The postmortem redistribution of aconitine(AC) and its influencing factors by orally ingested Aconitum brachypodum Diels (AbD) in rabbits were studied. The results showed that postmortem AC redistribution did exist, a...The postmortem redistribution of aconitine(AC) and its influencing factors by orally ingested Aconitum brachypodum Diels (AbD) in rabbits were studied. The results showed that postmortem AC redistribution did exist, and the diffusion along a concentration gradient was the major influencing factor on it. Change of temperature and incomplete distribution in life also influenced it.Besides those mentioned above, there were other influencing factors. These may be related to postmortem blood movement and toxin released from cells occurring as part of the processes of autolysis and putrefaction.展开更多
The concepts of postmortem redistribution(PMR,F)factor,and“theoretical”PMR(Ft)–based upon a drug’s characteristic L/P ratio–have been defined to express the direct relationship between postmortem peripheral blood...The concepts of postmortem redistribution(PMR,F)factor,and“theoretical”PMR(Ft)–based upon a drug’s characteristic L/P ratio–have been defined to express the direct relationship between postmortem peripheral blood and the corresponding antemortem whole-blood concentration.This paper applies recent data describing liver/peripheral blood(L/P)ratios for many commonly detected drugs to assess these models,and provide a ranking of drugs’propensity for(and degree of)PMR.展开更多
文摘The postmortem redistribution of aconitine(AC) and its influencing factors by orally ingested Aconitum brachypodum Diels (AbD) in rabbits were studied. The results showed that postmortem AC redistribution did exist, and the diffusion along a concentration gradient was the major influencing factor on it. Change of temperature and incomplete distribution in life also influenced it.Besides those mentioned above, there were other influencing factors. These may be related to postmortem blood movement and toxin released from cells occurring as part of the processes of autolysis and putrefaction.
文摘The concepts of postmortem redistribution(PMR,F)factor,and“theoretical”PMR(Ft)–based upon a drug’s characteristic L/P ratio–have been defined to express the direct relationship between postmortem peripheral blood and the corresponding antemortem whole-blood concentration.This paper applies recent data describing liver/peripheral blood(L/P)ratios for many commonly detected drugs to assess these models,and provide a ranking of drugs’propensity for(and degree of)PMR.
