微粒体谷胱甘肽S-转移酶1(microsomal glutathione S-transferase 1,MGST1)是谷胱甘肽S-转移酶(glutathione S-transferase,GST)超家族和花生四烯酸与谷胱甘肽代谢中的膜相关蛋白(membrane-associated proteins in eicosanoid and gluta...微粒体谷胱甘肽S-转移酶1(microsomal glutathione S-transferase 1,MGST1)是谷胱甘肽S-转移酶(glutathione S-transferase,GST)超家族和花生四烯酸与谷胱甘肽代谢中的膜相关蛋白(membrane-associated proteins in eicosanoid and glutathione metabolism,MAPEG)超家族的共同成员,它通过催化外源性物质的II相解毒过程,从而保护细胞膜免受氧化应激的损伤。众多研究发现MGST1与恶性肿瘤的发生发展密切相关,有望成为癌症治疗的新型分子靶点。本文就MGST1在恶性肿瘤中的研究进展予以综述。展开更多
目的:了解近10年护理硕士研究生教育领域在全球的研究热点、研究现状和发展趋势。方法:通过Web of Science检索2013年1月1日—2023年3月1日护理硕士研究生教育领域的英文文献,对收集到英文文献的年度发文量、国家发文量、作者发文量、...目的:了解近10年护理硕士研究生教育领域在全球的研究热点、研究现状和发展趋势。方法:通过Web of Science检索2013年1月1日—2023年3月1日护理硕士研究生教育领域的英文文献,对收集到英文文献的年度发文量、国家发文量、作者发文量、机构发文量、关键词聚类共现的数据进行可视化处理,分析其研究热点。CiteSpace软件用于检测关键字突现。结果:护理硕士研究生教育领域全球年度发文量呈整体逐步上升趋势;关键词共现聚类分析结果显示,研究热点主题集中在多领域服务实践、心理支持策略、跨专业教育课程、研究生教育模式。结论:近10年护理硕士研究生教育处于迅速发展阶段,护理硕士研究生模拟训练策略、临床思维能力、社会适应能力、跨学科模式等可能是未来该领域研究的热点和方向。未来发展跨学科研究生教育模式,充分发挥护理硕士研究生优势,提高其社会适应能力水平。展开更多
John Bunyan's The Pilgrim's Progress has been written to preach the Christian doctrines of salvation.Therefore its allegorical protagonists have gradually gone through four stages of development on the path to...John Bunyan's The Pilgrim's Progress has been written to preach the Christian doctrines of salvation.Therefore its allegorical protagonists have gradually gone through four stages of development on the path to salvation.This paper is focused on the earlier two stages,that is,the repentance of sins and the temptations after conversion.展开更多
Through a comparative analysis of The Pilgrim's Progress and The Journey to the West, the paper aims to reveal what common ground is shared by the two novels and what light is thrown on the theme of spiritual salv...Through a comparative analysis of The Pilgrim's Progress and The Journey to the West, the paper aims to reveal what common ground is shared by the two novels and what light is thrown on the theme of spiritual salvation. The fruit of the study leads to a conclusion that both novels have employed religious doctrines and social criticisms to make the theme of spiritual salvation more palatable for their readers.展开更多
Barrett's esophagus (BE) confers a significant increased risk for development of esophageal adenocarcinoma (EAC), with the pathogenesis appearing to progress through a "metaplasia-dysplasia-carcinoma" (M...Barrett's esophagus (BE) confers a significant increased risk for development of esophageal adenocarcinoma (EAC), with the pathogenesis appearing to progress through a "metaplasia-dysplasia-carcinoma" (MDC) sequence. Many of the genetic insults driving this MDC sequence have recently been characterized, providing targets for candidate biomarkers with potential clinical utility to stratify risk in individual patients. Many clinical risk factors have been investigated, and associations with a variety of genetic, specific gastrointestinal and other modifiable factors have been proposed in the literature. This review summarizes the current understanding of the mechanisms involved in neoplastic progression of BE to EAC and critically appraises the relative roles and contributions of these putative risk factors from the published evidence currently available.展开更多
Alzheimer's disease (AD), a fatal, progressive, neurodegener- ative disorder, is the most common cause of old-age demen- tia, accounting for 50-75% of dementia patients. Early stages of AD are marked by vocabulary ...Alzheimer's disease (AD), a fatal, progressive, neurodegener- ative disorder, is the most common cause of old-age demen- tia, accounting for 50-75% of dementia patients. Early stages of AD are marked by vocabulary shrinkage, spatial disori- entation, depression, apraxia, and deterioration of recent forms of declarative memory. In course of time, the patients require close supervision due to the loss of cognitive and functional abilities, and at the terminal stages of the disease, all forms of memory are severely impaired with the patients needing nursing home care (World Alzheimer Report, 2013).展开更多
Since 2015, the China Geological Survey has implemented a major program of "Geology Survey of Land Energy Mineral Resources". Till now, a total of billions of RMB have been invested and seven engineering projects ha...Since 2015, the China Geological Survey has implemented a major program of "Geology Survey of Land Energy Mineral Resources". Till now, a total of billions of RMB have been invested and seven engineering projects have been established, all of which has greatly enhanced the geological survey and exploration of China's continental shale gas in an attempt to overcome the oil and gas shortage.展开更多
The Pilgrim’s Progress in Mandarin translated by the British missionary William Chalmers Burns in the 1860s is regarded as one of the typical representatives of the early Europeanized vernacular texts.Compared with t...The Pilgrim’s Progress in Mandarin translated by the British missionary William Chalmers Burns in the 1860s is regarded as one of the typical representatives of the early Europeanized vernacular texts.Compared with the ancient vernacular,the frequency of the inclusive usage of“wǒmen”has increased significantly,which is directly influenced by the plural usage of first-person pronoun in English.Tracking back the origin of Chinese Europeanized grammar is an important part of the study of modern Chinese grammar,which not only is helpful to have a clear understanding of the characteristic of Europeanized grammar in the pre-development stage of modern Chinese,but also can lay a certain foundation for the comparative study of Europeanized grammar in different periods.In addition,this study can also provide linguistic basis for investigating the influence of western missionaries’Chinese translation on the formation of new literature.展开更多
Huntington’s disease(HD)is an autosomal dominant,monogenic,progressive,neurodegenerative and rare disease with a frequency of10 per 100,000 in the Caucasian population and occurring more rarely in other races(Squi...Huntington’s disease(HD)is an autosomal dominant,monogenic,progressive,neurodegenerative and rare disease with a frequency of10 per 100,000 in the Caucasian population and occurring more rarely in other races(Squitieri et al.,1994).HD is,nevertheless,one of the most frequently and extensively studied diseases of those caused by a dynamic mutation.The HD mutation is located on the short arm of the 4th chromosome within the HTT gene.展开更多
A myriad of medicinal effects has been attributed to Thymoquinone (TQ), the major biological-active component of Nigella sativa. TQ has been shown to exhibit potent anti-tumor activities. The present work was undertak...A myriad of medicinal effects has been attributed to Thymoquinone (TQ), the major biological-active component of Nigella sativa. TQ has been shown to exhibit potent anti-tumor activities. The present work was undertaken to further explore TQ’s chemopreventive efficacy against 1, 2-dimethylhydrazine (DMH)-induced colon carcinogenesis in the rat model through a two-phase study (initiation and post-initiation) and to evaluate its potential impact on tumor progression and invasion in vivo. TQ treatment in the initiation phase significantly reduced tumor incidence, multiplicity and mean tumor volume. However, although mean tumor volume and multiplicity were decreased upon TQ treatment in the post-initiation phase, TQ did not reduce incidence significantly. Cellular proliferation, as assessed by expression of colonic PCNA, was shown to be inhibited in consequence to TQ treatment in both phases, with a more pronounced reduction in the initiation phase. In addition, our results demonstrated an appreciable negative impact of TQ on vascular endothelial growth factor (VEGF) production in tumor-bearing rats. Furthermore, we provided evidence that TQ-treatment, in both phases, tended to considerably suppress tumor progression and invasion. Taken together, the present study demonstrated that TQ, at an orally daily dose of 10 mg/kg, has a chemopreventive effect in the initiation phase, and has the potential to attenuate tumor burden, suppress progression of pre-neoplastic lesions and to inhibit tumor growth in the post-initiation phase of DMH-induced colon carcinogenesis, We surmise that such effects of TQ may be due to suppression of cellular proliferation and inhibition of VEGF production. The results could provide an effective chemopreventive approach in the primary prevention of colon cancer in humans in the next future, and illuminate a promising horizon to combat progression of benign colonic pre-neoplastic lesions into malignant metastatic tumors and to manage colon cancer.展开更多
Liquid propellant rocket engines for a launch vehicle are an essential aerospace technology, representing the advanced level of hi-tech in a country. In recent years, China’s aerospace industry has made remarkable ac...Liquid propellant rocket engines for a launch vehicle are an essential aerospace technology, representing the advanced level of hi-tech in a country. In recent years, China’s aerospace industry has made remarkable achievements, and liquid rocket engine technology has also been effectively developed. In this article, the development processes of China’s liquid rocket engines are discussed. Then, the performance features of China’s new generation liquid rocket engines as well as the flight tests of the new-generation launch vehicles are introduced. Finally, the development direction and the most recent progress of the next generation large-thrust liquid rocket engine is presented.展开更多
In 2002, PetroChina have made obvious progress since it began to carry forward integrated exploration and development, in the first half year, exploration and development have gained a series of achievements through o...In 2002, PetroChina have made obvious progress since it began to carry forward integrated exploration and development, in the first half year, exploration and development have gained a series of achievements through optimizing deployment,deepening geological research, strengthening technological innovation, organizing elaborately and arranging carefully.展开更多
The National Road RN 91 has been threatened for about twenty-five years by a huge landslide, located 25 km south-east to the town of Grenoble (France). If several million cubic meters of rock fall down, the debris wil...The National Road RN 91 has been threatened for about twenty-five years by a huge landslide, located 25 km south-east to the town of Grenoble (France). If several million cubic meters of rock fall down, the debris will dam the valley. Then the failure of the dam by overtopping and rapid erosion might result in a catastrophic flood and dramatic consequences for human life, environment and economy throughout the valley. The paper presents the hazard assessment based on geological and hydrological surveys, including small scale hydraulic tests, as well as the risk evaluation that has been performed. The risk management relies first upon a high level monitoring and an emergency plan; various mitigation strategies have been considered.展开更多
To study Barrett’s esophagus (BE) in cirrhosis and assess progression to esophageal adenocarcinoma (EAC) compared to non-cirrhotic BE controls.METHODSCirrhotic patients who were found to have endoscopic evidence of B...To study Barrett’s esophagus (BE) in cirrhosis and assess progression to esophageal adenocarcinoma (EAC) compared to non-cirrhotic BE controls.METHODSCirrhotic patients who were found to have endoscopic evidence of BE confirmed by the presence of intestinal metaplasia on histology from 1/1/2000 to 12/1/2015 at Cleveland Clinic were included. Cirrhotic patients were matched 1:4 to BE controls without cirrhosis. Age, gender, race, BE length, hiatal hernia size, Child-Pugh (CP) class and histological findings were recorded. Cases and controls without high-grade dysplasia (HGD)/EAC and who had follow-up endoscopies were studied for incidence of dysplasia/EAC and to assess progression rates. Univariable conditional logistic regression was done to assess differences in baseline characteristics between the two groups.RESULTSA total of 57 patients with cirrhosis and BE were matched with 228 controls (BE without cirrhosis). The prevalence of dysplasia in cirrhosis and controls were similar with 8.8% vs 12% with low grade dysplasia (LGD) and 12.3 % vs 19.7% with HGD or EAC (P = 0.1). In the incidence cohort of 44 patients with median follow-up time of 2.7 years [interquartile range 1.0, 4.8], there were 7 cases of LGD, 2 cases of HGD, and 2 cases of EAC. There were no differences in incidence rates of HGD/EAC in nondysplastic BE between cirrhotic cases and noncirrhotic controls (1.4 vs 1.1 per 100 person- years, P = 0.8). In LGD, cirrhotic patients were found to have higher rates of progression to HGD/EAC compared to control group though this did not reach statistical significance (13.7 vs 8.1 per 100 person- years, P = 0.51). A significant association was found between a higher CP class and neoplastic progression of BE in cirrhotic patients (HR =7.9, 95%CI: 2.0-30.9, P = 0.003).CONCLUSIONCirrhotics with worsening liver function are at increased risk of progression of BE. More frequent endoscopic surveillance might be warranted in such patients.展开更多
The Information Office of the State Council, or China's Cabinet, issued a white paper on Progress in China's Human Rights in 2009 on Sept. 26, 2010. Following is the full text filed by Xinhua News Agency:
Foreword Since the arrival of the 21st cen- tury, the Chinese people have been making constant efforts in advanc- ing human rights protection along the path of building socialism with Chinese characteristics under th...Foreword Since the arrival of the 21st cen- tury, the Chinese people have been making constant efforts in advanc- ing human rights protection along the path of building socialism with Chinese characteristics under the leadership of the Communist Party of China (CPC) and the Chinese gov- ernment.展开更多
This paper presents the latest developments in the re search progress on mechanisms by which natural plants and crops respond to the doubled concentration of CO2 in the atmosphere, resultant climatic change and the mo...This paper presents the latest developments in the re search progress on mechanisms by which natural plants and crops respond to the doubled concentration of CO2 in the atmosphere, resultant climatic change and the modeling of vegetation and eco-systems in China. In addition, it points out that the future study on global change and terrestrial ecosystems should stress m(?)iti-disciplinary teamwork and inter-discipline penetration. Finally, the paper emphasizes 10 research realms in the field to be enhanced in the future.展开更多
AIM To evaluate annual incidence of low grade dysplasia(LGD) progression to high grade dysplasia(HGD) and/or esophageal adenocarcinoma(EAC) when diagnosis was made by two or more expert pathologists.METHODS Studies ev...AIM To evaluate annual incidence of low grade dysplasia(LGD) progression to high grade dysplasia(HGD) and/or esophageal adenocarcinoma(EAC) when diagnosis was made by two or more expert pathologists.METHODS Studies evaluating the progression of LGD to HGD or EAC were included. The diagnosis of LGD must be made by consensus of two or more expert gastrointestinal pathologists. Articles were searched in Medline, Pubmed, and Embase. Pooled proportions were calculated using fixed and random effects model. Heterogeneity among studies was assessed using the I2 statistic. RESULTS Initial search identified 721 reference articles, of which 53 were selected and reviewed. Twelve studies(n = 971) that met the inclusion criteria were included in this analysis. Among the total original LGD diagnoses in the included studies, only 37.49% reached the consensus LGD diagnosis after review by two or more expert pathologists. Total follow up period was 1532 patient-years. In the pooled consensus LGD patients, the annual incidence rate(AIR) of progression to HGD and or EAC was 10.35%(95%CI: 7.56-13.13) and progression to EAC was 5.18%(95%CI: 3.43-6.92). Among the patients down staged from original LGD diagnosis to No-dysplasia Barrett's esophagus, the AIR of progression to HGD and EAC was 0.65%(95%CI: 0.49-0.80). Among the patients down staged to Indefinite for dysplasia, the AIR of progression to HGD and EAC was 1.42%(95%CI: 1.19-1.65). In patients with consensus HGD diagnosis, the AIR of progression to EAC was 28.63%(95%CI: 13.98-43.27). CONCLUSION When LGD is diagnosed by consensus agreement of two or more expert pathologists, its progression towards malignancy seems to be at least three times the current estimates, however it could be up to 20 times the current estimates. Biopsies of all Barrett's esophagus patients with LGD should be reviewed by two expert gastroenterology pathologists. Follow-up strict surveillance programs should be in place for these patients.展开更多
Compensatory/adaptive mechanisms in the brain are hy- pothesized to be involved in its protection from the Alz- heimer's disease (AD) progression. These mechanisms are activated by malfunctioning of various brain s...Compensatory/adaptive mechanisms in the brain are hy- pothesized to be involved in its protection from the Alz- heimer's disease (AD) progression. These mechanisms are activated by malfunctioning of various brain systems: anti- oxidant, neurotrophic, neurotransmitter, immune, and oth- ers. Detailed analysis of compensatory^adaptive capabilities of these systems might be a start point for further discovery and development of perspective approaches for early diag- nostics and treatment of AD and associated neurodegenera- tive disorders.展开更多
The genetic and breeding progress of Dahen S06M line was analyzed, in order to improve the selection efficiency. The results showedthat six generations of selection was effective in selecting main characters of S06M l...The genetic and breeding progress of Dahen S06M line was analyzed, in order to improve the selection efficiency. The results showedthat six generations of selection was effective in selecting main characters of S06M line, especially the selection of growth rate had no adverse effecton reproductive performance. All indicators of reproductive performance were improved in varying degrees during breeding, particularly the egg production at 68 weeks of age. The breeding progress of main target traits significantly slowed down after the second generation, but they still maintained at higher levels and the characters of S06M tended to be stable.展开更多
文摘目的:了解近10年护理硕士研究生教育领域在全球的研究热点、研究现状和发展趋势。方法:通过Web of Science检索2013年1月1日—2023年3月1日护理硕士研究生教育领域的英文文献,对收集到英文文献的年度发文量、国家发文量、作者发文量、机构发文量、关键词聚类共现的数据进行可视化处理,分析其研究热点。CiteSpace软件用于检测关键字突现。结果:护理硕士研究生教育领域全球年度发文量呈整体逐步上升趋势;关键词共现聚类分析结果显示,研究热点主题集中在多领域服务实践、心理支持策略、跨专业教育课程、研究生教育模式。结论:近10年护理硕士研究生教育处于迅速发展阶段,护理硕士研究生模拟训练策略、临床思维能力、社会适应能力、跨学科模式等可能是未来该领域研究的热点和方向。未来发展跨学科研究生教育模式,充分发挥护理硕士研究生优势,提高其社会适应能力水平。
文摘John Bunyan's The Pilgrim's Progress has been written to preach the Christian doctrines of salvation.Therefore its allegorical protagonists have gradually gone through four stages of development on the path to salvation.This paper is focused on the earlier two stages,that is,the repentance of sins and the temptations after conversion.
文摘Through a comparative analysis of The Pilgrim's Progress and The Journey to the West, the paper aims to reveal what common ground is shared by the two novels and what light is thrown on the theme of spiritual salvation. The fruit of the study leads to a conclusion that both novels have employed religious doctrines and social criticisms to make the theme of spiritual salvation more palatable for their readers.
文摘Barrett's esophagus (BE) confers a significant increased risk for development of esophageal adenocarcinoma (EAC), with the pathogenesis appearing to progress through a "metaplasia-dysplasia-carcinoma" (MDC) sequence. Many of the genetic insults driving this MDC sequence have recently been characterized, providing targets for candidate biomarkers with potential clinical utility to stratify risk in individual patients. Many clinical risk factors have been investigated, and associations with a variety of genetic, specific gastrointestinal and other modifiable factors have been proposed in the literature. This review summarizes the current understanding of the mechanisms involved in neoplastic progression of BE to EAC and critically appraises the relative roles and contributions of these putative risk factors from the published evidence currently available.
基金in part supported by the German Ministry for Education and Research (BMBF) special network program KMU-Innovativ-2
文摘Alzheimer's disease (AD), a fatal, progressive, neurodegener- ative disorder, is the most common cause of old-age demen- tia, accounting for 50-75% of dementia patients. Early stages of AD are marked by vocabulary shrinkage, spatial disori- entation, depression, apraxia, and deterioration of recent forms of declarative memory. In course of time, the patients require close supervision due to the loss of cognitive and functional abilities, and at the terminal stages of the disease, all forms of memory are severely impaired with the patients needing nursing home care (World Alzheimer Report, 2013).
文摘Since 2015, the China Geological Survey has implemented a major program of "Geology Survey of Land Energy Mineral Resources". Till now, a total of billions of RMB have been invested and seven engineering projects have been established, all of which has greatly enhanced the geological survey and exploration of China's continental shale gas in an attempt to overcome the oil and gas shortage.
文摘The Pilgrim’s Progress in Mandarin translated by the British missionary William Chalmers Burns in the 1860s is regarded as one of the typical representatives of the early Europeanized vernacular texts.Compared with the ancient vernacular,the frequency of the inclusive usage of“wǒmen”has increased significantly,which is directly influenced by the plural usage of first-person pronoun in English.Tracking back the origin of Chinese Europeanized grammar is an important part of the study of modern Chinese grammar,which not only is helpful to have a clear understanding of the characteristic of Europeanized grammar in the pre-development stage of modern Chinese,but also can lay a certain foundation for the comparative study of Europeanized grammar in different periods.In addition,this study can also provide linguistic basis for investigating the influence of western missionaries’Chinese translation on the formation of new literature.
文摘Huntington’s disease(HD)is an autosomal dominant,monogenic,progressive,neurodegenerative and rare disease with a frequency of10 per 100,000 in the Caucasian population and occurring more rarely in other races(Squitieri et al.,1994).HD is,nevertheless,one of the most frequently and extensively studied diseases of those caused by a dynamic mutation.The HD mutation is located on the short arm of the 4th chromosome within the HTT gene.
文摘A myriad of medicinal effects has been attributed to Thymoquinone (TQ), the major biological-active component of Nigella sativa. TQ has been shown to exhibit potent anti-tumor activities. The present work was undertaken to further explore TQ’s chemopreventive efficacy against 1, 2-dimethylhydrazine (DMH)-induced colon carcinogenesis in the rat model through a two-phase study (initiation and post-initiation) and to evaluate its potential impact on tumor progression and invasion in vivo. TQ treatment in the initiation phase significantly reduced tumor incidence, multiplicity and mean tumor volume. However, although mean tumor volume and multiplicity were decreased upon TQ treatment in the post-initiation phase, TQ did not reduce incidence significantly. Cellular proliferation, as assessed by expression of colonic PCNA, was shown to be inhibited in consequence to TQ treatment in both phases, with a more pronounced reduction in the initiation phase. In addition, our results demonstrated an appreciable negative impact of TQ on vascular endothelial growth factor (VEGF) production in tumor-bearing rats. Furthermore, we provided evidence that TQ-treatment, in both phases, tended to considerably suppress tumor progression and invasion. Taken together, the present study demonstrated that TQ, at an orally daily dose of 10 mg/kg, has a chemopreventive effect in the initiation phase, and has the potential to attenuate tumor burden, suppress progression of pre-neoplastic lesions and to inhibit tumor growth in the post-initiation phase of DMH-induced colon carcinogenesis, We surmise that such effects of TQ may be due to suppression of cellular proliferation and inhibition of VEGF production. The results could provide an effective chemopreventive approach in the primary prevention of colon cancer in humans in the next future, and illuminate a promising horizon to combat progression of benign colonic pre-neoplastic lesions into malignant metastatic tumors and to manage colon cancer.
文摘Liquid propellant rocket engines for a launch vehicle are an essential aerospace technology, representing the advanced level of hi-tech in a country. In recent years, China’s aerospace industry has made remarkable achievements, and liquid rocket engine technology has also been effectively developed. In this article, the development processes of China’s liquid rocket engines are discussed. Then, the performance features of China’s new generation liquid rocket engines as well as the flight tests of the new-generation launch vehicles are introduced. Finally, the development direction and the most recent progress of the next generation large-thrust liquid rocket engine is presented.
文摘In 2002, PetroChina have made obvious progress since it began to carry forward integrated exploration and development, in the first half year, exploration and development have gained a series of achievements through optimizing deployment,deepening geological research, strengthening technological innovation, organizing elaborately and arranging carefully.
文摘The National Road RN 91 has been threatened for about twenty-five years by a huge landslide, located 25 km south-east to the town of Grenoble (France). If several million cubic meters of rock fall down, the debris will dam the valley. Then the failure of the dam by overtopping and rapid erosion might result in a catastrophic flood and dramatic consequences for human life, environment and economy throughout the valley. The paper presents the hazard assessment based on geological and hydrological surveys, including small scale hydraulic tests, as well as the risk evaluation that has been performed. The risk management relies first upon a high level monitoring and an emergency plan; various mitigation strategies have been considered.
文摘To study Barrett’s esophagus (BE) in cirrhosis and assess progression to esophageal adenocarcinoma (EAC) compared to non-cirrhotic BE controls.METHODSCirrhotic patients who were found to have endoscopic evidence of BE confirmed by the presence of intestinal metaplasia on histology from 1/1/2000 to 12/1/2015 at Cleveland Clinic were included. Cirrhotic patients were matched 1:4 to BE controls without cirrhosis. Age, gender, race, BE length, hiatal hernia size, Child-Pugh (CP) class and histological findings were recorded. Cases and controls without high-grade dysplasia (HGD)/EAC and who had follow-up endoscopies were studied for incidence of dysplasia/EAC and to assess progression rates. Univariable conditional logistic regression was done to assess differences in baseline characteristics between the two groups.RESULTSA total of 57 patients with cirrhosis and BE were matched with 228 controls (BE without cirrhosis). The prevalence of dysplasia in cirrhosis and controls were similar with 8.8% vs 12% with low grade dysplasia (LGD) and 12.3 % vs 19.7% with HGD or EAC (P = 0.1). In the incidence cohort of 44 patients with median follow-up time of 2.7 years [interquartile range 1.0, 4.8], there were 7 cases of LGD, 2 cases of HGD, and 2 cases of EAC. There were no differences in incidence rates of HGD/EAC in nondysplastic BE between cirrhotic cases and noncirrhotic controls (1.4 vs 1.1 per 100 person- years, P = 0.8). In LGD, cirrhotic patients were found to have higher rates of progression to HGD/EAC compared to control group though this did not reach statistical significance (13.7 vs 8.1 per 100 person- years, P = 0.51). A significant association was found between a higher CP class and neoplastic progression of BE in cirrhotic patients (HR =7.9, 95%CI: 2.0-30.9, P = 0.003).CONCLUSIONCirrhotics with worsening liver function are at increased risk of progression of BE. More frequent endoscopic surveillance might be warranted in such patients.
文摘The Information Office of the State Council, or China's Cabinet, issued a white paper on Progress in China's Human Rights in 2009 on Sept. 26, 2010. Following is the full text filed by Xinhua News Agency:
文摘Foreword Since the arrival of the 21st cen- tury, the Chinese people have been making constant efforts in advanc- ing human rights protection along the path of building socialism with Chinese characteristics under the leadership of the Communist Party of China (CPC) and the Chinese gov- ernment.
文摘This paper presents the latest developments in the re search progress on mechanisms by which natural plants and crops respond to the doubled concentration of CO2 in the atmosphere, resultant climatic change and the modeling of vegetation and eco-systems in China. In addition, it points out that the future study on global change and terrestrial ecosystems should stress m(?)iti-disciplinary teamwork and inter-discipline penetration. Finally, the paper emphasizes 10 research realms in the field to be enhanced in the future.
文摘AIM To evaluate annual incidence of low grade dysplasia(LGD) progression to high grade dysplasia(HGD) and/or esophageal adenocarcinoma(EAC) when diagnosis was made by two or more expert pathologists.METHODS Studies evaluating the progression of LGD to HGD or EAC were included. The diagnosis of LGD must be made by consensus of two or more expert gastrointestinal pathologists. Articles were searched in Medline, Pubmed, and Embase. Pooled proportions were calculated using fixed and random effects model. Heterogeneity among studies was assessed using the I2 statistic. RESULTS Initial search identified 721 reference articles, of which 53 were selected and reviewed. Twelve studies(n = 971) that met the inclusion criteria were included in this analysis. Among the total original LGD diagnoses in the included studies, only 37.49% reached the consensus LGD diagnosis after review by two or more expert pathologists. Total follow up period was 1532 patient-years. In the pooled consensus LGD patients, the annual incidence rate(AIR) of progression to HGD and or EAC was 10.35%(95%CI: 7.56-13.13) and progression to EAC was 5.18%(95%CI: 3.43-6.92). Among the patients down staged from original LGD diagnosis to No-dysplasia Barrett's esophagus, the AIR of progression to HGD and EAC was 0.65%(95%CI: 0.49-0.80). Among the patients down staged to Indefinite for dysplasia, the AIR of progression to HGD and EAC was 1.42%(95%CI: 1.19-1.65). In patients with consensus HGD diagnosis, the AIR of progression to EAC was 28.63%(95%CI: 13.98-43.27). CONCLUSION When LGD is diagnosed by consensus agreement of two or more expert pathologists, its progression towards malignancy seems to be at least three times the current estimates, however it could be up to 20 times the current estimates. Biopsies of all Barrett's esophagus patients with LGD should be reviewed by two expert gastroenterology pathologists. Follow-up strict surveillance programs should be in place for these patients.
基金supported by grant KOMFI 13-04-40106-H (Russia):"Structure-functional studies of р-75 receptor–molecular target for neurodegenerative diseases immunotherapy"Grant RFBR 13-04-00633A (Russia):"Study of role of receptor for advanced glycation end products (RAGE) in mechanisms of beta-amyloid neurotoxicity in model of sporadic Alzheimer’s disease"
文摘Compensatory/adaptive mechanisms in the brain are hy- pothesized to be involved in its protection from the Alz- heimer's disease (AD) progression. These mechanisms are activated by malfunctioning of various brain systems: anti- oxidant, neurotrophic, neurotransmitter, immune, and oth- ers. Detailed analysis of compensatory^adaptive capabilities of these systems might be a start point for further discovery and development of perspective approaches for early diag- nostics and treatment of AD and associated neurodegenera- tive disorders.
基金Supported by 13~(th) Five-year Broiler Breeding Project of Sichuan Province(2016NYZ0025,2016NY20043)
文摘The genetic and breeding progress of Dahen S06M line was analyzed, in order to improve the selection efficiency. The results showedthat six generations of selection was effective in selecting main characters of S06M line, especially the selection of growth rate had no adverse effecton reproductive performance. All indicators of reproductive performance were improved in varying degrees during breeding, particularly the egg production at 68 weeks of age. The breeding progress of main target traits significantly slowed down after the second generation, but they still maintained at higher levels and the characters of S06M tended to be stable.