The space charge behavior of a dielectric under HVDC is influenced by the charge trap energy distribution in it. Hence, we in- vestigated the charge trap distributions in several kinds of typical polymer materials usi...The space charge behavior of a dielectric under HVDC is influenced by the charge trap energy distribution in it. Hence, we in- vestigated the charge trap distributions in several kinds of typical polymer materials using thermally stimulated discharge (TSD) and photo-stimulated discharge (PSD) methods, respectively. The experimental results show that,there is a significant difference between the trap energy distributions obtained by the two methods, but the difference decreases with the increase of the melting point of polymers. This is attributed to the change of the trap center environment during TSD caused by the increasing movements of both main chains and branched chains in polymers. PSD method is more accurate for investigating charge trap distribution in dielectrics, especially for polymers with low melting points.展开更多
Presently,we develop a simplified corticothalamic(SCT)model and propose a single-pulse alternately resetting stimulation(SARS)with sequentially applying anodic(A,“+”)or cathodic(C,“−”)phase pulses to the thalamic ...Presently,we develop a simplified corticothalamic(SCT)model and propose a single-pulse alternately resetting stimulation(SARS)with sequentially applying anodic(A,“+”)or cathodic(C,“−”)phase pulses to the thalamic reticular(RE)nuclei,thalamus-cortex(TC)relay nuclei,and cortical excitatory(EX)neurons,respectively.Abatement effects of ACC-SARS of RE,TC,and EX for the 2 Hz-4 Hz spike and wave discharges(SWD)of absence seizures are then concerned.The m∶n on-off ACC-SARS protocol is shown to effectively reduce the SWD with the least current consumption.In particular,when its frequency is out of the 2 Hz-4 Hz SWD dominant rhythm,the desired seizure abatements can be obtained,which can be further improved by our proposed directional steering(DS)stimulation.The dynamical explanations for the SARS induced seizure abatements are lastly given by calculating the averaged mean firing rate(AMFR)of neurons and triggering averaged mean firing rates(TAMFRs)of 2 Hz-4 Hz SWD.展开更多
In this paper,a reduced globus pallidus internal(GPI)-corticothalamic(GCT)model is developed,and a tri-phase delay stimulation(TPDS)with sequentially applying three pulses on the GPI representing the inputs from the s...In this paper,a reduced globus pallidus internal(GPI)-corticothalamic(GCT)model is developed,and a tri-phase delay stimulation(TPDS)with sequentially applying three pulses on the GPI representing the inputs from the striatal D_(1)neurons,subthalamic nucleus(STN),and globus pallidus external(GPE),respectively,is proposed.The GPI is evidenced to control absence seizures characterized by 2 Hz–4 Hz spike and wave discharge(SWD).Hence,based on the basal ganglia-thalamocortical(BGCT)model,we firstly explore the triple effects of D_(1)-GPI,GPE-GPI,and STN-GPI pathways on seizure patterns.Then,using the GCT model,we apply the TPDS on the GPI to potentially investigate the alternative and improved approach if these pathways to the GPI are blocked.The results show that the striatum D_(1),GPE,and STN can indeed jointly and significantly affect seizure patterns.In particular,the TPDS can effectively reproduce the seizure pattern if the D_(1)-GPI,GPE-GPI,and STN-GPI pathways are cut off.In addition,the seizure abatement can be obtained by well tuning the TPDS stimulation parameters.This implies that the TPDS can play the surrogate role similar to the modulation of basal ganglia,which hopefully can be helpful for the development of the brain-computer interface in the clinical application of epilepsy.展开更多
Background Lennox-gastaut syndrome(LGS)is an epileptic encephalopathy often associated with behavioral and psychiatric disorders.Vagus nerve stimulation(VNS)has been approved effective for LGS treatment.Surgical resec...Background Lennox-gastaut syndrome(LGS)is an epileptic encephalopathy often associated with behavioral and psychiatric disorders.Vagus nerve stimulation(VNS)has been approved effective for LGS treatment.Surgical resection is also an option for LGS patients with focal pathology,offering a high probability of seizure control.However,it is challenging to accurately localize the seizure focus.Case presentation The case presented here is a 19-year-old male with a 16-year history of epilepsy with comorbid severe cognitive and psychiatric disorders.He was diagnosed with LGS due to generalized slow spike-wave discharges and multiple seizure types.He was treated with VNS in 2017 at the age of 15.After that,the frequency of the short tonic seizures decreased from 4–5 times per day to 2–5 times per year,and the generalized tonic–clonic seizure pattern did not recur,which had a frequency of 2–4 times per month before the surgery.In 2019,the generalized abnormal interictal epileptiform discharges changed to be localized in the right frontal–temporal lobe at the age of 17 years(2019).Conclusions This case report suggested that the generalized epileptiform discharges evolve into localized discharges after VNS treatment,which may help reveal the primary seizure focus for resection surgery in patients with LGS.展开更多
大气压氮气和空气介质阻挡均匀放电属于Townsend放电,并且以一种反常的方式熄灭,即放电在气隙电压上升过程中熄灭。为了实验研究阻挡介质材料表面"浅位阱"(能级<1 e V)对大气压均匀放电的影响,探究"反常熄灭"现...大气压氮气和空气介质阻挡均匀放电属于Townsend放电,并且以一种反常的方式熄灭,即放电在气隙电压上升过程中熄灭。为了实验研究阻挡介质材料表面"浅位阱"(能级<1 e V)对大气压均匀放电的影响,探究"反常熄灭"现象的机理,研制了一套热刺激电流测量装置,可施加最高25 kV直流电压,电流测量精度达0.1 p A,具有良好的抗干扰能力和重复性。测量陶瓷和石英玻璃的热刺激电流曲线,发现2种材料表面均存在一定数量的"浅位阱"。陶瓷浅位阱能级0.37 e V,石英玻璃为0.63 e V,陶瓷浅位阱能级更低,更易被轰击成为种子电子;陶瓷陷阱电荷量315.3 n C,石英玻璃为20.7 n C,陶瓷表面浅位阱数量远远多于石英玻璃。这与陶瓷材料能够实现大气压均匀介质阻挡放电(dielectric barrier discharge,DBD)但石英玻璃只是细丝放电的实验现象一致。证实材料表面浅位阱能够为放电提供种子电子,且数量越多越有利于实现大气压均匀DBD。展开更多
基金Project supported by National Natural Science Foundation of China （51077101, 51277133）, National Basic Research Program of China （973 Program） （2009CB 724505）.
文摘The space charge behavior of a dielectric under HVDC is influenced by the charge trap energy distribution in it. Hence, we in- vestigated the charge trap distributions in several kinds of typical polymer materials using thermally stimulated discharge (TSD) and photo-stimulated discharge (PSD) methods, respectively. The experimental results show that,there is a significant difference between the trap energy distributions obtained by the two methods, but the difference decreases with the increase of the melting point of polymers. This is attributed to the change of the trap center environment during TSD caused by the increasing movements of both main chains and branched chains in polymers. PSD method is more accurate for investigating charge trap distribution in dielectrics, especially for polymers with low melting points.
基金Project supported by the National Natural Science Foundation of China(Nos.11702018,11932003,and 11672074)。
文摘Presently,we develop a simplified corticothalamic(SCT)model and propose a single-pulse alternately resetting stimulation(SARS)with sequentially applying anodic(A,“+”)or cathodic(C,“−”)phase pulses to the thalamic reticular(RE)nuclei,thalamus-cortex(TC)relay nuclei,and cortical excitatory(EX)neurons,respectively.Abatement effects of ACC-SARS of RE,TC,and EX for the 2 Hz-4 Hz spike and wave discharges(SWD)of absence seizures are then concerned.The m∶n on-off ACC-SARS protocol is shown to effectively reduce the SWD with the least current consumption.In particular,when its frequency is out of the 2 Hz-4 Hz SWD dominant rhythm,the desired seizure abatements can be obtained,which can be further improved by our proposed directional steering(DS)stimulation.The dynamical explanations for the SARS induced seizure abatements are lastly given by calculating the averaged mean firing rate(AMFR)of neurons and triggering averaged mean firing rates(TAMFRs)of 2 Hz-4 Hz SWD.
基金supported by the National Natural Science Foundation of China(Nos.11932003,12072021,and 11672074)。
文摘In this paper,a reduced globus pallidus internal(GPI)-corticothalamic(GCT)model is developed,and a tri-phase delay stimulation(TPDS)with sequentially applying three pulses on the GPI representing the inputs from the striatal D_(1)neurons,subthalamic nucleus(STN),and globus pallidus external(GPE),respectively,is proposed.The GPI is evidenced to control absence seizures characterized by 2 Hz–4 Hz spike and wave discharge(SWD).Hence,based on the basal ganglia-thalamocortical(BGCT)model,we firstly explore the triple effects of D_(1)-GPI,GPE-GPI,and STN-GPI pathways on seizure patterns.Then,using the GCT model,we apply the TPDS on the GPI to potentially investigate the alternative and improved approach if these pathways to the GPI are blocked.The results show that the striatum D_(1),GPE,and STN can indeed jointly and significantly affect seizure patterns.In particular,the TPDS can effectively reproduce the seizure pattern if the D_(1)-GPI,GPE-GPI,and STN-GPI pathways are cut off.In addition,the seizure abatement can be obtained by well tuning the TPDS stimulation parameters.This implies that the TPDS can play the surrogate role similar to the modulation of basal ganglia,which hopefully can be helpful for the development of the brain-computer interface in the clinical application of epilepsy.
基金Natural Science Foundation of Yunnan Province(202105AC160029,KYRLMY20200026 and YNGXCXTD2018012)Major Science and Technology Special Project of Yunnan Province(202002AA100204).
文摘Background Lennox-gastaut syndrome(LGS)is an epileptic encephalopathy often associated with behavioral and psychiatric disorders.Vagus nerve stimulation(VNS)has been approved effective for LGS treatment.Surgical resection is also an option for LGS patients with focal pathology,offering a high probability of seizure control.However,it is challenging to accurately localize the seizure focus.Case presentation The case presented here is a 19-year-old male with a 16-year history of epilepsy with comorbid severe cognitive and psychiatric disorders.He was diagnosed with LGS due to generalized slow spike-wave discharges and multiple seizure types.He was treated with VNS in 2017 at the age of 15.After that,the frequency of the short tonic seizures decreased from 4–5 times per day to 2–5 times per year,and the generalized tonic–clonic seizure pattern did not recur,which had a frequency of 2–4 times per month before the surgery.In 2019,the generalized abnormal interictal epileptiform discharges changed to be localized in the right frontal–temporal lobe at the age of 17 years(2019).Conclusions This case report suggested that the generalized epileptiform discharges evolve into localized discharges after VNS treatment,which may help reveal the primary seizure focus for resection surgery in patients with LGS.
文摘大气压氮气和空气介质阻挡均匀放电属于Townsend放电,并且以一种反常的方式熄灭,即放电在气隙电压上升过程中熄灭。为了实验研究阻挡介质材料表面"浅位阱"(能级<1 e V)对大气压均匀放电的影响,探究"反常熄灭"现象的机理,研制了一套热刺激电流测量装置,可施加最高25 kV直流电压,电流测量精度达0.1 p A,具有良好的抗干扰能力和重复性。测量陶瓷和石英玻璃的热刺激电流曲线,发现2种材料表面均存在一定数量的"浅位阱"。陶瓷浅位阱能级0.37 e V,石英玻璃为0.63 e V,陶瓷浅位阱能级更低,更易被轰击成为种子电子;陶瓷陷阱电荷量315.3 n C,石英玻璃为20.7 n C,陶瓷表面浅位阱数量远远多于石英玻璃。这与陶瓷材料能够实现大气压均匀介质阻挡放电(dielectric barrier discharge,DBD)但石英玻璃只是细丝放电的实验现象一致。证实材料表面浅位阱能够为放电提供种子电子,且数量越多越有利于实现大气压均匀DBD。
