Effects of post-dilation on coronary blood flow and MACE events following primary percutaneous coronary intervention in patients with STEMI

Objective:This retrospective cohort study aimed to evaluate the effect of post-dilation on coronary blood flow and MACE events during hospitalization and 1 year follow-up following primary PCI in patients with ST-segment.Methods:419 eligible patients who underwent PPCI due to STEMI between January 2015 and October 2019 were enrolled.The CTFC,final QCA,and the incidence of no-reflow/slow-flow during different procedure moments were assayed.Study end points was to compare two groups of patients with clinical characteristics,compared two groups of patients with the incidence of no-reflow and slow-flow,and the incidence of MACE during hospitalization and 1-year follow-up.Results:The incidence of final no-reflow/slow-flow in the post-dilation group was not significantly higher than that in the non-post-dilation group(24.3%vs.19.4%;p=0.238).There was no significant statistical difference in MACE events during hospitalization,but for the 1-year follow-up,the incidence of Target vessel revascularization and Target lesion revascularization in the post-dilation group was lower than that in the non-post-dilation group.A multivariable logistic regression model revealed that age(OR=1.078,95%CI=1.038-1.120;P<0.001),history of diabetes(OR=3.009,95%CI=1.183-7.654;P=0.021),post-dilation(OR=0.192,95%CI=0.067-0.549;P=0.002)were independently correlated with long-term follow-up of MACE.Conclusion:Post-dilation does not increase poor prognosis during hospitalization,and reduces the incidence of TVR and TLR events during long-term follow-up.