Conceptual design and safety characteristics of a new multi-mission high flux research reactor

Research reactors with neutron fluxes higher than 10^(14) n cm^(−2) s^(−1) are widely used in nuclear fuel and material irradiation,neutron-based scientific research,and medical and industrial isotope production.Such high flux research reactors are not only important scientific research facilities for the development of nuclear energy but also represent the national comprehensive technical capability.China has several high flux research reactors that do not satisfy the requirements of nuclear energy development.A high flux research reactor has the following features:a compact core arrangement,high power density,plate-type fuel elements,a short refueling cycle,and high coolant velocity in the core.These characteristics make it difficult to simultaneously realize high neutron flux and optimal safety margin.A new multi-mission high flux research reactor was designed by the Institute of Nuclear and New Energy Technology at Tsinghua University in China;the reactor can simul-taneously realize an average neutron flux higher than 2.0×10^(15) n cm^(−2) s^(−1) and fulfill the current safety criterion.This high flux research reactor features advanced design concepts and has sufficient safety margins according to the preliminary safety analysis.Based on the analysis of the station blackout accident,loss of coolant accident,and reactivity accident of a single-control drum rotating out accidently,the maximum temperature of the cladding surface,minimum departure from nucleate boiling ratio,and temperature difference to the onset of nucleate boiling temperature satisfy the design limits.

“Blind men and an elephant”:The need for animals in research,drug safety studies,and understanding civilizational diseases

Animal-based research and drug safety studies are essential to understanding the mysteries of nature and the long-term survival of humans.Due to the rapid increase in the global human population,conflict-and economically driven human migration,tourism-related activities,densely populated metropolitan areas,and local policies,humans will be affected by a multitude of novel disease-causing microorganisms and civilizational diseases.Despite disparities among countries,recent and planned changes in regulations concerning animal research and drug safety studies could have detrimental effects on both the animal research community and nations lacking sufficient social support systems.Based on existing scientific literature,I argue that we need animal research encompassing aspects such as animal development,behavior,drug safety studies,and for the understanding of future civilizational diseases.Depending on the nature of the research questions and local challenges,a suitable animal model organism should be made mandatory.

Obtaining research biopsies during pediatric colonoscopy: Safety and adverse events

AIM: To investigate the safety profile of acquiring additional intestinal biopsies for research purposes in children undergoing a medically indicated colonoscopy. METHODS: A retrospective review of 122 pediatric patients who underwent colonoscopy over a 9 mo time period was completed. 38/122 participants consented to a research study in which 4 additional biopsies were obtained, in addition to routine biopsies. The outcomes after colonoscopy were measured in the research participants, and compared to 84 control participants who did not consent for the study. Groups were compared with regard to number of biopsies obtained, underlying diagnosis, and both serious and minor adverse outcomes. Data was collected including: age, gender, race, indication, diagnosis, number of biopsies obtained per case and post procedure adverse events. Medical records were reviewed and a questionnaire was completed by each of the ten gastroenterologists who performed procedures during the study. Physicians were asked about individual patient outcomes to ensure that all adverse events, such as perforation, excessive bleeding, infection, and minor gastrointestinal outcomes, were captured and included.RESULTS: The research group had more biopsies obtained(mean = 13.58 ± 4.21) compared to controls(mean = 9.33 ± 4.40), P ≤ 0.0001, however there was no difference in adverse events. Serious outcomes, defined as perforation, bleeding and infection, did not occur, in either group. As such, the relationship between serious adverse events and number of biopsies obtained was not determined. Minor gastrointestinal outcomes, such as abdominal pain, diarrhea or vomiting, were reported in 21 patients(8 research participants and 13 control participants) however the incidence of minor gastrointestinal outcomes between the two groups did not vary significantly, P = 0.45. Additionally, the meannumber of biopsies obtained in patients who had a minor outcome(mean = 12.1 ± 0.77), compared to those with no adverse outcome(mean = 10.34 ± 0.5), revealed no statistical difference between the groups(P = 0.12), suggesting that number of biopsies is not associated with incidence of minor adverse events.CONCLUSION: Patients participating in research requiring acquisition of additional biopsies for research purposes alone, are not at an increased risk of adverse outcomes.

Looking ahead to significant improvements in mining safety and health through innovative research and effective diffusion into the industry

Mining safety and health improvements over the past decades are remarkable by many metrics, and yet the expectation of society, and the goal of the mining industry, is zero harm. If we examine the underlying enablers for the significant gains that have been achieved, the key role that research to help understand the causes of problems and to develop lasting solutions is clear. Many of the remaining challenges have been resistant to solutions by various approaches. Some, such as fatalities and injuries from ground control or powered haulage are prominent year after year. Different approaches are indicated and new solutions will be required if we are to achieve a goal of zero harm. These will originate with research, but into which topics, and what are some of these different approaches? This paper examines the current state of mine safety in the United States and highlights areas of significant opportunity for research that will lead to solutions. The likely direction of research that will enable realization of the ‘‘zero harm'' goal is described in terms of evolutionary and revolutionary approaches. Both are important, but the author's view is that some of the largest gains will be made with trans-disciplinary approaches that break from the past. Topical areas of research are suggested and several research questions are given to illustrate the direction of future research in mining safety and health.

Co-word clustering analysis for nursing safety management research focuses by PubMed

Objective： To analyze hot research areas and the present research status of nursing safety management in PubMed. Methods： PubMed was searched using ＂safety management＂ for the literature on nursing safety management. BICOMB 2.0 and SPSS 20.0 software were used to analyze high-frequency keywords and conduct co-word clustering analysis. Results： We searched for totally 2353 articles related to our topic and extracted 19 high-frequency keywords （27.50%）. Five research focuses were concluded, including： study on nursing safety culture; team work to promote nursing safety; practice of nursing safety management; workplace violence against nursing staffs; nursing safety and quality evaluation standard. Conclusion： Analysis of the hotspots of nursing safety management in the past 10 years will contribute to understanding the research emphases and trend of development, and provide reference for the study and practice of nursing safety management.

Status and Development Trend of Evaluation of Post-Marketing Traditional Chinese Medicines in China

Evaluation of traditional Chinese medicines after the market has achieved fruitful results after years of development.The real-world research concept has been first proposed by Chief Researcher Xie Yanming in 2010 and to 2020 with the approval of the National Medical Products Administration to use real-world evidence to support drug development and review in 2020.Real-world data application and transformation continue to cause heated discussions in the industry.Real-world research concepts have been added new motivation into the evaluation of Chinese medicines after they are marketed.The development of the Chinese patent medicine industry is facing unprecedented opportunities and challenges.

Safety of the express freight train running over a long-span bridge

Purpose-Express freight transportation is in rapid development currently.Owing to the higher speed of express freight train,the deformation of the bridge deck worsens the railway line condition under the action of wind and train moving load when the train runs over a long-span bridge.Besides,the blunt car body of vehicle has poor aerodynamic characteristics,bringing a greater challenge on the running stability in the crosswind.Design/methodology/approach-In this study,the aerodynamic force coefficients of express freight vehicles on the bridge are measured by scale model wind tunnel test.The dynamic model of the train-long-span steel truss bridge coupling system is established,and the dynamic response as well as the running safety of vehicle are evaluated.Findings-The results show that wind speed has a significant influence on running safety,which is mainly reflected in the over-limitation of wheel unloading rate.The wind speed limit decreases with train speed,and it reduces to 18.83 m/s when the train speed is 160 km/h.Originality/value-This study deepens the theoretical understanding of the interaction between vehicles and bridges and proposes new methods for analyzing similar engineering problems.It also provides a new theoretical basis for the safety assessment of express freight trains.

Ethical framework for artificial intelligence in healthcare research:A path to integrity

The integration of Artificial Intelligence(AI)into healthcare research promises unprecedented advancements in medical diagnostics,treatment personalization,and patient care management.However,these innovations also bring forth significant ethical challenges that must be addressed to maintain public trust,ensure patient safety,and uphold data integrity.This article sets out to introduce a detailed framework designed to steer governance and offer a systematic method for assuring that AI applications in healthcare research are developed and executed with integrity and adherence to medical research ethics.

Quality Control and Nonclinical Research on CAR-T Cell Products: General Principles and Key Issues

Adoptive cell therapy using chimeric antigen receptor T (CAR-T) cells, which is a promising cancer immunotherapy strategy, has been developing very rapidly in recent years. CAR-T cells are genetically modified T cells that can specifically recognize tumor specific antigens on the surface of tumor cells, and then effectively kill tumor cells. At present, exciting results are being achieved in clinical applications of CAR-T cells for patients with hematological malignancies. The research and development of CAR-T cells for various targets and for the treatment of solid tumors have become a hot topic worldwide, so an increasing number of investigational new drug applications (INDAs) and new drug applications (NDAs) of CAR-T cell products are expected to be submitted in future. The quality control and nonclinical research of these products are of great significance in ensuring the safety and effectiveness of these products;however, they also present great challenges and difficulties. This article discusses the general principles of and key issues regarding the quality control and nonclinical research of CAR-T cell products based on their product characteristics and on relevant guidelines for gene and cell therapy products.

Transplantation of autologous peripheral blood mononuclear cells in the subarachnoid space for amyotrophic lateral sclerosis:a safety analysis of 14 patients

There is a small amount of clinical data regarding the safety and feasibility of autologous peripheral blood mononuclear cell transplantation into the subarachnoid space for the treatment of amyotrophic lateral sclerosis.The objectives of this retrospective study were to assess the safety and efficacy of peripheral blood mononuclear cell transplantation in 14 amyotrophic lateral sclerosis patients to provide more objective data for future clinical trials.After stem cell mobilization and collection,autologous peripheral blood mononuclear cells（1 × 109） were isolated and directly transplanted into the subarachnoid space of amyotrophic lateral sclerosis patients.The primary outcome measure was incidence of adverse events.Secondary outcome measures were electromyography 1 week before operation and 4 weeks after operation,Functional Independence Measurement,Berg Balance Scale,and Dysarthria Assessment Scale 1 week preoperatively and 1,2,4 and 12 weeks postoperatively.There was no immediate or delayed transplant-related cytotoxicity.The number of leukocytes,serum alanine aminotransferase and creatinine levels,and body temperature were within the normal ranges.Radiographic evaluation showed no serious transplant-related adverse events.Muscle strength grade,results of Functional Independence Measurement,Berg Balance Scale,and Dysarthria Assessment Scale were not significantly different before and after treatment.These findings suggest that peripheral blood mononuclear cell transplantation into the subarachnoid space for the treatment of amyotrophic lateral sclerosis is safe,but its therapeutic effect is not remarkable.Thus,a large-sample investigation is needed to assess its efficacy further.

Neutronic design investigation of a liquid injection-based second shutdown system for a typical research reactor using MCNPX

Safety systems, built on state-of-the-art technology, are essential for achieving acceptable levels of plant safety to minimize hazards to the reactor and the general public. The second shutdown system(SSS) as an engineered safety feature and a part of the reactor protection system(RPS) is a means for rapidly shutting down a nuclear reactor, keeping it in a subcritical state and serving as a backup to the first shutdown system(FSS). In this research, one SSS with two types of optimum chamber designs is proposed that take into account the main current characteristic features of the Tehran research reactor with improvements over earlier designs. They are based on a liquid neutron absorber injection that is preferably different, diverse, and independent from the FSS based on the rod drop mechanism. The major design characteristics of this SSS with two different chambers were investigated using MCNPX 2.6.0 code. The performed calculations showed that the designed SSS is a reliable shutdown system, assuring an appropriate shutdown margin and injection time, with no significant effects on the effective delayed neutron fraction while causing minimal variations to the core structure. Further, the reasonable financial cost and the prolongation of the operation cycle are additional advantages of this design.

Study on Net Hauler Safety Device for Fishing Vessels

[Objective] To design a safety device set for fishing vessel net hauler, in order to reduce the severe potential safety hazards in offshore operation. [Method] In view of the operation and structure of net hauler on the fishing trawler, this paper investigated the existing safety protection devices and designed a new set of purely mechanical structure without changing the original structures of the vessel significantly. [Result] Using the easily-adjustable functions of the main shaft of CNC lathe, and simulating the operation performance of different hauling line speeds and testing the safety device, the results showed that the new device could protect the crew from safety accidents caused by net hauler. [Conclusion] The result provides references for the design and application of mechanical protection devices for net haulers on other fishing trawlers.

Analysis of Potential Causes of Safety Failure of New Energy Vehicle Power Batteries

The aim of this paper is to analyze the potential reasons for the safety failure of batteries for new-energy vehicles.Firstly,the importance and popularization of new energy batteries are introduced,and the importance of safety failure issues is drawn out.Then,the composition and working principle of the battery is explained in detail,which provides the basis for the subsequent analysis.Then,the potential impacts of factors such as overcharge and over-discharge,high and low temperature environments,internal faults,and external shocks and vibrations on the safety of the batteries are analyzed.Finally,some common safety measures and solutions are proposed to improve the safety of new energy batteries,in hopes of improving the safety of batteries for new-energy vehicle.

基于文献计量学分析的全球食品追溯研究进展

食品追溯是确保食品质量与安全的重要手段,本文对2001—2022年科学引文索引数据库收录的食品追溯论文进行计量分析和可视化呈现,以便为国内食品追溯的进一步研究和开发提供参考。结果发现:全球共有80个国家/地区、1 136个研究机构、3 020名作者、255种期刊开展了食品追溯研究,跨国家/地区合作、多学科交叉融合频繁;中国、意大利、美国、西班牙、荷兰等表现出较大的研究体量与较强的合作关系,意大利、美国、荷兰、西班牙食品追溯研究的总体质量较高,研究领域集中在食品科学技术、化学、农业、工程学上,在计算机科学、生态学与环境学、饮食与营养学领域也有较多研究成果。研究热点有食品质量与安全、食品供应链管理、原产地、追溯技术、食品鉴别与认证、支付意愿等。未来学术前沿将围绕基于工业4.0的智能食品追溯系统、以全基因组学和下一代测序技术为代表的食品真实性检测鉴别技术以及食品追溯系统主体参与动力、利益博弈和溢价支付的机制3个方面展开。

Nurses’ Perceptions of Patient Safety in Community Mental Health Settings: A Qualitative Study

Mental health care has moved from hospital settings to community mental health settings, and there is a need to explore the perceptions of patient safety among registered nurses working in this field. Patient safety is to include everyone and to be the goal in all aspects of health care. The aim of the study was to explore registered nurses’ perceptions of patient safety in community mental health settings for people with serious mental illness. The study was qualitative and descriptive in nature and interviews were carried out during spring 2012, with seven registered nurses working in community mental health settings for people with serious mental illness in five municipalities in the middle of Sweden. The sampling was purposive and data were analysed using qualitative content analysis. The findings showed that the registered nurses understood patient safety as providing support to people with serious mental illness in regaining and maintaining health through good treatment and respecting self-determination and avoiding coercion. The terms of daily living in small community mental health settings within the a large community health care organization, communication, sufficient knowledge of psychiatric disabilities among people in the residents’ network, and national laws and regulations, all had implications for patient safety. The registered nurses perceived patient safety as involving a wide range of issues that in other areas of care are more often discussed in terms of quality of care. Determining the boundaries of patient safety in community mental health settings for people with serious mental illness can be a first step in establishing workable routines that ensure safe patient care.

高速公路风险防控设施应用研究综述与展望

高速公路风险防控设施的合理应用能够显著降低交通运行风险。本文首先针对高速公路风险防控设施的研究现状进行了回顾与总结,将高速公路风险防控设施划分为非电气化防控设施和电气化防控设施。其次,归纳了高速公路非电气化和电气化防控设施在风险防控中的作用以及研究中的关键问题,讨论了不同电气化风险防控设施的应用场景及其效用。然后,对由电气化设施构成的风险防控系统在多种典型场景中的应用效果进行了分析。最后,对高速公路风险防控设施应用综述结果及未来发展情况进行了总结。文献综述结果表明,高速公路风险防控设施和系统在不同场景中均能起到积极的效果;非电气化防控设施受限于自身物理特性,在应对动态信息发布和主动性、针对性风险防控上存在一定的不足;电气化风险防控设施以及风险防控系统的应用越来越广泛,对交通拥堵、不良天气等交通风险的防控愈加完善。同时,日渐成熟的车路协同技术和不断发展的智慧公路系统也是未来保障高速公路交通安全的重要一环。本文的研究成果可在一定程度上为今后高速公路风险防控设施的选型、设置及应用提供一定的借鉴。

高校实验室“双重预防”机制建设

双重预防机制是在安全工作中从风险管控和隐患治理入手,严防安全事故发生的重要策略,体现的是“为之于未有,治之于未乱”的哲学思想,实现了安全管理关口前移。文章分析双重预防机制内在机理、存在问题,从危险源辨识、管控风险、做好应急准备三个方面构建实验室风险管控体系,从排查和治理两方面构建实验室隐患排查治理体系,并从压实责任、事前预防、闭环治理等方面提出高校实验室安全实践建议和措施。

消费者生理和行为暴露参数研究进展

随着经济发展,日常使用的消费品成为普通人群接触化学污染物的重要来源之一。为保障消费者人身健康安全,更好地开展消费品安全暴露风险评估,本文聚焦消费品中化学危害源暴露评估中的消费者特异参数,介绍了体重、呼吸速率、皮肤表面积等生理参数和消费者行为参数的研究方法和进展,分析各种研究方法的优势和不足,对现有消费品安全有关暴露参数的数据可用性进行评述,并展望了暴露参数研究的发展方向。

安全资源学的学科理论研究

为形成安全资源学和更好地开发与利用安全资源,以安全本身作为一类重要资源的新视角,开展安全资源学的学科基础理论研究。站在科学学的高度和以交叉科学的视角,采用调查研究法、创新思维法、理论分析法、逻辑归纳法、预测法等研究方法,阐述安全资源和安全资源学的定义及内涵,安全资源的性质与分类,安全资源学的研究对象和内容、基本原理和研究方法,以及安全资源学的主要研究方向和展望等。结果表明:安全资源兼具有安全和资源的主要特性,安全资源的特性可分为社会特性和自身特性2大类,从不同的视角和层面,给出安全资源学8个方面的主要研究内容;从学科基础层凝炼出安全资源学的10条基本原理;根据交叉学科的关联性质,归纳出安全资源学的典型研究方法。研究结果形成了安全资源学的核心基础理论和雏形,对后续开展安全资源学的具体内容研究和加速形成一门独立的安全资源学新学科具有参考和引领作用。

基于知识图谱的食品领域数智化研究进展

随着大数据和云计算等技术的发展,食品领域的数据规模正在以惊人的速度增长。这些数据不仅来源多样、结构复杂,且缺乏统一的术语标准,给食品数据的有效整合和利用带来了挑战。知识图谱作为实现通用人工智能的重要基石,以其在数据整合和语义理解方面的能力,为食品领域的数据组织、管理与应用提供了支持。通过总结近年来知识图谱在食品领域应用的研究成果,介绍了食品领域知识图谱的构建方法,涵盖本体构建、知识抽取、知识融合和加工等关键环节;重点梳理了当前食品领域知识图谱在食品营养与健康、食品创新与研发、食品安全与溯源3个方面的数智化应用;基于食品领域知识图谱的发展现状,从多模态数据融合技术、大语言模型构建以及食品领域工业设备智能化发展角度展望了食品领域知识图谱的未来发展方向。