The inducing effect of potassium citrate （K3cit） on simultaneous growth of calcium oxalate mono-（COM）, di-（COD）, and trihydrate （COT） crystals in synthetic urine was observed with double diffusion gelatinous t...The inducing effect of potassium citrate （K3cit） on simultaneous growth of calcium oxalate mono-（COM）, di-（COD）, and trihydrate （COT） crystals in synthetic urine was observed with double diffusion gelatinous technique. K3cit can induce the formation of COD and COT, inhibit the aggregation and decrease the surface area of COM crystals. It supported the clinical use of K3cit and may provide important clues to this disease in cure and in search for new drugs.展开更多
Background: A very strict control of urinary pH is recommended to maintain it between 5.5 and 6.2, preventing formation or recurrence of crystals. Kidney stones are a common problem, with a high rate of recurrence, no...Background: A very strict control of urinary pH is recommended to maintain it between 5.5 and 6.2, preventing formation or recurrence of crystals. Kidney stones are a common problem, with a high rate of recurrence, not altered by the success of surgery. Medical treatment prevents recurrence. Potassium Citrate inhibits crystallization of calcium salts. It influences calculogenesis by increasing urinary citrates and alkalinizing the urine. Purpose: to evaluate the similarity in the effect of three K citrate products, K citrate reference product Urocit®10 mEq, and K citrate from Laboratorios LETI S.A.V., 10 mEq and 15 mEq, on urinary pH. Materials and Methods: We carried out a prospective, randomized study of three parallel groups. We admitted female and male patients with history of kidney stones or evidence of lithiasis (grit, microlithiasis) in the renal echosonogram. Laboratory assessments: urine, 24-hour urine, urinary pH, Calcium, uric acid, Phosphorus, Sodium, protein and urinary creatinine at times: start, day 7, day 21, 30 of treatment. Results: all three products produced a slight increase in urinary pH in the simple urine test and 24-hour urine, with no differences between groups or their logarithmically transformed means and their CI95, which did not exceed the range between 80% and 125%. Conclusions: K Citrate, 10 mEq and 7.5 mEq, from Laboratorios LETI, S.A.V., at a dose of 30 mEq daily in patients with history of kidney stones are equivalent to the reference product Urocit®, in its effects on urinary pH in 24-hour urine, and in the simple urine test.展开更多
To prepare potassium titanate catalyst, a novel citrate acid complex-combustion method using CH3COOK and Ti(OC4H9 ) 4 as raw materials was developed. The crystalline phase and surface morphology of K2Ti2O5 were invest...To prepare potassium titanate catalyst, a novel citrate acid complex-combustion method using CH3COOK and Ti(OC4H9 ) 4 as raw materials was developed. The crystalline phase and surface morphology of K2Ti2O5 were investigated by X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM) and transmission electron microscope (TEM). The impact of some factors, such as the type of contact between K2Ti2O5 and soot, the content of water vapor and SO2 in exhaust, and the repeated use on catalytic activity of K2Ti2O5 were studied by temperature programmed reaction (TPR). A comparison between the new method and the reported ones on catalytic activity of potassium titanate was investigated. The results showed that K2Ti2O5 had high catalytic activity and good stability.展开更多
Background In 2008, a sharp increase of the number of children diagnosed with urinary calculi was observed in China, 9433 children were diagnosed as having melamine-induced urinary calculi at outpatient clinic in Beij...Background In 2008, a sharp increase of the number of children diagnosed with urinary calculi was observed in China, 9433 children were diagnosed as having melamine-induced urinary calculi at outpatient clinic in Beijing Children＇s Hospital. This study examined the therapeutic efficacy of potassium sodium hydrogen citrate （PSHC） used to treat melamine-induced urinary stones in Chinese children who consumed melamine-containing infant formula. Methods Seventy-two infants and children （average age （18.2±7.7） months） who were diagnosed with urinary calculi were icuidomly divided into three treatment groups using the SAS Plan program. Group 1 was given a low dose （1 g/d） of PSHC, group 2 was given high dose of PSHC （2 g/d） and group 3 was given no PSHC （control group）. The dose of drug was adjusted according to the baseline urinary pH. This study analyzed the influence of the dose of PSHC, the age of patients, stone size and position, and urinary pH on the level of efficacy of PSHC （cured, effectively treated or not cured）.Results After 1-6 months of therapy, 19 patients from group 1, five patients from group 2 and six patients from group 3 were cured. Five patients from group 1, five patients from group 2 and four patients from group 3 were effectively treated. There were significant differences in therapeutic efficacy between the two treatment doses after 3 and 6 months as measured by the increase in the successful expulsion rate and time of melamine-induced urinary calculi. After 6 months the mean time of expulsion of urinary calculi in groups 1 and 2 was significantly shorter than in the control group. Conclusions PSHC can significantly increase the successful expulsion rate and time of melamine-induced urinary calculi. The therapeutic efficacy is affected by PSHC dose, treatment duration, calculi position, and urinary pH. There is no relationship between the therapeutic efficacy and the stone size or patient age.展开更多
目的:研究经筋微创痛风石切除术联合枸橼酸氢钾钠应用于巨大痛风石患者中的效果及对神经体液的影响。方法:选取安宁市第一人民医院从2020年11月~2022年4月收治的213例巨大痛风石患者作为研究对象。将其以电脑编号奇偶数字法随机分作研究...目的:研究经筋微创痛风石切除术联合枸橼酸氢钾钠应用于巨大痛风石患者中的效果及对神经体液的影响。方法:选取安宁市第一人民医院从2020年11月~2022年4月收治的213例巨大痛风石患者作为研究对象。将其以电脑编号奇偶数字法随机分作研究组(n=107)及对照组(n=106)。对照组选用传统手术联合枸橼酸氢钾钠治疗,研究组则选用经筋微创痛风石切除术联合枸橼酸氢钾钠治疗。对比两组疗效,疼痛程度及关节功能,肾功能指标水平,神经体液因子水平。结果:研究组治疗总有效率高于对照组(97.19%vs 86.79%,P<0.05)。术后两组视觉模拟评分法(visual analogue scale,VAS)评分均低于术前,而美国特种外科医院(Hospital for Special Surgery,HSS)评分均高于术前;且研究组VAS评分低于对照组,而HSS评分高于对照组(均P<0.05)。术后两组各项肾功能指标水平均低于术前,且研究组低于对照组(均P<0.05)。术后两组各项神经体液因子水平均高于术前,但研究组低于对照组(均P<0.05)。结论:经筋微创痛风石切除术联合枸橼酸氢钾钠治疗巨大痛风石的效果较佳,可有效改善患者疼痛程度、关节功能、肾功能及神经体液因子水平。展开更多
基金This research work was granted by the National Natural Science Foundation of China （No 20471024）.
文摘The inducing effect of potassium citrate （K3cit） on simultaneous growth of calcium oxalate mono-（COM）, di-（COD）, and trihydrate （COT） crystals in synthetic urine was observed with double diffusion gelatinous technique. K3cit can induce the formation of COD and COT, inhibit the aggregation and decrease the surface area of COM crystals. It supported the clinical use of K3cit and may provide important clues to this disease in cure and in search for new drugs.
文摘Background: A very strict control of urinary pH is recommended to maintain it between 5.5 and 6.2, preventing formation or recurrence of crystals. Kidney stones are a common problem, with a high rate of recurrence, not altered by the success of surgery. Medical treatment prevents recurrence. Potassium Citrate inhibits crystallization of calcium salts. It influences calculogenesis by increasing urinary citrates and alkalinizing the urine. Purpose: to evaluate the similarity in the effect of three K citrate products, K citrate reference product Urocit®10 mEq, and K citrate from Laboratorios LETI S.A.V., 10 mEq and 15 mEq, on urinary pH. Materials and Methods: We carried out a prospective, randomized study of three parallel groups. We admitted female and male patients with history of kidney stones or evidence of lithiasis (grit, microlithiasis) in the renal echosonogram. Laboratory assessments: urine, 24-hour urine, urinary pH, Calcium, uric acid, Phosphorus, Sodium, protein and urinary creatinine at times: start, day 7, day 21, 30 of treatment. Results: all three products produced a slight increase in urinary pH in the simple urine test and 24-hour urine, with no differences between groups or their logarithmically transformed means and their CI95, which did not exceed the range between 80% and 125%. Conclusions: K Citrate, 10 mEq and 7.5 mEq, from Laboratorios LETI, S.A.V., at a dose of 30 mEq daily in patients with history of kidney stones are equivalent to the reference product Urocit®, in its effects on urinary pH in 24-hour urine, and in the simple urine test.
基金the financial supports provided for this research by the Education Department of Liaoning Province of China(No.2009T061)the Ministry of Education of China(No.[2010]1561)
文摘To prepare potassium titanate catalyst, a novel citrate acid complex-combustion method using CH3COOK and Ti(OC4H9 ) 4 as raw materials was developed. The crystalline phase and surface morphology of K2Ti2O5 were investigated by X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM) and transmission electron microscope (TEM). The impact of some factors, such as the type of contact between K2Ti2O5 and soot, the content of water vapor and SO2 in exhaust, and the repeated use on catalytic activity of K2Ti2O5 were studied by temperature programmed reaction (TPR). A comparison between the new method and the reported ones on catalytic activity of potassium titanate was investigated. The results showed that K2Ti2O5 had high catalytic activity and good stability.
文摘Background In 2008, a sharp increase of the number of children diagnosed with urinary calculi was observed in China, 9433 children were diagnosed as having melamine-induced urinary calculi at outpatient clinic in Beijing Children＇s Hospital. This study examined the therapeutic efficacy of potassium sodium hydrogen citrate （PSHC） used to treat melamine-induced urinary stones in Chinese children who consumed melamine-containing infant formula. Methods Seventy-two infants and children （average age （18.2±7.7） months） who were diagnosed with urinary calculi were icuidomly divided into three treatment groups using the SAS Plan program. Group 1 was given a low dose （1 g/d） of PSHC, group 2 was given high dose of PSHC （2 g/d） and group 3 was given no PSHC （control group）. The dose of drug was adjusted according to the baseline urinary pH. This study analyzed the influence of the dose of PSHC, the age of patients, stone size and position, and urinary pH on the level of efficacy of PSHC （cured, effectively treated or not cured）.Results After 1-6 months of therapy, 19 patients from group 1, five patients from group 2 and six patients from group 3 were cured. Five patients from group 1, five patients from group 2 and four patients from group 3 were effectively treated. There were significant differences in therapeutic efficacy between the two treatment doses after 3 and 6 months as measured by the increase in the successful expulsion rate and time of melamine-induced urinary calculi. After 6 months the mean time of expulsion of urinary calculi in groups 1 and 2 was significantly shorter than in the control group. Conclusions PSHC can significantly increase the successful expulsion rate and time of melamine-induced urinary calculi. The therapeutic efficacy is affected by PSHC dose, treatment duration, calculi position, and urinary pH. There is no relationship between the therapeutic efficacy and the stone size or patient age.
文摘目的:研究经筋微创痛风石切除术联合枸橼酸氢钾钠应用于巨大痛风石患者中的效果及对神经体液的影响。方法:选取安宁市第一人民医院从2020年11月~2022年4月收治的213例巨大痛风石患者作为研究对象。将其以电脑编号奇偶数字法随机分作研究组(n=107)及对照组(n=106)。对照组选用传统手术联合枸橼酸氢钾钠治疗,研究组则选用经筋微创痛风石切除术联合枸橼酸氢钾钠治疗。对比两组疗效,疼痛程度及关节功能,肾功能指标水平,神经体液因子水平。结果:研究组治疗总有效率高于对照组(97.19%vs 86.79%,P<0.05)。术后两组视觉模拟评分法(visual analogue scale,VAS)评分均低于术前,而美国特种外科医院(Hospital for Special Surgery,HSS)评分均高于术前;且研究组VAS评分低于对照组,而HSS评分高于对照组(均P<0.05)。术后两组各项肾功能指标水平均低于术前,且研究组低于对照组(均P<0.05)。术后两组各项神经体液因子水平均高于术前,但研究组低于对照组(均P<0.05)。结论:经筋微创痛风石切除术联合枸橼酸氢钾钠治疗巨大痛风石的效果较佳,可有效改善患者疼痛程度、关节功能、肾功能及神经体液因子水平。
