An oxidative tandem(4+2)-cyclization/aromatization of N-aryl glycine derivatives with electron-deficient alkenes was first achieved using Ru(bpy)_(3)Cl_(2) as a photocatalyst and TBHP as an oxidant in combination with...An oxidative tandem(4+2)-cyclization/aromatization of N-aryl glycine derivatives with electron-deficient alkenes was first achieved using Ru(bpy)_(3)Cl_(2) as a photocatalyst and TBHP as an oxidant in combination with visible-light irradiation by blue LEDs.One-electron oxidation and the followingα-deprotonation of glycine derivatives affordα-amino alkyl radicals,which were then trapped by electrophilic maleimides.As an atom-economic and efficient method,a variety of pyrrolo[3,4-c]quinoline-1,3-diones have been obtained in good yields under mild reaction conditions.展开更多
One-pot synthesis of substituted pyrano- and furano[3,2-c]quinoline derivatives from appropriately substituted anilines, substituted benzaldehydes and dienophiles via Povarov reaction catalyzed by HCl-ethanol were rep...One-pot synthesis of substituted pyrano- and furano[3,2-c]quinoline derivatives from appropriately substituted anilines, substituted benzaldehydes and dienophiles via Povarov reaction catalyzed by HCl-ethanol were reported. Good to excellent yields with high diastereoselectivity were obtained in all entries tested.展开更多
基金We thank the National Natural Science Foundation of China(No.21961033)for financially supporting this work.
文摘An oxidative tandem(4+2)-cyclization/aromatization of N-aryl glycine derivatives with electron-deficient alkenes was first achieved using Ru(bpy)_(3)Cl_(2) as a photocatalyst and TBHP as an oxidant in combination with visible-light irradiation by blue LEDs.One-electron oxidation and the followingα-deprotonation of glycine derivatives affordα-amino alkyl radicals,which were then trapped by electrophilic maleimides.As an atom-economic and efficient method,a variety of pyrrolo[3,4-c]quinoline-1,3-diones have been obtained in good yields under mild reaction conditions.
基金Project supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0610000)the National Key R&D Program of China(No.2021YFA1500100)+2 种基金the National Natural Science Foundation of China(Nos.21821002,91956112,22101294)the Science and Technology Commission of Shanghai Municipality of Shanghai(Nos.21ZR1476500,20XD1425100)the Natural Science Foundation of Ningbo(No.2023J035)。
基金the National Natural Science Foundation of China for financial support(Nos.30873137, 30772645 and 81172927)
文摘One-pot synthesis of substituted pyrano- and furano[3,2-c]quinoline derivatives from appropriately substituted anilines, substituted benzaldehydes and dienophiles via Povarov reaction catalyzed by HCl-ethanol were reported. Good to excellent yields with high diastereoselectivity were obtained in all entries tested.
