目的观察调神益智针刺治疗痰瘀闭阻型卒中后痴呆(post-stroke dementia,PSD)的临床疗效及对氧化应激激素水平和血流变的影响。方法将94例痰瘀闭阻型PSD患者随机分为基础治疗组(31例)、对照组(32例)和观察组(31例)。基础治疗组给予内科...目的观察调神益智针刺治疗痰瘀闭阻型卒中后痴呆(post-stroke dementia,PSD)的临床疗效及对氧化应激激素水平和血流变的影响。方法将94例痰瘀闭阻型PSD患者随机分为基础治疗组(31例)、对照组(32例)和观察组(31例)。基础治疗组给予内科常规治疗,对照组在基础治疗组的基础上采用常规针刺治疗,观察组在基础治疗组的基础上采用调神益智针法治疗。观察3组治疗前后蒙特利尔认知评估(Montreal cognitive assessment,MoCA)和简易精神状态检查(mini-mental state examination,MMSE)评分、中医证候积分、日常生活活动(activities of daily living,ADL)量表评分、氧化应激水平[超氧化物歧化酶(superoxide dismutase,SOD)和丙二醛(malondialdehyde,MDA)]、血脂水平[甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)和低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)]、血流变学指标[全血高切黏度、全血低切黏度和血浆黏度]变化,并比较3组临床疗效。结果观察组总有效率优于其余两组,差异有统计学意义(P<0.05)。3组治疗后MoCA和MMSE评分较治疗前提高(P<0.05),且观察组高于其余两组(P<0.05)。观察组和对照组治疗后中医证候各项积分较治疗前显著降低(P<0.05);基础治疗组除体态臃肿外,中医证候各项积分均较前显著降低(P<0.05)。3组治疗后中医证候各项积分除体态臃肿外,中医证候各项积分低于其余两组(P<0.05)。3组治疗后ADL评分较治疗前均升高,差异具有统计学意义(P<0.05);3组治疗后ADL评分比较,差异无统计学意义(P>0.05)。3组治疗后血清SOD水平较治疗前均升高(P<0.05),且观察组SOD水平高于其余两组(P<0.05);3组治疗后MDA水平较治疗前均降低(P<0.05),且观察组MDA水平低于其余两组(P<0.05)。3组治疗后血清TG、TC、LDL-C水平较治疗前均降低(P<0.05),且观察组低于其余两组(P<0.05)。3组治疗后全血高切黏度、全血低切黏度、血浆黏度均低于治疗前(P<0.05),且观察组低于其余两组(P<0.05)。结论在内科常规治疗的基础上,调神益智针法治疗痰瘀闭阻型PSD可改善患者MoCA和MMSE评分、中医证候积分、氧化应激激素水平、血脂水平以及血流变学指标。展开更多
The research investigates the efficacy of brain transcatheter laser revascularization in patients who have had extensive ischemic stroke. 1125 patients aged 29 - 81 (average age 75) with cerebral atherosclerosis were ...The research investigates the efficacy of brain transcatheter laser revascularization in patients who have had extensive ischemic stroke. 1125 patients aged 29 - 81 (average age 75) with cerebral atherosclerosis were examined. The examination plan included: CT brain scan, magnetic resonance imaging (MRI), brain scintigraphy (SG), rheoencephalography (REG), cerebral multi-gated angiography (MUGA), laboratory tests, assessment of severity of dementia (CDR), cognitive impairment (MMSE) and activities of daily living (IB). 93 patients suffered extensive ischemic stroke of whom 7 (7.53%) had 10 - 15 IB points, 25 (26.88%)—20 - 30 IB points, 61 (65.59%)—35 - 45 IB points. 69 patients underwent transcatheter treatment (Test Group). 24 patients underwent conservative treatment (Control Group). High-energy laser systems were used for revascularization of major intracranial arteries;lowenergy laser systems were used for revascularization of distal intracranial branches. Test Group: 67 (97.10%) patients had good immediate angiographic outcome manifested in the restoration of lumen and patency of the affected vessels as well as in collateral revascularization. 12 - 24 months later the following positive trend was observed: 14 (20.59%) patients demonstrated good clinical outcome (IB 90 - 100);26 (38.24%) patients had satisfactory clinical outcome (IB 75 - 85);28 (41.18%) patients showed relatively satisfactory clinical outcome (IB 60 - 70);relatively positive clinical outcome (IB < 60) was not obtained in any case. Control Group: 4 (16.67%) patients showed relatively satisfactory clinical outcome (IB 60 - 70), relatively positive clinical outcome (IB < 60) was achieved in 20 (83.33%) cases. Evaluating the data obtained, it can be concluded that the method of transluminal laser revascularization of cerebral blood vessels is an effective one for the treatment of extensive ischemic strokes. The effect is maintained for a long time;it causes regression of mental, intellectual and motor disorders, promotes regression of post-stroke dementia and significantly improves the quality of life, which makes it noticeably different from the conservative methods of treatment.展开更多
目的探讨恩必普软胶囊对卒中后痴呆的发生以及认知功能和行为功能的影响。方法急性脑梗死178例,随机分为恩必普软胶囊治疗组和对照组,每组89例,发病3月检测各组痴呆发生、简易智能状态检测量表(Mini-mental state examination,MMSE)和...目的探讨恩必普软胶囊对卒中后痴呆的发生以及认知功能和行为功能的影响。方法急性脑梗死178例,随机分为恩必普软胶囊治疗组和对照组,每组89例,发病3月检测各组痴呆发生、简易智能状态检测量表(Mini-mental state examination,MMSE)和日常生活能力评分(Activities of daily living scale,ADL)。结果恩必普软胶囊治疗组卒中后痴呆发病率(5/89)显著少于对照组(13/89),恩必普软胶囊治疗患者认知(25.3±2.79)和行为能力(57.1±13.3)好于对照组(24.20±4.43,52.4±17.7)。结论恩必普软胶囊可以减少卒中后痴呆的发生。展开更多
文摘目的观察调神益智针刺治疗痰瘀闭阻型卒中后痴呆(post-stroke dementia,PSD)的临床疗效及对氧化应激激素水平和血流变的影响。方法将94例痰瘀闭阻型PSD患者随机分为基础治疗组(31例)、对照组(32例)和观察组(31例)。基础治疗组给予内科常规治疗,对照组在基础治疗组的基础上采用常规针刺治疗,观察组在基础治疗组的基础上采用调神益智针法治疗。观察3组治疗前后蒙特利尔认知评估(Montreal cognitive assessment,MoCA)和简易精神状态检查(mini-mental state examination,MMSE)评分、中医证候积分、日常生活活动(activities of daily living,ADL)量表评分、氧化应激水平[超氧化物歧化酶(superoxide dismutase,SOD)和丙二醛(malondialdehyde,MDA)]、血脂水平[甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)和低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)]、血流变学指标[全血高切黏度、全血低切黏度和血浆黏度]变化,并比较3组临床疗效。结果观察组总有效率优于其余两组,差异有统计学意义(P<0.05)。3组治疗后MoCA和MMSE评分较治疗前提高(P<0.05),且观察组高于其余两组(P<0.05)。观察组和对照组治疗后中医证候各项积分较治疗前显著降低(P<0.05);基础治疗组除体态臃肿外,中医证候各项积分均较前显著降低(P<0.05)。3组治疗后中医证候各项积分除体态臃肿外,中医证候各项积分低于其余两组(P<0.05)。3组治疗后ADL评分较治疗前均升高,差异具有统计学意义(P<0.05);3组治疗后ADL评分比较,差异无统计学意义(P>0.05)。3组治疗后血清SOD水平较治疗前均升高(P<0.05),且观察组SOD水平高于其余两组(P<0.05);3组治疗后MDA水平较治疗前均降低(P<0.05),且观察组MDA水平低于其余两组(P<0.05)。3组治疗后血清TG、TC、LDL-C水平较治疗前均降低(P<0.05),且观察组低于其余两组(P<0.05)。3组治疗后全血高切黏度、全血低切黏度、血浆黏度均低于治疗前(P<0.05),且观察组低于其余两组(P<0.05)。结论在内科常规治疗的基础上,调神益智针法治疗痰瘀闭阻型PSD可改善患者MoCA和MMSE评分、中医证候积分、氧化应激激素水平、血脂水平以及血流变学指标。
文摘The research investigates the efficacy of brain transcatheter laser revascularization in patients who have had extensive ischemic stroke. 1125 patients aged 29 - 81 (average age 75) with cerebral atherosclerosis were examined. The examination plan included: CT brain scan, magnetic resonance imaging (MRI), brain scintigraphy (SG), rheoencephalography (REG), cerebral multi-gated angiography (MUGA), laboratory tests, assessment of severity of dementia (CDR), cognitive impairment (MMSE) and activities of daily living (IB). 93 patients suffered extensive ischemic stroke of whom 7 (7.53%) had 10 - 15 IB points, 25 (26.88%)—20 - 30 IB points, 61 (65.59%)—35 - 45 IB points. 69 patients underwent transcatheter treatment (Test Group). 24 patients underwent conservative treatment (Control Group). High-energy laser systems were used for revascularization of major intracranial arteries;lowenergy laser systems were used for revascularization of distal intracranial branches. Test Group: 67 (97.10%) patients had good immediate angiographic outcome manifested in the restoration of lumen and patency of the affected vessels as well as in collateral revascularization. 12 - 24 months later the following positive trend was observed: 14 (20.59%) patients demonstrated good clinical outcome (IB 90 - 100);26 (38.24%) patients had satisfactory clinical outcome (IB 75 - 85);28 (41.18%) patients showed relatively satisfactory clinical outcome (IB 60 - 70);relatively positive clinical outcome (IB < 60) was not obtained in any case. Control Group: 4 (16.67%) patients showed relatively satisfactory clinical outcome (IB 60 - 70), relatively positive clinical outcome (IB < 60) was achieved in 20 (83.33%) cases. Evaluating the data obtained, it can be concluded that the method of transluminal laser revascularization of cerebral blood vessels is an effective one for the treatment of extensive ischemic strokes. The effect is maintained for a long time;it causes regression of mental, intellectual and motor disorders, promotes regression of post-stroke dementia and significantly improves the quality of life, which makes it noticeably different from the conservative methods of treatment.
文摘目的探讨恩必普软胶囊对卒中后痴呆的发生以及认知功能和行为功能的影响。方法急性脑梗死178例,随机分为恩必普软胶囊治疗组和对照组,每组89例,发病3月检测各组痴呆发生、简易智能状态检测量表(Mini-mental state examination,MMSE)和日常生活能力评分(Activities of daily living scale,ADL)。结果恩必普软胶囊治疗组卒中后痴呆发病率(5/89)显著少于对照组(13/89),恩必普软胶囊治疗患者认知(25.3±2.79)和行为能力(57.1±13.3)好于对照组(24.20±4.43,52.4±17.7)。结论恩必普软胶囊可以减少卒中后痴呆的发生。
文摘目的 :探讨分析羟基红花黄色素A(hydroxysafflor yellow A,HSYA)对脑卒中患者痴呆发生率的影响。方法 :对2012年1月~2014年1月期间我院神经内科收治的120例脑卒中患者的临床资料进行回顾性分析。我们将这120例患者随机分为观察组和对照组,每组各有60例患者。为对照组患者进行常规治疗,为观察组患者在进行常规治疗的基础上(方法与对照组相同),加用HSYA进行治疗。治疗结束后,比较两组患者痴呆的发生率。使用简易智能状态检测量表(Mini-mental state examination,MMSE)和日常生活能力评分量表(Activities of daily living scale,ADL)对这些患者的认知能力和日常生活能力进行评定。结果 :治疗结束后,观察组患者发生痴呆的几率明显低于对照组患者,二者相比差异具有显著性((P<0.05)。观察组患者的MMSE评分和ADL评分均明显高于对照组患者,二者相比差异具有显著性((P<0.05)。结论 :使用HSYA对脑卒中患者进行治疗,可以降低其发生痴呆的几率,有效改善患者的认知能力,提高其日常生活能力。此治疗方法值得在临床上推广应用。
