AIM:To explore the risk factors of oculomotor nerve palsy(ONP)in patients with intracranial aneurysm(IA)and develop a nomogram model for predicting ONP of IA patients.METHODS:A total of 329 IA patients were included.L...AIM:To explore the risk factors of oculomotor nerve palsy(ONP)in patients with intracranial aneurysm(IA)and develop a nomogram model for predicting ONP of IA patients.METHODS:A total of 329 IA patients were included.Logistic regression analysis was applied to identify independent factors,which were then integrated into the nomogram model.The performance of the nomogram model was evaluated by calibration cur ve,receiver operating curve(ROC),and decision curve analysis.RESULTS:Univariate and multivariate logistic regression analysis indicated posterior communicating artery(PCo A)aneur ysm[hazard ratio(HR)=17.13,P<0.001]and aneurysm diameter(HR=1.31,P<0.001)were independent risk factors of ONP in IA patients.Based on the results of logistic regression analysis,a nomogram model for predicting the ONP in IA patients was constructed.The calibration curve indicated the nomogram had a good agreement between the predictions and observations.The nomogram showed a high predictive accuracy and discriminative ability with an area under the curve(AUC)of 0.863.The decision curve analysis showed that the nomogram was powerful in the clinical decision.PCo A aneurysm(HR=3.38,P=0.015)was identified to be the only independent risk factor for ONP severity.CONCLUSION:PCo A aneurysm and aneurysm diameter are independent risk factors of ONP in IA patients.The nomogram established is performed reliably and accurately for predicting ONP.PCo A aneurysm is the only independent risk factor for ONP severity.展开更多
BACKGROUND Aneurysm compression,diabetes,and traumatic brain injury are well-known causative factors of oculomotor nerve palsy(ONP),while cases of ONP induced by neurovascular conflicts have rarely been reported in th...BACKGROUND Aneurysm compression,diabetes,and traumatic brain injury are well-known causative factors of oculomotor nerve palsy(ONP),while cases of ONP induced by neurovascular conflicts have rarely been reported in the medical community.Here,we report a typical case of ONP caused by right posterior cerebral artery(PCA)compression to increase neurosurgeons’awareness of the disease and reduce misdiagnosis and recurrence.CASE SUMMARY A 54-year-old man without a known medical history presented with right ONP for the past 5 years.The patient presented to the hospital with right ptosis,diplopia,anisocoria(rt 5 mm,lt 2.5 mm),loss of duction in all directions,abduction,and light impaired pupillary reflexes.Magnetic resonance angiography and computed tomography venography examinations showed no phlebangioma,aneurysm,or intracranial lesion.After conducting oral glucose tolerance and prostigmin tests,diabetes and myasthenia gravis were excluded.Cranial nerve magnetic resonance imaging showed that the right PCA loop was in direct contact with the cisternal segment of the right oculomotor nerve(ON).Microvascular decompression(MVD)of the culprit vessel from the ON through a right subtemporal craniotomy was carried out,and the ONP symptoms were significantly relieved after 3 mo.CONCLUSION Vascular compression of the ON is a rare pathogeny of ONP that may be refractory to drug therapy and ophthalmic strabismus surgery.MVD is an effective treatment for ONP induced by neurovascular compression.展开更多
目的:分析显微夹闭与介入栓塞治疗伴动眼神经麻痹(oculomotor never palsy,ONP)的颈内-后交通动脉瘤(internal carotid-posterior communication artery aneurysm,IC-PcomA)患者术后ONP恢复情况,并对影响ONP恢复因素进行分析。方法:回...目的:分析显微夹闭与介入栓塞治疗伴动眼神经麻痹(oculomotor never palsy,ONP)的颈内-后交通动脉瘤(internal carotid-posterior communication artery aneurysm,IC-PcomA)患者术后ONP恢复情况,并对影响ONP恢复因素进行分析。方法:回顾性分析重庆医科大学附属第一医院神经外科50例伴ONP的IC-PcomA患者,其中行显微夹闭手术37例,介入栓塞治疗13例,对不同手术后3个月、6个月后ONP恢复程度进行对比。并对患者年龄、性别、高血压、糖尿病、动脉瘤有无破裂、治疗间隔、麻痹程度、动脉瘤直径、Hunt-Hess分级、手术方式与术后ONP恢复程度进行多因素logistic回归分析。结果:单因素分析术前各因素,治疗间隔对ONP术后恢复有统计学意义(P<0.05);再进行logistic回归分析,治疗间隔是术后恢复的独立影响因素(P<0.05),OR为0.134(0.034,0.528),回归系数为-2.009,治疗间隔与治疗效果呈负相关,其余因素未见明显统计学差异(P>0.05)。术后3个月时,夹闭组OPN的完全恢复率(62.16%)高于介入组(38.46%),夹闭组部分恢复率(27.03%)较介入组(46.15%)低,2组比较无统计学差异(P>0.05),手术6个月后夹闭组的完全恢复率(75.68%)高于介入组(61.54%),夹闭组部分恢复率(13.51%)低于介入组(23.08%),2组比较无统计学差异(P>0.05)。结论:显微夹闭和介入栓塞均能有效改善IC-PcomA的ONP症状,总体恢复情况无统计学差异(P>0.05)。治疗间隔是术后ONP完全恢复的独立影响因素,治疗间隔越短,完全恢复率越高。展开更多
基金Supported by National Natural Science Foundation of China(No.81970822)。
文摘AIM:To explore the risk factors of oculomotor nerve palsy(ONP)in patients with intracranial aneurysm(IA)and develop a nomogram model for predicting ONP of IA patients.METHODS:A total of 329 IA patients were included.Logistic regression analysis was applied to identify independent factors,which were then integrated into the nomogram model.The performance of the nomogram model was evaluated by calibration cur ve,receiver operating curve(ROC),and decision curve analysis.RESULTS:Univariate and multivariate logistic regression analysis indicated posterior communicating artery(PCo A)aneur ysm[hazard ratio(HR)=17.13,P<0.001]and aneurysm diameter(HR=1.31,P<0.001)were independent risk factors of ONP in IA patients.Based on the results of logistic regression analysis,a nomogram model for predicting the ONP in IA patients was constructed.The calibration curve indicated the nomogram had a good agreement between the predictions and observations.The nomogram showed a high predictive accuracy and discriminative ability with an area under the curve(AUC)of 0.863.The decision curve analysis showed that the nomogram was powerful in the clinical decision.PCo A aneurysm(HR=3.38,P=0.015)was identified to be the only independent risk factor for ONP severity.CONCLUSION:PCo A aneurysm and aneurysm diameter are independent risk factors of ONP in IA patients.The nomogram established is performed reliably and accurately for predicting ONP.PCo A aneurysm is the only independent risk factor for ONP severity.
基金Supported by National Natural Science Foundation of China,No.32070791the Key Scientific Research Projects of Military Logistics,No.BWJ20J002.
文摘BACKGROUND Aneurysm compression,diabetes,and traumatic brain injury are well-known causative factors of oculomotor nerve palsy(ONP),while cases of ONP induced by neurovascular conflicts have rarely been reported in the medical community.Here,we report a typical case of ONP caused by right posterior cerebral artery(PCA)compression to increase neurosurgeons’awareness of the disease and reduce misdiagnosis and recurrence.CASE SUMMARY A 54-year-old man without a known medical history presented with right ONP for the past 5 years.The patient presented to the hospital with right ptosis,diplopia,anisocoria(rt 5 mm,lt 2.5 mm),loss of duction in all directions,abduction,and light impaired pupillary reflexes.Magnetic resonance angiography and computed tomography venography examinations showed no phlebangioma,aneurysm,or intracranial lesion.After conducting oral glucose tolerance and prostigmin tests,diabetes and myasthenia gravis were excluded.Cranial nerve magnetic resonance imaging showed that the right PCA loop was in direct contact with the cisternal segment of the right oculomotor nerve(ON).Microvascular decompression(MVD)of the culprit vessel from the ON through a right subtemporal craniotomy was carried out,and the ONP symptoms were significantly relieved after 3 mo.CONCLUSION Vascular compression of the ON is a rare pathogeny of ONP that may be refractory to drug therapy and ophthalmic strabismus surgery.MVD is an effective treatment for ONP induced by neurovascular compression.
文摘目的:分析显微夹闭与介入栓塞治疗伴动眼神经麻痹(oculomotor never palsy,ONP)的颈内-后交通动脉瘤(internal carotid-posterior communication artery aneurysm,IC-PcomA)患者术后ONP恢复情况,并对影响ONP恢复因素进行分析。方法:回顾性分析重庆医科大学附属第一医院神经外科50例伴ONP的IC-PcomA患者,其中行显微夹闭手术37例,介入栓塞治疗13例,对不同手术后3个月、6个月后ONP恢复程度进行对比。并对患者年龄、性别、高血压、糖尿病、动脉瘤有无破裂、治疗间隔、麻痹程度、动脉瘤直径、Hunt-Hess分级、手术方式与术后ONP恢复程度进行多因素logistic回归分析。结果:单因素分析术前各因素,治疗间隔对ONP术后恢复有统计学意义(P<0.05);再进行logistic回归分析,治疗间隔是术后恢复的独立影响因素(P<0.05),OR为0.134(0.034,0.528),回归系数为-2.009,治疗间隔与治疗效果呈负相关,其余因素未见明显统计学差异(P>0.05)。术后3个月时,夹闭组OPN的完全恢复率(62.16%)高于介入组(38.46%),夹闭组部分恢复率(27.03%)较介入组(46.15%)低,2组比较无统计学差异(P>0.05),手术6个月后夹闭组的完全恢复率(75.68%)高于介入组(61.54%),夹闭组部分恢复率(13.51%)低于介入组(23.08%),2组比较无统计学差异(P>0.05)。结论:显微夹闭和介入栓塞均能有效改善IC-PcomA的ONP症状,总体恢复情况无统计学差异(P>0.05)。治疗间隔是术后ONP完全恢复的独立影响因素,治疗间隔越短,完全恢复率越高。
