Analysis of factors impacting postoperative pain and quality of life in patients with mixed hemorrhoids:A retrospective study

BACKGROUND Hemorrhoids are among the most common and frequently encountered chronic anorectal diseases in anorectal surgery.They are venous clusters formed by con-gestion,expansion,and flexion of the venous plexus in the lower part of the rec-tum.Mixed hemorrhoids bleed easily and recurrently,and this can result in severe anemia.Hence,they may have a negative effect on the health of the patient and surgical treatment is required.Milligan-Morgan hemorrhoidectomy has been widely used since 1937 for the treatment of grade III and IV hemorrhoids.How-ever,most patients experience different degrees of postoperative pain that may cause anxiety.with mixed hemorrhoids post-surgery.METHODS The clinical data of patients with mixed hemorrhoids who underwent Milligan-Morgan hemorrhoidectomy were collected retrospectively.The basic character-istics of the enrolled patients with mixed hemorrhoids were recorded,and based on the Goligher clinical grading system,the hemorrhoids were classified as grades III or IV.The endpoint of this study was the disappearance of pain in all patients.Quantitative data were presented as mean±SD,such as age,pain score,and QoL score.Student’s t-test was used to compare the groups.RESULTS A total of 164 patients were enrolled.The distribution of the visual analog scale pain scores of all patients at 3,7,14 and 28 d after surgery showed that post-surgery pain was significantly reduced with the passage of time.Fourteen days after the operation,the pain had completely disappeared in some patients.Twenty-eight days after the surgery,none of the patients experienced any pain.Comparing the World Health Or-ganization Quality of Life-BREF self-reporting questionnaire scores of patients between 14 and 28 d after surgery,we observed that the quality-of-life scores of the patients post-surgery had significantly improved.There were six items that were compared at 14-and 28-d post-surgery.The mean QoL score 28 d after surgery(4.79±0.46)was higher than that at 14 d post-surgery(3.79±0.57).The mean health condition score 28 d after surgery(4.80±0.41)was also higher than that at 14 d post-surgery(4.01±0.62).The mean physical health score 28 d after surgery(32.10±2.96)was significantly higher than that at 14 d post-surgery(23.41±2.85).The mean psychological health score 28 d after surgery(27.22±1.62)was significantly higher than that at 14 d post-surgery(21.37±1.70).The mean social relations score 28 d after surgery(12.21±1.59)was significantly higher than that at 14 d post-surgery(6.32±1.66).The mean surrounding environment score 28 d after surgery(37.13±2.88)was significantly higher than that at 14 d post-surgery(28.42±2.86).The differences in quality-of-life scores at day 14 and day 28 post-surgery were ob-served to be statistically significant(P<0.001).CONCLUSION Milligan-Morgan hemorrhoidectomy can significantly improve the postoperative QoL of patients.Age,sex,and the number of surgical resections were important factors influencing Milligan-Morgan hemorrhoidectomy.

Clinical Observation of Chinese Medicinal Prescriptions for Swelling and Pain in The Postoperative Treatment of Mixed Hemorrhoids

Objective:To observe the clinical effect of traditional Chinese medicine(TCM)on reducing swelling and pain in patients with mixed hemorrhoids.Methods:Sixty patients with mixed hemorrhoids who were admitted to the Hospital of Traditional Chinese Medicine of Qiqihar from January 2023 to January 2024 were selected and divided into two groups.The treatment group(n=30)was treated with mixed hemorrhoid ligation combined with traditional Chinese swelling and pain medicine,and the control group(n=30)was only treated with mixed hemorrhoid ligation.The pain level,edema score,and prognosis of the two groups after the intervention were analyzed.The clinical efficacy was used as the evaluation criterion to compare the clinical effects of different treatment options.Results:After the treatment,the pain score,edema score,and prognostic wound score of the treatment group were all lower than those of the control group(P 0.05).The total clinical effectiveness of the treatment group(100%)was higher than that of the control group(76.67%),(χ^(2)=4.2857,P<0.05).Conclusion:The application of traditional Chinese swelling and pain medicine in treating patients with mixed hemorrhoids effectively reduced the patient’s pain,reduced the degree of wound edema,promoted wound healing,and improved the patient’s prognosis.The curative effect was significant and had a positive impact.

Milligan-Morgan hemorrhoidectomy with anal cushion suspension and partial internal sphincter resection for circumferential mixed hemorrhoids

AIM:To identify a more effective treatment protocol for circumferential mixed hemorrhoids.METHODS:A total of 192 patients with circumferential mixed hemorrhoids were randomized into the treatment group,where they underwent Milligan-Morgan hemorrhoidectomy with anal cushion suspension and partial internal sphincter resection,or the control group,where traditional external dissection and internal ligation were performed.Postoperative recovery and complications were monitored.RESULTS:The time to wound healing was 12.96 ± 2.25 d in the treatment group shorter than 19.58 ± 2.71 d in the control group.Slight pain rate was 58.3% in the treatment group higher than 22.9% in the control group;moderate pain rate was 33.3% in the treatment group lower than 56.3% in the control group severe pain rate was 8.4% in the treatment group lower than 20.8% in the control group.No edema rate was 70.8% in the treatment group higher than 43.8% in the control group;mild local edema rate was 26% in the treatment group lower than 39.6% in the control group obvious local edema was 3.03% in the treatment group lower than 16.7% in the control group.No stenosis rate was 85.4% in the treatment group higher than 63.5% in the control group;moderate stenosis rate was 14.6% in the treatment group Lower than 27.1% in the control group severe anal stenosis rate was 0% in the treatment group lower than 9.4% in the control group.CONCLUSION:Milligan-Morgan hemorrhoidectomy with anal cushion suspension and partial internal sphincter resection is the optimal treatment for circumferential mixed hemorrhoids and can be widely applied in clinical settings.

Clinical Observation on 80 Cases of Anal Edema after Mixed Hemorrhoids Operation with Chinese Medicine Hot Election Package

The subjects of this study were 80 patients who underwent mixed hemorrhoids surgery in our hospital from January to October 2020 (mixed hemorrhoids external and internal ligation, internal hemorrhoids ligation or Xiaozhiling injection) and developed anal edge edema after surgery. According to the order of hospitalization, the patients were randomly divided into treatment group and control group, with 40 cases each. In the control group, blank hot pack was applied on the basis of anorectal No. 1 lotion for prevention and treatment of anal edge edema after operation;in the treatment group, hot pack of Traditional Chinese medicine was applied on the basis of anorectal No. 1 lotion for prevention and treatment of anal edge edema. The course of treatment was 7 days. The edema subsidence and postoperative pain scores were observed in both groups. Results: The scores of anal edema and pain in the treatment group were significantly lower than those in the control group (P < 0.05), and the significant efficiency and total effective rate in the treatment group were significantly better than those in the control group, with statistical difference (P < 0.05). Conclusion: Chinese medicine hot election package is effective in treating postoperative anal edema of mixed hemorrhoids, and the method is simple and suitable for clinical promotion.

Research progress of traditional Chinese medicine nursing techniques for the management of postoperative complications in mixed hemorrhoids

Mixed hemorrhoids,especially ring-shaped mixed hemorrhoid,is still a headache for anorectal surgeons due to its post-operative complications.In recent years,clinicians have been studying and exploring to avoid and alleviate these complications.In the Chinese medicine industry,the application of traditional Chinese medicine nursing technology has good and unique effect in prevent local pain,perianal edema,promote wound healing,relieve urinary retention,improve constipation,relieve anxiety,and so on.This article summarized the evidences of investigated the role of traditional Chinese medicine nursing technique in preventing and treating mixed hemorrhoid so that practitioners can make decision based on the best available evidences.

Effect of auricular acupoint sticking and pressing on postoperative pain of patients with mixed hemorrhoids:A Meta-analysis

Objective:To systematically evaluate the application effect of auricular acupuncture in postoperative analgesia in patients with mixed hemorrhoids.Methods:We searched Chinese Biomedical Literature Database,CNKI,WanFang,PubMed,Embase,and The Cochrane Library to collect randomized controlled trials about auricular acupuncture on Postoperative patients with mixed hemorrhoids.According to the inclusion criteria and exclusion criteria screening literature.RevMan 5.3 software was used for meta-analysis.Results:A total of 20 articles and 21 studies were included,including 1999 patients after mixed hemorrhoids.The control group was treated with routine nursing analgesia.The experimental group was treated with auricular acupressure beans based on the control group.The meta-analysis showed that the pain relief rate of the experimental group was better than that of the control group[OR=2.84,95%CI(2.12,3.80),P<0.05].Subgroup analysis showed that the application of auricular acupressure after milligan morgan was superior to the control group in the analgesic effect[OR=3.68,95%CI(2.62,5.18),P<0.05],but it is not yet possible to apply auricular acupoint pressing to relieve pain after Stapler hemorrhoidectomy(P>0.05).The pain scores of 24 hours and 48 hours after operation in the experimental group were lower than those of the control group,indicating that auricular acupoint sticking can relieve the pain after operation.The improvement of the postoperative anal margin edema was better in the experimental group than in the control group,24 h[SMD=-1.99,95%CI(-2.84,-1.14),P<0.05],48 h[SMD=-1.92,95%CI(-2.72,-1.11),P<0.05].The adverse reactions were lower than the control group.Conclusion:The application of ear acupoint pressure pea after external exfoliation of mixed hemorrhoids can improve the analgesic effect and reduce the symptoms of postoperative anal edge edema,and the price is low,the operation is convenient,and the side effects are few.It is recommended to be popularized in clinical practice.

Progress in the Treatment of Edema After Surgery for Mixed Hemorrhoids

Edema is a common postoperative complication in mixed hemorrhoids.With the development of medical treatment,surgical improvement has greatly reduced surgical trauma to the body,but the issue of postoperative edema still exists.In order to explore the treatment progress of edema after surgery for mixed hemorrhoids,literatures on integrated traditional Chinese and western medicine for postoperative edema in hemorrhoids have been reviewed in hope to better understand the complication and provide reference for relevant clinical studies in the future.

Effect of moxibustion combined with five‑element music therapy on postoperative pain relief after mixed hemorrhoid operation

Objective:To investigate the effect of moxibustion combined with five‑element music therapy on the postoperative pain relief of patients undergoing surgical operation for mixed hemorrhoid with damp‑heat syndrome.Methods:Totally,159 patients meeting the inclusion criteria were assigned to the control group,study group 1,and study group 2,with 53 cases in each group.All patients received routine care after surgical treatment,including acupoint application and Chinese herbal fumigation.In addition,patients in the study group 1 received moxibustion,and those in the study group 2 were given moxibustion combined with five‑element music therapy.The degree of postoperative pain was evaluated using visual analog scale(VAS).Results:There was no significant difference in VAS score on pain during dressing changes among three groups(P>0.05).After 3,5,and 7 days of intervention,there was a significant difference in VAS score on pain at rest among three groups(P<0.001),and VAS score in the study group 2 was lower than that in the study group 1 and the control group after 3 and 5 days of intervention,respectively(P<0.05).Conclusion:Moxibustion combined with five‑element music therapy is effective to relieve the postoperative pain of patients undergoing a surgical operation for mixed hemorrhoids with damp‑heat syndrome.

Redefining hemorrhoid therapy with endoscopic polidocanol foam sclerobanding

Hemorrhoids are a common and painful condition,with conventional treatments such as endoscopic rubber band ligation(ERBL)and injection sclerotherapy often falling short due to high recurrence rates and significant post-operative pain.A clinical trial by Qu et al introduces a novel approach called endoscopic polidocanol foam sclerobanding(EFSB).This multicenter randomized trial involved 195 patients with grade II and III internal hemorrhoids and demonstrated that EFSB significantly reduced recurrence rates and post-procedural pain while improving symptom relief and patient satisfaction compared to ERBL.The study's strengths include its robust design,comprehensive outcome evaluation,and patient-centered approach.Despite limitations such as the single-blind design and relatively short follow-up period,the findings suggest that EFSB could enhance clinical practice by offering a more effective and patient-friendly treatment option.Further research is needed to validate these results and explore the long-term benefits and cost-effectiveness of EFSB.

Clinical Experience Sharing Of 218 Cases without Hemorrhage after Procedure for Prolapse and Hemorrhoids

Objective:To summarize the experience without hemorrhage after PPH of 218 patients with mixed hemorrhoid.Methods:PPH(Procedure for prolapse and hemorrhoids)was performed routinely.During operation,it is paid attention that the hemorrhoid artery should be completely mutilated,the anastomat should be squeezed before and after the anastomosis,the anastomosis should be carefully examined,the hemostasis should be completely performed,and relevant hemostasis measures should be taken after the operation.Results:None of the 218 patients had postoperative hemorrhage.Conclusion:Relevant measures can be taken after operation to prevent the occurrence of postoperative hemorrhage.

次髎穴埋线治疗对混合痔病人术后疼痛和营养状况的影响

目的:探讨次髎穴埋线用于混合痔术后镇痛治疗的效果以及对病人营养状况的影响。方法:2019年9月至2021年7月本院收治的混合痔手术病人90例,随机分为3组:埋线组、针刺组和药物组,每组30例。术后不同时间对病人进行疼痛评分,检测病人血清总蛋白、白蛋白和球蛋白水平,记录住院时间、住院费用和镇痛治疗费用。结果:术后12 h、24 h、3 d、5 d及7 d,次髎穴埋线组病人疼痛评分均明显低于针刺组和药物组(P<0.05)。术后7 d,埋线组病人血清总蛋白水平明显高于针刺组(P<0.05)。埋线组病人住院时间和住院费用均低于针刺组和药物组(P<0.01)。结论:次髎穴埋线具有良好的镇痛作用,有助于改善病人营养状况,缩短住院日,降低医疗费用,加快病人术后康复,具有较好的临床应用前景。

痔疮栓联合中药熏洗坐浴对混合痔术后疼痛水肿的治疗作用分析

【目的】探究痔疮栓联合中药熏洗坐浴对混合痔术后疼痛水肿的临床疗效。【方法】将62例拟行手术治疗的混合痔患者随机分为试验组和对照组,每组各31例。2组患者均给予混合痔手术治疗(高位套扎术或混合痔外剥内扎术)和术后常规护理,在此基础上,对照组给予痔疮栓塞肛治疗,试验组给予痔疮栓塞肛联合中药熏洗坐浴(中药熏洗方由红花、桃仁、延胡索、滑石、川楝子、枳壳、黄柏、没药、乳香等组成)治疗,疗程为2周。观察2组患者治疗前后疼痛程度评分和水肿程度评分的变化情况,比较2组患者的症状缓解时间、临床疗效及治疗满意度。【结果】(1)治疗2周后,试验组的总有效率为96.77%(30/31),对照组为80.65%(25/31),组间比较(χ2检验),试验组的疗效明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的疼痛程度评分和水肿程度评分均较治疗前明显降低(P<0.05),且试验组对疼痛程度评分及水肿程度评分的降低作用均明显优于对照组,差异均有统计学意义(P<0.01)。(3)试验组的疼痛消失时间和水肿消失时间均较对照组明显缩短,差异均有统计学意义(P<0.01)。(4)试验组的总满意率为96.77%(30/31),对照组为77.42%(24/31),组间比较(χ2检验),试验组的治疗满意度明显优于对照组,差异有统计学意义(P<0.05)。【结论】痔疮栓联合中药熏洗坐浴对混合痔术后疼痛水肿的治疗作用显著,可有效改善患者的水肿程度和疼痛感,促进机体康复,提高患者的治疗满意度。

腕踝针联合商调音乐在混合痔术后病人中的应用

目的:探讨腕踝针联合商调音乐对混合痔术后疼痛和相关并发症发生情况的影响。方法:选择2021年11月—2022年7月在我院肛肠科诊断为湿热下注型混合痔拟行混合痔外剥内扎术的114例病人,随机分为对照组、干预1组及干预2组各38例。对照组进行常规镇痛和中药换药、熏洗等常规护理;干预1组在对照组基础上给予腕踝针治疗法;干预2组在对照组基础上给予腕踝针与商调音乐疗法的联合治疗。于术后第3天、术后第5天采用视觉模拟疼痛评分(VAS)、Wexner便秘评分、便后出血评分、肛缘水肿评分评估病人的肛门疼痛、便秘、便后出血、肛缘水肿并发症发生情况。结果:与对照组相比,干预1组及干预2组的术后VAS评分明显降低(P<0.05),首次排尿用时和尿流状况等排尿功能评分、Wexner便秘评分、术后便时出血评分及肛缘水肿评分明显降低(P<0.05),且干预2组术日、术后第3天、术后第5天VAS评分的改善优于干预1组(P<0.05),术后首次排尿时长、小腹状况评分及术后第3天Wexner便秘评分的改善优于干预1组(P<0.05)。结论:腕踝针联合商调音乐应用于混合痔术后病人,可减轻病人疼痛,改善术后便秘、便血、肛缘水肿等并发症,提高排尿功能。

外剥内扎术加内痔柱状缝扎悬吊联合痔科生肌散治疗环状混合痔的临床研究

目的探究外剥内扎术加内痔柱状缝扎悬吊联合痔科生肌散治疗环状混合痔的临床效果和安全性。方法选取2021年1月至2022年8月江苏省无锡市中医院收治的90例环状混合痔患者,采用随机数字表法将其分为对照组(外剥内扎术加内痔柱状缝扎悬吊治疗)和试验组(外剥内扎术加内痔柱状缝扎悬吊联合痔科生肌散治疗),各45例。治疗后1、3、7 d,比较两组肛周疼痛和水肿评分,比较两组治疗前及治疗后2周肛门狭窄情况、血清炎症因子水平,记录两组不良反应发生情况。结果治疗后3、7 d,两组肛周疼痛和水肿评分均低于治疗后1 d,治疗后7 d低于治疗后3 d,试验组治疗后1、3、7 d肛周疼痛和水肿评分低于同期对照组(P<0.05)。试验组肛门狭窄率低于对照组(P<0.05)。治疗后2周,两组肛门功能评分高于治疗前,且试验组高于对照组(P<0.05)。治疗后2周,两组白细胞计数、血清降钙素原水平均低于治疗前,且试验组低于对照组(P<0.05)。试验组不良反应总发生率低于对照组(P<0.05)。结论外剥内扎术加内痔柱状缝扎悬吊联合痔科生肌散治疗环状混合痔的临床效果较好,可在临床上推广使用。

紫冰疮愈膏外敷对混合痔外剥内扎术后创面的影响

目的观察紫冰疮愈膏外敷对混合痔外剥内扎术后创面的影响。方法将70例混合痔患者随机分为观察组和对照组,每组35例。术后两组患者均接受抗感染、止痛等对症治疗,观察组、对照组患者分别加用紫冰疮愈膏、肛泰软膏换药。术后1、4、7、14 d,分别检测两组患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)水平,采用视觉模拟量表(visual analogue scale,VAS)评估创面疼痛程度,观察创面分泌物、创缘水肿、肉芽组织生长情况和创面愈合情况。结果术后4、7、14 d,观察组患者血清VEGF水平均显著高于对照组(P<0.05);观察组患者创面疼痛VAS评分、创面分泌物评分、创面肉芽组织生长情况评分、创缘水肿评分、创面面积少于对照组(P>0.05)或显著少于对照组(P<0.05)。结论紫冰疮愈膏外敷可减轻混合痔外剥内扎术后创面疼痛,减少创面分泌物,减轻创缘水肿,促进肉芽组织生长和创面愈合。

中药痔科止血方治疗湿热下注型混合痔的临床效果

目的探究中药痔科止血方治疗湿热下注型混合痔的临床效果。方法选取2022年1月至2023年5月我院肛肠科收治的80例湿热下注型混合痔患者作为研究对象,将其随机分为治疗组和对照组,每组40例。两组均在小剂量腰麻下行混合痔内痔结扎外痔切除术,治疗组术后口服痔科止血方,对照组为空白对照。比较两组的治疗效果。结果术前、术后第5天,两组的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)及凝血酶时间(TT)无显著差异(P>0.05)。治疗组的术后第3、5天出血评分低于对照组,出血停止时间短于对照组(P<0.05)。术后第3、5天,治疗组的视觉模拟评分法(VAS)评分低于对照组(P<0.05)。治疗组的治疗总有效率高于对照组(P<0.05)。结论中药痔科止血方治疗湿热下注型混合痔效果明确,不仅能有效缓解术后早期肛门疼痛,还能减少出血量,促进创面快速恢复。

布比卡因+亚甲蓝混合液肛周封闭联合中药熏蒸对混合痔嵌顿术后的效果观察

目的:探究布比卡因+亚甲蓝混合液肛周封闭术联合中药熏蒸对混合痔嵌顿术后的效果。方法:2022年8月—2023年8月选取于九江市第一人民医院行手术治疗的混合痔嵌顿患者80例,用随机抽签法分为对照组(行中药熏蒸治疗)与观察组(行布比卡因+亚甲蓝混合液肛周封闭联合中药熏蒸治疗),各40例。比较两组临床疗效、疼痛程度、肛门功能、术后并发症。结果:与对照组(75.00%)比较,观察组总有效率(92.50%)显著更高(P<0.05)。术后24 h及治疗14 d后,两组视觉模拟评分法评分均较术前显著降低,且观察组[(3.39±0.87)、(1.82±0.56)分]较对照组[(4.27±1.03)、(2.37±0.70)分]均显著更低(P<0.05)。术后1个月,两组肛管最大收缩压、肛管静息压均升高,肛管高压带均缩短,且与对照组[(112.36±10.87)mmHg、(51.11±4.25)mmHg、(2.94±0.36)cm]比较,观察组肛管最大收缩压[(119.48±11.31)mmHg]、肛管静息压[(54.56±4.39)mmHg]均显著更高,肛管高压带[(2.71±0.28)cm]显著更短(P<0.05)。与对照组(27.50%)比较,观察组术后并发症发生率(10.00%)显著更低(P<0.05)。结论:布比卡因+亚甲蓝混合液肛周封闭联合中药熏蒸可减轻混合痔嵌顿患者术后疼痛,改善肛门功能,降低术后并发症发生率,促进患者术后恢复。

消胀止痛锭治疗混合痔术后肛门坠胀疼痛的临床疗效观察

目的:观察消胀止痛锭治疗混合痔术后肛门坠胀疼痛的临床疗效。方法:选取2021年1月到2022年8月住院患者。将符合纳入标准的120例混合痔术后患者进行随机分组,分为治疗组和对照组,两组患者各60例。治疗组给予消胀止痛锭直肠给药,对照组给予复方角菜酸脂酸直肠给药。比较两组患者术后肛门坠胀、水肿、疼痛、抑郁、焦虑评分,住院时间、手术创面愈合时间、肛门直肠测压、盆底表面肌电图等指标。结果:治疗组术后3、5、7天的肛门水肿、坠胀、疼痛、抑郁、焦虑评分均较对照组明显缓解(P<0.01),治疗组的住院时间较对照组减少(P<0.05),治疗组的伤口愈合时间较对照组明显缩短(P<0.01),治疗组患者术前与术后盆底肌电图和肛门直肠压力未发生明显变化(P>0.05),其中对照组在术后的初始感觉、最大耐受以及排便感觉阈值较术前增高(P<0.01),肛管长度增加(P<0.05),力排时直肠收缩压明显降低(P<0.01)。表面肌电图测量中,治疗组患者术后7天与术前相比较差异无统计学意义(P>0.05),对照组术后7天盆底肌力较术前比较则有明显的降低(P<0.01)。结论:消胀止痛锭直肠给药对混合痔术后肛门坠胀疼痛有明显疗效,能缓解混合痔术后患者焦虑紧张的情绪,缩短了住院时间,促进了术后创面的愈合,未见明显不良反应,操作简便,值得临床推广应用。

情绪释放疗法联合药物缓解混合痔手术病人术后疼痛的效果观察

目的:探讨对混合痔手术病人采取情绪释放疗法联合药物干预的临床应用价值及对缓解其术后疼痛的效果。方法:选取2021年1月—2022年12月我院收治的混合痔手术病人70例,随机分为对照组及研究组,各35例。对照组采取常规药物干预,研究组采取情绪释放疗法联合药物干预。比较两组术后不同时点的疼痛水平、疼痛缓解效果、凝血指标、并发症发生情况。结果:研究组术后24 h、36 h、72 h、7 d疼痛视觉模拟评分(VAS)均低于对照组(P<0.05);研究组疼痛缓解总有效率高于对照组(P<0.05);研究组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)均长于对照组(P<0.05);研究组术后并发症发生率低于对照组(P<0.05)。结论:对混合痔手术病人采取情绪释放疗法联合药物干预,术后疼痛缓解效果显著,可改善凝血功能,减少并发症,促进术后康复。

选择性痔上黏膜切除吻合术治疗Ⅲ度混合痔的5-HT、PGE2及IL-6水平变化及疗效

目的 分析选择性痔上黏膜切除吻合术(TST)治疗Ⅲ度混合痔的神经递质及5-羟色胺(5-HT)、前列腺素E2(PGE2)及白介素-6(IL-6)水平变化及临床疗效。方法 本研究采用单中心回顾性研究方法,收集2020年5月至2023年1月大连市中心医院收治的108例Ⅲ度混合痔患者,依据治疗方式分为对照组[n=53,予吻合器痔上黏膜环切术(PPH)治疗]和观察组(n=55,予TST治疗)。对比两组临床疗效、围手术期指标(手术时长、术中出血量、住院时间、术后首次排便时间、术后卧床时间)、5-HT、PGE2、炎性因子[IL-6、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平]、肛肠动力学指标[直肠感知阈值(RSTV)、肛管静息压(RASP)、直肠最大容量阈值(RMTV)]及并发症发生率。结果 观察组临床总有效率(94.55%)比对照组(81.13%)高,差异有统计学意义(P<0.05);观察组术后首次排便时间、手术时长、术后卧床时间及住院时间比对照组短,术中出血量比对照组少,差异有统计学意义(P<0.05);治疗后,两组5-HT、PGE2水平均下降,且观察组比对照组低,差异有统计学意义(P<0.05);治疗后,两组IL-6、CRP、TNF-α水平均下降,且观察组比对照组低,差异有统计学意义(P<0.05);治疗后,观察组RSTV、RMTV比对照组高,RASP比对照组低,差异有统计学意义(P<0.05);观察组并发症总发生率(7.28%)比对照组(20.75%)低,差异有统计学意义(P<0.05)。结论 采用TST治疗Ⅲ度混合痔患者疗效更显著,明显改善了患者围术期指标,降低了患者5-HT、PGE2及IL-6、TNF-α、CRP炎性因子水平,降低术后并发症发生率,利于术后恢复。