Through systematic experimental and clinical studies,the physiological regulation of utero-placental circulation and the relation of the disturbance in this acirculation to pathogenic mechanisms of high risk pregnanci...Through systematic experimental and clinical studies,the physiological regulation of utero-placental circulation and the relation of the disturbance in this acirculation to pathogenic mechanisms of high risk pregnancies-Intrauterine Growth Retardation (IUfGR)and Pregnancy-induced hypertension(PIH) were explored.The pharmacological effects and mechanism of a Chinese herbal medicine-Qingxintong in improving the uteroplacental circulation and the therapeutic efficacy in treatment of IUGR and PIH,both accompanied by disturbance of utero-placental circulation.were investigated as well.展开更多
Objective To explore the interactions between pre-pregnancy body mass index(BMI) and age on offspring neuropsychological development from 1 to 24 months in China.Methods In this birth cohort study, a total of 2,253 mo...Objective To explore the interactions between pre-pregnancy body mass index(BMI) and age on offspring neuropsychological development from 1 to 24 months in China.Methods In this birth cohort study, a total of 2,253 mother-child pairs were enrolled in Tianjin, China,between July 2015 and May 2018. The China Developmental Scale for Children was used to assess developmental quotient(DQ) of children aged from 1 to 24 months.Results Mixed-models analysis revealed significant age × pre-pregnancy BMI interactions for total DQ and five neurobehavioral domains(gross motor, fine motor, adaptive, language, and social;P < 0.001).Age × pre-pregnancy BMI ≥ 25 kg/m^2 was associated with a negative effect on total DQ and five neurobehavioral domains, as compared to pre-pregnancy BMI < 25 kg/m^2(P < 0.01). Multiple comparisons showed pre-pregnancy BMI ≥ 25 kg/m^2 of mothers had a positive effect on child total DQ at the age of 1 month but a negative effect at 24 months(P < 0.05).Conclusions This study supported the age × pre-pregnancy BMI interaction on offspring neuropsychological development. It also revealed a short-term positive impact of high pre-pregnancy BMI on neuropsychological development at 1 month of age, but a long-term negative effect(from 1 to24 months).展开更多
Objective To understand the pre-pregnancy health knowledge and service needs among un-pregnant married women in Shanghai. Methods A total of 968 newly-married un-pregnant women in Changqiao, Lingyun sub-districts and ...Objective To understand the pre-pregnancy health knowledge and service needs among un-pregnant married women in Shanghai. Methods A total of 968 newly-married un-pregnant women in Changqiao, Lingyun sub-districts and Huajing town of Xuhui district, Shanghai, were recruited and interviewed by structured questionnaire to collect the information on pre-pregnancy health knowledge and service demands. Results 1） Newly-married women thought the contraceptive methods suitable for them was male condom（84.4%）, followed by oral contraceptives（54%）, emergent contraceptive（52.5%） and contraceptive suppository （48.3%）. 2） The score of pre-pregnancy health knowledge was 54.7±14.5 among the subjects. The participants with junior college or a bachelor had more knowledge than those with junior or senior high school, and those who were engaged in medicine /education/science field had higher score. 3） They had higher knowing rate on the common knowledge, and the rate was above 80%. But the knowing rate on the knowledge of birth defect was low, and all below 50%. 4）A proportion of 52. 7% of the respondents knew that there was a station for reproductive health service in their communities, but only 45.5% received the service from the station, 87.0% thought they had insufficient or scarce knowledge, 73.6% planned to consult before pregnancy training courses on preparing pregnancy. and 63.6% were willing to attend the Conclusion The participants had certain pre-pregnancy health knowledge, but still need being improved,＂ in addition, they had higher needs on knowledge and service of birth defect prevention, at the same time they can＇t make full use of the existing reproductive health institution.展开更多
Background/Aims: Obesity along with high prepregnancy body mass index (PP-BMI) is known to cause many adverse pregnancy outcomes. In Thailand, there is not much study showing both the prevalence and complications of t...Background/Aims: Obesity along with high prepregnancy body mass index (PP-BMI) is known to cause many adverse pregnancy outcomes. In Thailand, there is not much study showing both the prevalence and complications of these conditions. The objectives of this study were to estimate the prevalence of prepregnancy overweight and obesity and their impacts on adverse pregnancy outcomes. Methods: This study was a cross sectional study. Data were collected retrospectively from hospital electronic database along with manual retrieval from medical charts and labor records. Data of all delivery women from 1st February 2011 to 31st August 2012 were collected. When excluded cases with incomplete data and those without PP-BMI, 5420 cases were into analysis. Descriptive and inferential data analyses were used with both univariate and multivariate methods. Results: The proportion of pregnant women with overweight and obesity were 11.1% and 3.9%. After multiple logistic regression analysis was done, women in obesity group were correlated with having 1, 2 and 3 complications. They were also correlated with preeclampsia, gestational diabetes, cesarean section, higher birth weight group and long neonatal length. Conclusions: This Thai prevalence of obesity in pregnancyshould alarm health care providers to be more prepared, for a future health problem of the country. Many complications that come with obese pregnant women that were reported in western countries also happen in Thai population. Decreasing body weight before conception, giving correct health education, well planned pregnancy;antenatal lifestyle intervention and even gestational weight gain restricttion could help avoiding these uneventful morbidities.展开更多
Eugene Nida was a linguist who developed the dynamic-equivalence translation theory.As a comparative literature and transla tion scholar from a younger generation,Edwin Gentzler examines the main points of Nida's ...Eugene Nida was a linguist who developed the dynamic-equivalence translation theory.As a comparative literature and transla tion scholar from a younger generation,Edwin Gentzler examines the main points of Nida's translation theory from a deconstructionist perspective and challenges Nida's authority as a pioneer in the fields of translation theory.The paper analyzes Gentzler's criticism against Nida's work.展开更多
Under the core guideline of creating a reading response that is the same on both sides of the native and target readers,Eugene A.Nida puts his translation theory in form of functional equivalence.Thus translation beco...Under the core guideline of creating a reading response that is the same on both sides of the native and target readers,Eugene A.Nida puts his translation theory in form of functional equivalence.Thus translation becomes a task of reproduction of providing in the target language the closest version that is natural and idiomatic in style,context and semantics.Due to various reasons,creative translations can be made to fulfill that purpose.The second thought and the thorough manipulation of words and expressions help bridge the discrepancy in comprehending the source language and the translated one,whose requirements literal and traditional ways of handling translation may fail to meet.展开更多
目的探讨南平市罕见地中海贫血基因突变类型的分布情况。方法选取2017年1月至2022年12月在南平市妇幼保健院产前诊断中心进行地中海贫血筛查的4962例患者作为研究对象,其中男2435例,女2527例,年龄19~48岁。通过地中海贫血外周血筛查、...目的探讨南平市罕见地中海贫血基因突变类型的分布情况。方法选取2017年1月至2022年12月在南平市妇幼保健院产前诊断中心进行地中海贫血筛查的4962例患者作为研究对象,其中男2435例,女2527例,年龄19~48岁。通过地中海贫血外周血筛查、基因检测、Sanger测序等方法分析患者罕见地中海贫血基因突变类型。结果共检出121例罕见类型地中海贫血基因突变,以α地中海贫血和β地中海贫血为主,分别占50.41%(61/121)和37.19%(45/121)。此外,γ地中海贫血3例,δ地中海贫血10例,αβ复合型地中海贫血2例。共发现57种基因突变类型,以IVS-Ⅱ-55(T>G) in α2为主,占比20.66%(25/121),其次为CD113(T>A) in β( Hb New York)、IVS-Ⅱ-81(C>T) in β 和CD56(G>A) in β (Hb J-Bangkok),分别占4.96%(6/121)、4.96%(6/121)和4.13%(5/121)。发现了多种地中海贫血基因突变类型,包括9种α基因突变[-21G>A in α1、+3(T>C) in α1、CD16(A>C) in α1、CD106(C>G) in α2、IVS-I-9(C>T) in α1、IVS-Ⅱ-17(G>A) in α2、IVS-Ⅱ-35(G>A) in α1、IVS-Ⅱ-88(G>A) in α2、-35T>C in α1合并IVS-Ⅱ-55(T>G) in α2]、7种β基因突变[-96(G>T) in β、IVS-Ⅱ-827(A>T) in β、CD10(C>T) in β合并CD81(C>A) in β、CD17(A>T) in β合并CD56(C>T) inβ、IVS-Ⅱ-81(C>T) in β合并CD56(G>A) in β、IVS-Ⅱ-81 C>T in β合并CD113(T>A) in β、IVS-Ⅱ-806(G>C) in β合并-84(A>G) in β]、3种γ基因突变[-365(G>C) in Aγ合并-352(A>G) in Aγ合并-158(C>T) in Gγ、-158(C>T) in Aγ 合并-158(C>T) in Gγ、-196(C>T) in Aγ]、1 种δ 基因突变[(CD38(C>A) in δ合并CD39(C>A) in δ)]和2种αβ复合型基因突变[IVS-Ⅱ-65(G>A) in α1合并CD 22(A>C) in β、IVS-Ⅱ-55(T>G) in α2合并IVS-Ⅱ-81(C>T) in β]。结论 南平地区人群存在一定比例的罕见类型地中海贫血基因突变情况。罕见类型地中海贫血基因突变的准确检测对本地区人群地中海贫血的临床诊断起到了重要补充作用,可为本地区地中海贫血基因产前诊断、遗传咨询和优生优育提供有价值的参考资料。展开更多
文摘Through systematic experimental and clinical studies,the physiological regulation of utero-placental circulation and the relation of the disturbance in this acirculation to pathogenic mechanisms of high risk pregnancies-Intrauterine Growth Retardation (IUfGR)and Pregnancy-induced hypertension(PIH) were explored.The pharmacological effects and mechanism of a Chinese herbal medicine-Qingxintong in improving the uteroplacental circulation and the therapeutic efficacy in treatment of IUGR and PIH,both accompanied by disturbance of utero-placental circulation.were investigated as well.
基金supported by a grant from the National Natural Science Foundation of China [No.81472967 and No.81602849]Young Elite Scientists Sponsorship Program by CAST [No.2017QNRC001]
文摘Objective To explore the interactions between pre-pregnancy body mass index(BMI) and age on offspring neuropsychological development from 1 to 24 months in China.Methods In this birth cohort study, a total of 2,253 mother-child pairs were enrolled in Tianjin, China,between July 2015 and May 2018. The China Developmental Scale for Children was used to assess developmental quotient(DQ) of children aged from 1 to 24 months.Results Mixed-models analysis revealed significant age × pre-pregnancy BMI interactions for total DQ and five neurobehavioral domains(gross motor, fine motor, adaptive, language, and social;P < 0.001).Age × pre-pregnancy BMI ≥ 25 kg/m^2 was associated with a negative effect on total DQ and five neurobehavioral domains, as compared to pre-pregnancy BMI < 25 kg/m^2(P < 0.01). Multiple comparisons showed pre-pregnancy BMI ≥ 25 kg/m^2 of mothers had a positive effect on child total DQ at the age of 1 month but a negative effect at 24 months(P < 0.05).Conclusions This study supported the age × pre-pregnancy BMI interaction on offspring neuropsychological development. It also revealed a short-term positive impact of high pre-pregnancy BMI on neuropsychological development at 1 month of age, but a long-term negative effect(from 1 to24 months).
文摘Objective To understand the pre-pregnancy health knowledge and service needs among un-pregnant married women in Shanghai. Methods A total of 968 newly-married un-pregnant women in Changqiao, Lingyun sub-districts and Huajing town of Xuhui district, Shanghai, were recruited and interviewed by structured questionnaire to collect the information on pre-pregnancy health knowledge and service demands. Results 1） Newly-married women thought the contraceptive methods suitable for them was male condom（84.4%）, followed by oral contraceptives（54%）, emergent contraceptive（52.5%） and contraceptive suppository （48.3%）. 2） The score of pre-pregnancy health knowledge was 54.7±14.5 among the subjects. The participants with junior college or a bachelor had more knowledge than those with junior or senior high school, and those who were engaged in medicine /education/science field had higher score. 3） They had higher knowing rate on the common knowledge, and the rate was above 80%. But the knowing rate on the knowledge of birth defect was low, and all below 50%. 4）A proportion of 52. 7% of the respondents knew that there was a station for reproductive health service in their communities, but only 45.5% received the service from the station, 87.0% thought they had insufficient or scarce knowledge, 73.6% planned to consult before pregnancy training courses on preparing pregnancy. and 63.6% were willing to attend the Conclusion The participants had certain pre-pregnancy health knowledge, but still need being improved,＂ in addition, they had higher needs on knowledge and service of birth defect prevention, at the same time they can＇t make full use of the existing reproductive health institution.
文摘Background/Aims: Obesity along with high prepregnancy body mass index (PP-BMI) is known to cause many adverse pregnancy outcomes. In Thailand, there is not much study showing both the prevalence and complications of these conditions. The objectives of this study were to estimate the prevalence of prepregnancy overweight and obesity and their impacts on adverse pregnancy outcomes. Methods: This study was a cross sectional study. Data were collected retrospectively from hospital electronic database along with manual retrieval from medical charts and labor records. Data of all delivery women from 1st February 2011 to 31st August 2012 were collected. When excluded cases with incomplete data and those without PP-BMI, 5420 cases were into analysis. Descriptive and inferential data analyses were used with both univariate and multivariate methods. Results: The proportion of pregnant women with overweight and obesity were 11.1% and 3.9%. After multiple logistic regression analysis was done, women in obesity group were correlated with having 1, 2 and 3 complications. They were also correlated with preeclampsia, gestational diabetes, cesarean section, higher birth weight group and long neonatal length. Conclusions: This Thai prevalence of obesity in pregnancyshould alarm health care providers to be more prepared, for a future health problem of the country. Many complications that come with obese pregnant women that were reported in western countries also happen in Thai population. Decreasing body weight before conception, giving correct health education, well planned pregnancy;antenatal lifestyle intervention and even gestational weight gain restricttion could help avoiding these uneventful morbidities.
文摘Eugene Nida was a linguist who developed the dynamic-equivalence translation theory.As a comparative literature and transla tion scholar from a younger generation,Edwin Gentzler examines the main points of Nida's translation theory from a deconstructionist perspective and challenges Nida's authority as a pioneer in the fields of translation theory.The paper analyzes Gentzler's criticism against Nida's work.
文摘Under the core guideline of creating a reading response that is the same on both sides of the native and target readers,Eugene A.Nida puts his translation theory in form of functional equivalence.Thus translation becomes a task of reproduction of providing in the target language the closest version that is natural and idiomatic in style,context and semantics.Due to various reasons,creative translations can be made to fulfill that purpose.The second thought and the thorough manipulation of words and expressions help bridge the discrepancy in comprehending the source language and the translated one,whose requirements literal and traditional ways of handling translation may fail to meet.
文摘目的探讨南平市罕见地中海贫血基因突变类型的分布情况。方法选取2017年1月至2022年12月在南平市妇幼保健院产前诊断中心进行地中海贫血筛查的4962例患者作为研究对象,其中男2435例,女2527例,年龄19~48岁。通过地中海贫血外周血筛查、基因检测、Sanger测序等方法分析患者罕见地中海贫血基因突变类型。结果共检出121例罕见类型地中海贫血基因突变,以α地中海贫血和β地中海贫血为主,分别占50.41%(61/121)和37.19%(45/121)。此外,γ地中海贫血3例,δ地中海贫血10例,αβ复合型地中海贫血2例。共发现57种基因突变类型,以IVS-Ⅱ-55(T>G) in α2为主,占比20.66%(25/121),其次为CD113(T>A) in β( Hb New York)、IVS-Ⅱ-81(C>T) in β 和CD56(G>A) in β (Hb J-Bangkok),分别占4.96%(6/121)、4.96%(6/121)和4.13%(5/121)。发现了多种地中海贫血基因突变类型,包括9种α基因突变[-21G>A in α1、+3(T>C) in α1、CD16(A>C) in α1、CD106(C>G) in α2、IVS-I-9(C>T) in α1、IVS-Ⅱ-17(G>A) in α2、IVS-Ⅱ-35(G>A) in α1、IVS-Ⅱ-88(G>A) in α2、-35T>C in α1合并IVS-Ⅱ-55(T>G) in α2]、7种β基因突变[-96(G>T) in β、IVS-Ⅱ-827(A>T) in β、CD10(C>T) in β合并CD81(C>A) in β、CD17(A>T) in β合并CD56(C>T) inβ、IVS-Ⅱ-81(C>T) in β合并CD56(G>A) in β、IVS-Ⅱ-81 C>T in β合并CD113(T>A) in β、IVS-Ⅱ-806(G>C) in β合并-84(A>G) in β]、3种γ基因突变[-365(G>C) in Aγ合并-352(A>G) in Aγ合并-158(C>T) in Gγ、-158(C>T) in Aγ 合并-158(C>T) in Gγ、-196(C>T) in Aγ]、1 种δ 基因突变[(CD38(C>A) in δ合并CD39(C>A) in δ)]和2种αβ复合型基因突变[IVS-Ⅱ-65(G>A) in α1合并CD 22(A>C) in β、IVS-Ⅱ-55(T>G) in α2合并IVS-Ⅱ-81(C>T) in β]。结论 南平地区人群存在一定比例的罕见类型地中海贫血基因突变情况。罕见类型地中海贫血基因突变的准确检测对本地区人群地中海贫血的临床诊断起到了重要补充作用,可为本地区地中海贫血基因产前诊断、遗传咨询和优生优育提供有价值的参考资料。
