithm detectors.The main aim of the optimal detector generation technique is maximal nonself space coverage with reduced number of diversified detectors.Conventionally,researchers opted clonal selection based optimization methods to achieve the maximal nonself coverage milestone;however,detectors cloning process results in generation of redundant similar detectors and inefficient detector distribution in nonself space.In approach proposed in the present paper,the maximal nonself space coverage is associated with bi-objective optimization criteria including minimization of the detector overlap and maximization of the diversity factor of the detectors.In the proposed methodology,a novel diversity factorbased approach is presented to obtain diversified detector distribution in the nonself space.The concept of diversified detector distribution is studied for detector coverage with 2-dimensional pentagram and spiral self-patterns.Furthermore,the feasibility of the developed fault detection methodology is tested the fault detection of induction motor inner race and outer race bearings.展开更多
The physical and chemical properties have significant differences for the positive and negative charged particles generated by discharge.In this work,a positive and negative corona discharge system was established,and...The physical and chemical properties have significant differences for the positive and negative charged particles generated by discharge.In this work,a positive and negative corona discharge system was established,and two discharge reactors for charged particles restraining and acting were designed by a needle electrode covered with a quartz tube and a plate electrode filled with water.The corona discharges happened within the needle-plate electrodes were excited by a positive and negative high voltage source,and the characteristics of both water volatilization and oxides generation were examined within influence of the distances of both quartz tube inside and outside.The results show that the characteristics of both the water volatilization and oxides generation can be affected by the distances of both quartz tube inside and outside.When the distances of tube inside were increased from 5.00 to 13.00 mm,the water volatilizations decreased under negative corona,and increased firstly and declined immediately under positive corona.The maximum value of the water volatilization appeared in the distances of tube inside with 6.00–8.00 mm.In addition,the concentrations of the HNO_(x) and H_(2)O_(2)in treated water decreased with increasing the distances of tube inside.Moreover,with increasing the distances of tube outside from 4.00 to 14.00 mm,the change trends of both the water volatilizations and oxides presented the same as the distances of tube inside,and the maximum value of the water volatilization and oxides appeared in the distance of tube outside with about 9.00 mm.Overall,the positive corona can generate more water volatilizations and oxides in water than negative corona,and non H_(2)O_(2)can be produced by negative corona.The results reflect the difference between positive and negative corona interaction with water,which can provide reference for plasma application.展开更多
文摘Xianyang Lake is the abbreviation of Weihe River(Xianyang Urban Area Section) Comprehensive Treatment Project,which is to build a partition wall in the middle of the 500 wide Weihe River Valley,then a 270 m wide water storage channel on the north side and a 230 m wide muddy water floodway channel on the south side will be formed.Two rubber dams are constructed in the water storage channels to form a 'Xianyang Lake' with an area of 1.24×106 m2,meanwhile,along both sides of Weihe River in this section,slope protection and flood prevention as well as a series of greening and cultural landscape projects are to be constructed.This project,with flood prevention as the core,aims to improve the living environment and protect ecological environment,and realize the comprehensive treatment of river way flood-proofing,desilting,sewage purification,greening and beautification.The construction of Xianyang Lake greatly improves the image of Xianyang City and generates considerable economic,social and ecological benefits,however,it also has negative effects,such as insufficient lake water supply,original ecology being intervened by human activities,aggravating local fiscal burden,and potential threats to the flood-proofing in the lower reaches of Weihe River.The author puts forwards that 'creating a lake by damming the river' in the process of urbanization and solving the conflicts between sectional interests and integrated interests should follow natural laws and go along the track of sustainable development,which is also the orientation of future work,and the concrete reform scheme is to be further studied.
基金Key Project of National Natural Science Foundation of China, No.40930531 National Youth Science Foundation of China, No.40801148 Anhui Provincial Natural Science Foundation. No. 090412062
文摘The Loess positive and negative terrains (P-N terrains), which are widely distributed on the Loess Plateau, are discussed for the first time by introducing its characteristic, demarcation as well as extraction method from high-resolution Digital Elevation Models. Using 5 m-resolution DEMs as original test data, P-N terrains of 48 geomorphological units in different parts of Shaanxi Loess Plateau are extracted accurately. Then six indicators for depicting the geomorphologic landscape and spatial configuration characteristic of P-N terrains are proposed. The spatial distribution rules of these indicators and the relationship between the P-N terrains and Loess relief are discussed for further understanding of Loess landforms. Finally, with the integration of P-N terrains and traditional terrain indices, a series of un-supervised classification methods are applied to make a proper landform classification in northern Shaanxi. Results show that P-N terrains are an effect clue to reveal energy and substance distribution rules on the Loess Plateau. A continuous change of P-N terrains from south to north in Shaanxi Loess Plateau shows an obvious spatial difference of Loess land-forms and the positive terrain area only accounted for 60.5% in this region. The P-N terrains participant landform classification method increases validity of the result, especially in the Loess tableland, Loess tableland-ridge and the Loess low-hill area. This research is significant on the study of Loess landforms with the Digital Terrains Analysis methods.
基金National Natural Science Foundation of China (No. 30571009).
文摘Vegetative insecticidal proteins (VIPs), produced during the vegetative stage of their growth in Bacillus thuringiensis, are a group of insecticidal proteins and represent the second generation of insecticidal trans-genes that will complement the novel δendotoxins in future. Fewer structural and functional relationships of Vip proteins are known in comparison with those of δ-endotoxins. In this study, both the maximum-likelihood methods and the maximum parsimony based sliding window analysis were used to evaluate the molecular evolution of Vip proteins. As a result, strong evidence was found that Vip proteins are subject to the high rates of positive selection, and 16 sites are identified to be under positive selection using the Bayes Empirical Bayesian method. Interestingly, all these positively selected sites are located from site-705 to site-809 in the C-terminus of the Vip proteins. Most of these sites are exposed and clustered in the loop regions when mapped onto its computational predicted secondary tertiary and a part of the tertiary structure. It has been postulated that the high divergence in the C-terminal of Vip proteins may not result from the lack of functional constraints, but rather from the rapid mutation to adapt their targeted insects, driven by positive selection. The potential positive selection pressures may be an attempt to adapt for the "arm race" between Vip proteins and the targeted insects, or to enlarge their target's host range. Sites identified to be under positive selection may be related to the insect host range, which may shed a light on the investigation of the Vip proteins' structural and functional relationships.
基金supported by the National Natural Science Foundation of China (NO. 41201464, 41371424)the Fundamental Research Funds for the Central Universities of China (GK201703042)
文摘The positive and negative terrains(P-N terrains) widely distributed across China's Loess Plateau constitute the dual structure characteristic of loess landforms. Analysis of loess P-N terrains at the watershed scale can serve to elucidate the structural characteristics and spatial patterns of P-N terrains, which benefits a better understanding of watershed evolution and suitable scales for loess landform research. The Two-Term Local Quadrat Variance Analysis(TTLQV) is calculated as the average of the square of the difference between the block totals of all possible adjacent pairs of block size, which can be used to detect both the scale and the intensity of landscape patches(e.g., plant/animal communities and gully networks). In this study, we determined the latitudinal and longitudinal spatial scale of P-N terrain patterns within 104 uniformly distributed watersheds in our target soil and water conservation region. The results showed that TTLQV is very effective for examining the scale of P-N terrain patterns. There were apparently three types of P-N terrain pattern in latitudinal direction(i.e., Loess Tableland type, Loess Hill type, and Transitional Form between Sand and Loess type), whereas there were both lower and higher values for P-N terrain pattern scales in all loess landforms in the longitudinal direction. The P-N terrain pattern alsoclearly presented anisotropy, suggesting that gully networks in the main direction were well-developed while others were relatively undeveloped. In addition, the relationships between the first scales and controlling factors(i.e., gully density, nibble degree, watershed area, mean watershed slope, NDVI, precipitation, loess thickness, and loess landforms) revealed that the first scales are primarily controlled by watershed area and loess landforms. This may indicate that the current spatial pattern of P-N terrains is characterized by internal force. In selecting suitable study areas in China' Loess Plateau, it is crucial to understand four control variables: the spatial scale of the P-N terrain pattern, the watershed area, the main direction of the watershed, and the loess landforms.
文摘The oscillatory behavior of neutral differential equation with positive and negative coefficients is investigated by mathematics analysis technique and the fixed point principle. Some sufficient conditions for oscillation of neutral differential equation with positive and negative coefficients are obtained.
文摘Human enterovirus 71 viruses have been long circulating throughout the world. In this study, we performed a positive selection analysis of the VP1 genes of capsid proteins from Enterovirus 71 viruses. Our results showed that although most sites were under negative or neutral evolution, four positions of the VP1 genes were under positive selection pressure. This might account for the spread and frequent outbreaks of the viruses and the enhanced neurovirulence. In particular, position 98 might be involved in neutralizing antibodies, modulating the virus-receptor interaction and enhancing the virulence of the viruses. Moreover, both positions 145 and 241 might correlate to determine the receptor specificity. However, these positions did not display much difference in amino acid polymorphism. In addition, no position in the VP1 genes of viruses isolated from China was under positive selection.
基金Sponsored by the National Natural Science Foundation of China(Grant No.50875056)
文摘To overcome the limitations of traditional monitoring methods, based on vibration parameter image of rotating machinery, this paper presents an abnormality online monitoring method suitable for rotating machinery using the negative selection mechanism of biology immune system. This method uses techniques of biology clone and learning mechanism to improve the negative selection algorithm to generate detectors possessing different monitoring radius, covers the abnormality space effectively, and avoids such problems as the low efficiency of generating detectors, etc. The result of an example applying the presented monitoring method shows that this method can solve the difficulty of obtaining fault samples preferably and extract the turbine state character effectively, it also can detect abnormality by causing various fault of the turbine and obtain the degree of abnormality accurately. The exact monitoring precision of abnormality indicates that this method is feasible and has better on-line quality, accuracy and robustness.
文摘T cells are derived from progenitor thymocytes, of which only a minority receive the appropriate TCR signal, undergo positive selection and mature. Owing to the very short lifespan of thymocytes, the prerequisite for posi- tive selection is survival. TCR signal-induced Bcl-2 expression is believed to play a dominant role in the survival of positively selecting thymocytes, but how Bcl-2 is directly regulated is unknown. Here we report that the immediate early gene (IEG) c-Fos can stimulate the expression of Bcl-2, depending on a specific AP-l-binding site in the Bcl-2 promoter. In c-Fos transgenic (Fos-Tg) mice, c-Fos binds to this site and promotes the expression of Bcl-2. As a result, Fos-Tg thymocytes exhibited enhanced survival, and more mature single-positive (SP) thymocytes were generated, even on a unique TCR background. The TCR repertoire remained normal in Fos-Tg mice. Our results identified c-Fos as the mediator of the stimulatory effect of TCR signaling on Bcl-2 expression. Therefore, c-Fos, as an IEG, because of its early response ability, can quickly rescue the survival of short-lived thymocytes during positive selection. Our results provide novel insight into the mechanism regulating the survival of positively selecting thymocytes.
基金supported by the National Natural Science Foundation of China (Grant Nos. 41630425, 41761144074)
文摘Leader propagation is a fundamental issue in lightning physics. The propagation characteristics of positive leaders and negative leaders are summarized and compared based on data from high-speed camera and electromagnetic field in rocket-triggered lightning and tower-initiated lightning discharges; available channel base current data recorded in rocket-triggered lightning are also used. The negative leaders propagate in a stepped fashion accompanied by many branches. The stems ahead of the negative leader tip determine the manner and direction of the leader propagation, and even the branching and winding of the lightning channel. The impulsive current, electromagnetic field, and related optical images suggest that the positive leader may develop in a step-like fashion at its initial stage of triggered lightning. However, the stepping processes of the positive leader are obviously different from those of the negative leader. Tower-initiated lightning revealed that the most conspicuous characteristics of the stepwise positive leader involve the intermittent brush-like corona zone in front of the leader tip and the luminosity enhancement of the channel behind the tip. In rockettriggered lightning flashes, the charge transferred during an individual step for the negative leader was nearly an order greater than for the positive counterpart. The successive streamers ahead of the leader tip are essential for both negative and positive leader propagation, and the stems could be formed from one or more streamers in the previous negative streamer zone with the main leader channel dim. High-resolution observation of tower lightning also revealed a new type of bidirectional recoil leader, with polarity contrary to the traditional one, traversing in negative channels associated with tower-initiated and rocket-triggered lightning.
基金the Science Foundation of Educational Committee of Hunan Provinc
文摘A neutral difference equation with positive and negative coefficientsΔ(x n-c nx n-k )+p nx n-l -q nx n-r =0, n=0,1,2,...,is considered and a sufficient condition for the global attractivity of the zero solution of this equation is obtained, which improves and extends the all known results in the literature.
基金the National Natural Science Foundation of China(1 0 0 71 0 1 8)
文摘In this paper the sufficient conditions for the existence of positive solutions of the neutral difference equations with positive and negative coefficients are established. The results improve some known conclusions in the literature.
文摘People living on the high plateaus of the world have long fascinated biological anthropologists and geneticists because they live in "thin air" and epitomize an extreme of human biological adaptation.
基金Sponsored by the National Natural Science Foundation of China (Grant No. 60671049)the Subject Chief Foundation of Harbin (Grant No.2003AFXXJ013)+1 种基金the Education Department Research Foundation of Heilongjiang Province(Grant No. 10541044 and 1151G012)the Postdoctoral Science-research Developmental Foundation of Heilongjiang Province(Grant No. LBH-Q09075)
文摘This paper proposes a negative selection with neighborhood representation named as neighborhood negative selection algorithm.This algorithm employs a new representation method which uses the fully adjacent but mutually disjoint neighborhoods to present the self samples and detectors.After normalizing the normal samples into neighborhood shape space,the algorithm uses a special matching rule similar as Hamming distance to train mature detectors at the training stage and detect anomaly at the detection stage.The neighborhood negative selection algorithm is tested using KDD CUP 1999 dataset.Experimental results show that the algorithm can prevent the negative effect of the dimension of shape space,and provide a more accuracy and stable detection performance.
基金Supported by the the NNSF of China(60404022 60604004) Supported by the Special Projects in Mathematics Funded by Natural Science Foundation of Hebei Province(07M005)
文摘In this paper,we consider the forced neutral advanced dynamic equations with positive and negative coeffcients[x(t)-R(t)x(t+r)]+P(t)x(t+τ)△Q(t)x(t+δ)= f(t),t≥t0 on a time scale T.Several suffcient conditions are obtained for the oscillation of the dynamic equations.The main result is illustrated by an example.
基金Sponsored by the National Natural Science Foundation of China (Grant No. 60671049)the Subject Chief Foundation of Harbin (Grant No.2003AFXXJ013)+1 种基金the Education Department Research Foundation of Heilongjiang Province(Grant No. 10541044, 1151G012)the Postdoctor Foundation of Heilongjiang Province(Grant No.LBH-Z05092)
文摘Point-wise negative selection algorithms,which generate their detector sets based on point of self data,have lower training efficiency and detection rate.To solve this problem,a self region based real-valued negative selection algorithm is presented.In this new approach,the continuous self region is defined by the collection of self data,the partial training takes place at the training stage according to both the radius of self region and the cosine distance between gravity of the self region and detector candidate,and variable detectors in the self region are deployed.The algorithm is tested using the triangle shape of self region in the 2-D complement space and KDD CUP 1999 data set.Results show that,more information can be provided when the training self points are used together as a whole,and compared with the point-wise negative selection algorithm,the new approach can improve the training efficiency of system and the detection rate significantly.
基金This study was supported by the National Natural Science Foundation of China(30901909).
文摘Objective:To determine the effect of an immunosuppressive active component (periploside A) isolated from the stem bark of Periplocae Cortex (Periploca sepium Bge.),a Chinese medicinal herb used in the treatment of rheumatoid arthritis for centuries in China,on positive selection of thymocytes in vitro.Methods:Female C57BL/6 mice at 6 weeks of age were housed in specific pathogen-free conditions.Double-positive thymocytes from C57BL/6 mice were induced into positive selection in vitro with or without periploside A treatment.Cell viability and expression of CD69,CD4,and CD8 were analyzed by flow cytometry.Results:Flow cytometric examination of thymocyte populations revealed that the percentage of CD8+ single-positive thymocytes was decreased by periploside A upon differentiation induced by an anti-CD3 antibody.However,the percentage of CD4+ single-positive thymocytes was decreased by periploside A upon differentiation induced by phorbol 12-myristate 13-acetate/ionomycin.Expression of CD69 plays a major role in prohibiting differentiation of thymocytes.Treatment with periploside A decreased CD69 expression in thymocytes.Conclusion:These results demonstrate that periploside A influences positive selection of thymocytes in vitro.
文摘In this paper,negative selection and genetic algorithms are combined and an improved bi-objective optimization scheme is presented to achieve optimized negative selection algorithm detectors.The main aim of the optimal detector generation technique is maximal nonself space coverage with reduced number of diversified detectors.Conventionally,researchers opted clonal selection based optimization methods to achieve the maximal nonself coverage milestone;however,detectors cloning process results in generation of redundant similar detectors and inefficient detector distribution in nonself space.In approach proposed in the present paper,the maximal nonself space coverage is associated with bi-objective optimization criteria including minimization of the detector overlap and maximization of the diversity factor of the detectors.In the proposed methodology,a novel diversity factorbased approach is presented to obtain diversified detector distribution in the nonself space.The concept of diversified detector distribution is studied for detector coverage with 2-dimensional pentagram and spiral self-patterns.Furthermore,the feasibility of the developed fault detection methodology is tested the fault detection of induction motor inner race and outer race bearings.
基金partially supported by Natural Science Foundation of the Jiangsu Province(No.BK20191162)Fundamental Research Funds for the Central Universities(No.B210203006)+1 种基金National Natural Science Foundation of China(No.11874140)Changzhou Science and Technology Program(No.CJ20190046)。
文摘The physical and chemical properties have significant differences for the positive and negative charged particles generated by discharge.In this work,a positive and negative corona discharge system was established,and two discharge reactors for charged particles restraining and acting were designed by a needle electrode covered with a quartz tube and a plate electrode filled with water.The corona discharges happened within the needle-plate electrodes were excited by a positive and negative high voltage source,and the characteristics of both water volatilization and oxides generation were examined within influence of the distances of both quartz tube inside and outside.The results show that the characteristics of both the water volatilization and oxides generation can be affected by the distances of both quartz tube inside and outside.When the distances of tube inside were increased from 5.00 to 13.00 mm,the water volatilizations decreased under negative corona,and increased firstly and declined immediately under positive corona.The maximum value of the water volatilization appeared in the distances of tube inside with 6.00–8.00 mm.In addition,the concentrations of the HNO_(x) and H_(2)O_(2)in treated water decreased with increasing the distances of tube inside.Moreover,with increasing the distances of tube outside from 4.00 to 14.00 mm,the change trends of both the water volatilizations and oxides presented the same as the distances of tube inside,and the maximum value of the water volatilization and oxides appeared in the distance of tube outside with about 9.00 mm.Overall,the positive corona can generate more water volatilizations and oxides in water than negative corona,and non H_(2)O_(2)can be produced by negative corona.The results reflect the difference between positive and negative corona interaction with water,which can provide reference for plasma application.